Publications by authors named "Filipe Ivan Daniel"

7 Publications

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Diagnostic Challenge and Clinical Management of Juvenile Mandibular Chronic Osteomyelitis.

Head Neck Pathol 2020 Sep 28;14(3):842-846. Epub 2019 Nov 28.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

Juvenile mandibular chronic osteomyelitis (JMCO) is a rare, idiopathic disease of chronic bone inflammation without suppuration, sinus tract formation, or sequestration. As the name suggests, this condition predominately affects children. The few cases of JMCO reported in the literature describe different treatments, and thus a standard therapy protocol has not yet been established. The aim of this paper is to report a clinical case in a 9-year-old girl that was misdiagnosed and unsuccessfully treated for 1 year. After experiencing persistent symptoms, a correct diagnosis was subsequently rendered based on the physical and radiographic examination as well as successful treatment with non-steroidal anti-inflammatory drugs (NSAIDs). The patient received drug therapy followed by periods of remission over a 4 year follow-up period. Diagnosis and treatment of JMCO is a challenge given the rarity and nonspecific signs and symptoms of this condition. Treatment with NSAIDs and regular follow-up is a conservative option for these patients.
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http://dx.doi.org/10.1007/s12105-019-01087-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413939PMC
September 2020

Salivary evaluation in radioactive I treated patients with thyroid carcinoma.

Acta Odontol Scand 2018 Mar 10;76(2):148-152. Epub 2017 Nov 10.

a Department of Pathology, Health Science Center , Federal University of Santa Catarina , Florianopolis , SC , Brazil.

Background And Objective: radioiodine treatment (I) used to treat thyroid carcinomas produces side effects (sialadenitis, xerostomia, dysphagia and caries susceptibility) reflecting in a poor patient quality of life. This study aimed to evaluate the effect of I on salivary function and possible oral impairment.

Material And Methods: Thirty-seven patients undergoing I were submitted to oral examination, answer questions regarding xerostomia/hyposalivation and collect saliva at three moments (M1: 30-45 days before I, M2: 1-2 days after I and M3: 7-10 days after treatment). Saliva was assayed for flow rate and calcium/phosphate concentrations.

Results And Conclusions: significant difference in calcium/phosphate concentration was shown between M1 and M2, with evident decrease at M2. Flow rate reduced right after treatment with 41% of patients returning to previous rate at M3 (no statistical difference). A higher number of patients related xerostomia and difficulty in swallowing food at M2. The results showed that xerostomia/hyposalivation, dysphagia and calcium/phosphate concentration decrease may be considered early radioiodine side effects.
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http://dx.doi.org/10.1080/00016357.2017.1399214DOI Listing
March 2018

Histone modifications: A review about the presence of this epigenetic phenomenon in carcinogenesis.

Pathol Res Pract 2017 Nov 28;213(11):1329-1339. Epub 2017 Jun 28.

Department of Pathology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. Electronic address:

Among the epigenetic changes, histone acetylation has been recognized as a fundamental process that strongly affects gene expression regulation. Disrupt of this phenomenon has been linked to carcinogenesis. In this review, we analysed studies reporting the process of histone modification, the enzymes associated and affected genes concerning human malignancies and histone enzyme inhibitor drugs used in cancer treatment. Variable degrees of expression of HDACs (histone deacetylases) and HATs (histone acetyltransferases) are found in many human malignant tissues and the histones acetylation seems to influence different processes including the progression of cell cycle, the dynamics of chromosomes, DNA recombination, DNA repair and apoptosis. Thus, the control of aberrant activity and/or expression of these proteins have been favorable in treatment of diseases as cancer. HDACi have shown efficacy in clinical trials in solid and hematological malignancies. Therefore, the development and use of HDACs inhibitors are increasing, leading to continue studying these enzyme expressions and behavior, aiming to determine tumors that will respond better to this type of treatment.
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http://dx.doi.org/10.1016/j.prp.2017.06.013DOI Listing
November 2017

Proliferative verrucous leukoplakia: diagnosis, management and current advances.

Braz J Otorhinolaryngol 2017 Sep - Oct;83(5):585-593. Epub 2017 Jan 24.

Universidade Federal de Santa Catarina (UFSC), Departamento de Patologia, Florianopolis, SC, Brazil. Electronic address:

Introduction: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

Objective: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update.

Methods: A Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with Proliferative verrucous leukoplakia was realized.

Results: There are not enough studies about Proliferative verrucous leukoplakia in the literature. The few found studies not present a consensus about its etiology and diagnosis criteria. Although several treatment strategies have been proposed, most of them still show a high recurrence rate.

Conclusion: More research about Proliferative verrucous leukoplakia is necessary to understand and treat this disease.
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http://dx.doi.org/10.1016/j.bjorl.2016.12.005DOI Listing
December 2017

Utility of cell block in the cytological preoperative diagnosis of keratocystic odontogenic tumor.

Pathol Res Pract 2014 Apr 30;210(4):224-7. Epub 2013 Dec 30.

Department of Pathology, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

In most cases involving jaw lesions, a biopsy and a histopathological analysis are necessary to establish the final diagnosis. However, biopsy may be a complex procedure at some maxillomandibular sites, and some systemic conditions could contraindicate the procedure. Thus, a search for new, less invasive techniques, which could eventually replace biopsy and simplify the diagnostic process, would benefit both professionals and patients. The aim of this study was to evaluate the cell block technique, prepared from the aspiration of luminal contents, in the preoperative diagnosis of keratocystic odontogenic tumors (KCOT). From 135 cases of lesions aspirated and processed by the cell block technique, we selected those containing keratin. In all cases selected, histological diagnosis was based on surgical biopsy. From 20 cases containing keratin in the cytological analyses, 19 were KCOTs and one was an orthokeratinized odontogenic cyst (OOC). In all KCOT cases, we observed the presence of parakeratin, even in those with intense inflammation. In the cytological analysis of the OOC, parakeratin was not observed. In conclusion, there is strong evidence that KCOT can be confidently diagnosed preoperatively by cytological analyses of lesions punctured and processed by the cell block technique.
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http://dx.doi.org/10.1016/j.prp.2013.12.006DOI Listing
April 2014

Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.

Arch Oral Biol 2010 Dec 16;55(12):1024-30. Epub 2010 Oct 16.

School of Dentistry, Oral Medicine Division, Pontifical Catholic University of Rio Grande do Sul, Brazil.

Unlabelled: Over-expression of DNA methyltransferases DNMT1, DNMT3a and DNMT3b has been reported in various cancers and precancerous lesions.

Objective: To investigate DNMT1, DNMT3a and DNMT3b enzymes in oral squamous cell carcinoma (SCC) and leukoplakia, and their relationship with histopathologic/clinical parameters.

Study Design: Immunohistochemistry was carried out to evaluate the three DNMTs in 60 samples of oral SCC and 37 samples of oral leukoplakia.

Results: DNMT3a immunoreactivity in the three groups of oral SCC (39.8%) was significantly higher than in control (22.6%) (ANOVA, Student-Newman-Keuls test, P<0.05), but not when compared to oral leukoplakia groups (28.2%). For DNMT1 and DNMT3b, there were no statistically significant differences between oral SCC groups (65% and 74.7%), oral leukoplakia groups (68.3% and 70.9%) and control (65.4% and 76.5%). There was a significantly higher mean percentage of DNMT1 immunoreactivity in non-smokers (ANOVA, P=0.048), and a higher DNMT3a immunoreactivity in alcohol users (ANOVA, P=0.01).

Conclusions: Higher DNMT3a immunopositivity may be associated with oral SCC and alcohol use, whilst lower levels of DNMT1 may be related with smoking habit. However, there was a significantly higher mean percentage of DNMT1 immunoreactivity in non-smokers (ANOVA, P=0.048), and a higher DNMT3a immunoreactivity in alcohol users (ANOVA, P=0.010).
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http://dx.doi.org/10.1016/j.archoralbio.2010.08.009DOI Listing
December 2010

The role of epigenetic transcription repression and DNA methyltransferases in cancer.

Cancer 2011 Feb 13;117(4):677-87. Epub 2010 Oct 13.

School of Dentistry, Oral Medicine Division, Pontifical Catholic University of Rio Grande do Sul, Brazil.

Epigenetic alterations such as DNA methylation have been implicated in the development and progression of various cancers. DNA methylation consists of the reversible addition of a methyl group to the carbon 5 position of cytosine in CpG dinucleotides and is considered essential for normal embryonic development. However, global genomic hypomethylation and aberrant hypermethylation of regulatory regions of tumor suppressor genes have been associated with chromosomal instability and transcription repression, respectively, providing neoplastic cells with a selective advantage. DNA methyltransferases are the enzymes responsible for the addition of methyl groups to CpG dinucleotides, which, together with histone modifiers, initiate the events necessary for transcription repression to occur. It has been demonstrated that increased expression of DNA methyltransferases may contribute to tumor progression through methylation-mediated gene inactivation in various human cancers. Given their importance, this article reviews the main epigenetic mechanisms for regulating transcription and its implications in cancer development.
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http://dx.doi.org/10.1002/cncr.25482DOI Listing
February 2011