Publications by authors named "Flemming Hansen"

120Publications

A distal regulatory region of a class I human histone deacetylase.

Nat Commun 2020 07 31;11(1):3841. Epub 2020 Jul 31.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.

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July 2020

Multiquantum Chemical Exchange Saturation Transfer NMR to Quantify Symmetrical Exchange: Application to Rotational Dynamics of the Guanidinium Group in Arginine Side Chains.

J Phys Chem Lett 2020 Jul 2;11(14):5649-5654. Epub 2020 Jul 2.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.

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July 2020

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.

Cell Rep 2020 02;30(8):2699-2711.e8

Leicester Institute of Chemical and Molecular Biology, Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 7RH, UK. Electronic address:

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February 2020

Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit.

Bioorg Med Chem Lett 2020 03 9;30(5):126926. Epub 2020 Jan 9.

Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK. Electronic address:

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March 2020

Intra-residue methyl-methyl correlations for valine and leucine residues in large proteins from a 3D-HMBC-HMQC experiment.

J Biomol NMR 2019 Dec 12;73(12):749-757. Epub 2019 Nov 12.

Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.

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December 2019

Determining isoleucine side-chain rotamer-sampling in proteins from C chemical shift.

Chem Commun (Camb) 2019 Dec 23;55(94):14107-14110. Epub 2019 Oct 23.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UKWC1E 6BT.

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December 2019

Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B.

J Org Chem 2019 09 29;84(18):11493-11512. Epub 2019 Aug 29.

Department of Chemistry , University College London , 20 Gordon Street , London WC1H 0AJ , U.K.

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September 2019

Interaction Between the a3 Region of Factor VIII and the TIL'E' Domains of the von Willebrand Factor.

Biophys J 2019 08 11;117(3):479-489. Epub 2019 Jul 11.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom. Electronic address:

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August 2019

Using Deep Neural Networks to Reconstruct Non-uniformly Sampled NMR Spectra.

J Biomol NMR 2019 Nov 10;73(10-11):577-585. Epub 2019 Jul 10.

Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.

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November 2019

Characterising side chains in large proteins by protonless C-detected NMR spectroscopy.

Nat Commun 2019 04 15;10(1):1747. Epub 2019 Apr 15.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK, WC1E 6BT.

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April 2019

Importance of the Force Field Choice in Capturing Functionally Relevant Dynamics in the von Willebrand Factor.

J Phys Chem Lett 2019 Apr 8;10(8):1928-1934. Epub 2019 Apr 8.

Department of Chemistry, Faculty of Maths & Physical Sciences , University College London , London WC1H 0AJ , United Kingdom.

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April 2019

Arginine Side-Chain Hydrogen Exchange: Quantifying Arginine Side-Chain Interactions in Solution.

Chemphyschem 2019 01 24;20(2):252-259. Epub 2018 Sep 24.

Institute of Structural and Molecular Biology Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.

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January 2019

The DnaA Tale.

Front Microbiol 2018 28;9:319. Epub 2018 Feb 28.

Department of Science and Environment, Roskilde University, Roskilde, Denmark.

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February 2018

CPMG Experiments for Protein Minor Conformer Structure Determination.

Methods Mol Biol 2018 ;1688:223-242

TIFR Centre for Interdisciplinary Sciences, 21 Brundavan Colony, Narsingi, Hyderabad, 500075, India.

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July 2018

A C-detected N double-quantum NMR experiment to probe arginine side-chain guanidinium N chemical shifts.

J Biomol NMR 2017 Nov 10;69(3):123-132. Epub 2017 Nov 10.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.

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November 2017

Determining rotational dynamics of the guanidino group of arginine side chains in proteins by carbon-detected NMR.

Chem Commun (Camb) 2017 Sep 25;53(72):10062-10065. Epub 2017 Aug 25.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.

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September 2017

Measurement of N longitudinal relaxation rates in NH spin systems to characterise rotational correlation times and chemical exchange.

J Magn Reson 2017 06;279:91-98

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom. Electronic address:

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June 2017

Interplay of buried histidine protonation and protein stability in prion misfolding.

Sci Rep 2017 04 13;7(1):882. Epub 2017 Apr 13.

Program in Molecular Structure and Function, Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1A8, Canada.

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April 2017