Publications by authors named "Ferhat Geneci"

8 Publications

  • Page 1 of 1

The retreatment abilities of ProTaper Next and F6 Skytaper: a micro-computed tomography study.

Eur Oral Res 2021 May;55(2):74-79

Department of Anatomy, Faculty of Medicine, Hacettepe University, Ankara,Turkey.

Purpose: The aim of this study was to evaluate the retreatment abilities of the ProTaper Next (PTN) and F6 SkyTaper (F6) systems by using micro-computed tomography (microct), radiographic and microscopic imaging techniques.

Materials And Methods: The root canals of twenty-six extracted mandibular premolar teeth were prepared and obturated. For the retreatment procedure, the teeth were randomly divided into two equal groups according to endodontic instruments: PTN (X4) and F6 (#40/.06). Pre- and post-operative filling material volumes were measured with micro-ct, and areas were measured with radiographic and microscopic imaging techniques. The percentages of residual material were calculated, and then statistically compared. The significance level was set at p<0.05.

Results: There was no statistically significant difference between F6 and PTN for retreatment efficacy in the micro-ct and radiographic imaging techniques (p>0.05). PTN demonstrated better cleaning ability when evaluated by microscopic imaging. (p<0.05). The correlation was moderate between micro-ct and radiographic, and micro-ct and microscopic imaging groups; however, it was strong between radiographic and microscopic imaging methods.

Conclusion: The PTN and F6 files had similar effects in the removal of filling material with microct evaluation. The radiographic imaging method gave similar results with micro-ct imaging.
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http://dx.doi.org/10.26650/eor.20210009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244941PMC
May 2021

Investigation of the effect of ghrelin on bone fracture healing in rats.

Clin Exp Pharmacol Physiol 2021 Oct 5;48(10):1382-1390. Epub 2021 Jul 5.

Department of Biochemistry, Bakırköy Training and Research Hospital, Health Sciences University, İstanbul, Turkey.

Ghrelin is known to have effects on proliferation and differentiation of osteoblasts and improvement of bone mineral density in rats. However, no experimental research on ghrelin's effects on fracture healing has been reported. In this context, the effect of ghrelin on the union of femoral shaft fractures was examined in this study by evaluating whether ghrelin will directly contribute to fracture healing. Forty male Wistar-Albino rats were divided into two groups as control and experimental (ghrelin treated) and standard closed shaft fractures were created in the left femurs of all rats. Daily ghrelin injections were applied to the experimental groups and equal numbers of rats were killed after 14 and 28 days following fracture formation. Tissue samples were examined with radiological, biomechanical, biochemical and histological analyses. Densitometry study showed that bone mineral density was improved after 28 days of ghrelin treatment compared to control. On histological examination, at the end of the 14 and 28 days of recovery, significant union was observed in the ghrelin-treated group. The ghrelin-treated group had higher breaking strength and stiffness at the end of 28 days of recovery. Biochemically, ALP levels were found to be higher in the ghrelin-treated group at the end of 28 days of recovery. Results showed that ghrelin directly contributes to fracture healing and it is promising to consider the effect of ghrelin on fracture healing in human studies with pharmacological applications.
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http://dx.doi.org/10.1111/1440-1681.13544DOI Listing
October 2021

Filling quality of several obturation techniques in the presence of apically separated instruments: A Micro-CT study.

Microsc Res Tech 2021 Jun 30;84(6):1265-1271. Epub 2020 Dec 30.

Faculty of Medicine, Department of Anatomy, Hacettepe University, Ankara, Turkey.

Separated root canal instruments may affect the quality of root canal obturation and hence the survival of endodontically treated teeth. Obturation techniques may influence filling-quality. The aim was to evaluate the obturation quality of teeth filled with different obturation techniques in the presence of apically separated instruments using micro-computed tomography (μ-CT). Notched ProTaper F2 rotary-files were separated in the apical third of 36-human mandibular incisors with single root/canal and mature apex. Samples were filled by an endodontist according to one of the following obturation techniques (n = 12): cold lateral-compaction (CLC), single-cone (SC) and thermoplastic injection (TI). Samples were scanned by the Skyscan 1,274® μ-CT device after 1-week at 37°C in 100% humidity. Images of the sections were evaluated with CTan software in terms of total-volume and volume percentage of the filling materials and voids between coronal end of the separated instrument and gutta-percha/sealer filled void-free sections. Data was analyzed using Kruskal-Wallis and Mann Whitney-U tests with a significance level of 5%. Kruskal-Wallis revealed differences among groups (p < 0.05).Pairwise comparisons revealed that less volume of voids were measured in SC (0.02 ± 0.03 mm ) compared to CLC (0.15 ± 0.16 mm ) and TI (0.18 ± 0.24 mm ) (p < 0.05); while TI was statistically similar with CLC (p > 0.05). Percentages of volumes of voids and filling materials were as follows for SC, CLC and TI, respectively: 8.88 ± 18.52% and 24.45 ± 38.40%, 46.92 ± 33.53% and 53.07 ± 33.53%, 40.54 ± 33.85% and 42.79 ± 34.45%. The obturation technique may have a significant impact on the volume of voids in the presence of a separated file. No obturation technique produced a void-free root canal filling.
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http://dx.doi.org/10.1002/jemt.23685DOI Listing
June 2021

Microcomputed Assessment of Transportation, Centering Ratio, Canal Area, and Volume Increase after Single-file Rotary and Reciprocating Glide Path Instrumentation in Curved Root Canals: A Laboratory Study.

J Endod 2019 Jun 30;45(6):791-796. Epub 2019 Mar 30.

Department of Anatomy, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: The aim of this study was to compare the transportation and centering abilities of the ProGlider (PG; Dentsply-Sirona, Ballaigues, Switzerland), WaveOne Gold Glider (WOGG; Dentsply-Sirona), and R-Pilot (RP; VDW, Munich, Germany) file systems and the changes in the structure model index (SMI), surface area, and root canal volume (after creating the glide path in the mandibular first molar teeth's mesial canals with moderate curvature) using the micro-computed tomographic (micro-CT) method.

Methods: In the present study, 24 mandibular first molar teeth with 2 separate mesial canals and moderate (10°-20°) curvature were used. After scanning with micro-CT imaging before the procedure, the teeth were divided into 3 groups, PG, WOGG, and RP (n = 10/each group), followed by the glide path procedure. After the root canal preparation, changes in the root canals regarding the volume, surface area, SMI, transportation made by the files, and the change of their centering ability in the apical, middle, and coronal third were analyzed by micro-CT imaging. The data were statistically evaluated using 1-way analysis of variance and the Kruskal-Wallis test with a significance level set at 5% (P < .05).

Results: The WOGG and RP file systems showed better centering abilities at all thirds compared with the PG file system (P < .05). No significant difference was found in the apical third between the groups in terms of canal transportation degree (P > .05). However, in the WOGG and RP groups, less transportation was observed in the middle and coronal thirds compared with the PG group (P < .05). When the SMI changed, after the root canal preparation was compared, no significant differences were found between the groups (P > .05). Nevertheless, the changes in volume and surface area of the root canal in the WOGG and RP groups were significantly lower than in the PG group (P < .05).

Conclusions: The WOGG and RP file systems caused similar levels of change in the root canal systems based on all parameters. Moreover, it was determined that the PG file system caused a significantly higher volume and surface area increase than the WOGG and RP file systems.
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http://dx.doi.org/10.1016/j.joen.2019.02.012DOI Listing
June 2019

Evaluation of XP-endo Shaper, Reciproc Blue, and ProTaper Universal NiTi Systems on Dentinal Microcrack Formation Using Micro-Computed Tomography.

J Endod 2019 Mar;45(3):338-342

Anatomy Department, Faculty of Dentistry, Ankara University, Ankara, Turkey.

Introduction: The purpose of the present study was to evaluate the frequency of dentinal microcracks observed after root canal preparation with XP-endo Shaper (XP), Reciproc Blue (RB), and ProTaper Universal (PTU) instruments using micro-computed tomographic (μCT) analysis.

Methods: Thirty extracted mandibular first and second molars with mesial roots having 2 separate canals with an angle between 10°and 20° were randomly assigned to 3 experimental groups (n = 10) according to the different nickel-titanium systems used for root canal preparation: XP, RB, and PTU. The specimens were scanned using μCT imaging before and after root canal preparation. Then, preoperative and postoperative cross-sectional images of the teeth were evaluated to identify the presence of dentinal defects. For each group, the number of microcracks was determined as a percentage rate. The McNemar test was used to determine significant differences before and after instrumentation. The level of significance was set at P ≤ .05.

Results: No new dentinal microcracks were observed in the XP and RB groups. The PTU system significantly increased the percentage rate of microcracks compared with preoperative specimens (P < .05).

Conclusions: Root canal preparations with XP and RB systems might not induce the formation of new dentinal microcracks on the mesial roots of mandibular molars. Further assessments are suggested for the examination of the morphology of microcracks after the use of these instruments.
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http://dx.doi.org/10.1016/j.joen.2018.12.005DOI Listing
March 2019

Evaluation of maxillary trabecular microstructure as an indicator of implant stability by using 2 cone beam computed tomography systems and micro-computed tomography.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Mar 1;127(3):247-256. Epub 2018 Dec 1.

Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Gulhane Health Sciences University, Ankara, Turkey.

Objective: The aim of this study was to assess the trabecular microarchitecture of the maxilla by using cone beam computed tomography (CBCT) and micro-computed tomography (micro-CT) ex vivo.

Study Design: Seventeen maxillary cadaver specimens were scanned by using micro-CT and CBCT devices. Samples were scanned with 2 CBCT devices at different voxel sizes (0.08, 0.125, and 0.160 mm for 3-D Accuitomo 170; 0.75 and 0.200 mm for Planmeca Promax 3-D Max). Morphometric parameters, such as bone volume/total volume (BV/TV) ratio, trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular number (Tb.N), and degree of anisotropy (DA) were assessed by using CTAnalyzer software. Bland-Altman limits of agreement and intraclass correlation coefficient (ICC) were performed to evaluate agreement between CBCT and micro-CT in consideration of measured morphometric parameters. Statistical significance was set at P < .05.

Results: The BV/TV, Tb.Th, Tb.Sp, and DA values were higher for CBCT images compared with micro-CT images, whereas the Tb.N value was lower with CBCT images than with micro-CT images. The BV/TV and DA parameters showed the highest agreement between CBCT and micro-CT devices (ICC = 0.421 for BV/TV and ICC = 0.439 for DA; P < .01).

Conclusions: The BV/TV and DA parameters measured on CBCT obtained at the smallest voxel size were found to be useful for the assessment of maxillary trabecular microstructure.
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http://dx.doi.org/10.1016/j.oooo.2018.11.014DOI Listing
March 2019

Evaluation of 3 Different Retreatment Techniques in Maxillary Molar Teeth by Using Micro-computed Tomography.

J Endod 2018 Mar 8;44(3):480-484. Epub 2017 Dec 8.

Department of Anatomy, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: Nonsurgical retreatment procedure involves the complete removal of the previous filling material to allow thorough instrumentation, disinfection, and refilling of root canal system. We aimed to determine the residuals of the root-filling material by using 3 different retreatment techniques with the aid of micro-computed tomography.

Methods: Thirty extracted human maxillary molar teeth were included. All root canals were also obturated with F2 ProTaper single cones and AH Plus sealer. The following retreatment techniques were performed: group 1, ProTaper retreatment files; group 2, Mtwo retreatment files; and group 3, ProFile files. For the assessment of residual filling material, preoperative and postoperative micro-computed tomography scans were compared with each other, and the working time was recorded. One-way analysis of variance was used to analyze the differences between the groups. The significance level was set at P < .05.

Results: None of the retreatment techniques were capable of removing the whole filling material. The percentages of the residual filling materials for groups 1, 2, and 3 were 34.45, 45.43, and 23.63, respectively. There was a statistically significant difference between groups 2 and 3 (P < .05). ProTaper and ProFile instruments required less time for the removal of filling materials when compared with Mtwo instrument.

Conclusions: ProFile files revealed the best results for endodontic retreatment in terms of both removing capacity and time requirement.
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http://dx.doi.org/10.1016/j.joen.2017.09.006DOI Listing
March 2018

Micro-computed Tomographic Evaluation of Dentinal Microcrack Formation after Using New Heat-treated Nickel-titanium Systems.

J Endod 2017 Oct 27;43(10):1736-1739. Epub 2017 Jul 27.

Department of Anatomy, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: The aim of the present study was to evaluate the frequency of dentinal microcracks observed after root canal preparation with HyFlex CM (Coltène/Whaledent, Altstätten, Switzerland), HyFlex EDM (Coltène/Whaledent), Vortex Blue (Dentsply Tulsa Dental Specialties, Tulsa, OK), and TRUShape (Dentsply Tulsa Dental Specialties) systems using micro-computed tomographic (micro-CT) analysis.

Methods: Forty human mandibular incisors with 1 and straight root canals were randomly assigned to 4 experimental groups (n = 10) and 1 control group for root canal preparation: group 1, HyFlex CM; group 2, HyFlex EDM; group 3, Vortex Blue; and group 4, TRUShape. The specimens were scanned using high-resolution micro-CT imaging before and after root canal preparation. Afterward, preoperative and postoperative cross-sectional images of the teeth were screened to identify the presence of dentinal defects. The number of microcracks was determined as a percentage for each group.

Results: Before and after canal preparation, 36,152 cross-sectional images were examined. Four thousand four hundred fifty-two (12.31%) dentinal defects were observed. No new microcracks were observed after root canal instrumentation with the tested systems.

Conclusions: Root canal preparation with the HyFlex CM, HyFlex EDM, Vortex Blue, and TRUShape systems did not induce the formation of new dentinal microcracks on straight root canals of mandibular incisors.
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http://dx.doi.org/10.1016/j.joen.2017.05.024DOI Listing
October 2017
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