Publications by authors named "Fevziye Canbaz Tosun"

5 Publications

  • Page 1 of 1

Does the SUVmax of FDG-PET/CT Correlate with the ADC Values of DWI in Musculoskeletal Malignancies?

J Belg Soc Radiol 2021 Feb 22;105(1):11. Epub 2021 Feb 22.

Department of Radiology, Ondokuz Mayis University Faculty of Medicine, TR.

Purpose: To evaluate the correlation of maximum standardized uptake values (SUV) of F-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) with the apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) in musculoskeletal malignancies.

Methods: Institutional ethics committee approved this retrospective study. Twenty-seven patients (mean age: 44.85 ± 24.07; 17 men and 10 women) with a total of 29 musculoskeletal tumors underwent both FDG-PET/CT and DWI between January 2017 and March 2020. Region-of-interest (ROI)-based maximal standardized uptake values (SUV) of the tumors were measured on FDG-PET/CT images. Two radiologists measured lesions' mean and minimum apparent diffusion coefficient (ADC and ADC) using five distinct ROIs on DWI images. Pearson correlation analysis was used to assess the correlation between SUV and ADC values.

Results: There were 18 soft tissue tumors (62.1%) and 11 bone tumors (37.9%) with a mean maximum diameter of 9.4 ± 6.2 cm. The mean SUV, ADC and ADC of the whole lesions were 12.93 ± 9.63, 0.85 ± 0.28 × 10mm/s and 0.61 ± 0.27 × 10mm/s, respectively. SUV had a weak correlation with tumor maximum diameter (r = 0.378, p = 0.043), whereas ADC and ADC had none. There was strong inverse correlation between SUV and both ADC (r = -0.616, p < 0.001) and ADC (r = -0.638, p < 0.001).

Conclusion: In musculoskeletal tumors, quantitative markers of FDG uptake and diffusion restriction strongly correlate.
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http://dx.doi.org/10.5334/jbsr.2378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908928PMC
February 2021

Marine-Lenhart syndrome with papillary thyroid carcinoma.

J Res Med Sci 2015 Apr;20(4):412-5

Department of Nuclear Medicine, Ondokuz Mayis University Medical School, Samsun, Turkey.

Graves' disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves' thyroid tissue are almost always bening in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves' disease and AFTN. Total thyroidectomy was performed. The hyperfunctioning nodule with centrally hypoactive foci detected by technetium-99m thyroid scanning was histologically diagnosed as papillary thyroid carcinoma that was 2.5 cm in diameter. We report the presence of papillary thyroid carcinoma within AFTN in patients with Marine-Lenhart syndrome, which has not been reported so far.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468460PMC
April 2015

Osteopoikilosis: report of a familial case and review of the literature.

Rheumatol Int 2015 May 29;35(5):921-4. Epub 2014 Oct 29.

Department of Pediatrics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey,

Osteopoikilosis (OPK) is a benign, rare, asymptomatic osteosclerotic bone dysplasia which is inherited as an autosomal dominant trait. It may develop during childhood and persists throughout life. Diagnosis is usually made incidentally according to radiographs. It may be confused with other conditions, such as osteoblastic metastases. OPK must be in differential diagnosis when multiple, small, well-defined, symmetric bone lesions are identified on plain radiograph to avoid alarming the patient with more serious disease and misdiagnosis. Bone scintigraphy is normal and useful for differential diagnosis. Although it is usually asymptomatic, effusion and joint pain can be found in 15-20 % of patients. In this study, we report a 17-year-old boy who suffers from low back pain and has a mother with similar involvement. He was diagnosed OPK radiologically. We also review the clinical manifestation, pathophysiology, diagnosis and treatment of OPK in this paper.
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http://dx.doi.org/10.1007/s00296-014-3160-6DOI Listing
May 2015

Evaluation of primary bone lymphoma and the importance of positron emission tomography.

Acta Orthop Traumatol Turc 2014 ;48(3):371-8

Department of Pediatrics, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey.

Primary lymphoma of the bone is an extremely rare tumor in the form of non-Hodgkin lymphoma or Hodgkin lymphoma. The majority of primary bone lymphomas are non-Hodgkin lymphoma, of which the most common subtype is diffuse large cell lymphoma. Patients can present with pain, swelling or pathologic fracture. Definitive diagnosis is made after biopsy examination. Treatment consists of chemotherapy, radiotherapy and surgery. We report 3 male patients who presented with pain and swelling. Involvement was in the distal femur, proximal fibula and iliac crest in all patients. Patients were diagnosed with non-Hodgkin lymphoma in biopsy examination and underwent chemotherapy. The patient with distal femoral involvement underwent distal femoral resection prosthesis. Another patient with involvement of the fibular head experienced foot drop and delayed wound healing. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography revealed complete response to the treatment. Patients are in remission and continue schooling.
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http://dx.doi.org/10.3944/AOTT.2014.3014DOI Listing
July 2015

Early spondyloarthropathy: scintigraphic, biological, and clinical findings in MRI-positive patients.

Clin Rheumatol 2008 Apr 15;27(4):469-74. Epub 2007 Sep 15.

Department of Physical Medicine and Rehabilitation, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey.

There are no specific diagnostic tests or a gold standard method for measuring disease activity and outcome in spondyloarthropathies (SpA). Many different methods have been developed to assess the signs and symptoms in SpA. The aim of this study was to evaluate the value of scintigraphy, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and Bath Ankilosing Spondylitis Disease Activity Index (BASDAI) in the evaluation of disease activity in early axial SpA diagnosed with magnetic resonance imaging (MRI). Thirty early MRI-positive axial SpA patients (23 males, 7 females) with a median age of 35 (18-55) years and a median duration of inflammatory low back pain of 24 (8-60) months were included in the study. In the patients with sacroiliitis, the sensitivity, specificity, and positive and negative predictive values of disease activity parameters were determined regarding MRI as the gold standard method. The sensitivities of quantitative scintigraphy, visual scintigraphy, ESR, CRP, and BASDAI were 32, 82, 35, 71, and 60%, respectively. The specificities of quantitative scintigraphy, ESR, CRP, and BASDAI were 100, 100, 50, and 100%, respectively. The positive predictive values of quantitative scintigraphy, visual scintigraphy, ESR, CRP, and BASDAI were 100, 92, 100, 95, and 100%, respectively. The negative predictive values of quantitative scintigraphy, ESR, CRP, and BASDAI were 9, 10, 11, and 15%, respectively. Regarding MRI as the gold standard in the evaluation of disease activity, combined visual and quantitative bone scintigraphy can be valuable in patients with MRI-incompatible implants. Additionally, use of cheaper, simple, and readily reproducible tests such as CRP and BASDAI together could be valuable and practical in detecting disease activity in long-term follow-up of these patients.
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http://dx.doi.org/10.1007/s10067-007-0730-yDOI Listing
April 2008