Fernando Lopez-Rios

Fernando Lopez-Rios

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Fernando Lopez-Rios

Fernando Lopez-Rios

Publications by authors named "Fernando Lopez-Rios"

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Correlation of ROS1 Immunohistochemistry With Fusion Status Determined by Fluorescence In Situ Hybridization.

Arch Pathol Lab Med 2019 Sep 11. Epub 2019 Sep 11.

From Roche Molecular Solutions, Pleasanton, California (Dr Huang, Mr Smith, Dr Le, Mr Liu, Dr Ordinario, Dr Manohar, Mr Lee, Mr Rajamani, Mr Truong, Dr Jing Li, Ms Choi, Dr Jingchuan Li, Dr Pati, Ms Hanlon Newell, Mr Pate, and Dr Menzl); Institute of Pathology, University Hospital Basel, Basel, Switzerland (Dr Bubendorf); Institute for Pathology, University Hospital, Cologne, Germany (Dr Buettner); the Department of Pathology, Aberdeen University Medical School & Aberdeen Royal Infirmary, Foresterhill, Aberdeen, United Kingdom (Dr Kerr); Laboratorio de Dianas Terapeuticas, HM Hospitales, Spain (Dr Lopez-Rios); Center of Predictive Molecular Medicine, CeSIMeT, University of Chieti-Pescara, Italy (Dr Marchetti); Pfizer Oncology, International Developed Markets, Berlin, Germany (Ms Marondel); the Department of Histopathology, Royal Brompton and Harefield Hospitals, and National Heart and Lung Division, Imperial College, London, United Kingdom (Dr Nicholson); the Pathology Department, Istanbul University, Cerrahpassa Medical Faculty, Istanbul, Turkey (Dr Öz); CORE, Antwerp University, and the Department of Pathology, Antwerp University Hospital, Antwerp, Belgium (Mr Pauwels); the Department of Biopathology, Centre Jean Perrin & INSERM U240 IMoST and Université Clermont Auvergne, Clermont-Ferrand, France (Dr Penault-Llorca); Operative Unit of Pathology, AUSL della Romagna, Hospital S. Maria delle Croci, Ravenna, Italy (Dr Rossi); and the Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands (Dr Thunnissen).

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http://dx.doi.org/10.5858/arpa.2019-0085-OADOI Listing
September 2019

Could WNT inhibitors really knock on the treatment door of small cell lung cancer?

J Thorac Dis 2019 Mar;11(Suppl 3):S381-S384

Medical Oncology Department, Centro Integral Oncología Clara Campal Barcelona, HM-Delfos, Barcelona, Spain.

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http://dx.doi.org/10.21037/jtd.2018.12.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424724PMC
March 2019

Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non-Small-Cell Lung Cancer.

J Clin Oncol 2017 Dec 20;35(34):3867-3876. Epub 2017 Oct 20.

Reinhard Büttner, University Hospital Cologne, Cologne; Manfred Dietel, Charité Universitätsmedizin Berlin, Berlin, Germany; John R. Gosney, Royal Liverpool University Hospital, Liverpool; Andrew C. Wotherspoon, Royal Marsden Hospital, London; Keith M. Kerr, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom; Birgit Guldhammer Skov, Copenhagen University Hospital, Copenhagen, Denmark; Julien Adam, Gustave Roussy Cancer Center, Villejuif; Frédérique Penault-Llorca, Jean Perrin Comprehensive Cancer Center, Clermont-Ferrand, France; Noriko Motoi, National Cancer Center Hospital, Tokyo, Japan; Kenneth J. Bloom, Human Longevity, San Diego, CA; John W. Longshore, Carolinas Pathology Group, Charlotte, NC; Fernando López-Ríos, Hospital Universitario HM Sanchinarro, Madrid, Spain; Giuseppe Viale, University of Milan, Milan, Italy; and Ming-Sound Tsao, University Health Network, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2017.74.7642DOI Listing
December 2017

Treating -mutant NSCLC: latest evidence and clinical consequences.

Ther Adv Med Oncol 2017 Sep 24;9(9):589-597. Epub 2017 Jul 24.

Centro de Investigaciones Biomédicas en Red en Cáncer (CIBER-ONC), Madrid, Spain Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Universidad de Alcalá (IRYCIS), Madrid, Spain.

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http://dx.doi.org/10.1177/1758834017719829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564881PMC
September 2017

Biological therapies in nonsmall cell lung cancer.

Eur Respir J 2017 03 2;49(3). Epub 2017 Mar 2.

Medical Oncology Dept, Hospital Universitario 12 de Octubre and Instituto de Investigación i+12, Madrid, Spain

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01520
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http://dx.doi.org/10.1183/13993003.01520-2016DOI Listing
March 2017

Phase II Trial of Target-guided Personalized Chemotherapy in First-line Metastatic Colorectal Cancer.

Am J Clin Oncol 2016 06;39(3):236-42

*Centro Integral Oncológico Clara Campal ‡Therapeutics Targets Laboratory †Universidad CEU San Pablo §Centro Nacional de Investigaciones Oncologicas, Madrid, Spain.

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http://dx.doi.org/10.1097/COC.0000000000000045DOI Listing
June 2016

Profile of Ventana ALK (D5F3) companion diagnostic assay for non-small-cell lung carcinomas.

Expert Rev Mol Diagn 2016 06 15;16(6):707-13. Epub 2016 Apr 15.

a Laboratorio de Dianas Terapéuticas , Hospital Universitario HM Sanchinarro , Madrid , Spain.

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http://dx.doi.org/10.1586/14737159.2016.1172963DOI Listing
June 2016

MicroRNA-dependent regulation of transcription in non-small cell lung cancer.

PLoS One 2014 13;9(3):e90524. Epub 2014 Mar 13.

Molecular Oncology and New Therapies Group. Instituto de Biomedicina de Sevilla (IBIS) (HUVR, CSIC, Universidad de Sevilla), Sevilla, Spain; Medical Oncology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090524PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953115PMC
January 2016

The anaplastic lymphoma kinase testing conundrum.

Expert Rev Mol Diagn 2015 Feb 12;15(2):161-3. Epub 2015 Jan 12.

Laboratorio de Dianas Terapéuticas, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Faculty of Medicine, C/Oña, 10. 28050 Madrid, Spain.

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http://dx.doi.org/10.1586/14737159.2015.997713DOI Listing
February 2015

Relevance of insulin-like growth factor 1 receptor gene expression as a prognostic factor in non-small-cell lung cancer.

J Cancer Res Clin Oncol 2015 Jan 1;141(1):43-53. Epub 2014 Aug 1.

Translational Oncology, Instituto de Investigación Hospital 12 de Octubre (i+12), Avda de Córdoba S/N, 28041, Madrid, Spain.

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http://dx.doi.org/10.1007/s00432-014-1787-zDOI Listing
January 2015

Multicenter immunohistochemical ALK-testing of non-small-cell lung cancer shows high concordance after harmonization of techniques and interpretation criteria.

J Thorac Oncol 2014 Nov;9(11):1685-92

*Institute of Pathology, Charité BERLIN, Berlin, Germany; †Institute of Pathology, University of Heidelberg, Heidelberg, Germany; ‡Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom; §Department of Pathology and Cytology, Karolinska University Hospital, Solna, Stockholm, Sweden; ‖Department of Pathology, University Hospital Cologne, Cologne, Germany; ¶Laboratorio de Dianas Terapeuticas, Hospital Universitario Sanchinarro, Madrid, Spain; #Institute of Pathology, Klinikum Großhadern Ludwig-Maximilians-Universität, Munich, Germany; **Institute of Pathology, UZ ANTWERPEN, Edegem, Belgium; ††Institute of Pathology, Klinikum rechts der Isar, TU, Munich, Germany; ‡‡Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany; §§Institute of Pathology, Universitätsspital Basel, Basel, Germany; ‖‖Institute of Pathology, HSK Dr.-Horst-Schmidt-Kliniken GmbH, Wiesbaden, Germany; ¶¶Institute of Pathology, Universitäts Spital Zürich, Zurich, Switzerland; ##Institute of Pathology, Centre Jean Perrin, Clermont-Ferrand, France; ***Patologisk Institut, Århus Universitetshospital, Århus, Denmark; †††Pathology-Berlin, Bioptisches Institut Gemeinschaftspraxis für Pathologie, Berlin, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000332DOI Listing
November 2014

A new generation of companion diagnostics: cobas BRAF, KRAS and EGFR mutation detection tests.

Expert Rev Mol Diagn 2014 Jun;14(5):517-24

Hospital Universitario Sanchinarro - Laboratorio de Dianas Terapeuticas, Centro Integral Oncologico Clara Campal C/Oña, 10. 28050, Madrid, Spain.

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http://dx.doi.org/10.1586/14737159.2014.910120DOI Listing
June 2014

Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment.

Clin Cancer Res 2014 May 14;20(9):2476-84. Epub 2014 Mar 14.

Authors' Affiliations: Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Champions Oncology, Baltimore, Maryland; Personal Genome Diagnostics, Inc., Baltimore, Maryland; Laboratorio Dianas Terapéuticas, Hospital Universitario Madrid-Sanchinarro, Madrid, Spain; Centro Integral Oncológico Clara Campal, Hospital Universitario Madrid-Sanchinarro, Madrid, Spain; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322867PMC
http://dx.doi.org/10.1158/1078-0432.CCR-13-3047DOI Listing
May 2014

A prospective pilot study of target-guided personalized chemotherapy with intensity-modulated radiotherapy in patients with early rectal cancer.

Am J Clin Oncol 2014 Apr;37(2):117-21

*Centro Integral Oncológico Clara Campal §Therapeutics Targets Laboratory †Department of Clinical Medicine, Universidad CEU San Pablo ‡Centro Nacional de Investigaciones Oncologicas, Madrid, Spain.

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http://dx.doi.org/10.1097/COC.0b013e31826e0703DOI Listing
April 2014

Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab.

J Clin Oncol 2013 Dec 14;31(35):4445-52. Epub 2013 Oct 14.

Carlos Gomez-Martin, Elena Garralda, and Manuel Hidalgo, Spanish National Cancer Research Centre; Carlos Gomez-Martin, Jose Carlos Plaza, Fernando Lopez-Rios, and Manuel Hidalgo, Laboratorio Dianas Terapeuticas, Cenro Integral Oncologico Clara Campal, Hospital Universitario Sanchinarro; Federico Rojo and Ana Leon, Fundacion Jimenez Diaz, Madrid; Pilar Sanz-Moncasi, Hospital Royo-Villanova; Roberto Pazo-Cid and Elena del Valle, Hospital Universitario Miguel Servet, Zaragoza; Antonieta Salud and Felipe Vilardell, Hospital Universitario Arnau de Vilanova, Lérida; Francesc Pons, Mar Iglesias, and Clara Montagut, Hospital de Mar; Maria Alsina and Stefania Landolfi, Hospital Universitari Vall d'Hebrón; M. Carmen Galan and M. Jose Paulés, Instituto Catalan de Oncologia; Miriam Cuatrecasas and Laura Visa, Hospital Clinic Universitari, Barcelona; Paula Fonseca and Soledad Fernandez, Hospital Universitario Central de Asturias, Oviedo; Fernando Rivera and Marta Mayorga, Hospital Universitario Marques de Valdecilla, Santander, Spain.

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http://dx.doi.org/10.1200/JCO.2013.48.9070DOI Listing
December 2013

Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer.

Int J Cancer 2013 Aug 9;133(4):898-907. Epub 2013 Mar 9.

Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/ijc.28090DOI Listing
August 2013

The ALK translocation in advanced non-small-cell lung carcinomas: preapproval testing experience at a single cancer centre.

Histopathology 2013 Mar 5;62(4):609-16. Epub 2013 Feb 5.

Laboratorio de Dianas Terapéuticas, Centro Integral Oncológico Clara Campal, Hospital Universitario Madrid Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain.

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http://dx.doi.org/10.1111/his.12037DOI Listing
March 2013

A comparison of EGFR mutation testing methods in lung carcinoma: direct sequencing, real-time PCR and immunohistochemistry.

PLoS One 2012 27;7(8):e43842. Epub 2012 Aug 27.

Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico Clara Campal, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428292PMC
February 2013

Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer.

Cancer Res 2012 Jan 14;72(1):176-86. Epub 2011 Nov 14.

Genes and Cancer Group, Cancer Epigenetics and Biology Program, PEBC, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3506DOI Listing
January 2012

Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors.

Hum Mutat 2011 Feb 7;32(2):E1999-2017. Epub 2010 Dec 7.

Genes and Cancer Group, Cancer Epigenetics and Biology Program-PEBC (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://doi.wiley.com/10.1002/humu.21415
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http://dx.doi.org/10.1002/humu.21415DOI Listing
February 2011

Lung cancer genomic signatures.

J Thorac Oncol 2010 Oct;5(10):1673-91

Servicio de Oncología, Hospital Universitario 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1097/JTO.0b013e3181f1900eDOI Listing
October 2010

Clinicopathological study of 21 cases of eyelid actinic keratosis.

Int Ophthalmol 2009 Oct 17;29(5):379-84. Epub 2008 Jul 17.

Department of Ophthalmology, Madrid, Spain.

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http://dx.doi.org/10.1007/s10792-008-9251-1DOI Listing
October 2009

[Prognostic value study of lung cancer molecular markers].

Med Clin (Barc) 2009 Apr 14;132(14):529-36. Epub 2009 Apr 14.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, España.

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http://dx.doi.org/10.1016/j.medcli.2008.10.060DOI Listing
April 2009

Management of primary pulmonary artery sarcoma: experience of a single center.

Angiology 2008 Oct-Nov;59(5):636-9. Epub 2008 Apr 2.

Department of Cardiology, Hospital Virgen de la Salud, Toledo, Spain.

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http://dx.doi.org/10.1177/0003319707305981DOI Listing
November 2008

Mycosis fungoides after solid-organ transplantation: report of 2 new cases.

Am J Dermatopathol 2008 Apr;30(2):150-5

Department of Surgical Pathology and Cytopathology, University Hospital "12 de Octubre", Madrid, Spain.

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http://dx.doi.org/10.1097/DAD.0b013e318164cf6eDOI Listing
April 2008

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas.

Lung Cancer 2007 Dec 8;58(3):303-9. Epub 2007 Aug 8.

Programa de Oncología Translacional, Instituto de Biología Molecular y Celular del Cáncer, CSIC, Universidad de Salamanca, Spain.

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http://dx.doi.org/10.1016/j.lungcan.2007.06.023DOI Listing
December 2007

Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas.

Cancer Res 2007 Oct;67(19):9013-7

Hospital Universitario 12 de Octubre, CIBER de Enfermedades Respiratorias, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Cientificas, Madrid, Spain.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-07-1678DOI Listing
October 2007

Prognostic value of KIT expression in small cell lung cancer.

Lung Cancer 2007 Jun 8;56(3):405-13. Epub 2007 Apr 8.

Medical Oncology Department, Hospital Universitario Doce de Octubre, Avd. de Córdoba Km 5.4., 28041 Madrid, Spain.

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http://dx.doi.org/10.1016/j.lungcan.2007.01.029DOI Listing
June 2007

Cutaneous metastasis of occult hepatocellular carcinoma: a case report.

Acta Cytol 2007 Mar-Apr;51(2):214-6

Department of Pathology, "12 de Octubre" University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1159/000325720DOI Listing
May 2007

[Nonbacterial thrombotic endocarditis: clinicopathologic study of a necropsy series].

Rev Esp Cardiol 2007 May;60(5):493-500

Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain.

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May 2007

Fine needle aspiration of chromophobe renal cell carcinoma.

Acta Cytol 2007 Jan-Feb;51(1):9-15

Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1159/000325675DOI Listing
March 2007

Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung.

Int J Cancer 2006 Dec;119(11):2603-6

Lung Cancer Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1002/ijc.22211DOI Listing
December 2006

Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.

Nature 2006 Mar;440(7084):702-6

Tumor Suppression Group, Spanish National Cancer Research Center (CNIO), E-28029 Madrid, Spain.

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http://www.nature.com/articles/nature04585
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http://dx.doi.org/10.1038/nature04585DOI Listing
March 2006

Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling.

Clin Cancer Res 2006 Feb;12(3 Pt 1):710-7

Lung Cancer Group, Spanish National Cancer Centre, Hospital Universitario 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1362DOI Listing
February 2006

Malignant mesothelioma.

N Engl J Med 2006 Jan;354(3):305-7; author reply 305-7

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January 2006

Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure.

Eur J Heart Fail 2005 Oct;7(6):1011-6

Heart Failure and Transplant Unit, Hospital Doce de Octubre, Avenida de Córdoba sn, Km 5,400. 28041 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ejheart.2004.10.021DOI Listing
October 2005

Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.

Hum Mol Genet 2005 Apr 24;14(7):973-82. Epub 2005 Feb 24.

Lung Cancer Group, Molecular Pathology Programme, Spanish National Cancer Centre, C/Melchior Fernandez Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1093/hmg/ddi091DOI Listing
April 2005

Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids.

Lancet 2004 Sep 25-Oct 1;364(9440):1157-66

Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/S0140-6736(04)17102-XDOI Listing
October 2004

Cytopathology in Spain.

Diagn Cytopathol 2003 Jan;28(1):61-2

Departmento de Anatomica Patologica, Hospita Universitario, Madrid, Spain.

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http://dx.doi.org/10.1002/dc.10212DOI Listing
January 2003

Keratinocyte dysplasia: an usual finding after transplantation or chemotherapy.

J Cutan Pathol 2002 Nov;29(10):579-84

Department of Dermatology, Hospital Universitario 12 de Octubre, and Staticon International España, SA, Madrid, Spain.

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http://dx.doi.org/10.1034/j.1600-0560.2002.291002.xDOI Listing
November 2002

Mitotically active juvenile xanthogranuloma.

Arch Pathol Lab Med 2002 Oct;126(10):1219-21

Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1043/0003-9985(2002)126<1219:MAJX>2.0.CO;2DOI Listing
October 2002

Plexiform fibrohistiocytic tumor without multinucleated giant cells: a case report.

Am J Dermatopathol 2002 Oct;24(5):399-401

Department of Pathology, "12 de Octubre" University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1097/00000372-200210000-00004DOI Listing
October 2002

Fine-needle aspiration biopsy of the retroperitoneum: a series of 111 cases not including specific organs.

Diagn Cytopathol 2002 Aug;27(2):85-9

Department of Pathology, "12 de Octubre" University Hospital, Carretera de Andalucía, Madrid, Spain.

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http://dx.doi.org/10.1002/dc.10149DOI Listing
August 2002

Trichoblastoma arising within an apocrine poroma.

Am J Dermatopathol 2002 Feb;24(1):59-62

Departamento de Anatomía Patológica, Hospital Universitario, Madrid, Spain.

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http://dx.doi.org/10.1097/00000372-200202000-00012DOI Listing
February 2002