Fiona Powrie

Fiona Powrie

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Fiona Powrie

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TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.

Cell Rep 2019 Sep;28(12):3077-3091.e5

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.050DOI Listing
September 2019

Regulatory T cell adaptation in the intestine and skin.

Nat Immunol 2019 04 19;20(4):386-396. Epub 2019 Mar 19.

University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK.

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http://dx.doi.org/10.1038/s41590-019-0351-zDOI Listing
April 2019

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease.

Immunity 2019 04;50(4):992-1006

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, UK; Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.03.017DOI Listing
April 2019

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.

Immunity 2019 02 23;50(2):432-445.e7. Epub 2019 Jan 23.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, OX3 7FY, UK; Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183056
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http://dx.doi.org/10.1016/j.immuni.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382411PMC
February 2019

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.

Immunity 2019 02 5;50(2):493-504.e7. Epub 2019 Feb 5.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382439PMC
February 2019

Author Correction: Pathogenic stromal cells as therapeutic targets in joint inflammation.

Nat Rev Rheumatol 2019 Jan;15(1):61

NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1038/s41584-018-0134-1DOI Listing
January 2019

Pathogenic stromal cells as therapeutic targets in joint inflammation.

Nat Rev Rheumatol 2018 12;14(12):714-726

NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.

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http://www.nature.com/articles/s41584-018-0112-7
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http://dx.doi.org/10.1038/s41584-018-0112-7DOI Listing
December 2018

Innate Lymphoid Cells: 10 Years On.

Cell 2018 08;174(5):1054-1066

Department of Experimental Immunology Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.cell.2018.07.017DOI Listing
August 2018

Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease.

Gastroenterology 2018 07 9;155(1):231-234. Epub 2018 Jun 9.

Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, UK; Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1053/j.gastro.2018.03.069DOI Listing
July 2018

Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease.

Annu Rev Immunol 2018 04;36:755-781

Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom; email:

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http://www.annualreviews.org/doi/10.1146/annurev-immunol-042
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http://dx.doi.org/10.1146/annurev-immunol-042617-053055DOI Listing
April 2018

polysaccharide induces an anti-inflammatory response in intestinal macrophages.

Microb Cell 2018 Mar 22;5(4):208-211. Epub 2018 Mar 22.

Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.15698/mic2018.04.626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878688PMC
March 2018

Circulating and Tissue-Resident CD4 T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.

Gastroenterology 2017 11 4;153(5):1320-1337.e16. Epub 2017 Aug 4.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.07.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687320PMC
November 2017

Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.

J Crohns Colitis 2017 Sep;11(9):1124-1134

Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/ecco-jcc/jjx050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637950PMC
September 2017

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

Nat Commun 2016 05 19;7:11627. Epub 2016 May 19.

Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1038/ncomms11627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874038PMC
May 2016

Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes.

Sci Rep 2016 Apr 15;6:24491. Epub 2016 Apr 15.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.

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http://dx.doi.org/10.1038/srep24491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832251PMC
April 2016

RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

J Allergy Clin Immunol 2016 Mar 21;137(3):960-3. Epub 2015 Nov 21.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom; National Institute for Health Research, Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.09.048DOI Listing
March 2016

Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

PLoS One 2015 6;10(5):e0124307. Epub 2015 May 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124307PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422593PMC
February 2016

Immunotherapy Not Working? Check Your Microbiota.

Cancer Cell 2015 Dec;28(6):687-689

Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7LF, UK; Translational Gastroenterology Unit, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.11.010DOI Listing
December 2015

Emerging cytokine networks in colorectal cancer.

Nat Rev Immunol 2015 Oct 11;15(10):615-29. Epub 2015 Sep 11.

Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7LF, UK.

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http://dx.doi.org/10.1038/nri3896DOI Listing
October 2015

MICROBIOME. Microbiota RORgulates intestinal suppressor T cells.

Science 2015 Aug;349(6251):929-30

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford OX3 7FY, UK. Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1126/science.aad0865DOI Listing
August 2015

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Authors:
Jenny C Taylor Hilary C Martin Stefano Lise John Broxholme Jean-Baptiste Cazier Andy Rimmer Alexander Kanapin Gerton Lunter Simon Fiddy Chris Allan A Radu Aricescu Moustafa Attar Christian Babbs Jennifer Becq David Beeson Celeste Bento Patricia Bignell Edward Blair Veronica J Buckle Katherine Bull Ondrej Cais Holger Cario Helen Chapel Richard R Copley Richard Cornall Jude Craft Karin Dahan Emma E Davenport Calliope Dendrou Olivier Devuyst Aimée L Fenwick Jonathan Flint Lars Fugger Rodney D Gilbert Anne Goriely Angie Green Ingo H Greger Russell Grocock Anja V Gruszczyk Robert Hastings Edouard Hatton Doug Higgs Adrian Hill Chris Holmes Malcolm Howard Linda Hughes Peter Humburg David Johnson Fredrik Karpe Zoya Kingsbury Usha Kini Julian C Knight Jonathan Krohn Sarah Lamble Craig Langman Lorne Lonie Joshua Luck Davis McCarthy Simon J McGowan Mary Frances McMullin Kerry A Miller Lisa Murray Andrea H Németh M Andrew Nesbit David Nutt Elizabeth Ormondroyd Annette Bang Oturai Alistair Pagnamenta Smita Y Patel Melanie Percy Nayia Petousi Paolo Piazza Sian E Piret Guadalupe Polanco-Echeverry Niko Popitsch Fiona Powrie Chris Pugh Lynn Quek Peter A Robbins Kathryn Robson Alexandra Russo Natasha Sahgal Pauline A van Schouwenburg Anna Schuh Earl Silverman Alison Simmons Per Soelberg Sørensen Elizabeth Sweeney John Taylor Rajesh V Thakker Ian Tomlinson Amy Trebes Stephen Rf Twigg Holm H Uhlig Paresh Vyas Tim Vyse Steven A Wall Hugh Watkins Michael P Whyte Lorna Witty Ben Wright Chris Yau David Buck Sean Humphray Peter J Ratcliffe John I Bell Andrew Om Wilkie David Bentley Peter Donnelly Gilean McVean

Nat Genet 2015 Jul 18;47(7):717-726. Epub 2015 May 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601524PMC
July 2015

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.

Immunity 2015 Jul;43(1):187-99

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, UK; Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613150027
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http://dx.doi.org/10.1016/j.immuni.2015.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518500PMC
July 2015

Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis.

Vaccine 2015 Apr 4;33(15):1808-14. Epub 2015 Mar 4.

The Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.02.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377097PMC
April 2015

The alarmin IL-33 promotes regulatory T-cell function in the intestine.

Nature 2014 Sep 16;513(7519):564-568. Epub 2014 Jul 16.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1038/nature13577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339042PMC
September 2014

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

Gastroenterology 2014 Apr 11;146(4):1028-39. Epub 2014 Jan 11.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002656PMC
April 2014

Controlling the frontier: regulatory T-cells and intestinal homeostasis.

Semin Immunol 2013 Nov 31;25(5):352-7. Epub 2013 Oct 31.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1016/j.smim.2013.09.002DOI Listing
November 2013

Immunology. Feed your Tregs more fiber.

Science 2013 Aug;341(6145):463-4

Translational Gastroenterology Unit, Experimental Medicine Division-NDM, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1126/science.1242674DOI Listing
August 2013

Regulatory T cells and immune tolerance in the intestine.

Cold Spring Harb Perspect Biol 2013 Jul 1;5(7). Epub 2013 Jul 1.

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a018341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685893PMC
July 2013

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.

J Exp Med 2013 May;210(5):917-31

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Headington, Oxford OX3 9DU, UK

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http://dx.doi.org/10.1084/jem.20122308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646494PMC
May 2013

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.

J Immunol 2013 Apr 1;190(7):3235-45. Epub 2013 Mar 1.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7AE, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1201396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607399PMC
April 2013

CD4(+) T-cell subsets in intestinal inflammation.

Immunol Rev 2013 Mar;252(1):164-82

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/imr.12039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736165PMC
March 2013

Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.

Vaccine 2013 Feb 21;31(7):1086-93. Epub 2012 Dec 21.

University of Oxford, The Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.

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http://dx.doi.org/10.1016/j.vaccine.2012.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566543PMC
February 2013

Innate lymphoid cells--a proposal for uniform nomenclature.

Nat Rev Immunol 2013 Feb;13(2):145-9

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nri3365DOI Listing
February 2013

Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation.

Immunity 2012 Dec 29;37(6):1116-29. Epub 2012 Nov 29.

Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.immuni.2012.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664922PMC
December 2012

Gender equality: is it real?

Eur J Immunol 2012 Dec;42(12):3095-6

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December 2012

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

J Exp Med 2012 Jul 25;209(7):1309-24. Epub 2012 Jun 25.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, England, UK.

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http://dx.doi.org/10.1084/jem.20120239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405508PMC
July 2012

Immunology: Malnutrition promotes rogue bacteria.

Nature 2012 Jul 25;487(7408):437-9. Epub 2012 Jul 25.

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http://dx.doi.org/10.1038/487437aDOI Listing
July 2012

Lymphoid microenvironments and innate lymphoid cells in the gut.

Trends Immunol 2012 Jun 10;33(6):289-96. Epub 2012 May 10.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1016/j.it.2012.04.004DOI Listing
June 2012

Microbiota, disease, and back to health: a metastable journey.

Sci Transl Med 2012 Jun;4(137):137rv7

Gastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020897PMC
June 2012

Gut reactions: immune pathways in the intestine in health and disease.

Authors:
Fiona Powrie

EMBO Mol Med 2012 Feb 25;4(2):71-4. Epub 2012 Jan 25.

Experimental Medicine Division, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1002/emmm.201100197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376842PMC
February 2012

Re-establishing immunological self-tolerance in autoimmune disease.

Nat Med 2012 Jan 6;18(1):54-8. Epub 2012 Jan 6.

Laboratory of Experimental Immunology, World Premier Initiative Immunology Frontier Research Center, Osaka University, Suita, Japan.

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http://dx.doi.org/10.1038/nm.2622DOI Listing
January 2012

IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease.

J Exp Med 2011 Jun 16;208(6):1127-33. Epub 2011 May 16.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 9DU, England, UK.

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http://dx.doi.org/10.1084/jem.20101712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173242PMC
June 2011

Intestinal homeostasis and its breakdown in inflammatory bowel disease.

Nature 2011 Jun 15;474(7351):298-306. Epub 2011 Jun 15.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1038/nature10208DOI Listing
June 2011

Immunology. The gut's Clostridium cocktail.

Science 2011 Jan;331(6015):289-90

Translational Gastroenterology Unit, University of Oxford, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1126/science.1201291DOI Listing
January 2011

Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease.

Gastroenterology 2010 Aug 28;139(2):519-29, 529.e1-2. Epub 2010 Apr 28.

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2010.04.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739016PMC
August 2010

An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.

J Exp Med 2010 Aug;207(8):1573-7

Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK.

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http://dx.doi.org/10.1084/jem.20101330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916138PMC
August 2010

Interleukin-23 drives intestinal inflammation through direct activity on T cells.

Immunity 2010 Aug;33(2):279-88

Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK.

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http://dx.doi.org/10.1016/j.immuni.2010.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078329PMC
August 2010

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

Immunity 2010 May 20;32(5):605-15. Epub 2010 May 20.

Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613100016
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http://dx.doi.org/10.1016/j.immuni.2010.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148263PMC
May 2010

OX40 is required for regulatory T cell-mediated control of colitis.

J Exp Med 2010 Apr 5;207(4):699-709. Epub 2010 Apr 5.

Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK.

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http://dx.doi.org/10.1084/jem.20091618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856021PMC
April 2010

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

Nature 2010 Apr;464(7293):1371-5

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1038/nature08949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796764PMC
April 2010

E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.

Immunity 2010 Apr 15;32(4):557-67. Epub 2010 Apr 15.

Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.

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http://dx.doi.org/10.1016/j.immuni.2010.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938478PMC
April 2010

TLR2-independent induction and regulation of chronic intestinal inflammation.

Eur J Immunol 2010 Feb;40(2):516-24

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/eji.200939669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812679PMC
February 2010

Immunology: Dendritic-cell genealogy.

Nature 2009 Dec;462(7274):732-3

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http://dx.doi.org/10.1038/462732aDOI Listing
December 2009

Regulatory T cells reinforce intestinal homeostasis.

Immunity 2009 Sep;31(3):401-11

Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1016/j.immuni.2009.08.011DOI Listing
September 2009

Mouse models of intestinal inflammation as tools to understand the pathogenesis of inflammatory bowel disease.

Eur J Immunol 2009 Aug;39(8):2021-6

Children's Hospital, Section of Paediatric Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1002/eji.200939602DOI Listing
August 2009

Hybrid Treg cells: steel frames and plastic exteriors.

Nat Immunol 2009 Jun;10(6):563-4

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ni0609-563DOI Listing
June 2009

Regulatory lymphocytes and intestinal inflammation.

Annu Rev Immunol 2009 ;27:313-38

Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.

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http://dx.doi.org/10.1146/annurev.immunol.021908.132657DOI Listing
May 2009

Regulatory mechanisms in graft-versus-host responses.

Biol Blood Marrow Transplant 2009 Jan;15(1 Suppl):2-6

Department of Hematology & Oncology, University Hospital Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2008.10.013DOI Listing
January 2009

The interleukin-23 axis in intestinal inflammation.

Immunol Rev 2008 Dec;226:147-59

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00705.xDOI Listing
December 2008

Dendritic cells in intestinal immune regulation.

Nat Rev Immunol 2008 Jun;8(6):435-46

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.

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http://dx.doi.org/10.1038/nri2335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674208PMC
June 2008

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.

Immunity 2008 Apr;28(4):559-70

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.

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http://dx.doi.org/10.1016/j.immuni.2008.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292821PMC
April 2008

Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.

Immunology 2008 Jan;123(1):6-10

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2007.02778.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2433286PMC
January 2008

Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.

J Immunol 2007 Nov;179(10):6836-44

Transcription Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln's Inn Fields Laboratories, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515877PMC
http://dx.doi.org/10.4049/jimmunol.179.10.6836DOI Listing
November 2007

The IL23 axis plays a key role in the pathogenesis of IBD.

Gut 2007 Oct;56(10):1333-6

Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK.

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http://dx.doi.org/10.1136/gut.2006.115402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000291PMC
October 2007

Emerging challenges in regulatory T cell function and biology.

Science 2007 Aug;317(5838):627-9

Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1126/science.1142331DOI Listing
August 2007

FOXP3+ regulatory T cells: Current controversies and future perspectives.

Eur J Immunol 2006 Nov;36(11):2832-6

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1002/eji.200636459DOI Listing
November 2006

Eosinophilic bowel disease controlled by the BB rat-derived lymphopenia/Gimap5 gene.

Gastroenterology 2006 Nov 5;131(5):1475-85. Epub 2006 Oct 5.

The Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1053/j.gastro.2006.09.023DOI Listing
November 2006

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.

J Immunol 2006 Oct;177(7):4376-83

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108417PMC
http://dx.doi.org/10.4049/jimmunol.177.7.4376DOI Listing
October 2006

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

J Exp Med 2006 Oct 9;203(11):2485-94. Epub 2006 Oct 9.

Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20061082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118119PMC
October 2006

Interleukin-23 drives innate and T cell-mediated intestinal inflammation.

J Exp Med 2006 Oct 9;203(11):2473-83. Epub 2006 Oct 9.

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK.

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http://dx.doi.org/10.1084/jem.20061099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118132PMC
October 2006

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.

Immunol Rev 2006 Aug;212:256-71

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/j.0105-2896.2006.00423.xDOI Listing
August 2006

Fueling regulation: IL-2 keeps CD4+ Treg cells fit.

Nat Immunol 2005 Nov;6(11):1071-2

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http://dx.doi.org/10.1038/ni1105-1071DOI Listing
November 2005

The role of mucosal T lymphocytes in regulating intestinal inflammation.

Springer Semin Immunopathol 2005 Sep 15;27(2):167-80. Epub 2005 Jun 15.

Department of Pediatric Gastroenterology, University Children's Hospital, University of Leipzig, Oststrasse 21-25, 04317, Leipzig, Germany.

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http://dx.doi.org/10.1007/s00281-005-0206-6DOI Listing
September 2005

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level.

Eur J Immunol 2005 Jun;35(6):1681-91

Monoclonal Antibodies Unit, Biotechnology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1002/eji.200526189DOI Listing
June 2005

Involvement of innate immunity in the development of inflammatory and autoimmune diseases.

Ann N Y Acad Sci 2005 Jun;1051:787-98

Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 1st Faculty of Medicine, Charles University, Víde-ská 1083, Prague 4, Czech Republic.

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http://dx.doi.org/10.1196/annals.1361.122DOI Listing
June 2005

Regulatory T cells and intestinal homeostasis.

Immunol Rev 2005 Apr;204:184-94

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1111/j.0105-2896.2005.00250.xDOI Listing
April 2005