Fernando Setien

Fernando Setien

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Fernando Setien

Fernando Setien

Publications by authors named "Fernando Setien"

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42Publications

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Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer.

Oncogene 2019 Nov 13;38(45):7106-7112. Epub 2019 Aug 13.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1038/s41388-019-0936-xDOI Listing
November 2019

Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer.

Breast Cancer Res 2019 07 5;21(1):79. Epub 2019 Jul 5.

New Therapeutics Targets Lab (TargetsLab), Department of Medical Sciences, University of Girona, E-17071, Girona, Catalonia, Spain.

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http://dx.doi.org/10.1186/s13058-019-1160-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612099PMC
July 2019

Germline variation in O-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer.

Cancer Lett 2019 04 21;447:86-92. Epub 2019 Jan 21.

Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Program in Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell), IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.01.019DOI Listing
April 2019

Circular RNA CpG island hypermethylation-associated silencing in human cancer.

Oncotarget 2018 Jun 26;9(49):29208-29219. Epub 2018 Jun 26.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.18632/oncotarget.25673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044373PMC
June 2018

Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer.

Oncotarget 2017 Aug 29;8(31):51621-51629. Epub 2017 May 29.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.18632/oncotarget.18255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584274PMC
August 2017

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.

Cancer Res 2015 Sep 24;75(18):3936-45. Epub 2015 Jul 24.

Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3702DOI Listing
September 2015

DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers.

Breast Cancer Res Treat 2015 Jul 14;152(2):271-82. Epub 2015 Jun 14.

Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, 28029, Madrid, Spain.

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http://dx.doi.org/10.1007/s10549-015-3459-3DOI Listing
July 2015

Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene.

J Natl Cancer Inst 2015 Mar 11;107(5). Epub 2015 Mar 11.

: Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre, Madrid, Spain (AC, ICM, MCF, AAdC, VM, LIP, RL, AGG, MAR, CRA, MR); Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain (AC, LC, LIP, CRA, JS, MU, MR); Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid and Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain (LC, JS); Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (SR, MP, GE); Departments of Pathology (APB) and Endocrinology and Nutrition Service (MC), Hospital 12 de Octubre, Madrid, Spain; Endocrinology Service, Hospital Infanta Sofía, San Sebastián de los Reyes, Spain (SA); Department of Endocrinology and Nutrition Service, Hospital de Fuenlabrada, Madrid, Spain (RVV); Endocrinology Service, Hospital Puerta de Hierro, Majadahonda, Madrid, Spain (JA); Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Spain (FS, SM, ME); Department of Pathology, MD Anderson Cancer Center Madrid, Madrid, Spain (JFG); Molecular Cytogenetics Group (ARM), Monoclonal Antibodies Unit, Biotechnology Programme (GR), and Familial Cancer Clinical Unit (MU), Spanish National Cancer Research Centre, Madrid, Spain.

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http://dx.doi.org/10.1093/jnci/djv053DOI Listing
March 2015

DNA methylation plasticity of human adipose-derived stem cells in lineage commitment.

Am J Pathol 2012 Dec 29;181(6):2079-93. Epub 2012 Sep 29.

Cancer Epigenetics Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Biomedical Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ajpath.2012.08.016DOI Listing
December 2012

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer.

EMBO Mol Med 2012 Jul 11;4(7):603-16. Epub 2012 Apr 11.

Genes and Cancer Group, Cancer Epigenetics and Biology Program-PEBC, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/emmm.201200236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407948PMC
July 2012

Distinct DNA methylomes of newborns and centenarians.

Proc Natl Acad Sci U S A 2012 Jun 11;109(26):10522-7. Epub 2012 Jun 11.

Cancer Epigenetics and Biology Program, Spanish Biomedical Research Centre Network for Epidemiology and Public Health, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L’Hospitalet, Barcelona, Catalonia 08908, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1120658109
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http://dx.doi.org/10.1073/pnas.1120658109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387108PMC
June 2012

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context.

Nucleic Acids Res 2011 Nov 16;39(21):9194-205. Epub 2011 Aug 16.

Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain.

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http://dx.doi.org/10.1093/nar/gkr658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241660PMC
November 2011

The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: differences between normal controls and children with the Zellweger syndrome.

Lipids Health Dis 2010 Sep 9;9:98. Epub 2010 Sep 9.

Manuela Martinez Foundation for Children with Metabolic Diseases, Research Laboratory, Plaza Karl Marx 1, Barcelona 08042, Spain.

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http://dx.doi.org/10.1186/1476-511X-9-98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949860PMC
September 2010

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma.

Proc Natl Acad Sci U S A 2009 Dec 14;106(51):21830-5. Epub 2009 Dec 14.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, 08907 L'Hospitalet, Spain.

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http://dx.doi.org/10.1073/pnas.0906831106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793312PMC
December 2009

Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.

Cancer Res 2009 Nov 27;69(21):8447-54. Epub 2009 Oct 27.

Bellvitge Biomedical Research Institute, l'Hospitalet, and Institució Catalana de Recerca i Estudis Avançats, Catalonia, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0551DOI Listing
November 2009

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Exp Mol Pathol 2008 Dec 11;85(3):201-6. Epub 2008 Oct 11.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

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http://dx.doi.org/10.1016/j.yexmp.2008.09.006DOI Listing
December 2008

Combinatorial effects of splice variants modulate function of Aiolos.

J Cell Sci 2007 Aug;120(Pt 15):2619-30

Cancer Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1242/jcs.007344DOI Listing
August 2007

CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.

Carcinogenesis 2007 Jun 1;28(6):1264-8. Epub 2007 Feb 1.

Department of Neurosurgery, University of Dresden, Fetscherstrasse 74, Dresden, Germany.

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http://dx.doi.org/10.1093/carcin/bgm014DOI Listing
June 2007

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells.

Cancer Res 2007 Feb;67(4):1424-9

Cancer Epigenetics Laboratory and Lung Cancer Laboratory, Spanish National Cancer Centre (CNIO), Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4218DOI Listing
February 2007

Proteolytic regulation of activated STAT6 by calpains.

J Immunol 2005 Mar;174(5):2843-8

Unidad de Investigacion, Hospital San Pedro de Alcantara, Caceres, Spain.

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http://dx.doi.org/10.4049/jimmunol.174.5.2843DOI Listing
March 2005

The impact of MECP2 mutations in the expression patterns of Rett syndrome patients.

Hum Genet 2005 Jan 11;116(1-2):91-104. Epub 2004 Nov 11.

Cancer Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Centre, Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://link.springer.com/content/pdf/10.1007/s00439-004-1200
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http://link.springer.com/10.1007/s00439-004-1200-0
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http://dx.doi.org/10.1007/s00439-004-1200-0DOI Listing
January 2005