Fengmin Lu

Fengmin Lu

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A global scientific strategy to cure hepatitis B.

Lancet Gastroenterol Hepatol 2019 Jul 10;4(7):545-558. Epub 2019 Apr 10.

INSERM Unit 1052, Cancer Research Center of Lyon, Lyon, France; Hepatology Department, Hospices Civils de Lyon, Lyon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24681253193011
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http://dx.doi.org/10.1016/S2468-1253(19)30119-0DOI Listing
July 2019

Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis.

J Cell Physiol 2019 Jun 14;234(6):9045-9051. Epub 2018 Oct 14.

Department of General Surgery, Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

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http://doi.wiley.com/10.1002/jcp.27579
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http://dx.doi.org/10.1002/jcp.27579DOI Listing
June 2019

HBV T1719G mutation reduced HBV replication through mutant Enh II and HBx protein in vitro.

J Viral Hepat 2019 Jun 28;26(6):710-717. Epub 2019 Feb 28.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P.R. China.

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http://doi.wiley.com/10.1111/jvh.13070
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http://dx.doi.org/10.1111/jvh.13070DOI Listing
June 2019

Serum GP73 combined AST and GGT reflects moderate to severe liver inflammation in chronic hepatitis B.

Clin Chim Acta 2019 Jun 20;493:92-97. Epub 2019 Feb 20.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193008
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http://dx.doi.org/10.1016/j.cca.2019.02.019DOI Listing
June 2019

Roadmap to Functional Cure of Chronic Hepatitis B: an expert consensus.

J Viral Hepat 2019 May 13. Epub 2019 May 13.

Treatment and Research Center for Infectious Diseases, Fifth Medical Center, General Hospital of PLA, Beijing, China.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jvh.13126
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http://dx.doi.org/10.1111/jvh.13126DOI Listing
May 2019

Nonalcoholic fatty liver disease is associated with lower hepatitis B viral load and antiviral response in pediatric population.

J Gastroenterol 2019 May 27. Epub 2019 May 27.

Department of Pathology and Hepatology, The 5th Medical Centre, Chinese PLA General Hospital, Xisihuan Middle Road NO.100, Beijing, 100039, P. R. China.

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http://dx.doi.org/10.1007/s00535-019-01594-6DOI Listing
May 2019

Long-term functional maintenance of primary human hepatocytes in vitro.

Science 2019 04;364(6438):399-402

School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100191, China.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aau7307
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http://dx.doi.org/10.1126/science.aau7307DOI Listing
April 2019

Over-gap PCR amplification to identify presence of replication-competent HBV DNA from integrated HBV DNA: An updated occult HBV infection definition.

J Hepatol 2019 Mar 23;70(3):557-559. Epub 2018 Nov 23.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.10.003DOI Listing
March 2019

Elevated apolipoprotein B predicts poor postsurgery prognosis in patients with hepatocellular carcinoma.

Onco Targets Ther 2019 12;12:1957-1964. Epub 2019 Mar 12.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China,

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http://dx.doi.org/10.2147/OTT.S192631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420103PMC
March 2019

Hepatocellular Carcinoma Surveillance and Treatment: A Way to Reduce Cancer-related Mortality in Cirrhotic Patients.

J Clin Transl Hepatol 2019 Mar 21;7(1):1-2. Epub 2019 Mar 21.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.14218/JCTH.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441639PMC
March 2019

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection.

Emerg Microbes Infect 2019 ;8(1):879-894

a State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences , Peking University Health Science Center , Beijing , People's Republic of China.

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http://dx.doi.org/10.1080/22221751.2019.1625728DOI Listing
January 2019

Diacylglycerol kinase γ predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.

Exp Cell Res 2018 Dec 3;373(1-2):211-220. Epub 2018 Nov 3.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2018.11.001DOI Listing
December 2018

One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide.

Biomater Sci 2018 Dec;7(1):104-112

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1039/c8bm01096jDOI Listing
December 2018

Integration of Prealbumin into Child-Pugh Classification Improves Prognosis Predicting Accuracy in HCC Patients Considering Curative Surgery.

J Clin Transl Hepatol 2018 Dec 26;6(4):377-384. Epub 2018 Jul 26.

Department of Minimally Invasive Intervention, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.

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http://dx.doi.org/10.14218/JCTH.2018.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328733PMC
December 2018

Serum Golgi protein 73 is a marker comparable to APRI for diagnosing significant fibrosis in children with liver disease.

Sci Rep 2018 Nov 13;8(1):16730. Epub 2018 Nov 13.

The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University; Department of Pediatrics, Shanghai Medical College of Fudan University, Shanghai, 201102, China.

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http://www.nature.com/articles/s41598-018-34714-y
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http://dx.doi.org/10.1038/s41598-018-34714-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233211PMC
November 2018

Methylation of PCDH19 predicts poor prognosis of hepatocellular carcinoma.

Asia Pac J Clin Oncol 2018 Oct 11;14(5):e352-e358. Epub 2018 May 11.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1111/ajco.12982DOI Listing
October 2018

Serum HBV RNA is a Potential Predictor of Hepatitis B Surface Antigen Reversion.

Hepatol Commun 2018 Oct 24;2(10):1168-1171. Epub 2018 Sep 24.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences Peking University Health Science Center Beijing China.

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http://doi.wiley.com/10.1002/hep4.1249
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http://dx.doi.org/10.1002/hep4.1249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167077PMC
October 2018

PCR screening of antimicrobial resistance genes in faecal samples from Australian and Chinese children.

J Glob Antimicrob Resist 2018 Sep 31;14:178-181. Epub 2018 Mar 31.

School of Public Health, Curtin University, Kent Street, Perth, WA 6102, Australia; Curtin Health Innovation Research Institute, Curtin University, Kent Street, Perth, WA 6102, Australia.

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http://dx.doi.org/10.1016/j.jgar.2018.03.003DOI Listing
September 2018

Early Env-specific CTLs effectively suppress viral replication in SHIV controller macaques.

Cell Immunol 2018 09 5;331:30-37. Epub 2018 May 5.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Haidian District, Beijing 100191, China; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2018.05.001DOI Listing
September 2018

Integration of hepatitis B virus S gene impacts on hepatitis B surface antigen levels in patients with antiviral therapy.

J Gastroenterol Hepatol 2018 Jul 4;33(7):1389-1396. Epub 2018 Mar 4.

Department of Infectious Disease, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

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http://dx.doi.org/10.1111/jgh.14075DOI Listing
July 2018

RFX1 participates in doxorubicin-induced hepatitis B virus reactivation.

Cancer Med 2018 05 30;7(5):2021-2033. Epub 2018 Mar 30.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1002/cam4.1468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943424PMC
May 2018

The gRNA-miRNA-gRNA Ternary Cassette Combining CRISPR/Cas9 with RNAi Approach Strongly Inhibits Hepatitis B Virus Replication.

Theranostics 2017 22;7(12):3090-3105. Epub 2017 Jul 22.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.7150/thno.18114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566108PMC
April 2018

HBV RNA virion-like particles produced under nucleos(t)ide analogues treatment are mainly replication-deficient.

J Hepatol 2018 04 4;68(4):847-849. Epub 2017 Nov 4.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278173241
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http://dx.doi.org/10.1016/j.jhep.2017.10.030DOI Listing
April 2018

The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review.

Clin Rev Allergy Immunol 2018 Apr;54(2):282-294

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, People's Republic of China.

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http://dx.doi.org/10.1007/s12016-017-8655-yDOI Listing
April 2018

Serum HBV DNA plus RNA shows superiority in reflecting the activity of intrahepatic cccDNA in treatment-naïve HBV-infected individuals.

J Clin Virol 2018 Feb - Mar;99-100:71-78. Epub 2018 Jan 6.

Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13866532173035
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http://dx.doi.org/10.1016/j.jcv.2017.12.016DOI Listing
January 2018

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide analogs.

Front Med 2017 Dec 23;11(4):502-508. Epub 2017 Nov 23.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.

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http://dx.doi.org/10.1007/s11684-017-0590-zDOI Listing
December 2017

Catheter Ablation of Idiopathic Left Posterior Fascicular Ventricular Tachycardia: Predicting the Site of Origin via Mapping and Electrocardiography.

Circ Arrhythm Electrophysiol 2017 Nov;10(11)

From the Tianjin Medical University, China (W.M., H.C.); Heart Institute, Tianjin Chest Hospital, China (W.M., F.L., F.Z., B.C., D.W., L.H., S.S., A.C., J.D., H.C., J.X.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (M.S., X.W.).

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http://dx.doi.org/10.1161/CIRCEP.117.005240DOI Listing
November 2017

STABLE-SR (Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm) for the Treatment of Nonparoxysmal Atrial Fibrillation: A Prospective, Multicenter Randomized Clinical Trial.

Circ Arrhythm Electrophysiol 2017 Nov;10(11)

From the Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, China (B.Y., G.Y., M.C.); Department of Cardiology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.J.); Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China (Y.L.); Department of Cardiology, Ningbo First Hospital, Zhejiang University, Ningbo, China (H. Chu); Department of Cardiology, General Hospital, Tianjin Medical University, China (H. Cai); Department of Cardiology, Tianjin Chest Hospital, China (F.L.); Department of Cardiology, Guangdong Province People's Hospital, Guangzhou, China (X.Z.); Department of Cardiology, Anhui Provincial Hospital, Hefei, China (J.X.); Department of Cardiology, Renji Hospital, Shanghai Jiaotong University, China (X.W.); Department of Cardiology, National Heart Centre Singapore (C.-K.C.); Department of Electrophysiology and Cardiac Pacing, Medanta, The Medicity Hospital, Gurgaon, Haryana, India (B.S.); and Department of Cardiology, Korea University Hospital, Seoul (Y.-H.K.).

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http://dx.doi.org/10.1161/CIRCEP.117.005405DOI Listing
November 2017

Digenic mutations on and predispose to premature myocardial infarction.

Oncotarget 2017 Nov 24;8(59):100141-100149. Epub 2017 Oct 24.

Department of Cardiology, Peking University People's Hospital, Xicheng District, Beijing, China.

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http://dx.doi.org/10.18632/oncotarget.22045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725008PMC
November 2017

PCDH9 acts as a tumor suppressor inducing tumor cell arrest at G0/G1 phase and is frequently methylated in hepatocellular carcinoma.

Mol Med Rep 2017 Oct 8;16(4):4475-4482. Epub 2017 Aug 8.

Beijing Artificial Liver Treatment & Training Center, Beijing Youan Hospital Capital Medical University, Beijing 100069, P.R. China.

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http://dx.doi.org/10.3892/mmr.2017.7193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647006PMC
October 2017

Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance.

Oncotarget 2017 Aug 23;8(34):56041-56050. Epub 2016 Jun 23.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing 100191, P. R. China.

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http://dx.doi.org/10.18632/oncotarget.10241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593543PMC
August 2017

Long-distance interaction of the integrated HPV fragment with MYC gene and 8q24.22 region upregulating the allele-specific MYC expression in HeLa cells.

Int J Cancer 2017 08 19;141(3):540-548. Epub 2017 May 19.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1002/ijc.30763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518216PMC
August 2017

Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.

Microb Pathog 2017 Aug 3;109:49-55. Epub 2017 May 3.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.micpath.2017.04.028DOI Listing
August 2017

CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice.

Sci Rep 2017 06 5;7(1):2796. Epub 2017 Jun 5.

Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, P.R. China.

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http://dx.doi.org/10.1038/s41598-017-03070-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459841PMC
June 2017

CCR6 B lymphocytes responding to tumor cell-derived CCL20 support hepatocellular carcinoma progression via enhancing angiogenesis.

Am J Cancer Res 2017 1;7(5):1151-1163. Epub 2017 May 1.

Department of Immunology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021, P. R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446480PMC
May 2017

Serum Golgi protein 73 is not a suitable diagnostic marker for hepatocellular carcinoma.

Oncotarget 2017 Mar;8(10):16498-16506

Department of Microbiology & Infectious Disease Center, School of Basic Medicine, Peking University Health Science Center, Beijing 100191, P.R. China.

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http://dx.doi.org/10.18632/oncotarget.14954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369980PMC
March 2017

Reply to: "Serum HBV pgRNA as a clinical marker for cccDNA activity": Consistent loss of serum HBV RNA might predict the "para-functional cure" of chronic hepatitis B.

J Hepatol 2017 02 5;66(2):462-463. Epub 2016 Nov 5.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.10.034DOI Listing
February 2017

Prognostic value of mutation for poor outcome of Asian primary liver cancer patients: evidence from a cohort study and meta-analysis of 988 patients.

Onco Targets Ther 2016 8;9:7425-7433. Epub 2016 Dec 8.

Beijing Artificial Liver Treatment and Training Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.

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https://www.dovepress.com/prognostic-value-of-p53-mutation-f
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http://dx.doi.org/10.2147/OTT.S121594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153317PMC
December 2016

Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound.

J Hepatol 2016 10 28;65(4):700-710. Epub 2016 May 28.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.05.029DOI Listing
October 2016

Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population.

Int J Biol Markers 2011 Jul-Sep;26(3):181-7. Epub 2011 Jul 27.

Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing - PR China.

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http://journals.sagepub.com/doi/10.5301/JBM.2011.8580
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http://dx.doi.org/10.5301/JBM.2011.8580DOI Listing
September 2016

Possible Involvement of Multidrug-Resistant Hepatitis B Virus sW172* Truncation Variant in the ER Stress Signaling Pathway during Hepatocarcinogenesis.

Jpn J Infect Dis 2016 Jul 13;69(4):306-13. Epub 2015 Nov 13.

Department of Laboratory Medicine, Peking University Third Hospital.

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http://dx.doi.org/10.7883/yoken.JJID.2015.359DOI Listing
July 2016

DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma.

Epigenomics 2015 27;7(4):581-92. Epub 2015 Mar 27.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.

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https://www.futuremedicine.com/doi/10.2217/epi.15.23
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http://dx.doi.org/10.2217/epi.15.23DOI Listing
June 2016

Lamivudine-resistant rtL180M and rtM204I/V are persistently dominant during combination rescue therapy with entecavir and adefovir for hepatitis B.

Exp Ther Med 2016 Jun 6;11(6):2293-2299. Epub 2016 Apr 6.

Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P.R. China.

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http://dx.doi.org/10.3892/etm.2016.3230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888018PMC
June 2016

Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell.

Mol Carcinog 2016 May 25;55(5):732-42. Epub 2015 Mar 25.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.

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http://dx.doi.org/10.1002/mc.22317DOI Listing
May 2016

Study on 2-arylthio-5-iodo pyrimidine derivatives as novel nonnucleoside inhibitors against hepatitis B virus DNA replication.

Future Med Chem 2016 05 13;8(7):751-63. Epub 2016 May 13.

Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

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http://dx.doi.org/10.4155/fmc.16.13DOI Listing
May 2016

Dysregulation of host cellular genes targeted by human papillomavirus (HPV) integration contributes to HPV-related cervical carcinogenesis.

Int J Cancer 2016 Mar 26;138(5):1163-74. Epub 2015 Oct 26.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.29872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057319PMC
March 2016

Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues.

Gut 2016 Feb 13;65(2):313-20. Epub 2015 Jan 13.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.

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http://gut.bmj.com/content/early/2015/01/13/gutjnl-2014-3085
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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2014-308546
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http://dx.doi.org/10.1136/gutjnl-2014-308546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752655PMC
February 2016

Delayed Reduction of Hepatitis B Viral Load and Dynamics of Adefovir-Resistant Variants during Adefovir plus Entecavir Combination Rescue Therapy.

Int J Med Sci 2015 15;12(5):416-22. Epub 2015 May 15.

1. Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.

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http://www.medsci.org/v12p0416.htm
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http://dx.doi.org/10.7150/ijms.11687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441066PMC
February 2016

Traceability, reproducibility and clinical evaluation of Sansure Realtime HCV RNA assay.

BMC Infect Dis 2016 Feb 1;16:47. Epub 2016 Feb 1.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.

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http://dx.doi.org/10.1186/s12879-016-1390-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736550PMC
February 2016

[Correlation between red blood cell count and liver function status].

Zhonghua Gan Zang Bing Za Zhi 2016 Feb;24(2):119-22

Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2016.02.009DOI Listing
February 2016

Alpha-fetoprotein still is a valuable diagnostic and prognosis predicting biomarker in hepatitis B virus infection-related hepatocellular carcinoma.

Oncotarget 2016 Jan;7(4):3702-8

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medicine, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.18632/oncotarget.6913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826163PMC
January 2016

Decreased Expression of BNC1 and BNC2 Is Associated with Genetic or Epigenetic Regulation in Hepatocellular Carcinoma.

Int J Mol Sci 2016 Jan 25;17(2). Epub 2016 Jan 25.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.3390/ijms17020153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783887PMC
January 2016

Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.

Exp Ther Med 2016 Jan 12;11(1):117-123. Epub 2015 Nov 12.

Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, P.R. China.

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http://dx.doi.org/10.3892/etm.2015.2855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726847PMC
January 2016

Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma.

Oncotarget 2015 Dec;6(39):42040-52

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.18632/oncotarget.5969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747208PMC
December 2015

Coinfection with HIV-1 alleviates iron accumulation in patients with chronic hepatitis C virus infection.

PLoS One 2014 13;9(6):e98039. Epub 2014 Jun 13.

Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098039PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057081PMC
October 2015

Alpha fetoprotein mediates HBx induced carcinogenesis in the hepatocyte cytoplasm.

Int J Cancer 2015 Oct 21;137(8):1818-29. Epub 2015 Apr 21.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1002/ijc.29548DOI Listing
October 2015

Influence of CCND1 G870A polymorphism on the risk of HBV-related HCC and cyclin D1 splicing variant expression in Chinese population.

Tumour Biol 2015 Sep 8;36(9):6891-900. Epub 2015 Apr 8.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China.

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http://dx.doi.org/10.1007/s13277-015-3401-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644212PMC
September 2015

Cavotricuspid-Dependent Atrial Flutter in Patients With Prior Atriotomy: 12-Lead ECG Interpretation and Electroanatomical Characteristics.

J Cardiovasc Electrophysiol 2015 Sep;26(9):969-977

Heart Institute, Tianjin Chest Hospital, Tianjin, China.

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http://dx.doi.org/10.1111/jce.12722DOI Listing
September 2015

Failure recovery of circulating NKG2DCD56NK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence.

Oncoimmunology 2016;5(1):e1048061. Epub 2015 Jul 7.

State Key Laboratory of Natural and Biomimetic Drugs; The Department of Microbiology & Infectious Disease Center; School of Basic Medicine; Peking University Health Science Center ; Beijing, China.

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http://dx.doi.org/10.1080/2162402X.2015.1048061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760296PMC
July 2015

Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR.

PLoS One 2014 11;9(9):e106658. Epub 2014 Sep 11.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, United State of America; National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, Jilin, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106658PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161356PMC
May 2015

Hepatitis B Virus X Protein Stabilizes Cyclin D1 and Increases Cyclin D1 Nuclear Accumulation through ERK-Mediated Inactivation of GSK-3β.

Cancer Prev Res (Phila) 2015 May 24;8(5):455-63. Epub 2015 Feb 24.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing, P.R. China.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0384DOI Listing
May 2015

[Risk factors for heart failure after right ventricular apical pacing].

Zhonghua Yi Xue Za Zhi 2015 Apr;95(15):1144-8

Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China; Email:

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April 2015

CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression.

Oncotarget 2015 Mar;6(7):4733-44

The Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467111PMC
http://dx.doi.org/10.18632/oncotarget.2900DOI Listing
March 2015

Reduced red blood cell count predicts poor survival after surgery in patients with primary liver cancer.

Medicine (Baltimore) 2015 Feb;94(8):e577

From the Department of Epidemiology and Biostatistics (XX, KW, FL), College of Public Health, Zhengzhou University, Zhengzhou; Department of Microbiology and Infectious Disease Center (MY, XC, FL), School of Basic Medical Sciences, Peking University Health Science Center, Beijing; Department of Medical Records (WL), Henan Cancer Hospital; Department of Nutrition and Food Hygiene (QL), College of Public Health, Zhengzhou University; and Department of Hepatobiliary Surgery (LZ), Henan Cancer Hospital, Zhengzhou, China.

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https://insights.ovid.com/crossref?an=00005792-201502040-000
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http://dx.doi.org/10.1097/MD.0000000000000577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554158PMC
February 2015

Analysis of hepatitis B virus intrahepatic covalently closed circular DNA and serum viral markers in treatment-naive patients with acute and chronic HBV infection.

PLoS One 2014 13;9(2):e89046. Epub 2014 Feb 13.

Department of Microbiology, Peking University Health Science Center, Beijing, China ; Institute of Infectious Diseases and Medical Center for Liver Failure, Beijing 302 Hospital, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089046PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923869PMC
October 2014

Selection of reference genes for RT-qPCR analysis in tumor tissues from male hepatocellular carcinoma patients with hepatitis B infection and cirrhosis.

Cancer Biomark 2013 ;13(5):345-9

Department of Microbiology and Infectious Disease Center, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.3233/CBM-130365DOI Listing
September 2014

Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine.

Vaccine 2014 Sep 29;32(41):5316-22. Epub 2014 Jul 29.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing 100191, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X140101
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http://dx.doi.org/10.1016/j.vaccine.2014.07.064DOI Listing
September 2014

Protocadherin 9 inhibits epithelial-mesenchymal transition and cell migration through activating GSK-3β in hepatocellular carcinoma.

Biochem Biophys Res Commun 2014 Sep 27;452(3):567-74. Epub 2014 Aug 27.

Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.08.101DOI Listing
September 2014

The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinoma.

J Hepatol 2014 May 19;60(5):975-84. Epub 2013 Dec 19.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278130088
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http://dx.doi.org/10.1016/j.jhep.2013.12.014DOI Listing
May 2014

An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection.

Cell Mol Immunol 2014 May 17;11(3):294-304. Epub 2014 Feb 17.

1] Department of Microbiology, Peking University Health Science Center, Beijing, China [2] Center of Infectious Diseases, Peking University, Beijing, China.

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http://dx.doi.org/10.1038/cmi.2013.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085489PMC
May 2014

Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer.

Biochem Biophys Res Commun 2014 Apr 2;447(1):158-64. Epub 2014 Apr 2.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.1016/j.bbrc.2014.03.129DOI Listing
April 2014

[A preliminary assessment of the clinical utility of measuring hepatitis C virus antibody to evaluate infection status].

Zhonghua Gan Zang Bing Za Zhi 2014 Apr;22(4):244-50

Department of Microbiology and Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2014.04.002DOI Listing
April 2014

microRNA expression in hepatitis B virus infected primary treeshrew hepatocytes and the independence of intracellular miR-122 level for de novo HBV infection in culture.

Virology 2014 Jan 1;448:247-54. Epub 2013 Nov 1.

School of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, 5 Dongdan Santiao, Beijing 100005, China; National Institute of Biological Sciences, Beijing, 7 Science Park Road, Zhongguancun Life Science Park, Changping, Beijing 102206, China.

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http://dx.doi.org/10.1016/j.virol.2013.10.016DOI Listing
January 2014

Identification of a novel DRB1 allele through intergenic recombination between HLA-DRB1 and HLA-DRB3∗02 in a Chinese family.

Hum Immunol 2013 Dec 2;74(12):1603-9. Epub 2013 Aug 2.

Department of Microbiology, Peking University Health Science Center, Beijing 100191, China; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing 100050, China.

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http://dx.doi.org/10.1016/j.humimm.2013.07.013DOI Listing
December 2013

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy.

Apoptosis 2013 Oct;18(10):1224-34

Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10495-013-0864-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778057PMC
October 2013

The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis.

J Med Microbiol 2013 Aug 4;62(Pt 8):1226-34. Epub 2013 Apr 4.

Department of Gastroenterology, Peking University Third Hospital, Beijing, 100191, China.

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http://dx.doi.org/10.1099/jmm.0.056903-0DOI Listing
August 2013

1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit.

Cancer Cell 2013 Apr;23(4):541-56

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cell Biology, Peking University Cancer Hospital and Institute, Beijing 100142, People's Republic of China.

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http://dx.doi.org/10.1016/j.ccr.2013.02.025DOI Listing
April 2013

Methylation-mediated repression of microRNA 129-2 enhances oncogenic SOX4 expression in HCC.

Liver Int 2013 Mar;33(3):476-86

Department of Microbiology & Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1111/liv.12097DOI Listing
March 2013

Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naïve patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma.

J Med Virol 2013 Feb 20;85(2):219-27. Epub 2012 Nov 20.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://doi.wiley.com/10.1002/jmv.23461
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February 2013

AKR1B10 overexpression in breast cancer: association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker.

Int J Cancer 2012 Sep 21;131(6):E862-71. Epub 2012 May 21.

Department of Medical Microbiology, Immunology, and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL 62794, USA.

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http://dx.doi.org/10.1002/ijc.27618DOI Listing
September 2012

Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma.

J Hepatol 2012 Aug 18;57(2):322-9. Epub 2012 Apr 18.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278120028
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http://dx.doi.org/10.1016/j.jhep.2012.03.029DOI Listing
August 2012

CCND1 G870A polymorphism with altered cyclin D1 transcripts expression is associated with the risk of glioma in a Chinese population.

DNA Cell Biol 2012 Jun 3;31(6):1107-13. Epub 2012 Feb 3.

Department of Microbiology, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1089/dna.2011.1521DOI Listing
June 2012

Aberrant expression of microRNA 155 may accelerate cell proliferation by targeting sex-determining region Y box 6 in hepatocellular carcinoma.

Cancer 2012 May 11;118(9):2431-42. Epub 2011 Oct 11.

Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1002/cncr.26566DOI Listing
May 2012

Quantitative methylation analysis reveals gender and age differences in p16INK4a hypermethylation in hepatitis B virus-related hepatocellular carcinoma.

Liver Int 2012 Mar 23;32(3):420-8. Epub 2011 Dec 23.

Department of Microbiology, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1111/j.1478-3231.2011.02696.xDOI Listing
March 2012

Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission.

Infect Genet Evol 2012 Mar 28;12(2):428-34. Epub 2012 Jan 28.

Department of Microbiology, School of Basic Medical Sciences, Peking University, Peking University Infectious Disease Center, Beijing 100191, China.

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http://dx.doi.org/10.1016/j.meegid.2012.01.017DOI Listing
March 2012

Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71.

Arch Virol 2012 Jan 9;157(1):37-41. Epub 2011 Oct 9.

National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China.

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http://dx.doi.org/10.1007/s00705-011-1136-3DOI Listing
January 2012

Impaired nuclear export of tumor-derived c-terminal truncated cyclin D1 mutant in ESCC cancer.

Oncol Lett 2011 Nov 2;2(6):1203-1211. Epub 2011 Sep 2.

Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang 150081.

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http://dx.doi.org/10.3892/ol.2011.404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406500PMC
November 2011

Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.

Virol J 2011 Jun 7;8:279. Epub 2011 Jun 7.

Department of Microbiology, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.1186/1743-422X-8-279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129323PMC
June 2011

The biomarker N-terminal pro-brain natriuretic peptide and liver diseases.

Clin Invest Med 2011 Feb 1;34(1):E30-7. Epub 2011 Feb 1.

Department of Microbiology, Peking University Health Science Center, China.

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February 2011