Publications by authors named "Fereshteh Motiee"

4 Publications

  • Page 1 of 1

An intelligent method based on feed-forward artificial neural network and least square support vector machine for the simultaneous spectrophotometric estimation of anti hepatitis C virus drugs in pharmaceutical formulation and biological fluid.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Dec 22;263:120190. Epub 2021 Jul 22.

Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.

This study proposed simple and reliable spectrophotometry method for simultaneous analysis of hepatitis C antiviral binary mixture containing sofosbuvir (SOF) and daclatasvir (DAC). This technique is based on the use of feed-forward artificial neural network (FF-ANN) and least square support vector machine (LS-SVM). FF-NN with Levenberg-Marquardt (LM) and Cartesian genetic programming (CGP) algorithms was trained to determine the best number of hidden layers and the number of neurons. This comparison demonstrated that the LM algorithm had the minimum mean square error (MSE) for SOF (1.59 × 10) and DAC (4.71 × 10). In LS-SVM model, the optimum regularization parameter (γ) and width of the function (σ) were achieved with root mean square error (RMSE) of 0.9355 and 0.2641 for SOF and DAC, respectively. The coefficient of determination (R) value of mixtures containing SOF and DAC was 0.996 and 0.997, respectively. The percentage recovery values were in the range of 94.03-104.58 and 94.04-106.41 for SOF and DAC, respectively. Statistical test (ANOVA) was implemented to compare high-performance liquid chromatography (HPLC) and spectrophotometry, which showed no significant difference. These results indicate that the proposed method possesses great potential ability for prediction of concentration of components in pharmaceutical formulations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2021.120190DOI Listing
December 2021

Application of Silica Supported Calix[4]arene Derivative as Anti-reversion Agent in Tire Tread Formulation.

Acta Chim Slov 2021 Mar;68(1):128-136

In this research the influence of the silica supported calix[4]arene derivative (SS-Calix) on the reversion resistance, mechanical properties and thermal behavior of NR/BR tire tread formulation was investigated by the oscillating disc rheometer, FTIR, TGA and tensile testing. The results revealed that the reversion behavior of NR/BR vulcanizate is affected by SS-Calix. The data obtained from curing characteristics and thermal stability of test pieces indicate that, SS-Calix acts as an anti-reversion for rubbery materials that are exposed to thermal shock in the early stages of temperature rise. It's predicted that these results are due to the interaction between the OH groups present in the SS-Calix surface and the carbon of the polymer chains. The broad peak observed in the IR spectrum around 1824 cm-1 which is referred to C=O bond, confirms this prediction. In addition, the presence of SS-Calix in compound causes to increase modulus and hardness but reduce elongation and resilience.
View Article and Find Full Text PDF

Download full-text PDF

Source
March 2021

Improved spectral resolution for the rapid simultaneous spectrophotometric determination of sofosbuvir and daclatasvir as anti hepatitis C virus drugs in pharmaceutical formulation and biological fluid using continuous wavelet and derivative transform.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 5;251:119429. Epub 2021 Jan 5.

Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.

In this study, the simultaneous spectrophotometric estimation of Sofosbuvir (SOF) and Daclatasvir (DAC) in synthetic mixtures and tablet formulation in the presence of overlapping spectra was performed based on continuous wavelet transform (CWT) and derivative spectrophotometry (DS) methods without any separation process. The Coiflet (Coif2) and Daubechies (Db3) wavelet families with wavelength of 256 nm and 218 nm were obtained as the best families for the simultaneous determination of SOF and DAC, respectively. Also, the first derivative absorption spectra revealed the best results corresponding to the analysis of SOF and DAC at 237 nm and 291 nm, respectively. The ranges of limit of detection (LOD) and limit of quantitation (LOQ) related to the CWT and DS methods were 2.45 × 10 to 0.5054 and 6.91 × 10 to 0.6027, respectively. Mean recovery values of SOF and DAC in synthetic mixtures for CWT approach were 98.55%, 98.09% and in DS method were 98.78% and 95.83%, respectively. Real samples, including Sovodak tablet and urine was used for accurate simultaneous determination of the mentioned components. Analyzing Sovodak tablet was implemented using high-performance liquid chromatography (HPLC) as a reference method that the results were near to the CWT and DS methods. In order to investigate the existence of significant differences between the methods, analysis of variance (ANOVA) test at the 95% confidence level was performed but no significant differences were observed. In addition, the amounts of SOF and DAC in the complex matrix of biological sample were well predicted by the proposed methods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2021.119429DOI Listing
April 2021

Preparation and characterization of a new sawdust/MNP/PEI nanocomposite and its applications for removing Pb (II) ions from aqueous solution.

Water Sci Technol 2018 Dec;78(12):2469-2480

Department of Chemistry, Islamic Azad University, North Tehran Branch, P.O. Box 1913674711, Tehran, Iran E-mail:

A new sawdust/magnetite nanoparticles/polyethyleneimine (SD/MNP/PEI) nanocomposite was synthesized by grafting polyethyleneimine (PEI) to magnetic sawdust. Features of SD/MNP/PEI were characterized using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and scanning electron microscopy (SEM). SD/MNP/PEI was used as an adsorbent for the removal of lead (Pb (II)) from aqueous solution. The effects of independent variables including pH of solution, adsorbent dose and contact time were performed and adsorption isotherms were obtained. Experimental results show that priority effective variables were pH and the amount of nanocomposite, and it was found that the sorption capacity increases with the increasing phase contact time. The adsorption process followed the Langmuir adsorption isotherm. Although SD and SD/MNP do not show a high affinity for the adsorption of Pb (II) in aqueous media, polyethyleneimine cross-linked on SD/MNP showed 40 and 66% increases, respectively, in the adsorption of Pb (II) compared to the SD and SD/MNP. It was found that SD/MNP/PEI removes more efficiently lead ions from aqueous solutions than the SD, SD/MNP. Desorption of the lead from the SD/MNP/PEI was conducted. It was proved that SD/MNP/PEI has excellent properties and can be used as a sorbent of multi-use.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2166/wst.2018.521DOI Listing
December 2018
-->