Publications by authors named "Filippo G Giancotti"

52 Publications

A heterotrimeric SMARCB1-SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex.

Cell Discov 2020 22;6:66. Epub 2020 Sep 22.

State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.

View Article and Find Full Text PDF
September 2020

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

Cancer Cell 2019 08 18;36(2):139-155.e10. Epub 2019 Jul 18.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Unit 1906, PO Box 301429, Houston, TX 77054/77030-1429, USA; Department of Genitourinary Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address:

View Article and Find Full Text PDF
August 2019

Clonal Evolution and Epithelial Plasticity in the Emergence of AR-Independent Prostate Carcinoma.

Trends Cancer 2019 07 29;5(7):440-455. Epub 2019 Jun 29.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

View Article and Find Full Text PDF
July 2019

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance.

Cancer Cell 2019 03;35(3):347-367

Department of Cancer Biology and David H. Koch Center for Applied Research of Genitourinary Cancers, UT MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address:

View Article and Find Full Text PDF
March 2019

Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses Loss-Driven Tumorigenesis.

Mol Cancer Ther 2017 08 3;16(8):1693-1704. Epub 2017 May 3.

Department of Cancer Biology and David H. Koch Center for Applied Research of Genitourinary Cancers, University of Texas MD Anderson Cancer Center, Houston, Texas.

View Article and Find Full Text PDF
August 2017

Cancer: a new role for non-canonical Hippo signaling.

Cell Res 2017 04 28;27(4):459-460. Epub 2017 Feb 28.

Department of Cancer Biology and David H Koch Center for Applied Research of Genitourinary Cancers, UT MD Anderson Cancer Center, Houston, TX 77230, USA.

View Article and Find Full Text PDF
April 2017

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling.

Cell 2016 Jun;166(1):47-62

Cell Biology Program and Center for Metastasis Research, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Cancer Biology and David H. Koch Center for Applied Research of Genitourinary Cancers, UT MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address:

View Article and Find Full Text PDF
June 2016

Alan Hall 1952-2015.

Nat Cell Biol 2015 Jul 25;17(7):839-40. Epub 2015 May 25.

Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065 USA.

View Article and Find Full Text PDF
July 2015

Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation.

Proc Natl Acad Sci U S A 2014 Nov 5;111(46):16532-7. Epub 2014 Nov 5.

Cell Biology Program and Metastasis Research Center and

View Article and Find Full Text PDF
November 2014

Molecular insights into NF2/Merlin tumor suppressor function.

FEBS Lett 2014 Aug 12;588(16):2743-52. Epub 2014 Apr 12.

Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, United States. Electronic address:

View Article and Find Full Text PDF
August 2014

Deregulation of cell signaling in cancer.

FEBS Lett 2014 Aug 20;588(16):2558-70. Epub 2014 Feb 20.

Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY, United States. Electronic address:

View Article and Find Full Text PDF
August 2014

Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas.

Neuro Oncol 2014 Jan 4;16(2):292-7. Epub 2013 Dec 4.

Corresponding author: Matthias A. Karajannis, MD, MS, NYU Langone Medical Center, Hassenfeld Children's Center for Cancer and Blood Disorders, 160 East 32nd Street, 2nd floor, New York, NY 10016.

View Article and Find Full Text PDF
January 2014

Mechanisms governing metastatic dormancy and reactivation.

Cell 2013 Nov;155(4):750-64

Cell Biology Program, Sloan-Kettering Institute for Cancer Research and Metastasis Research Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

View Article and Find Full Text PDF
November 2013

β4 Integrin signaling induces expansion of prostate tumor progenitors.

J Clin Invest 2013 Feb 25;123(2):682-99. Epub 2013 Jan 25.

Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, New York, USA.

View Article and Find Full Text PDF
February 2013

The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites.

Cell 2012 Aug;150(4):764-79

Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

View Article and Find Full Text PDF
August 2012

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

EMBO Rep 2012 Mar;13(3):204-15

Cell Biology Program, Sloan–Kettering Institute for Cancer Research, Memorial Sloan–Kettering Cancer Center, 1275 York Avenue, Box 216, New York, New York 10065, USA.

View Article and Find Full Text PDF
March 2012

Integrin β4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF.

Ann Biomed Eng 2011 Aug 10;39(8):2223-2241. Epub 2011 May 10.

Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031.

View Article and Find Full Text PDF
August 2011

Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1).

Cell Cycle 2010 Nov 15;9(22):4433-6. Epub 2010 Nov 15.

Sloan-Kettering Institute for Cancer Research, New York, NY, USA.

View Article and Find Full Text PDF
November 2010