Publications

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
Neuron 2017 Mar;93(5):1015-1034
Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. Electronic address:

CCT complex restricts neuropathogenic protein aggregation via autophagy.
Nat Commun 2016 Dec 8;7:13821. Epub 2016 Dec 8.
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Nat Commun 2015 Aug 20;6:8045. Epub 2015 Aug 20.
Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.


IGF-1 receptor antagonism inhibits autophagy.
Hum Mol Genet 2013 Nov 25;22(22):4528-44. Epub 2013 Jun 25.
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 2012 Apr;8(4):445-544
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

Lysosomal positioning coordinates cellular nutrient responses.
Nat Cell Biol 2011 Apr 13;13(4):453-60. Epub 2011 Mar 13.
Department of Medical Genetics, Cambridge Institute for Medical Genetics, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.


α-Synuclein impairs macroautophagy: implications for Parkinson's disease.
J Cell Biol 2010 Sep;190(6):1023-37
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK.

Mammalian macroautophagy at a glance.
J Cell Sci 2009 Jun;122(Pt 11):1707-11
Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

Rapamycin alleviates toxicity of different aggregate-prone proteins.
Hum Mol Genet 2006 Feb 20;15(3):433-42. Epub 2005 Dec 20.
Department of Medical Genetics,Cambridge Institute for Medical Research,Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.
Nat Commun 2018 01 17;9(1):256. Epub 2018 Jan 17.
Institute for Cell and Molecular Biosciences (ICaMB), Newcastle University Institute for Ageing (NUIA), Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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