Publications by authors named "Filiz Acun Kaya"

9 Publications

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Investigation of the effect of combined use of alloplastic-based tricalcium phosphate bone graft and antihemorrhagic plant extract (ABS) on bone regeneration in surgically induced bone defects in nondiabetic rats: an experimental animal study

Turk J Med Sci 2018 Dec 12;48(6):1302-1314. Epub 2018 Dec 12.

Department of Histology and Embryology, Faculty of Medicine, Dicle University Diyarbakir, Turkey

Background/aim: In this experimental study, we aimed to evaluate the late period effects of the combination of Ankaferd Blood Stopper (ABS), which has bone wound healing effects, and β-tricalcium phosphate (TCP) on the regeneration of bone tissue through histopathological, immunohistochemical, and radiological (dual energy X-ray absorptiometry - DEXA) methods in nondiabetic rats.

Materials And Methods: Sixty-four Wistar albino male rats were used. In the calvaria of the rats, a bone defect 7.0 mm in diameter was created. These rats were divided into 4 different groups. Group 1 was the control group without any treatment, a 0.125 mL Β-TCP graft was applied to Group 2, a 0.125 mL ABS was applied to Group 3, and a 0.125 mL (β-TCP + ABS) mixture was applied to group 4. Half of the rats were sacrificed on day 28 and the other half on day 56. Histopathological, immunohistochemical, and DEXA analyses of the specimens were performed after the experiment.

Results: As a result of the histopathological analysis, osteoblastic activity and new bone formation were found to be significantly higher in Group 2, Group 3, and Group 4 than the control group on day 28 (P < 0.05). However, inflammatory cell infiltration and vascular dilatation and hemorrhage decreased significantly compared to the control group (P < 0.05). The histopathological analysis in rats on day 56 showed that osteoblastic activity in Group 2 and Group 4 was significantly higher than in the control group, but there was a statistically significant decrease in inflammatory cell infiltration and vascular dilatation and hemorrhage compared to the control group (P < 0.05). New bone formation in Group 2, Group 3, and Group 4 was significantly higher than in the control group. Western blotting findings revealed that the osteonectin and osteopontin expression on day 28 was increased significantly in Group 2 and Group 4. DEXA analyses revealed that BMC values in Group 2 and Group 4 on day 28 were significantly higher than in the control group (P < 0.05). There was no significant difference in bone mineral density values on the 28th and 56th days (P > 0.05).

Conclusion: The use of both β-TCP + ABS and only ABS had positive effects on wound healing and bone formation in nondiabetic rats.
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http://dx.doi.org/10.3906/sag-1803-201DOI Listing
December 2018

Clinical Evaluation of Complications in Implant-Supported Dentures: A 4-Year Retrospective Study.

Med Sci Monit 2017 Dec 27;23:6137-6143. Epub 2017 Dec 27.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakır, Turkey.

BACKGROUND Implants that can be used in the prosthetic rehabilitation of full and partial edentulous patients are now frequently used due to advances in dentistry. Despite advanced methods of applications, failures and complications can still be seen. The aim of our study was to evaluate clinical prosthetic values and complications that occurred during 4-year follow-up in implant-supported restorations. MATERIAL AND METHODS This retrospective study included 40 patients who received oral rehabilitation with an implant-supported prosthesis. A total of 162 implants were placed: 99 in the maxilla and 63 in the mandible. The prosthetic and surgical data were recorded. Data including prosthetic complications and implant loss were recorded and statistically analyzed using Cox proportional hazard regression analysis. RESULTS In total, 159 implants (98.14%) survived, 3 implants (1.86%) failed, and 100% of the protheses were successful. There were 62 dental implants used as abutments for removable dentures and 97 for fixed dentures. The most frequent prosthetic complications after placement of an implant-supported prosthesis were loss of retention, mucositis, abutment screw loosening, and fracture. Patient satisfaction after prosthesis use was also evaluated, showing that satisfaction was systematically increased. CONCLUSIONS To minimize the frequency of complications, protocols must be established from diagnosis to the completion of treatment and follow-up of implant-supported prostheses, especially in terms of adequate technical steps and careful radiographic evaluation of the components.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751727PMC
http://dx.doi.org/10.12659/msm.907840DOI Listing
December 2017

Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree.

Turk J Pediatr 2017 ;59(1):56-61

Departments of Dermatology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Talo-Yıldırım T, Acun-Kaya F, Taşkesen M, Dündar S, Bozoğlan A, Tekin GG, Akdeniz S. Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree. Turk J Pediatr 2017; 59: 56-61. Kindler syndrome (KS) is a rare genetic disorder. The clinical features include aggressive periodontal disease and severe desquamative gingivitis. Five individuals with KS were assessed by oral examination, radiographic analysis and periodontal measurements. All the patients' indexes were recorded prior to periodontal treatment and at the end of the 1th, 3th , 6th, 9th and 12th month respectively. All the patients had improvement of periodontal status and enhancement in index scores. The affected individuals were previously screened for FERMT1 mutations. KS patients' periodontal disease activity could be taken under control with regular follow-up.
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http://dx.doi.org/10.24953/turkjped.2017.01.009DOI Listing
December 2017

Associations of alveolar bone loss and interleukin-1β levels in one- and two-stage surgical procedures: a randomized prospective trial.

Acta Odontol Scand 2017 Nov 21;75(8):608-615. Epub 2017 Aug 21.

h Department of Periodontology, Faculty of Dentistry , Hacettepe University , Ankara , Turkey.

Objective: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1β levels in one- and two-stage surgical procedures.

Materials And Methods: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II). All clinical periodontal parameters were recorded; peri-implant crevicular fluid (PICF) samples were collected before loading (T0) and during the third (T1) and sixth (T2) months after loading. ABLR values were evaluated at T0 and T2 by using dental tomography. PICF was analysed after T2 samples were collected. The study was registered through clinicaltrials.gov; identifier NCT03045458.

Results: This study found that, the probing pocket depth was found to be significantly higher in Group I than Group II at both T1 and T2 (p < .05). There was no significant difference in other clinical parameters between the groups (p > .05). There was a significant difference between Group I ABLR values at T0 and T2 (p < .05). The PICF IL-1β levels were not significantly different between groups (p > .05).

Conclusions: Within the limitations of the short observational period and small sample size of this study, two-stage implant placement shows comparable clinical outcomes to implants placed using a one-stage placement protocol.
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http://dx.doi.org/10.1080/00016357.2017.1367959DOI Listing
November 2017

Is there a relation between dental anxiety, fear and general psychological status?

PeerJ 2017 15;5:e2978. Epub 2017 Feb 15.

Department of Oral and Maxillofacial Surgery, Inonu University , Malatya , Turkey.

Background: Dental anxiety is a widespread problem in many populations. This problem can be a barrier to dental care and may lead to poor oral health. Dental anxiety may be related to psychological status.

Aims: The aim of the present study was to assess the levels of dental anxiety, dental fear, Beck Depression, and state-trait anxiety according to age, gender and education level in patients at the periodontology clinic in the Diyarbakır Mouth and Dental Health Center.

Study Design: A total of 231 patients (115 males, 116 females) filled out dental fear scale (DFS), dental anxiety scale (DAS), Beck Depression Inventory (BDI), state-trait anxiety inventory-state (STAI-S), and state-trait anxiety inventory-trait (STAI-T) questionnaires, and evaluations of DFS, DAS, BDI, STAI-S, and STAI-T were conducted according to age, gender, and education level.

Results: The mean DFS, DAS, BDI, STAI-T, and STAI -S were 45.64, 9.15, 13.16, 38.90, and 40.18, respectively. There was a significant association among DFS, DAS, BDI, STAI-S, and STAI-T ( < 0.05). These surveys scores were significantly higher in females than males ( < 0.05). The results of this study indicated that gender age and education level have important effects on DFS, DAS, BDI, STAI-S, and STAI-T ( < 0.05).

Conclusion: Dental anxiety and dental fear were found to be related to psychological status (BDI, STAI-S, and STAI-T) over time. There are some patients with unaddressed psychological distress.
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http://dx.doi.org/10.7717/peerj.2978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314953PMC
February 2017

Identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement.

Eur J Orthod 2012 Jun 7;34(3):357-61. Epub 2011 Apr 7.

Department of Orthodontics, Dicle University, Diyarbakır, Turkey.

The aim of this study was to identify the levels of interleukin (IL)-2, IL-6, and IL-8 around miniscrews used for anchorage during canine distalization. Sixteen patients (eight males and eight females; mean age, 16.6 ± 2.4 years) who were treated with bilateral upper first premolar extractions were included in the study. Thirty-two maxillary miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for maxillary canine distalization. Three groups were constructed. The treatment, miniscrew, and control groups consisted of upper canines, miniscrew implants, and upper second premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid (GCF) were obtained at baseline (T1) and at 1 (T2), 24 (T3), and 48 (T4) hours, 7 (T5) and 21 (T6) days, and 3 months (T7) after force application. Paired sample t-tests were used to determine within-group changes and Dunnett's t and Tukey's honestly significant difference tests for between-group multiple comparisons. During the 3 month period, IL-2 levels significantly increased (P < 0.01) but only in the treatment group after 24 hours. IL-6 levels were unchanged at all times points in the three groups. IL-8 levels increased significantly at 1 (P < 0.05), 24 (P < 0.01), and 48 (P < 0.01) hours in the treatment group and at 24 (P < 0.05) and 48 (P < 0.01) hours in the miniscrew group. It appears that miniscrews can be used for anchorage in orthodontics when correct physiological forces are applied.
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http://dx.doi.org/10.1093/ejo/cjr019DOI Listing
June 2012

Bilateral twinned teeth and multiple supernumerary teeth: a case report.

Quintessence Int 2008 Jul-Aug;39(7):567-72

Dicle University, Faculty of Dentistry, Department of Pedodontics, Diyarbakir, Turkey.

Dental twinning can result from the fusion of the developing dental germinal elements or the gemination of a single germ. In bilateral anterior and posterior dental twinning, problems such as poor esthetics, dental caries, arch-length problems, and periodontal disease often occur as a result of the irregular morphology. Several treatment methods have been described in the literature with respect to the different types and morphologic variations of twinned teeth, including endodontic, restorative, surgical, periodontal, and orthodontic treatment. This report documents the case of a young patient with an exceedingly rare phenomenon of permanent twinned teeth and multiple supernumerary teeth in both sides of the mandibular and maxillary arches, as a result of combined fusion and gemination.
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March 2009

Interleukine-1beta and tumor necrosis factor-alpha levels in the human gingival sulcus during orthodontic treatment.

Angle Orthod 2006 Sep;76(5):830-6

Dental Faculty, Dice University, Diyarbakir, Turkey.

Objective: To test whether interleukine 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels differ from each other in different treatment levels.

Materials And Methods: Eighteen patients, nine female and nine male (aged 16-19 years; mean 17.4 +/- 1.8 years), participated in this study. Each subject underwent a session on professional oral hygiene and received oral hygiene instructions. Two months later, a fixed orthodontic appliance was placed. The patients were seen at baseline, at days 7 and 21 and at the 3rd and 6th month as the leveling of the teeth occurred. Records of the baseline scores for the distalization forces were taken at the 6th month. Days 7 and 21 after 6 months of treatment were also recorded.

Results: There were increases in the volume of gingival crevicular fluid (GCF) and in the concentrations of IL-1beta and TNF-alpha.

Conclusions: Leveling and distalization of the teeth evoke increases in both the IL-1 and TNF-alpha levels that can be detected in GCF.
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http://dx.doi.org/10.1043/0003-3219(2006)076[0830:IATNFL]2.0.CO;2DOI Listing
September 2006

Interleukins 2, 6, and 8 levels in human gingival sulcus during orthodontic treatment.

Am J Orthod Dentofacial Orthop 2006 Jul;130(1):7.e1-6

School of Dentistry, Dicle University, Diyarbakir, Turkey.

Introduction: The aims of this study were to determine levels of interleukins 2, 6, and 8 during tooth movement, and test whether they differ from each other with leveling and distalization forces used in various treatment stages of standard orthodontic therapy.

Methods: Fifteen patients (9 female, 6 male; ages, 15-19 years; mean age, 16.7 +/- 2.3 years) participated in this study. Each underwent a session of professional oral hygiene and received oral hygiene instructions. Two months later, a fixed orthodontic appliance was placed. The patients were seen at baseline, at days 7 and 21, and as the teeth were leveled. Records of the baseline scores for the distalization forces were taken at the sixth month. Scores of days 7 and 21 after 6 months of the distalization treatment were also recorded.

Results: Increases were seen in the volume of gingival crevicular fluid and the concentrations of interleukins 2, 6, and 8.

Conclusions: Leveling and distalization of the teeth evoke increases in interleukins 2, 6, and 8 levels in the periodontal tissues that can be detected in gingival crevicular fluid.
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http://dx.doi.org/10.1016/j.ajodo.2005.12.027DOI Listing
July 2006
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