Publications by authors named "Fernando Alvira"

4 Publications

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The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance While Reducing Its Toxicity .

Pharmaceutics 2021 Feb 1;13(2). Epub 2021 Feb 1.

Universidad Nacional de Quilmes, Departamento de Ciencia y Tecnología, Laboratorio de Bio-Nanotecnología, Bernal, Buenos Aires 1876, Argentina.

Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse nanosystems as potential strategies to reduce side effects and drug quantities. Ultradeformable liposomes, ethosomes, colloidal liquid crystals, and dendrimers were able to transport Vismodegib to deep skin layers, while polymeric micelles failed at this. As lipidic systems were the most effective, we assessed the and toxicity of Vismodegib-loaded ultradeformable liposomes, apoptosis, and cellular uptake. Vismodegib emerges as a versatile drug that can be loaded in several delivery systems for topical application. These findings may be also useful for the consideration of topical delivery of other drugs with a low water solubility.
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http://dx.doi.org/10.3390/pharmaceutics13020186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912039PMC
February 2021

Laser-Induced Breakdown Spectroscopy (LIBS) Quality Control and Origin Identification of Handmade Manufactured Cigars.

Appl Spectrosc 2015 Oct;69(10):1205-9

Centro de Investigaciones Opticas (CONICET-CICPBA), Camino Centenario e/505 y 508, 1897 La Plata, Argentina.

Tobacco is an agricultural product originating in America that is obtained by processing the leaves of various plants of the genus Nicotiana tabacum. It is the inedible product occupying the most plantings in the world, according to a recent report from the United Nations Food and Agriculture Organization. It is consumed in various ways, but the most popular form of consumption is, undoubtedly, by smoking cigarettes. A particular segment of the tobacco industry is the manufacturing of handmade cigars, which for some third-world countries is an important source of income. There are different qualities of cigars, and a major problem is the adulteration that occurs, for example, when authentic high-quality leaves are replaced by lower quality leaves. A factor that influences the quality of the cigars is the smoke combustion process, which depends on several factors, particularly the composition of the leaves. We present a simple and quick technique for the quality control and origin identification of handmade cigars that measures the Mg/Ca ratios in the tobacco leaves and wrappers of the cigars using laser-induced breakdown spectroscopy.
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http://dx.doi.org/10.1366/15-07935DOI Listing
October 2015

Application of laser-induced breakdown spectroscopy (LIBS) and neural networks to olive oils analysis.

Appl Spectrosc 2013 Sep;67(9):1064-72

Departamento de Química Analítica. Facultad de Ciencias Químicas, Universidad Complutense, 28040 Madrid, Spain.

The adulteration and traceability of olive oils are serious problems in the olive oil industry. In this work, a method based on laser-induced breakdown spectroscopy (LIBS) and neural networks (NNs) has been developed and applied to the identification, quality control, traceability, and adulteration detection of extra virgin olive oils. Instant identification of the samples is achieved using a spectral library, which was obtained by analysis of representative samples using a single laser pulse and treatment by NNs. The samples used in this study belong to four countries. The study also included different regions of each country. The results obtained allow the identification of the oils tested with a certainty of more than 95%. Single-shot measurements were enough for clear identification of the samples. The method can be developed for automatic real-time, fast, reliable, and robust measurements, and the system can be packed into portable form for non-specialist users.
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http://dx.doi.org/10.1366/12-06916DOI Listing
September 2013

A new method for relative Sr determination in human teeth enamel.

J Anthropol Sci 2011 1;89:153-60. Epub 2011 Jul 1.

Centro de Investigaciones Opticas, (CONICET La Plata, CIC), CC 124, 1900, La Plata, Argentina.

We present a new method to determine Sr/Ca changes in hard dental tissues based on laser ablation and spectroscopic detection. By using femtosecond Laser Induced Breakdown Spectroscopy (fs-LIBS), we micro mapped the relative amount of strontium in the enamel of three human lower third molar. We also analyzed the Sr/Ca ratio along the striae of Retzius. Results show that microlibs allows detection of variation in relative Sr/Ca ratio through enamel. The same values of Sr/Ca ratio were found along a single stria. The method has a precision better than 95% and is sensitive enough to detect Sr/Ca ratio variations among striae and within stria. Fs-LIBS generates information in a fast and simple way that can be used by non-specialists to make inferences about diet or mobility in human populations and fossil hominids.
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http://dx.doi.org/10.4436/jass.89012DOI Listing
April 2012