Publications by authors named "Fernando Garcia-Souto"

30 Publications

  • Page 1 of 1

Localised vulvar and perianal pruritus as the first manifestation of Type 1 diabetes mellitus in a young woman.

Intern Med J 2021 Feb;51(2):305

Department of Dermatology, Valme University Hospital, Avenida Bellavista, Seville, Andalusia, Spain.

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http://dx.doi.org/10.1111/imj.15192DOI Listing
February 2021

Melanoma mortality in Spain: predictions up to 2043.

Int J Dermatol 2021 Feb 11. Epub 2021 Feb 11.

Department of Dermatology, Virgen del Rocio University Hospital, Sevilla, Spain.

Background: Melanoma mortality rates are stabilizing and in certain regions and age groups are trending down. Although there are some studies that predict melanoma mortality in other countries, there are currently no studies that predict mortality in Spain in the coming years. The main aim of this study is to calculate melanoma mortality projections in Spain for the period 2019-2043.

Methods: This is a population-based ecological study that utilized information from the Spanish National Statistics Institute. Analysis included deaths as a result of cutaneous melanoma in Spain in the period 1979-2018, and data was analyzed according to gender and age group. Projections were made until 2043 in five-year periods, calculated in Nordpred (within the R software).

Results: Our estimates predict that in the period 2019-2043, there will be 30,477.9 deaths from melanoma in Spain, with the age group of >85 years being the group with the highest number of deaths. The expected average annual death rate for melanoma in both genders for the period 2019-2043 is 1,269.9 deaths / year. The predicted age-standardized mortality rates varied between 4.62/100.000 inhabitants in the 2019-2023 period and 3.94/100.000 inhabitants in the 2039-2043 period.

Conclusions: Overall mortality rate and age-standardized melanoma death rates in older people of both genders will increase in the coming years in Spain, while rates in younger people will stabilize or decrease progressively. In the coming years, prevention efforts should focus on the young, but the emphasis should also be on educating the elderly in early detection of melanoma.
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http://dx.doi.org/10.1111/ijd.15438DOI Listing
February 2021

Craniofacial hyperhidrosis: Clinical characteristics and response to treatment in a cohort of 97 patients treated with oral oxybutynin.

Dermatol Ther 2021 Jan 15;34(1):e14658. Epub 2020 Dec 15.

Faculty of Medicine, University of Seville, Seville, Spain.

The term craniofacial hyperhidrosis (HH) refers to HH that affects the face and/or scalp. Few studies have focused on this specific location, and even fewer distinguish between the two areas. Our study aims are to describe the clinical characteristics of patients with craniofacial HH, specifying whether the condition affects the scalp, face or both, and to compare these cases with those recorded at other locations. As secondary objectives, we determine the effectiveness and adverse effects of oral oxybutynin (OOx), and assess patients' adherence to treatment. This prospective observational study was carried out with respect to the period 2007-2019. All patients diagnosed with HH of the scalp and/or face and who were treated with OOx at our HH unit were included in the study group. Of 292 patients treated with OOx, 97 (33.2%) had craniofacial HH. Of these, 4 (4.1%) presented HH exclusively on the scalp, 56 (57.7%) exclusively on the face and 37 (38.1%) in both locations. The patients in the latter category (compared with those with exclusively facial HH) were significantly older than the others, had a later onset of HH, a greater frequency of secondary HH, less simultaneous involvement of the classical areas of primary focal HH (the palms, soles, and armpits) and greater generalized HH and of the trunk. No significant differences were observed between the three locations (face, scalp, or both) regarding the efficacy and side effects of OOx. The patients with exclusively facial HH presented greater adherence to treatment.
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http://dx.doi.org/10.1111/dth.14658DOI Listing
January 2021

Eruptive lentiginosis confined to areas of regressing psoriatic plaques after adalimumab treatment.

An Bras Dermatol 2021 Jan-Feb;96(1):113-114. Epub 2020 Nov 18.

Deparment of Dermatology, Valme University Hospital, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.abd.2020.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838118PMC
March 2021

Asymptomatic plaque on the scalp.

Cutis 2020 07;106(1):25-27

Department of Dermatology, Valme University Hospital, Avenida Bellavista, Seville, Spain.

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http://dx.doi.org/10.12788/cutis.0046DOI Listing
July 2020

Adjusting oral glycopyrrolate medication for hyperhidrosis to reflect seasonal temperature variations.

Dermatol Ther 2020 11 14;33(6):e14249. Epub 2020 Sep 14.

Faculty of Medicine, University of Seville, Seville, Spain.

The condition of most patients with hyperhidrosis (HH) is known to worsen with increased temperature. However, most prior studies of oral glycopyrrolate (OGly) for the treatment of HH have assumed a stable treatment protocol, without taking into account seasonal variations in temperature. The main aim of this study is to evaluate the outcomes derived from performing a seasonal adjustment of the dose of OGly for patients with HH. A prospective study of patients who began OGly for HH, and maintained treatment for at least 1 year, was performed. All patients had experienced treatment failure with oral oxybutynin. All were recommended to vary the dose of medication according to the time of year. Of the 35 patients included in the study, 20 (57.14%) varied the dose. Those with palmar and plantar HH had a greater propensity to do so. The patients who varied the dose according to the time of year were significantly more likely to report an "Excellent" response after 12 months of treatment. The frequency of adverse effects was 71.4% with no significant differences among the study groups. However, there was a significantly higher proportion of adverse effects other than oral xerosis in the group that did not vary the dose.
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http://dx.doi.org/10.1111/dth.14249DOI Listing
November 2020

Survival study of treatment adherence by patients given oral glycopyrrolate for hyperhidrosis following treatment failure with oral oxybutynin.

Dermatol Ther 2020 11 7;33(6):e14210. Epub 2020 Sep 7.

Faculty of Medicine, University of Seville, Seville, Spain.

Oral anticholinergics such as oxybutynin (OOx) and glycopyrrolate (OGly) are frequently used in the management of hyperhidrosis. Although OOx is considered currently the anticholinergic drug of first choice, OGly is a safe and effective alternative if OOx fails. The aim of this study was to identify the main variables associated with treatment adherence by patients receiving OGly, for whom previous treatment with OOx had failed. A prospective study was conducted of patients with hyperhidrosis receiving treatment with OGly in the period 2012 to 2019. Epidemiological variables, treatment details, effectiveness and adverse effects were recorded. A total of 58 patients (41 women), with a mean age of 35.9 years, were included in the study. The median follow-up period was 32 months. At 3 months, 70.7% of the patients had responded to treatment (excellent response: 75.6%), and adverse effects were reported by 70.7%. At 12 months, 53.4% had responded (excellent response: 74.2%), with adverse effects in 70.9%. The variables associated with poorer adherence were affected areas: palms of the hands, soles of the feet and armpits. The only variable associated with greater adherence was the generalized presence of hyperhidrosis. Our results provide valuable insights into the outcomes achieved when OGly is used to treat hyperhidrosis.
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http://dx.doi.org/10.1111/dth.14210DOI Listing
November 2020

Pacemaker dermatitis.

Med Clin (Barc) 2021 03 8;156(6):314. Epub 2020 Aug 8.

Departamento de Dermatología, Hospital Universitario de Valme, Sevilla, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.medcli.2020.03.017DOI Listing
March 2021

Eroded plaques involving the breasts: a unique location of pemphigus vulgaris.

An Bras Dermatol 2020 Sep - Oct;95(5):670-671. Epub 2020 Jul 15.

Department of Dermatology, Valme University Hospital, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.abd.2020.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563004PMC
November 2020

Long-lasting contact dermatitis in patients with atopic dermatitis or psoriasis.

Australas J Dermatol 2020 Nov 13;61(4):342-345. Epub 2020 Jul 13.

Industrial Engineering School, Extremadura University, Badajoz, Spain.

Background: The aetiology of contact dermatitis, a common inflammatory skin disorder, is often complex and multifactorial.

Objectives: To describe the characteristics of patients with contact dermatitis who also have concomitant atopic dermatitis or psoriasis.

Methods: Between 2000 and 2011, adult patients with chronic contact dermatitis (six months or more), which also had concomitant atopic dermatitis or psoriasis, were recruited for a descriptive retrospective study in a tertiary care Spanish hospital. Univariate and multivariate analyses were used for the analysis of the collected data.

Results: 76 patients with atopic dermatitis and 130 with psoriasis were recruited. The most frequent site of contact dermatitis in both groups was the hands. The most frequent clinically relevant allergen in both groups was nickel sulphate. According to multivariate logistic regression, a statistically significant association was found between facial contact dermatitis and atopic dermatitis (adjusted OR 0.2 95% CI: 0.05-0.8; P = 0.022). No differences were found between the groups for patch test results (adjusted OR 0.6 CI 95%: 0.3-1.3; P = 0.194).

Conclusions: Although the number of patients was limited, our results provide valuable insight on the behaviour of contact dermatitis in patients with atopic dermatitis and with psoriasis. Facial contact dermatitis was positively associated with atopic dermatitis. No differences were found with respect to rates of contact hypersensitivity or positivity to different allergens.
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http://dx.doi.org/10.1111/ajd.13367DOI Listing
November 2020

Primary cutaneous carcinosarcoma: clinical, histological, and immunohistochemical analysis of eight cases.

Int J Dermatol 2021 Jan 12;60(1):93-98. Epub 2020 Jun 12.

Department of Dermatology, Hospital Universitario Virgen del Rocío, Seville, Spain.

Background: Cutaneous carcinosarcoma is a rare biphasic tumor comprising malignant epithelial and heterologous mesenchymal elements. Data on the clinical and histopathologic characteristics of this tumor are scarce. The objective of this study was to describe the clinicopathologic and immunohistochemical features of cutaneous carcinosarcoma.

Methods: A descriptive retrospective study was conducted in a tertiary care hospital from Spain. We reviewed the records of eight patients with cutaneous carcinosarcoma who were diagnosed from 2009 to 2019.

Results: The mean patient age at diagnosis was 72.13 years (range 44-91 years), and there was a male predilection (6 cases). The most common site of cutaneous carcinosarcoma was the head and neck (5 cases). Carcinosarcomas demonstrated variable histopathological and immunohistochemical features. Follow-up was available for 7-8 patients. There were two cases of local recurrence and one case of metastasis. Two patients died from the tumor during the entire follow-up.

Conclusions: Although the number of cases in this study was limited, our results provide valuable insight into the clinical, histopathologic, and immunohistochemical characteristics of primary cutaneous carcinosarcoma.
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http://dx.doi.org/10.1111/ijd.14996DOI Listing
January 2021

Skin necrosis in a patient with giant cell arteritis: a case report focusing on dermoscopic features.

Int J Dermatol 2020 Dec 2;59(12):e450-e452. Epub 2020 May 2.

Department of Dermatology, Hospital Universitario de Valme, Seville, Spain.

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http://dx.doi.org/10.1111/ijd.14912DOI Listing
December 2020

Visual Dermatology: Pemphigus Erythematosus (Senear-Usher Syndrome).

J Cutan Med Surg 2020 Mar/Apr;24(2):190

16583 Department of Pathology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1177/1203475420902054DOI Listing
February 2021

Visual Dermatology: Syphilis Cornee.

J Cutan Med Surg 2020 Mar/Apr;24(2):187

16583 Department of Dermatology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1177/1203475419888870DOI Listing
February 2021

Primary mucoepidermoid carcinosarcoma of the skin: an exceptional tumor.

Int J Dermatol 2020 Aug 28;59(8):e284-e286. Epub 2020 Feb 28.

Department of Dermatology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1111/ijd.14834DOI Listing
August 2020

Visual Dermatology: Gottron Papules in a Child: Juvenile Dermatomyositis.

J Cutan Med Surg 2020 Jan/Feb;24(1):95

16583 Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1177/1203475419860502DOI Listing
November 2020

Visual Dermatology: Erythrasma Fluorescence Under Wood's Lamp.

J Cutan Med Surg 2020 Jan/Feb;24(1):94

16583 Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1177/1203475419858935DOI Listing
November 2020

Erythema migrans.

Med Clin (Barc) 2021 01 25;156(2):103. Epub 2019 Nov 25.

Departamento de Dermatología, Hospital Universitario de Valme, Ctra. de Cádiz, Km. 548,9, 41001 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.medcli.2019.10.001DOI Listing
January 2021

Isomorphic phenomenon of Koebner.

Med Clin (Barc) 2020 11 18;155(10):470. Epub 2019 Nov 18.

Departamento de Dermatología, Hospital Universitario de Valme, Sevilla, España.

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http://dx.doi.org/10.1016/j.medcli.2019.08.004DOI Listing
November 2020

Visual Dermatology: Woolly Hair Nevus.

J Cutan Med Surg 2019 Nov/Dec;23(6):642

Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1177/1203475419858930DOI Listing
August 2020

Worsening of high-grade squamous intraepithelial lesion (HSIL) with pubic hair removal.

Int J Dermatol 2020 Feb 23;59(2):e46-e48. Epub 2019 Oct 23.

Department of Dermatology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1111/ijd.14680DOI Listing
February 2020

A singular association of vitiligo, psoriasis and frontal fibrosing alopecia.

Australas J Dermatol 2020 Feb 17;61(1):e127-e128. Epub 2019 Oct 17.

Department of Dermatology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1111/ajd.13164DOI Listing
February 2020

Ertapenem-induced vasculitis with striking targetoid lesions.

Int J Dermatol 2020 Feb 30;59(2):e28-e29. Epub 2019 Sep 30.

Department of Dermatology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1111/ijd.14656DOI Listing
February 2020

Diffuse papules, nodules, and ulcers in an adult man.

Int J Dermatol 2020 May 25;59(5):e133-e134. Epub 2019 Sep 25.

Department of Dermatology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1111/ijd.14650DOI Listing
May 2020

Pemphigoid gestationis.

Med Clin (Barc) 2020 04 7;154(8):327. Epub 2019 Sep 7.

Departamento de Dermatología, Hospital Universitario de Valme, Ctra. de Cádiz, Km. 548,9, 41001 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.medcli.2019.05.037DOI Listing
April 2020

Visual Dermatology: "Cluster of Jewels" Sign.

J Cutan Med Surg 2019 Sep/Oct;23(5):546

1 Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1177/1203475419840640DOI Listing
May 2020

Bilateral asymptomatic auricular nodules in an adult woman.

Int J Dermatol 2020 Mar 1;59(3):305-307. Epub 2019 Aug 1.

Department of Otorhinolaringology, Hospital Regional Universitario de Málaga, Malaga, Spain.

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http://dx.doi.org/10.1111/ijd.14609DOI Listing
March 2020