Fernando G Osorio

Fernando G Osorio

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Fernando G Osorio

Fernando G Osorio

Publications by authors named "Fernando G Osorio"

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Retraction Note: NF-κB activation impairs somatic cell reprogramming in ageing.

Nat Cell Biol 2019 Mar;21(3):410

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006, Oviedo, Spain.

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http://www.nature.com/articles/s41556-018-0259-0
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http://dx.doi.org/10.1038/s41556-018-0259-0DOI Listing
March 2019

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.

Nat Med 2019 03 18;25(3):423-426. Epub 2019 Feb 18.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/s41591-018-0338-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546610PMC
March 2019

Immune and inflammatory responses to DNA damage in cancer and aging.

Mech Ageing Dev 2017 07 5;165(Pt A):10-16. Epub 2016 Oct 5.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00476374163021
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http://dx.doi.org/10.1016/j.mad.2016.10.004DOI Listing
July 2017

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis.

Cell Cycle 2016 22;15(7):873-4. Epub 2016 Feb 22.

a Departamento de Bioquímica y Biología Molecular , Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo , Oviedo , Spain.

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http://dx.doi.org/10.1080/15384101.2016.1151725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889228PMC
April 2017

Proteostasis alterations in myeloproliferative neoplasms: Oncogenic relevance and therapeutic opportunities.

Exp Hematol 2016 07 14;44(7):574-7. Epub 2016 Apr 14.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.04.004DOI Listing
July 2016

MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling.

J Immunol 2016 07 3;197(1):296-302. Epub 2016 Jun 3.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain;

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http://dx.doi.org/10.4049/jimmunol.1600094DOI Listing
July 2016

Reprogramming aging through DOT1L inhibition.

Cell Cycle 2015 ;14(21):3345-6

a Departamento de Bioquímica y Biología Molecular ; Facultad de Medicina; Instituto Universitario de Oncología (IUOPA); Universidad de Oviedo ; Oviedo , Spain.

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http://dx.doi.org/10.1080/15384101.2015.1093443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825545PMC
February 2016

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

Nat Med 2016 Jan 21;22(1):91-6. Epub 2015 Dec 21.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/nm.4013DOI Listing
January 2016

NF-κB activation impairs somatic cell reprogramming in ageing.

Nat Cell Biol 2015 Aug 27;17(8):1004-13. Epub 2015 Jul 27.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1038/ncb3207DOI Listing
August 2015

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid.

EMBO J 2015 Jul 19;34(14):1875-88. Epub 2015 May 19.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA) Universidad de Oviedo, Oviedo, Spain

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http://dx.doi.org/10.15252/embj.201490594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547893PMC
July 2015

Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.

J Cell Physiol 2015 Jan;230(1):191-8

Departamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, c/ Julian Claveria s/n, Oviedo, 33006, Spain.

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http://dx.doi.org/10.1002/jcp.24698DOI Listing
January 2015

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.

J Proteomics 2013 Oct 20;91:466-77. Epub 2013 Aug 20.

Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2013.08.008DOI Listing
October 2013

Detection of nuclear envelope alterations in senescence.

Methods Mol Biol 2013 ;965:243-51

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1007/978-1-62703-239-1_16DOI Listing
June 2013

Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach.

Cell Commun Signal 2013 Mar 21;11(1):19. Epub 2013 Mar 21.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, 33006, Spain.

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http://dx.doi.org/10.1186/1478-811X-11-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608945PMC
March 2013

NF-kB in premature aging.

Aging (Albany NY) 2012 Nov;4(11):726-7

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560436PMC
http://dx.doi.org/10.18632/aging.100502DOI Listing
November 2012

A conserved splicing mechanism of the LMNA gene controls premature aging.

Hum Mol Genet 2011 Dec 29;20(23):4540-55. Epub 2011 Aug 29.

CNRS, UMR 5535, University of Montpellier, Institut de Génétique Moléculaire de Montpellier, 1919 Route de Mende, Montpellier 34293, France.

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http://dx.doi.org/10.1093/hmg/ddr385DOI Listing
December 2011

Cell autonomous and systemic factors in progeria development.

Biochem Soc Trans 2011 Dec;39(6):1710-4

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://www.biochemsoctrans.org/content/ppbiost/39/6/1710.ful
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http://biochemsoctrans.org/lookup/doi/10.1042/BST20110677
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http://dx.doi.org/10.1042/BST20110677DOI Listing
December 2011

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.

Aging Cell 2010 Dec 21;9(6):947-57. Epub 2010 Oct 21.

Departamento de Bioquímica y Biología Molecular Unidad de Epigenética, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1111/j.1474-9726.2010.00621.xDOI Listing
December 2010

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16268-73. Epub 2010 Aug 30.

Departamento de Bioquímica y Biología Molecular and Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1002696107
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http://dx.doi.org/10.1073/pnas.1002696107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941281PMC
September 2010

Accelerated ageing: from mechanism to therapy through animal models.

Transgenic Res 2009 Feb 18;18(1):7-15. Epub 2008 Nov 18.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, 33006, Oviedo, Spain.

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http://link.springer.com/content/pdf/10.1007/s11248-008-9226
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http://link.springer.com/10.1007/s11248-008-9226-z
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http://dx.doi.org/10.1007/s11248-008-9226-zDOI Listing
February 2009

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Nat Med 2008 Jul 29;14(7):767-72. Epub 2008 Jun 29.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, calle Fernando, Bongera s/n, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1038/nm1786DOI Listing
July 2008