Publications by authors named "Fengling Li"

100Publications

Comprehensive multi-factor analysis and exploration for the pathogenesis of non-ischemic cardiomyopathy and ischemic cardiomyopathy.

Cell Mol Biol (Noisy-le-grand) 2020 Jul 31;66(5):66-72. Epub 2020 Jul 31.

Department of Cardiology, Shan Xian Central Hospital, Shandong 274300, China.

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July 2020

Development of duplex real-time polymerase chain reaction for simultaneous detection of oilfish- and escolar-derived components.

J Sci Food Agric 2020 Sep 5. Epub 2020 Sep 5.

Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Qingdao, P. R. China.

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http://dx.doi.org/10.1002/jsfa.10793DOI Listing
September 2020

Methodology and application of PCR-RFLP for species identification in tuna sashimi.

Food Sci Nutr 2020 Jul 7;8(7):3138-3146. Epub 2020 Jun 7.

Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality Ministry of Agriculture and Rural Affairs Qingdao China.

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http://dx.doi.org/10.1002/fsn3.1552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382206PMC
July 2020

Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts.

Arch Med Res 2020 Jun 18. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China. Electronic address:

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http://dx.doi.org/10.1016/j.arcmed.2020.06.005DOI Listing
June 2020

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.

J Med Chem 2020 05 14;63(10):5477-5487. Epub 2020 May 14.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286362PMC
May 2020

BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor.

Oncol Rep 2020 May 10;43(5):1630-1640. Epub 2020 Mar 10.

Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China.

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http://dx.doi.org/10.3892/or.2020.7539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108087PMC
May 2020

Apigenin and Abivertinib, a novel BTK inhibitor synergize to inhibit diffuse large B-cell lymphoma .

J Cancer 2020 3;11(8):2123-2132. Epub 2020 Feb 3.

Department of Hematology, the First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, People's Republic of China.

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http://dx.doi.org/10.7150/jca.34981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052937PMC
February 2020

Chemical probes for protein arginine methyltransferases.

Methods 2020 03 3;175:30-43. Epub 2019 Dec 3.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2019.11.017DOI Listing
March 2020

Development and Evaluation of a Novel Armored RNA Technology Using Bacteriophage Qβ.

Food Environ Virol 2019 12 21;11(4):383-392. Epub 2019 Aug 21.

Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, People's Republic of China.

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http://dx.doi.org/10.1007/s12560-019-09400-5DOI Listing
December 2019

Abivertinib, a novel BTK inhibitor: Anti-Leukemia effects and synergistic efficacy with homoharringtonine in acute myeloid leukemia.

Cancer Lett 2019 Oct 13;461:132-143. Epub 2019 Jul 13.

Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, People's Republic of China; Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.07.008DOI Listing
October 2019

Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice.

Authors:
Fengling Li Lei Liu

Life Sci 2019 Sep 30;232:116621. Epub 2019 Jun 30.

Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.116621DOI Listing
September 2019

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).

J Med Chem 2019 10 24;62(20):8996-9007. Epub 2019 Jul 24.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00522DOI Listing
October 2019

Discovery of selective activators of PRC2 mutant EED-I363M.

Sci Rep 2019 04 25;9(1):6524. Epub 2019 Apr 25.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.

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http://dx.doi.org/10.1038/s41598-019-43005-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484020PMC
April 2019

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Nat Chem Biol 2019 08;15(8):846

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNCEshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/s41589-019-0242-5DOI Listing
August 2019

Distribution of perfluorinated alkyl substances in marine shellfish along the Chinese Bohai Sea coast.

J Environ Sci Health B 2019 10;54(4):271-280. Epub 2019 Jan 10.

a Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences , Qingdao , China.

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http://dx.doi.org/10.1080/03601234.2018.1559570DOI Listing
July 2019

Rapid subtyping of pathogenic and nonpathogenic Vibrio parahaemolyticus by fourier transform infrared spectroscopy with chemometric analysis.

J Microbiol Methods 2018 12 7;155:70-77. Epub 2018 Nov 7.

Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture, Yellow Sea Fishery Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, Shandong, China.

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https://linkinghub.elsevier.com/retrieve/pii/S01677012183064
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http://dx.doi.org/10.1016/j.mimet.2018.11.003DOI Listing
December 2018

Antimicrobial resistance, virulence and genetic relationship of Vibrio parahaemolyticus in seafood from coasts of Bohai Sea and Yellow Sea, China.

Int J Food Microbiol 2019 Feb 6;290:116-124. Epub 2018 Oct 6.

Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijfoodmicro.2018.10.005DOI Listing
February 2019

DNA Probes for Implementation of Multiple Molecular Computations Using a Lateral Flow Strip Biosensor as the Sensing Platform.

Anal Chem 2018 09 17;90(17):10311-10317. Epub 2018 Aug 17.

Guangdong Key Laboratory of Integrated Agro-Environmental Pollution Control and Management , Guangdong Institute of Eco-Environmental Science & Technology , Guangzhou 510650 , China.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b02103
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http://dx.doi.org/10.1021/acs.analchem.8b02103DOI Listing
September 2018

Tissue distribution and elimination features of florfenicol in hybrid sturgeon cultured in cool water.

J Vet Pharmacol Ther 2018 Dec 25;41(6):894-901. Epub 2018 Jul 25.

Fisheries Research Institute of Shanxi Province, Yellow River Fisheries Research Institute Chinese Academy of Fishery Science, Supervision & Test Center for Fisheries Environment and Quality of Fishery Products of Ministry of Agriculture, Xi'an, China.

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http://dx.doi.org/10.1111/jvp.12689DOI Listing
December 2018

Biocontrol of Salmonella Typhimurium in Raw Salmon Fillets and Scallop Adductors by Using Bacteriophage SLMP1.

J Food Prot 2018 08;81(8):1304-1312

3 Zhangzidao Group Co., Ltd., Dalian 116011, People's Republic of China.

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http://dx.doi.org/10.4315/0362-028X.JFP-17-525DOI Listing
August 2018

Phase-specific Surround suppression in Mouse Primary Visual Cortex Correlates with Figure Detection Behavior Based on Phase Discontinuity.

Neuroscience 2018 05 30;379:359-374. Epub 2018 Mar 30.

Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064522183023
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http://dx.doi.org/10.1016/j.neuroscience.2018.03.039DOI Listing
May 2018

Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

J Med Chem 2018 02 31;61(4):1541-1551. Epub 2018 Jan 31.

Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823789PMC
February 2018

Extensive hydrolysis of raw rice starch by a chimeric α-amylase engineered with α-amylase (AmyP) and a starch-binding domain from Cryptococcus sp. S-2.

Appl Microbiol Biotechnol 2018 Jan 20;102(2):743-750. Epub 2017 Nov 20.

Anhui Key Laboratory of Modern Biomanufacturing, School of Life Sciences, Anhui University, Hefei, 230601, Anhui, People's Republic of China.

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http://dx.doi.org/10.1007/s00253-017-8638-1DOI Listing
January 2018

MicroRNA-200c Inhibits Epithelial-Mesenchymal Transition by Targeting the BMI-1 Gene Through the Phospho-AKT Pathway in Endometrial Carcinoma Cells In Vitro.

Med Sci Monit 2017 Oct 28;23:5139-5149. Epub 2017 Oct 28.

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673031PMC
http://dx.doi.org/10.12659/msm.907207DOI Listing
October 2017

Instrument-free visual detection of tetracycline on an autocatalytic DNA machine using a caged G-quadruplex as the signal reporter.

Chem Commun (Camb) 2017 Aug 20;53(62):8743-8746. Epub 2017 Jul 20.

Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Guangdong Institute of Eco-environmental Science & Technology, Guangzhou 510650, China.

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http://dx.doi.org/10.1039/c7cc04083kDOI Listing
August 2017

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.

Bioorg Med Chem 2017 08 19;25(16):4414-4423. Epub 2017 Jun 19.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562403PMC
August 2017

Long Noncoding RNA MNX1-AS1 Knockdown Inhibits Cell Proliferation and Migration in Ovarian Cancer.

Cancer Biother Radiopharm 2017 Apr;32(3):91-99

1 Department of Obstetrics and Gynaecology, Qilu Hospital of Shandong University , Jinan, China .

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http://www.liebertpub.com/doi/10.1089/cbr.2017.2178
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http://dx.doi.org/10.1089/cbr.2017.2178DOI Listing
April 2017

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

ACS Comb Sci 2017 03 22;19(3):161-172. Epub 2017 Feb 22.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/acscombsci.6b00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376495PMC
March 2017

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

J Med Chem 2017 03 14;60(5):1876-1891. Epub 2017 Feb 14.

Department of Pharmacological Sciences and Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352984PMC
March 2017

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

J Med Chem 2016 11 2;59(21):9881-9889. Epub 2016 Nov 2.

Department of Pharmacological Sciences and Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148670PMC
November 2016

A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D.

SLAS Discov 2017 01 27;22(1):32-39. Epub 2016 Sep 27.

1 Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1087057116666276DOI Listing
January 2017

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.

Bioorg Med Chem Lett 2016 09 21;26(18):4518-4522. Epub 2016 Jul 21.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.07.041DOI Listing
September 2016

Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.

J Med Chem 2016 08 11;59(16):7617-33. Epub 2016 Aug 11.

Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Room 16-20B, Box 1677, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003625PMC
August 2016

Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma.

Gut Liver 2017 Jan;11(1):112-120

Department of Orthopedics, People's Hospital of Zhangqiu City, Zhangqiu, China.

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http://dx.doi.org/10.5009/gnl16063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221868PMC
January 2017

SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2.

Authors:
Fengling Li Lei Liu

Front Cell Neurosci 2016 27;10:171. Epub 2016 Jun 27.

Department of Anesthesiology, University of FloridaGainesville, FL, USA; Center for Translational Research in Neurodegenerative Disease, University of FloridaGainesville, FL, USA.

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http://journal.frontiersin.org/Article/10.3389/fncel.2016.00
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http://dx.doi.org/10.3389/fncel.2016.00171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922023PMC
July 2016

Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice.

Biomed Res Int 2016 4;2016:7631801. Epub 2016 May 4.

The Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, China.

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http://dx.doi.org/10.1155/2016/7631801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870344PMC
February 2017

Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model.

Mol Med Rep 2016 Jun 12;13(6):4904-10. Epub 2016 Apr 12.

Medical Imaging Center, Weifang Traditional Chinese Medicine Hospital, Weifang, Shandong 261041, P.R. China.

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http://dx.doi.org/10.3892/mmr.2016.5103DOI Listing
June 2016

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Nat Chem Biol 2016 Mar 25;12(3):180-7. Epub 2016 Jan 25.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nchembio.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755828PMC
March 2016

A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5.

J Biomol Screen 2016 Mar 23;21(3):290-7. Epub 2015 Dec 23.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1177/1087057115623264DOI Listing
March 2016

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

ACS Chem Biol 2016 Mar 8;11(3):772-781. Epub 2015 Dec 8.

Departments of Structural and Chemical Biology, Oncological Sciences, and Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acschembio.5b00839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798913PMC
March 2016

Effects of unstable elements with different hardness on lower limb loading.

Acta Bioeng Biomech 2015 ;17(2):85-92

Faculty of Sports Science, Ningbo University, China.

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June 2016

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells.

Clin Epigenetics 2015 21;7:84. Epub 2015 Aug 21.

Department of Surgery and Cancer, Ovarian Cancer Action Research Centre, Imperial College London, Hammersmith Hospital Campus, London, W12 ONN UK ; Section of Molecular Pathology, Institute of Cancer Research, Sutton, SM2 5NG UK.

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http://dx.doi.org/10.1186/s13148-015-0118-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545913PMC
August 2015

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.

Biochim Biophys Acta 2015 Sep 19;1850(9):1842-8. Epub 2015 May 19.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2015.05.013DOI Listing
September 2015

Discovery of a Dual PRMT5-PRMT7 Inhibitor.

ACS Med Chem Lett 2015 Apr 2;6(4):408-12. Epub 2015 Mar 2.

Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada ; The Department of Pharmacology and Toxicology, University of Toronto , Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1021/ml500467hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394339PMC
April 2015

Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.

Medchemcomm 2014 Dec 11;5(12):1821-1828. Epub 2014 Sep 11.

Department of Chemistry , Imperial College London , London SW7 2AZ , UK . Email: m. ; ; Tel: +44 (0)2075945815.

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http://xlink.rsc.org/?DOI=C4MD00274A
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http://dx.doi.org/10.1039/c4md00274aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349132PMC
December 2014

Function of VP2 protein in the stability of the secondary structure of virus-like particles of genogroup II norovirus at different pH levels: function of VP2 protein in the stability of NoV VLPs.

J Microbiol 2014 Nov 3;52(11):970-5. Epub 2014 Oct 3.

Key Laboratory of Test and Evaluation on Quality and Safety of Aquatic Products, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, P. R. China.

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http://dx.doi.org/10.1007/s12275-014-4323-6DOI Listing
November 2014

Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.

J Med Chem 2014 Aug 25;57(15):6822-33. Epub 2014 Jul 25.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, ‡Department of Pharmacology, School of Medicine, §Lineberger Comprehensive Cancer Center, and ∥Department of Biochemistry and Biophysics, UNC Macromolecular Interactions Facility, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/jm500871sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136711PMC
August 2014

Castration modulates singing patterns and electrophysiological properties of RA projection neurons in adult male zebra finches.

PeerJ 2014 10;2:e352. Epub 2014 Apr 10.

School of Life Science, South China Normal University, Key Laboratory of Ecology and Environmental Science in Higher Education of Guangdong Province , Guangzhou , China.

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http://dx.doi.org/10.7717/peerj.352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994634PMC
April 2014

Human mesenchymal stem cells with adenovirus-mediated TRAIL gene transduction have antitumor effects on esophageal cancer cell line Eca-109.

Acta Biochim Biophys Sin (Shanghai) 2014 Jun 15;46(6):471-6. Epub 2014 Apr 15.

Department of Thoracic Surgery, Qilu Hospital, Shandong University, Jinan 250012, China.

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http://dx.doi.org/10.1093/abbs/gmu024DOI Listing
June 2014

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.

ChemMedChem 2014 Mar 17;9(3):549-53. Epub 2014 Jan 17.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/cmdc.201300450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005005PMC
March 2014

Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.

PLoS One 2013 19;8(12):e83737. Epub 2013 Dec 19.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083737PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868588PMC
October 2014

Clinical application of iodine-eluting stent in patients with advanced esophageal cancer.

Oncol Lett 2013 Sep 15;6(3):713-718. Epub 2013 Jul 15.

Key Laboratory of Cancer Prevention and Therapy, Endoscopy Center, Tianjin Medical University, Cancer Institute and Hospital, Tianjin 300060, P.R. China.

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http://dx.doi.org/10.3892/ol.2013.1466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789014PMC
September 2013

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

J Med Chem 2013 Nov 31;56(21):8931-42. Epub 2013 Oct 31.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, ‡National Institute of Mental Health Psychoactive Drug Screening Program, §Department of Pharmacology, School of Medicine, and ∥Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/jm401480rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880643PMC
November 2013

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

ACS Chem Biol 2013 24;8(6):1324-34. Epub 2013 Apr 24.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, §Department of Biochemistry and Biophysics, School of Medicine, ∥Department of Pharmacology, School of Medicine, ⊥National Institute of Mental Health Psychoactive Drug Screening Program, and ¶Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/cb400133jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773059PMC
August 2014

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

J Med Chem 2013 Mar 27;56(5):2110-24. Epub 2013 Feb 27.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/jm3018332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319713PMC
March 2013

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Bioorg Med Chem 2013 Apr 30;21(7):1787-1794. Epub 2013 Jan 30.

Structural Genomics Consortium, University of Toronto; 101 College Street, MaRS Centre, South tower, Toronto, Ontario, M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.bmc.2013.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780262PMC
April 2013

Strategy to target the substrate binding site of SET domain protein methyltransferases.

J Chem Inf Model 2013 Mar 1;53(3):681-91. Epub 2013 Mar 1.

Structural Genomics Consortium, University of Toronto , MaRS Centre, South Tower, seventh floor, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

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http://dx.doi.org/10.1021/ci300596xDOI Listing
March 2013

Aβ(1-42) disrupts the expression and function of KLF2 in Alzheimer's disease mediated by p53.

Biochem Biophys Res Commun 2013 Feb 10;431(2):141-5. Epub 2013 Jan 10.

Department of Neurology, Affiliated Hospital of Weifang Medical University, No. 465 Yuhe Road Kuiwen, Weifang, Shandong 261031, China.

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http://dx.doi.org/10.1016/j.bbrc.2013.01.008DOI Listing
February 2013

In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery.

AAPS J 2013 Jan 30;15(1):288-98. Epub 2012 Nov 30.

Center for Nanotechnology in Drug Delivery, Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1208/s12248-012-9441-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535102PMC
January 2013