Fernanda Genre

Fernanda Genre

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Fernanda Genre

Fernanda Genre

Publications by authors named "Fernanda Genre"

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Disease Activity Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Psoriatic Arthritis.

J Rheumatol 2019 Nov 15. Epub 2019 Nov 15.

From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain; University of Cantabria - IDIVAL, Santander, Spain and CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; School of Medicine, University of Cantabria, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain. Address correspondence to Dr. Iván Ferraz-Amaro. Division of Rheumatology, Hospital Universitario de Canarias. 38320 Santa Cruz de Tenerife. Spain. Email: or Dr. Miguel Á. González-Gay. Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. Email:

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http://dx.doi.org/10.3899/jrheum.190729DOI Listing
November 2019

Rapid beneficial effect of the IL-6 receptor blockade on insulin resistance and insulin sensitivity in non-diabetic patients with rheumatoid arthritis.

Clin Exp Rheumatol 2019 May-Jun;37(3):465-473. Epub 2018 Nov 7.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Div., Hosp. Universitario Marqués de Valdecilla, IDIVAL and University of Cantabria, Santander; and Univ. of the Witwatersrand, South Africa.

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May 2019

Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound.

Arthritis Res Ther 2018 08 29;20(1):195. Epub 2018 Aug 29.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, 39008, Santander, Spain.

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http://dx.doi.org/10.1186/s13075-018-1684-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116452PMC
August 2018

Implication of osteoprotegerin and sclerostin in axial spondyloarthritis cardiovascular disease: study of 163 Spanish patients.

Clin Exp Rheumatol 2018 Mar-Apr;36(2):302-309. Epub 2017 Dec 15.

Epidemiol., Genetics, Atherosclerosis Res. Group on Systemic Inflamm. Diseases, IDIVAL; School of Medicine, Univ. of Cantabria, Santander, Spain; Cardiovascular Pathophysiol. & Genomics Res. Unit, Faculty of Health Sciences, Univ. Witwatersrand, S.Africa.

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June 2018

Cardiovascular risk stratification in axial spondyloarthritis: carotid ultrasound is more sensitive than coronary artery calcification score to detect high-cardiovascular risk axial spondyloarthritis patients.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):73-80. Epub 2017 Aug 28.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.

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April 2018

Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review.

Autoimmun Rev 2018 Mar 17;17(3):301-315. Epub 2018 Jan 17.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain; School of Medicine, University of Cantabria, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2017.11.024DOI Listing
March 2018

Relative Risk Chart Score for the Assessment of the Cardiovascular Risk in Young Patients with Ankylosing Spondylitis.

Int J Rheumatol 2018 15;2018:1847894. Epub 2018 Feb 15.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.

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http://dx.doi.org/10.1155/2018/1847894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832112PMC
February 2018

Proprotein convertase subtilisin/kexin type 9 in rheumatoid arthritis.

Clin Exp Rheumatol 2016 Nov-Dec;34(6):1013-1019. Epub 2016 Aug 31.

Dept.Rheumatology, Complejo Hosp.Univ. Santiago de Compostela, Spain; School of Medicine, Univ.Cantabria, Santander, Spain; Cardiovascular Pathophysiology & Genomics Res.Unit, School Physiology, Health Sciences, Univ. Witwatersran, Johannesburg, S.Africa.

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June 2017

Cardiovascular risk assessment in patients with rheumatoid arthritis: The relevance of clinical, genetic and serological markers.

Autoimmun Rev 2016 Nov 1;15(11):1013-1030. Epub 2016 Aug 1.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain; School of Medicine, University of Cantabria, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15689972163017
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http://dx.doi.org/10.1016/j.autrev.2016.07.026DOI Listing
November 2016

Interleukin 1 beta (IL1ß) rs16944 genetic variant as a genetic marker of severe renal manifestations and renal sequelae in Henoch-Schönlein purpura.

Clin Exp Rheumatol 2016 May-Jun;34(3 Suppl 97):S84-8. Epub 2016 Feb 1.

Epidemiology, Genetics & Atherosclerosis Res.Group, Systemic Inflammatory Diseases, IDIVAL; School of Medicine, Univ.of Cantabria, Santander, Spain; and Cardiovascular Pathophysiology & Genomics Research, Univ.of Witwatersrand, Johannesburg, South Africa.

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September 2016

Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy.

J Dermatol 2016 Apr 14;43(4):389-94. Epub 2015 Sep 14.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.

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http://dx.doi.org/10.1111/1346-8138.13094DOI Listing
April 2016

Decreased expression of methylene tetrahydrofolate reductase (MTHFR) gene in patients with rheumatoid arthritis.

Clin Exp Rheumatol 2016 Jan-Feb;34(1):106-10. Epub 2016 Feb 2.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain.

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April 2016

The Framingham Score and the Systematic Coronary Risk Evaluation at Low Cutoff Values Are Useful Surrogate Markers of High-risk Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis.

J Rheumatol 2016 Mar 15;43(3):486-94. Epub 2016 Jan 15.

From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; Department of Rheumatology, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Instituto de Investigación Santaria Valdecilla (IDIVAL); Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander; Cardiology Division, Hospital Lucus Augusti, Lugo; Health Research Institute of Santiago de Compostela (IDIS), Division of Rheumatology, Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.P.H. Dessein, MD, FCP (SA), FRCP (UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; A. Corrales, MD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL; R. Lopez-Mejias, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL; A. Solomon, MBChB, FCP (SA), Department of Rheumatology, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand; A.J. Woodiwiss, PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBERESP, IDIVAL; G.R. Norton, MBChB, PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; F.

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http://dx.doi.org/10.3899/jrheum.150510DOI Listing
March 2016

Vitamin D receptor GATG haplotype association with atherosclerotic disease in patients with rheumatoid arthritis.

Atherosclerosis 2016 Feb 11;245:139-42. Epub 2015 Dec 11.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Department, IDIVAL, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Health Research Institute of Santiago de Compostela (IDIS), Division of Rheumatology, Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.12.011DOI Listing
February 2016

Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis.

Biomed Res Int 2015 1;2015:318364. Epub 2015 Mar 1.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain ; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1155/2015/318364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359874PMC
December 2015

Anti-TNF-α therapy reduces endothelial cell activation in non-diabetic ankylosing spondylitis patients.

Rheumatol Int 2015 Dec 5;35(12):2069-78. Epub 2015 Jul 5.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla, s/n, 39008, Santander, Spain.

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http://dx.doi.org/10.1007/s00296-015-3314-1DOI Listing
December 2015

TNF-related apoptosis-inducing ligand and cardiovascular disease in rheumatoid arthritis.

Clin Exp Rheumatol 2015 Jul-Aug;33(4):491-7. Epub 2015 May 11.

Cardiovascular Pathophysiology and Genomics Research Unit, University of the Witwatersrand, Johannesburg, South Africa; and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology, IDIVAL, Santander, Spain.

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October 2015

IGF-1 and ADMA levels are inversely correlated in nondiabetic ankylosing spondylitis patients undergoing anti-TNF-alpha therapy.

Biomed Res Int 2014 11;2014:671061. Epub 2014 Sep 11.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain ; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1155/2014/671061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176640PMC
June 2015

Osteoprotegerin concentrations relate independently to established cardiovascular disease in rheumatoid arthritis.

J Rheumatol 2015 Jan 1;42(1):39-45. Epub 2014 Nov 1.

From the Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Department of Internal Medicine, Hospital Universitario Marques de Valdecilla, and the Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and Fundación Instituto de Investigación Marqués de Valdecilla, and Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), and CIBER Epidemiología y Salud Pública (CIBERESP), Santander; the Rheumatology Division, Hospital Universitario de Canarias, Tenerife; the Cardiology Division, Hospital Lucus Augusti, Lugo, Spain; the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.P.H. Dessein and M.A. Gonzalez-Gay share senior authorship.R. López-Mejias, PhD; B. Ubilla, BSc; F. Genre, PhD; A. Corrales, MD, PhD; R. Blanco, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IFIMAV; J.L. Hernández, MD, PhD, Department of Internal Medicine, Hospital Universitario Marques de Valdecilla, University of Cantabria, RETICEF, IFIMAV; I. Ferraz-Amaro, MD, Rheumatology Division, Hospital Universitario de Canarias; L. Tsang; P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBERESP, IFIMAV; C. Gonzalez-Juanatey, MD, PhD, Cardiology Division, Hospital Lucus Augusti; M.A. Gonzalez-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IFIMAV

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http://www.jrheum.org/content/42/1/39.full.pdf
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http://www.jrheum.org/cgi/doi/10.3899/jrheum.140690
Publisher Site
http://dx.doi.org/10.3899/jrheum.140690DOI Listing
January 2015

Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis.

Biomed Res Int 2014 18;2014:860651. Epub 2014 Mar 18.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain.

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http://dx.doi.org/10.1155/2014/860651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976882PMC
December 2014

Investigation of a PON1 gene polymorphism (rs662 polymorphism) as predictor of subclinical atherosclerosis in patients with rheumatoid arthritis.

Ann Rheum Dis 2014 Sep 15;73(9):1749-50. Epub 2014 May 15.

Department of Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain.

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http://dx.doi.org/10.1136/annrheumdis-2014-205543DOI Listing
September 2014

Lack of association between IL6 gene and Henoch-Schönlein purpura.

Clin Exp Rheumatol 2014 May-Jun;32(3 Suppl 82):S141-2. Epub 2014 Feb 11.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.

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July 2014

Antitumour necrosis factor α treatment reduces retinol-binding protein 4 serum levels in non-diabetic ankylosing spondylitis patients.

Ann Rheum Dis 2014 May 9;73(5):941-3. Epub 2013 Dec 9.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20448
Publisher Site
http://dx.doi.org/10.1136/annrheumdis-2013-204484DOI Listing
May 2014

Correlation between insulin resistance and serum ghrelin in non-diabetic ankylosing spondylitis patients undergoing anti-TNF-α therapy.

Clin Exp Rheumatol 2013 Nov-Dec;31(6):913-8. Epub 2013 Aug 26.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain.

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March 2014

Independent relationship of osteoprotegerin concentrations with endothelial activation and carotid atherosclerosis in patients with severe rheumatoid arthritis.

J Rheumatol 2014 Mar 1;41(3):429-36. Epub 2014 Feb 1.

From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain.

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http://www.jrheum.org/cgi/doi/10.3899/jrheum.131037
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http://dx.doi.org/10.3899/jrheum.131037DOI Listing
March 2014

Autoantibodies and biomarkers of endothelial cell activation in atherosclerosis.

Vasa 2014 Mar;43(2):83-5

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain.

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http://dx.doi.org/10.1024/0301-1526/a000333DOI Listing
March 2014

Asymmetric dimethylarginine serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy.

Clin Exp Rheumatol 2013 Sep-Oct;31(5):749-55. Epub 2013 Jun 14.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain.

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December 2013

Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis.

Clin Exp Rheumatol 2013 Sep-Oct;31(5):761-6. Epub 2013 Jul 24.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.

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December 2013

Apelin serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy.

Clin Exp Rheumatol 2013 Jul-Aug;31(4):532-7. Epub 2013 Mar 13.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IFIMAV, Santander, Spain.

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October 2013

B-cell overexpression of Bcl-2 cooperates with p21 deficiency for the induction of autoimmunity and lymphomas.

J Autoimmun 2010 Dec 5;35(4):316-24. Epub 2010 Aug 5.

Departmento de Biología Molecular, Universidad de Cantabria-Instituto de Formación e Investigación Marqués de Valdecilla, Santander, Spain.

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http://dx.doi.org/10.1016/j.jaut.2010.07.002DOI Listing
December 2010