Publications by authors named "Filomena Russo"

39 Publications

New-Onset Psoriasis Developing in Atopic Patient With Prurigo Nodularis After Treatment With Dupilumab.

Dermatitis 2021 Feb 27. Epub 2021 Feb 27.

Department of Medical, Surgical and Neurological Science Dermatology Section, University of Siena, Italy.

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http://dx.doi.org/10.1097/DER.0000000000000740DOI Listing
February 2021

Effect of dupilumab on sleep disturbances in adult patients with severe atopic dermatitis.

Ital J Dermatol Venerol 2021 Jul 20. Epub 2021 Jul 20.

Dermatology Section, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy -

Background: Sleep disturbances are common in patients with atopic dermatitis (AD). Considering their relevant burden on health, routine screening of sleep disturbances seems to be very useful in AD adults management. However, few studies have evaluated the association between sleep disturbances and AD in adults and real-life data are lacking. The aim is to assess the effect of treatment with dupilumab on sleep disturbances in adult patients with severe atopic dermatitis.

Methods: Retrospective, multicenter study including patients (age≥18 yr.s) with severe atopic dermatitis who were treated with dupilumab for at least 8 months from January 2019 to January 2020. Patients were evaluated three times: at treatment initiation (T0) and at 4 (T4) and 8 months (T8) from the start of treatment. At each visit disease activity was assessed by severity score (Eczema Area and Severity Index, EASI), patient-reported outcomes (Pruritus Numerical Rating Scale, NRS, Dermatology Life Quality Index,DLQI, and Pittsburgh Sleep Quality Index, PSQI). Kolmogorov-Smirnov test was performed to evaluate the normality distribution, Bartlett's test for homoscedasticity. Since the assumptions were met, ANOVA for repeated measures was performed to evaluate the mean difference of PSQI, EASI, DLQI and Pruritus NRS between baseline, 4th month and 8th month. In addition, Chi-square for Trend test was performed to evaluate the increasing/decreasing prevalence of poor sleepers.

Results: A total of 36 patients (15 females and 21 males) with a mean age of 42.5±14.3 (range 20-67) were included in the study. The mean score for PSQI at TO was 9.0 ±3.6. At week 16 (T4) the mean score for PSQI was 4.92±2.99 and at week 32 (T8), the mean score for PSQI was 4.3± 3.0. EASI, NRS pruritus and DLQI significantly improved during follow up (p<0.001) whereas PSQI improved significantly at 16 weeks (T4) but no significant further improvement was observed at 32 weeks. Of the 31 patients (86%) with baseline PSQI≥5, 17 (54%)experienced sleep quality improvement during treatment. Overall, we observed a total of 22 patients (61.1%) having a PSQI <5 at 32 weeks CONCLUSIONS: Our data show effectiveness of Dupilumab in improving sleep disturbances in adult patients with severe AD. However, further studies are required to uPnSdQeIr sctoaunld isf erve as useful evaluating tool.
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http://dx.doi.org/10.23736/S2784-8671.21.07072-9DOI Listing
July 2021

Psoriasis successfully treated with guselkumab in a patient with systemic lupus erythematosus and acquired hemophilia A.

Ital J Dermatol Venerol 2021 Jul 20. Epub 2021 Jul 20.

Dermatology Unit, Department of Medical, Surgical and Neurological sciences, Santa Maria alle Scotte Hospital, Siena University, Siena, Italy.

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http://dx.doi.org/10.23736/S2784-8671.21.07054-7DOI Listing
July 2021

Reticular erythematous mucinosis: a clinical challenge.

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Dermatology Section, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S2784-8671.21.06946-7DOI Listing
May 2021

Teledermatology in 2020: past, present and future perspectives.

Ital J Dermatol Venerol 2021 Apr;156(2):198-212

Unit of Dermatology, Department of Medical, Surgical and Neurosciences, University of Siena, Siena, Italy.

Born in 1995, teledermatology (TD) turns 25 years old today. Since then, TD evolved according to patients and physicians needs. The present review aimed to summarize all the efforts and experiences carried out in the field of TD and its subspecialties, the evolution and the future perspectives. A literature search was conducted in PubMed and Google Scholar. The state of the art of the "tele-dermo research" included TD and clinical trials, TD/TDS web platforms, TDS and artificial intelligence studies. Finally, the future perspective of TD/TDS in the era of social distancing was discussed. Using TD in specific situations adds several benefits including time-effectiveness of intervention and reduction in the waiting time for the first visit, reduced travel-costs, reduced sanitary costs, equalization of access from patient to specialistic consult. The communication technologies devices currently available can adequately support the growing needs of tele-assistance. A main limit is the current lack of a common clear European regulation for practicing TD, encompassing privacy issues and data management. The pandemic lockdown of 2020 has highlighted the importance of performing TD for all those patient, elderly and/or fragile, where the alternative would be no care at all. Many efforts are needed to develop efficient workflows and TD programs to facilitate the interplay among the different TD actors, along with practice guidelines or position statements.
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http://dx.doi.org/10.23736/S2784-8671.21.06731-6DOI Listing
April 2021

Secukinumab Exhibits Sustained and Stable Response in Patients with Moderate-to-Severe Psoriasis: Results from the SUPREME Study.

Acta Derm Venereol 2021 04 27. Epub 2021 Apr 27.

Department of Biomedical Sciences, Humanitas University, IRCCS Istituto Clinico Humanitas, IT-20089 Rozzano-Milan, Italy. E-mail:

Secukinumab, a fully human monoclonal antibody, neutralizes interleukin-17A, a cornerstone cytokine driving the multiple manifestations of psoriasis. This post-hoc analysis of the SUPREME study was performed to determine the sustainability of response to secukinumab in terms of Psoriasis Area and Severity Index (PASI) 90 in patients with moderate-to-severe plaque psoriasis. Based on PASI 90 response at week 16, patients were stratified as PASI 90 responders (PASI90R, n = 337) or non-responders (PASI90NR, n = 72). At week 20, 94.2% (n = 295/313) achieved PASI 90/100 response in PASI90R, with response maintained through week 48 (89.6%, n = 189/211). An increased proportion of patients achieved PASI 90/100 response in PASI90NR (week 20: 29.9%, n = 20/67; week 48: 57.1%, n = 20/35). Overall, 64.4% patients achieved absolute PASI score=0 at week 24 with response sustained to week 48 (66.9%). Secukinumab showed sustained and stable efficacy in maintaining PASI 90 response in patients with moderate-to-severe plaque psoriasis up to week 48.
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http://dx.doi.org/10.2340/00015555-3816DOI Listing
April 2021

Ixekizumab as treatment of erythrodermic psoriasis.

Dermatol Ther 2021 03 19;34(2):e14868. Epub 2021 Feb 19.

Dermatology Unit, Department of Medical, Surgical, and Neurosciences, University of Siena, Siena, Italy.

Erytrhodermic psoriasis (EP) is a rare subset of psoriasis that is considered a dermatologic emergency. Due to its limited clinical evidence, pathogenesis is largely unknown and its treatment represents a challenge. Conventional therapies such as methotrexate, cyclosporine, and acitretin are still considered first-line of treatment but it is necessary to study the efficacy and safety of biologics, including antitumor necrosis factor (TNF), anti-interleukin (IL)-23, and anti-IL17 agents to define new guidelines of treatment. Here, we report two cases of patients with EP treated with ixekizumab.
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http://dx.doi.org/10.1111/dth.14868DOI Listing
March 2021

Usefulness of in vivo reflectance confocal microscopy in Morbihan syndrome.

Skin Res Technol 2021 Jan 17. Epub 2021 Jan 17.

Department of Medical, Surgical and Neurological Science, Dermatology Section, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/srt.13002DOI Listing
January 2021

Dupilumab in Elderly Patients With Severe Atopic Dermatitis.

Dermatitis 2020 Dec 15;Publish Ahead of Print. Epub 2020 Dec 15.

From the Dermatology Section, Department of Medical, Surgical and Neurological Science, University of Siena, S. Maria alle Scotte Hospital, Siena Allergological and Pediatric Dermatology Unit, Department of Health Sciences, University of Florence, Florence Department of Medical Biotechnology, University of Siena, Siena Unit of Dermatology, Livorno Hospital, Livorno, Italy.

Background: Atopic dermatitis (AD) in the elderly has been poorly investigated, although its incidence is gradually increasing mainly in industrialized countries. Age-specific factors in older patients must be considered when selecting treatment options.

Objectives: To evaluate the efficacy and tolerability of dupilumab in treating elderly patients with severe AD.

Methods: This was a retrospective, multicenter study involving 26 elderly patients (age, ≥65 years) with severe AD who were treated with dupilumab for at least 16 weeks. Absolute and percentage frequencies were used to evaluate qualitative variables and mean and SD for quantitative ones. For Eczema Area and Severity Index (EASI), Pruritus Numeric Rating Scale (NRS), and Dermatology Life Quality Index (DLQI), the median was also calculated. Wilcoxon test was used to evaluate the variations in EASI, Pruritus NRS, and DLQI observed between the 2 examinations.

Results: After 4 months of therapy, the majority of patients showed a significant improvement in EASI (64.4%), Pruritus NRS (58.2%), and DLQI (44.9%). Only 11% of patients reported mild or moderate conjunctivitis.

Conclusions: To the best of our knowledge, this is the first study concerning the use of dupilumab in the elderly with severe AD. Our data show the effectiveness of dupilumab in this particular population with a lower percentage of conjunctivitis than observed in studies on adults and also excellent control of itching. Only larger, controlled case studies will be able to clarify whether the dosage or frequency of administration of dupilumab in these patients should be different from the protocol used for adults.
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http://dx.doi.org/10.1097/DER.0000000000000686DOI Listing
December 2020

Impact of dupilumab discontinuation in a patient with atopic prurigo.

Ital J Dermatol Venerol 2021 Jun 21;156(3):406. Epub 2020 Oct 21.

Unit of Allergological Dermatology, Section of Dermatology, Department of Medical, Surgical and Neurosciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.20.06714-0DOI Listing
June 2021

Extrapalmoplantar pustolosis in Sonozaki Syndrome.

Ital J Dermatol Venerol 2021 Apr 9;156(2):264-265. Epub 2020 Oct 9.

Section of Dermatology, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.20.06635-3DOI Listing
April 2021

Peripheral T3 signaling is the target of pesticides in zebrafish larvae and adult liver.

J Endocrinol 2020 10;247(1):53-68

Department of Science and Technology, University of Sannio, Benevento, Italy.

The intra-tissue levels of thyroid hormones (THs) regulate organ functions. Environmental factors can impair these levels by damaging the thyroid gland and/or peripheral TH metabolism. We investigated the effects of embryonic and/or long-life exposure to low-dose pesticides, ethylene thiourea (ETU), chlorpyrifos (CPF) and both combined on intra-tissue T4/T3 metabolism/signaling in zebrafish at different life stages. Hypothyroidism was evident in exposed larvae that showed reduced number of follicles and induced tshb mRNAs. Despite that, we found an increase in free T4 (fT4) and free T3 (fT3) levels/signaling that was confirmed by transcriptional regulation of TH metabolic enzymes (deiodinases) and T3-regulated mRNAs (cpt1, igfbp1a). Second-generation larvae showed that thyroid and TH signaling was affected even when not directly exposed, suggesting the role of parental exposure. In adult zebrafish, we found that sex-dependent damage of hepatic T3 level/signaling was associated with liver steatosis, which was more pronounced in females, with sex-dependent alteration of transcripts codifying the key enzymes involved in 'de novo lipogenesis' and β-oxidation. We found impaired activation of liver T3 and PPARα/Foxo3a pathways whose deregulation was already involved in mammalian liver steatosis. The data emphasizes that the intra-tissue imbalance of the T3 level is due to thyroid endocrine disruptors (THDC) and suggests that the effect of a slight modification in T3 signaling might be amplified by its direct regulation or crosstalk with PPARα/Foxo3a pathways. Because T3 levels define the hypothyroid/hyperthyroid status of each organ, our findings might explain the pleiotropic and site-dependent effects of pesticides.
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http://dx.doi.org/10.1530/JOE-20-0134DOI Listing
October 2020

Treatment of childhood pyogenic granuloma of the nail bed with topical timolol.

Dermatol Ther 2020 07 29;33(4):e13710. Epub 2020 Jun 29.

Dermatology Unit, Department of Medical, Surgical and Neurological Science, S. Maria Alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/dth.13710DOI Listing
July 2020

Amenorrhea secondary to vismodegib: An adverse event to consider especially in female patients with Gorlin-Goltz syndrome.

Dermatol Ther 2020 07 26;33(4):e13527. Epub 2020 May 26.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

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http://dx.doi.org/10.1111/dth.13527DOI Listing
July 2020

Severe Adult Atopic Dermatitis: Clinical Challenges.

Dermatitis 2020 Jul/Aug;31(4):e48-e49

Allergological Dermatology Unit, Dermatology Section, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Italy Allergological and Pediatric Dermatology Unit, Department of Health Sciences, University of Florence, Italy.

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http://dx.doi.org/10.1097/DER.0000000000000592DOI Listing
April 2021

Tuscan Consensus on the diagnosis, treatment and follow up of adult atopic dermatitis.

G Ital Dermatol Venereol 2020 Jun 10;155(3):253-260. Epub 2020 Mar 10.

Unit of Allergological and Pediatric Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.

Atopic dermatitis (AD) is an inflammatory disease with a chronic-relapsing course that is intensely itchy. A correct diagnosis of AD in adults and consequently appropriate clinical therapeutic management is a critical issue for extreme clinical expression heterogeneity and various grades of disease severity. In order to ensure high levels of care and standardization of clinical therapeutic management of Adult AD, the decision was taken to create an AD Tuscan Consensus Group (the Group), to work on and validate a consensus based regional clinical-therapeutic management model. The aims of the Group were to find agreement on the criteria for diagnosis, scoring of severity, multidisciplinary approach and treatment of adult atopic dermatitis and to create an easier way for patients to access specialized dermatology outpatient services and importantly to reduce waiting lists and costs related to the management of AD. The Tuscan Consensus Group adopted a simplified Delphi method, in three principal steps: 1) literature metanalysis and critical review of patient's clinical experience to identify the main areas considered questionable or uncertain; 2) discussion of those areas requiring consensus and statement definition through four different sub-committees (diagnosis, severity evaluation, scoring and comorbidities); 3) a consensus based simplified process with final approval of each statement by plenary vote with approval >80% of the participants. The Group here presents and discusses the consensus based recommendation statements on adult atopic dermatitis.
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http://dx.doi.org/10.23736/S0392-0488.19.06527-1DOI Listing
June 2020

Hidradenitis suppurativa in a female adolescent with Rett syndrome: a fortuitous association?

G Ital Dermatol Venereol 2020 Mar 10. Epub 2020 Mar 10.

Dermatology Unit, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.20.06500-1DOI Listing
March 2020

Efficacy of Dupilumab in two patients with severe and recalcitrant atopic dermatitis previously treated with extracorporeal photopheresis.

Dermatol Ther 2020 05 2;33(3):e13284. Epub 2020 Mar 2.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

Atopic dermatitis (AD) is a complex disease and can often be a clinical challenge for dermatologists. When standard immunosuppressive therapies fail, extracorporeal phototherapy (ECP) can be considered as a therapeutic option. In recent years, better understanding of the pathogenesis of AD allowed to improve treatment strategies with many emerging therapeutic options. Currently, Dupilumab, a monoclonal antibody that selectively inhibits IL-4 and IL-13, is the only biological drug authorized for the treatment of severe adult atopic dermatitis, refractory to traditional firstline and secondline therapies. ECP, compared to biological therapy, is associated with some disadvantages: it is costly and time-consuming for patients and personnel to administer. Moreover, it should be noted that the completion of the entire procedure takes about 3 hr and must be done in a hospital, while the administration of Dupilumab can be carried out by patients themselves at home. For these reasons and on the basis of our experience, it would be necessary to evaluate whether all patients with refractory atopic dermatitis in treatment with ECP with unsatisfactory clinical response should be switched to recent available target therapies.
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http://dx.doi.org/10.1111/dth.13284DOI Listing
May 2020

Insight into Function in Mouse Endoderm Patterning.

Int J Mol Sci 2019 Dec 18;21(1). Epub 2019 Dec 18.

Istituto di Ricerche Genetiche "G. Salvatore", Biogem s.c.ar.l, Ariano Irpino, 83031 Avellino, Italy.

Endoderm-derived organs as liver and pancreas are potential targets for regenerative therapies, and thus, there is great interest in understanding the pathways that regulate the induction and specification of this germ layer. Currently, the knowledge of molecular mechanisms that guide the in vivo endoderm specification is restricted by the lack of early endoderm specific markers. () is a gene whose expression characterizes the early stages of murine endoderm specification (E7.5-11.5) and encodes a secreted N-glycosylated protein. In the present study, we report the identification of a new transcript variant that is generated through alternative splicing. The new variant was found to have differential and tissue specific expression in the adult mouse. In order to better understand role during endoderm specification, we generated knock-out (KO) mice. mice were born at Mendelian ratios and displayed no evident phenotype compared to WT mice. In addition, we produced nullizygous mouse embryonic stem cell (mESC) line lacking by applying (CRISPR)/CRISPR-associated systems 9 (Cas9) and employed a differentiation protocol toward endoderm lineage. Our in vitro results revealed that loss affects the endoderm differentiation impairing the expression of posterior foregut-associated markers.
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http://dx.doi.org/10.3390/ijms21010008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981620PMC
December 2019

Primitive marginal lymphoma of the breast.

Breast J 2020 04 28;26(4):790-791. Epub 2019 Sep 28.

AOU Ospedale Maggiore di Parma, Parma, Italy.

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http://dx.doi.org/10.1111/tbj.13648DOI Listing
April 2020

Pigmentary demarcation lines of Voigt-Futcher: Dermoscopic and reflectance confocal microscopy features.

Skin Res Technol 2020 05 28;26(3):440-442. Epub 2019 Sep 28.

Dermatology Section, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/srt.12795DOI Listing
May 2020

Haploidentical hematopoietic stem cell transplantation in adults using the αβTCR/CD19-based depletion of G-CSF-mobilized peripheral blood progenitor cells.

Bone Marrow Transplant 2019 08;54(Suppl 2):698-702

Department of Medicine and Surgery, Hematology and BMT Unit, University of Parma, Parma, Italy.

In patients with hematological malignancies at high risk for relapse, a mismatched hematopoietic stem cells transplants can be offered with no undue delay between decision-making and transplantation as virtually all patients have a full-haplotype mismatched member who could serve immediately as a donor. Using a T-cell depletion approach, these patients can benefit from a graft-vs-leukemia effect in the absence of both acute and chronic graft-vs-host disease. Over the past decade, efforts have concentrated on developing new conditioning regimens, optimizing the graft processing and improving the posttransplant immunological recovery. The innovative strategy based on the selective depletion of alpha/beta-positive T lymphocytes from G-CSF-mobilized peripheral blood precursor cells has shown very promising results in the setting of the pediatric transplantation. This paper reports the outcome in adult patients with hematological malignancies.
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http://dx.doi.org/10.1038/s41409-019-0608-zDOI Listing
August 2019

Use of Secukinumab in a Cohort of Erythrodermic Psoriatic Patients: A Pilot Study.

J Clin Med 2019 May 31;8(6). Epub 2019 May 31.

Padeh and Ziv Hospitals, Azrieli Faculty of Medicine, Bar-Ilan University, 5290002 Ramat Gan, Israel.

Erythrodermic psoriasis (EP) is a dermatological emergency and its treatment with secukinumab is still controversial. Furthermore, no data exist regarding the prognostic value of drug abuse in such a condition. We performed a multi-center, international, retrospective study, enrolling a sample of EP patients (body surface area > 90%) who were treated with secukinumab (300 mg) during the study period from December 2015 to December 2018. Demographics and clinical data were collected. Drug abuses were screened and, specifically, smoking status (packages/year), cannabis use (application/week) and alcoholism-tested with the Alcohol Use Disorders Identification Test (AUDIT)-were assessed. All patients were followed for up to 52 weeks. We enrolled 13 EP patients, nine males, and four females, with a median age of 40 (28-52) years. Patients naïve to biologic therapy were 3/13. Regarding drug use, seven patients had a medium-high risk of alcohol addiction, three used cannabis weekly, and seven were smokers with a pack/year index of 295 (190-365). The response rate to secukinumab was 10/13 patients with a median time to clearance of three weeks (1.5-3). No recurrences were registered in the 52-week follow-up and a Psoriasis Area Severity Index (PASI) score of 90 was achieved. The entire cohort of non-responders ( = 3) consumed at least two drugs of abuse (alcohol, smoking or cannabis). Non-responders were switched to ustekinumab and obtained a PASI 100 in 24 weeks. However, given our observed number of patients using various drugs in combination with secukinumab in EP, further studies are needed to ascertain drug abuse prevalence in a larger EP cohort. Secukinumab remains a valid, effective and safe therapeutic option for EP.
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http://dx.doi.org/10.3390/jcm8060770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617329PMC
May 2019

Pyoderma gangrenosum secondary to total hip replacement.

G Ital Dermatol Venereol 2019 Apr 23. Epub 2019 Apr 23.

Dermatology Section, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.19.06256-4DOI Listing
April 2019

Hairy cell leukaemia mimicking multiple myeloma.

Lancet Oncol 2019 03;20(3):e187

Institute of Hematology and Center for Hemato-Oncology Research (C.R.E.O.), University and Hospital of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/S1470-2045(18)30609-0DOI Listing
March 2019

A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis.

Int J Environ Res Public Health 2019 01 4;16(1). Epub 2019 Jan 4.

IRGS, Biogem, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy.

Epidemiological and experimental studies emphasize the link between environmental chemicals exposure and thyroid cancer. However, this association is strongly debated and the mechanisms of action of environmental thyroid carcinogens still need to be identified. The analysis of in vitro transcriptomic data developed to investigate the effects of chlorpyrifos on immortalized thyrocytes highlighted the impaired expression of genes involved in endodermal carcinogenesis. This endodermal carcinogenic gene-network (ECGN, including , , ), was validated in cellular and mouse models of thyroid carcinogenesis, characterized by the constitutive activation of the mitogen-activated protein kinase (MAPK) pathway and in immortalized thyrocytes exposed to tetrachlorodibenzo--dioxin (TCDD) and chlorpyrifos (CPF). The mRNA levels of , and were increased in models characterized by MAPK activation or following TCDD exposure, whereas they were inhibited by CPF exposure. Overall, the ECGN transcripts identify a novel gene-regulatory network associated with thyroid carcinogenesis promoted by genetic mutation or by environmental carcinogens. The latter have opposite effects on the modulation of the ECGN transcripts according to their mechanisms of action in promoting carcinogenesis. Therefore, the analyses of ECGN might be helpful in discriminating compounds that promote cellular survival associated or not to proliferation of thyrocytes.
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http://dx.doi.org/10.3390/ijerph16010122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338918PMC
January 2019

Genetic background and window of exposure contribute to thyroid dysfunction promoted by low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.

Sci Rep 2018 11 5;8(1):16324. Epub 2018 Nov 5.

IRGS, Biogem, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy.

Genetic and environmental factors contribute to thyroid diseases. Although still debated, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is thought to induce thyroid dysfunction in humans and rodents. The data here reported point out the contribution of the exposure window and genetic background in mediating the low-dose TCDD effects on thyroid. Indeed, early (from E0.5 to PND30) and low-dose (0,001 μg/kg/day) TCDD exposure reduced the circulating fT4 and altered the expression of thyroid specific transcripts. The role of genetic components was estimated monitoring the same markers in Pax8 and Nkx2-1 mice, susceptible to thyroid dysfunction, exposed to 0, 1 μg/kg/day TCDD from E15.5 to PND60. Haploinsufficiency of either Pax8 or Nkx2-1 genes exacerbated the effects of the exposure impairing the thyroid enriched mRNAs in sex dependent manner. Such effect was mediated by mechanisms involving the Nkx2-1/p53/p65/IĸBα pathway in vitro and in vivo. Foetal exposure to TCDD impaired both thyroid function and genes expression while thyroid development and differentiation did not appear significantly affected. In mouse, stronger effects were related to earlier exposure or specific genetic background such as either Pax8 or Nkx2-1 haploinsufficiency, both associated to hypothyroidism in humans. Furthermore, our data underline that long exposure time are needed to model in vitro and in vivo results.
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http://dx.doi.org/10.1038/s41598-018-34427-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218492PMC
November 2018

Tuscan consensus on the use of UVBnb phototherapy in the treatment of psoriasis.

G Ital Dermatol Venereol 2019 Apr 29;154(2):99-105. Epub 2018 Oct 29.

Section of Dermatology, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

Psoriasis (PSO) is traditionally defined as an immune-mediated, inflammatory dermatological disease characterized by a chronic-relapsing course and associated with multifactorial inheritance (genetic predisposition and influence of various environmental factors). Considered until recently a dermatological disease only, today PSO is correctly known as a systemic one because of the involvement of multiple organs with important impact on social life and relationships. PSO is found in the 0.3-4.6% of the world's population, while its prevalence in the Italian population is estimated at 2.8%. Therefore, if we consider that in Tuscany more than 100,000 people out of 3,672,202 suffer of psoriasis, it is of paramount importance to focus on a shared clinical and therapeutic protocol to manage the disease. With the aim of ensuring diagnostic-therapeutic suitability, high levels of care and standardization of treatment, a unique clinical-therapeutic management model has been developed and validated in Tuscany, involving all accredited regional dermatological centers. Among the possible alternatives to be implemented in the treatment of patients with mild, moderate-severe psoriasis, UVBnb phototherapy is widely used alone or in association with other systemic and non-systemic devices. Despite this, there is still no universally shared therapeutic protocol. In this context the CO.FO.TO working group (Consensus Fototerapia Toscana) is born with the aim of defining and validating the main guidelines in the use of phototherapy with UVBnb in psoriasis; the guidelines are based both on the real-life experience of the different centers of reference in the region and on the revision of the recent literature.
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http://dx.doi.org/10.23736/S0392-0488.18.06223-5DOI Listing
April 2019

New onset psoriasis in a patient with chronic inflammatory demyelinating polyneuropathy treated with Rituximab.

G Ital Dermatol Venereol 2020 Dec 22;155(6):802-803. Epub 2018 Oct 22.

Section of Dermatology, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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December 2020

The psychological burden in psoriatic patients beyond PASI.

J Psychosom Res 2018 08 31;111:118-119. Epub 2018 May 31.

Dermatology Section, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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August 2018
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