Publications by authors named "Feroz R Papa"

36Publications

Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.

ACS Chem Biol 2019 12 14;14(12):2595-2605. Epub 2019 Oct 14.

Department of Chemistry , University of Washington , Seattle , Washington , United States.

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http://dx.doi.org/10.1021/acschembio.9b00482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925334PMC
December 2019

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes.

Mol Metab 2019 09;27S:S60-S68

Department of Medicine, University of California, San Francisco San Francisco, CA, 94143-2520, USA; Diabetes Center, University of California, San Francisco San Francisco, CA, 94143-2520, USA; Lung Biology Center, University of California, San Francisco San Francisco, CA, 94143-2520, USA; Quantitative Biosciences Institute, University of California, San Francisco San Francisco, CA, 94143-2520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768499PMC
September 2019

Small Molecules to Improve ER Proteostasis in Disease.

Trends Pharmacol Sci 2019 09 31;40(9):684-695. Epub 2019 Jul 31.

Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (FONDAP) Center for Geroscience, Brain Health, and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Science, University of Chile, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.07.003DOI Listing
September 2019

Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.

Proc Natl Acad Sci U S A 2019 06 17;116(23):11291-11298. Epub 2019 May 17.

Department of Medicine, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1904516116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561268PMC
June 2019

The Unfolded Protein Response and Cell Fate Control.

Mol Cell 2018 01 5;69(2):169-181. Epub 2017 Nov 5.

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA; UCSF Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.017DOI Listing
January 2018

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

Cell Metab 2017 Apr;25(4):883-897.e8

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497784PMC
April 2017

The role of endoplasmic reticulum stress in human pathology.

Annu Rev Pathol 2015 27;10:173-94. Epub 2014 Oct 27.

Department of Pathology.

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http://dx.doi.org/10.1146/annurev-pathol-012513-104649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568783PMC
June 2015

Druggable sensors of the unfolded protein response.

Nat Chem Biol 2014 Nov;10(11):892-901

1] Department of Medicine, University of California-San Francisco, San Francisco, California, USA. [2] Diabetes Center, University of California-San Francisco, San Francisco, California, USA. [3] Lung Biology Center, University of California-San Francisco, San Francisco, California, USA. [4] California Institute for Quantitative Biosciences, University of California-San Francisco, San Francisco, California, USA.

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http://www.nature.com/articles/nchembio.1664
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http://dx.doi.org/10.1038/nchembio.1664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664160PMC
November 2014

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

Cell 2014 Jul 10;158(3):534-48. Epub 2014 Jul 10.

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244221PMC
July 2014

Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells.

Lab Invest 2013 Nov 16;93(11):1254-8. Epub 2013 Sep 16.

Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine and Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1038/labinvest.2013.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090936PMC
November 2013

X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis.

PLoS Pathog 2013 22;9(8):e1003576. Epub 2013 Aug 22.

Department of Nephrology, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749957PMC
March 2014

Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.

Respir Res 2012 Nov 20;13:105. Epub 2012 Nov 20.

Department of Medicine, University of California, San Francisco School of Medicine, San Francisco, CA 94143-0111, USA.

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http://dx.doi.org/10.1186/1465-9921-13-105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547729PMC
November 2012

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.

Nat Chem Biol 2012 Dec 21;8(12):982-9. Epub 2012 Oct 21.

Department of Medicine, University of California-San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nchembio.1094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508346PMC
December 2012

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.

Authors:
Feroz R Papa

Cold Spring Harb Perspect Med 2012 Sep 1;2(9):a007666. Epub 2012 Sep 1.

Department of Medicine, The Diabetes Center, The Lung Biology Center, and The California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143-2520, USA.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a007666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426819PMC
September 2012

IRE1-dependent activation of AMPK in response to nitric oxide.

Mol Cell Biol 2011 Nov 6;31(21):4286-97. Epub 2011 Sep 6.

The University of Alabama at Birmingham, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Birmingham, Alabama 352941, USA.

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http://dx.doi.org/10.1128/MCB.05668-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209336PMC
November 2011

Signaling cell death from the endoplasmic reticulum stress response.

Curr Opin Cell Biol 2011 Apr 9;23(2):143-9. Epub 2010 Dec 9.

Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada.

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http://dx.doi.org/10.1016/j.ceb.2010.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078187PMC
April 2011

The UPR and cell fate at a glance.

J Cell Sci 2010 Apr;123(Pt 7):1003-6

Department of Medicine, Diabetes Center and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94143-2520, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.035832
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http://dx.doi.org/10.1242/jcs.035832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844313PMC
April 2010

Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.

J Biol Chem 2010 Feb 23;285(9):6693-705. Epub 2009 Dec 23.

Department of Medicine, Mass Spectrometry Resource, and Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.084293
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http://dx.doi.org/10.1074/jbc.M109.084293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825464PMC
February 2010

Rationalizing translation attenuation in the network architecture of the unfolded protein response.

Proc Natl Acad Sci U S A 2008 Dec 15;105(51):20280-5. Epub 2008 Dec 15.

California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1073/pnas.0803476105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603256PMC
December 2008

Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions.

Cell 2008 Nov 20;135(5):933-47. Epub 2008 Nov 20.

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.cell.2008.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739138PMC
November 2008

Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.

Mol Cell Biol 2008 Jun 21;28(12):3943-51. Epub 2008 Apr 21.

Department of Pathology, Medicine, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1128/MCB.00013-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423129PMC
June 2008

A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.

Biochem Biophys Res Commun 2008 Jan 21;365(4):777-83. Epub 2007 Nov 21.

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-2520, USA.

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http://papalab.ucsf.edu/sites/papalab.ucsf.edu/files/Han2008
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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0702448
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http://dx.doi.org/10.1016/j.bbrc.2007.11.040DOI Listing
January 2008

Intracellular signaling by the unfolded protein response.

Annu Rev Cell Dev Biol 2006 ;22:487-508

Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.cellbio.21.
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http://dx.doi.org/10.1146/annurev.cellbio.21.122303.120200DOI Listing
December 2006

On the mechanism of sensing unfolded protein in the endoplasmic reticulum.

Proc Natl Acad Sci U S A 2005 Dec 19;102(52):18773-84. Epub 2005 Dec 19.

Howard Hughes Medical Institute, Departments of Biochemistry and Biophysics and Medicine, University of California, San Francisco, CA 94143-2200, USA.

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http://www.pnas.org/content/102/52/18773.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.0509487102
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http://dx.doi.org/10.1073/pnas.0509487102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316886PMC
December 2005

Bypassing a kinase activity with an ATP-competitive drug.

Science 2003 Nov 16;302(5650):1533-7. Epub 2003 Oct 16.

Department of Medicine, University of California, San Francisco, CA 94143-2200, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1090031
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http://dx.doi.org/10.1126/science.1090031DOI Listing
November 2003