Publications by authors named "Fikriye Milletli Sezgin"

7 Publications

  • Page 1 of 1

Evaluation of Nasopharyngeal and Conjunctival Swab Samples of Hospitalised Patients with Confirmed COVID-19.

Ocul Immunol Inflamm 2021 Mar 4:1-4. Epub 2021 Mar 4.

Department of Emergency Medicine, Kırşehir Ahi Evran University School of Medicine, Kırşehir, Turkey.

Purpose: To evaluate the results of conjunctival and nasopharyngeal swab tests in patients with confirmed COVID-19.

Methods: This prospective study included 45 patients who were hospitalized for confirmed COVID-19. Nasopharyngeal swab samples were obtained from the patients before hospitalization. Only one eye of each patient was randomly selected for-conjunctival sampling. All participants underwent a complete slit-lamp examination. Conjunctival and nasopharyngeal swab samples were analyzed by reversetranscriptase-polymerase-chain reaction (RT-PCR).

Results: Twenty seven (60%) of the patients were male and 18 (40%) were female. Conjunctival swab was positive in only one (2.22%) patient. None of the COVID-19 patients showed ocular changes and symptoms. There were no abnormalities of the ocular surface, anterior chamber or posterior segment at slit-lamp examination.

Conclusions: The RT-PCR was not high positive in the conjunctiva as in nasopharyngeal swabs. Ocular changes were not common in COVID-19 patients.
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March 2021

Retinal Vessel Diameter Changes in COVID-19 Infected Patients.

Ocul Immunol Inflamm 2021 Jan 26:1-7. Epub 2021 Jan 26.

Department of Medical Microbiology, Amasya University School of Medicine, Amasya, Turkey.

: To evaluate the longitudinal changes in retinal vessel diameters in patients with coronavirus disease 2019 (COVID-19).: This study included 25 patients with COVID-19 (Group 1) and 25 healthy subjects (Group 2). The diameters of peripapillary temporal and nasal retinal arteries and veins were measured at baseline and at 4 months after remission.: The baseline diameters of the inferior temporal vein and the artery were increased in group 1 compared to controls ( = .007 and = .041, respectively). There was also an increase in the diameters of the inferior and superior nasal veins and arteries in group 1 at baseline ( = .001, = .019, = .037, and = .008, respectively). Retinal vessel diameters decreased after remission in all quadrants in comparison to baseline measurements (all < .05).: Increased retinal vessel diameters were measured in COVID-19 patients during the disease. Measurement of retinal vessel diameters may be a noninvasive method of estimating the vascular risk.
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January 2021

The effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life of women with morbid obesity.

Int J Biometeorol 2020 Sep 6;64(9):1463-1472. Epub 2020 May 6.

Department of Physical Medicine and Rehabilitation, Ahi Evran University Faculty of Medicine, Bağbaşı Mah. Şehit Sahir Kurutluoğlu Cad. No, 100 40100, Kırşehir, Turkey.

To investigate the effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life in women with morbid obesity. Fifty-four women with morbid obesity were included in the study. The body mass indexes (BMI) and waist/hip ratios (WHR) of the women were calculated. Subcutaneous fat thickness was measured using a *skinfold meter, and the percentage of adipose tissue was calculated. The *Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, and the Nottingham Health Profile (NHP) was used to assess quality of life. In addition to routine biochemical tests, leptin, adipokine, visfatin from blood, and cortisol from saliva samples were studied. Participants were given 15 sessions of balneotherapy for 20 min each. After treatment, the laboratory and clinical parameters of the participants were *reevaluated. There was no statistically significant difference of BMI, WHR, and percentage of adipose tissue between before and after treatment measurements (p ˃ 0.05).There was a statistically significant improvement in PSQI and NSP scores (p ˂ 0.001). The levels of blood glucose, leptin, and visfatin were significantly decreased, and adiponectin was significantly increased after treatment (p = 0.047, p ˂ 0.001, p ˂ 0.001, and p ˂ 0.001, respectively).There was no statistically significant changes in salivary cortisol levels (p = 0.848). Patients with diabetes showed a statistically significant decrease in glucose levels after treatment (p = 0.017).There was a statistically significant decrease in low-density lipoprotein cholesterol levels in patients with dyslipidemia compared with pre-treatment (p = 0.018). Balneotherapy improves sleep and quality of life of women with morbid obesity. After balneotherapy, glucose, leptin, adiponectin, and visfatin levels may change positively.
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September 2020

The Effect of Ocular Demodex Colonization on Schirmer test and OSDI Scores in Newly Diagnosed Dry Eye Patients.

Eye Contact Lens 2020 Jan;46 Suppl 1:S39-S41

Departments of Ophthalmology (T.A.) and Microbiology (F.M.S.), Kirşehir Ahi Evran University Medicine Faculty, Kirşehir, Turkey.

Objective: To determine whether ocular Demodex colonization results in differences in Schirmer test scores and Ocular Surface Disease Index (OSDI) questionnaire values in individuals with dry eye disease (DED) diagnosed for the first time.

Method: Eighty-eight adults aged 40 to 68 years who were admitted to Ophthalmology outpatient clinic for routine ophthalmological examination or presbyopia examination and diagnosed with DED for the first time and who do not have any chronic disease were included in the study. All the patients were asked to complete the OSDI, which is widely used for assessing dry eye symptom severity and vision-related functioning. The Schirmer test was performed, and then two eyelashes were taken from the inferior eyelids of each eyes. After saline (0.09% NaCl) was added to the sample, it was quickly taken to the microbiology laboratory, which is located next to the Ophthalmology policlinic. The sample was evaluated by a parasitologist experienced in Demodex.

Results: One hundred sixty-eight eyes of 84 patients were included in the study. Average Schirmer test score was 2.1±0.5, the OSDI questionnaire score was 61.82±10.95, and the mean age was 55.36±8.74 years in patients who had Demodex colonization (n=30), whereas the average Schirmer test score was 6.6±0.9 score, OSDI questionnaire score was 40.96±12.73, and the mean age was 49.12±6.87 years in patients without Demodex colonization (n=58). It has been observed that dry eye patients with Demodex colonization had a higher mean age (P: 0.001), higher mean OSDI score (P: 0.001), and lower average Schirmer test score (P: 0.001) compared with those without Demodex. The significant relationship between lower Schirmer test score and higher OSDI rates and occurrence of Demodex infestation continued after adjusting for mean age values (P=0.012; P=0.035).

Conclusion: It was determined that the presence of ocular Demodex colonization was associated with the average Schirmer test scores, OSDI scores, and age values in patients with newly diagnosed DED. Demodex quantity was found increased in older aged patients, but the significant relationship between lower Schirmer test score and higher OSDI rates and Demodex infestation persisted even after controlling the mean age values. Supporting these findings with large-numbered and randomized-controlled studies will help in clarifying the association of the Demodex infestation with etiopathogenesis of dry eye.
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January 2020

Pneumonia due to Enterobacter cancerogenus infection.

Folia Microbiol (Praha) 2014 Nov 29;59(6):527-30. Epub 2014 Jun 29.

Department of Microbiology, Ahi Evran University Research and Teaching Hospital, Kirsehir, Turkey,

Enterobacter cancerogenus (formerly known as CDC Enteric Group 19; synonym with Enterobacter taylorae) has rarely been associated with human infections, and little is known regarding the epidemiology and clinical significance of this organism. We describe a community-acquired pneumonia case in a 44-year-old female due to E. cancerogenus. Identification and antimicrobial susceptibility of the microorganism was performed by the automatized VITEK 2 Compact system (bioMerieux, France). The clinical case suggests that E. cancerogenus is a potentially pathogenic microorganism in determined circumstances; underlying diseases such as bronchial asthma, empiric antibiotic treatment, wounds, diagnostic, or therapeutic instruments.
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November 2014

[Effect of efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine to MIC values of ciprofloxacin in ciprofloxacin resistant gram-negative bacteria].

Mikrobiyol Bul 2009 Jul;43(3):457-61

Ondokuz Mayis Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Samsun.

Effective efflux pump systems play a crucial role in the development of multiple antimicrobial resistance in bacteria. In this study, the effects of an efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine on ciprofloxacin (CIP) minimum inhibitory concentration (MIC) values in gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae were investigated. Nineteen CIP-resistant P. aeruginosa, 37 extended spectrum beta-lactamase (ESBL) positive E. coli and 13 ESBL positive K. pneumoniae clinical isolates were included to the study. CIP MIC values of each isolate were determined by broth microdilution method as recommended by CLSI. MIC values were determined also in the presence of 100 microg/ml NMP. CIP MICs for all isolates were 4 microg/ml or higher. In the presence of 100 microg/ml NMP, CIP MICs did not change for P. aeruginosa isolates. While MICs decreased > or = 4-fold for 22 (59.4%) E. coli isolates, 2-fold decrease was detected only for 14 (37.8%) isolates. MIC value did not change for 1 isolate. While MICs decreased > or = 4-fold for 10 (76.9%) K. pneumoniae isolates, > or = 2-fold decrease was detected for 3 (23.1%) isolates. In conclusion, while NMP consistently reduced the MIC of ciprofloxacin in E. coli and K. pneumoniae clinical isolates, no effects was observed in P. aeruginosa isolates.
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July 2009