Publications by authors named "Feng-Chun Yang"

100Publications

Analysis of the Government Health Expenditure in the First Decade of Chinese New Medical Reform (2009-2018): Xinjiang Uygur Autonomous Region as an Example.

Risk Manag Healthc Policy 2020 14;13:387-395. Epub 2020 May 14.

Accounting College, Xinjiang University of Finance & Economics, Urumqi, Xinjiang, People's Republic of China.

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http://dx.doi.org/10.2147/RMHP.S252652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234958PMC
May 2020

Novel combinations to improve hematopoiesis in myelodysplastic syndrome.

Stem Cell Res Ther 2020 03 20;11(1):132. Epub 2020 Mar 20.

UT Health San Antonio, San Antonio, TX, 78229, USA.

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http://dx.doi.org/10.1186/s13287-020-01647-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083030PMC
March 2020

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice.

Cancer Cell 2019 12 27;36(6):645-659.e8. Epub 2019 Nov 27.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917035PMC
December 2019

Preoperative Planning for Total Hip Arthroplasty for Neglected Developmental Dysplasia of the Hip.

Orthop Surg 2019 Jun 13;11(3):348-355. Epub 2019 Jun 13.

Department of Orthopaedics, Jilin University First Hospital, Changchun, China.

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http://dx.doi.org/10.1111/os.12472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595139PMC
June 2019

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis.

Leukemia 2019 05 16;33(5):1287-1291. Epub 2019 Jan 16.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://www.nature.com/articles/s41375-018-0347-y
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http://dx.doi.org/10.1038/s41375-018-0347-yDOI Listing
May 2019

Cardiac Sca-1 Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair.

Circulation 2018 12;138(25):2919-2930

Riley Heart Research Center and Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis (L. Zhang, F.Y., C.-L.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366943PMC
December 2018

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.

J Clin Invest 2018 12 29;128(12):5383-5398. Epub 2018 Oct 29.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1172/JCI121366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264643PMC
December 2018

Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity.

Stem Cells Int 2018 10;2018:5921392. Epub 2018 Jul 10.

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

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http://dx.doi.org/10.1155/2018/5921392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079359PMC
July 2018

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC).

Genomics Proteomics Bioinformatics 2018 06 13;16(3):172-186. Epub 2018 Jun 13.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076382PMC
June 2018

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Cancer Cell 2018 06;33(6):1111-1127.e5

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191185PMC
June 2018

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.

Leukemia 2018 08 2;32(8):1834-1837. Epub 2018 Apr 2.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41375-018-0126-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168429PMC
August 2018

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia.

J Cancer Res Clin Oncol 2018 Jun 28;144(6):1065-1077. Epub 2018 Mar 28.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

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http://dx.doi.org/10.1007/s00432-018-2631-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948279PMC
June 2018

Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates.

Cell Discov 2018 23;4. Epub 2018 Jan 23.

1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.

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http://dx.doi.org/10.1038/s41421-017-0004-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802628PMC
January 2018

TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2-Driven Myeloid Malignancy Progression.

Stem Cell Reports 2018 01 28;10(1):166-179. Epub 2017 Dec 28.

Department of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768963PMC
January 2018

Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia.

Stem Cell Investig 2017 2;4:48. Epub 2017 Jun 2.

Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.21037/sci.2017.05.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460107PMC
June 2017

Loss of Asxl2 leads to myeloid malignancies in mice.

Nat Commun 2017 06 8;8:15456. Epub 2017 Jun 8.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1038/ncomms15456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472177PMC
June 2017

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells.

Nat Commun 2017 04 25;8:15102. Epub 2017 Apr 25.

Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1038/ncomms15102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414116PMC
April 2017

PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia.

Int J Cancer 2017 07 8;141(2):324-335. Epub 2017 May 8.

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Department of Stem Cell and Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

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http://dx.doi.org/10.1002/ijc.30739DOI Listing
July 2017

[Role of Histone Methylation in Myeloid Malignancies -Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Feb;25(1):235-239

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China. E-mail:

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http://dx.doi.org/10.7534/j.issn.1009-2137.2017.01. 042DOI Listing
February 2017

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.

Sci Adv 2017 Jan 20;3(1):e1601602. Epub 2017 Jan 20.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1126/sciadv.1601602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249256PMC
January 2017

Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 10;38(5):583-588

State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Disease Hospital,CAMS and PUMC,Tianjin 300020,China.

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http://dx.doi.org/10.3881/j.issn.1000-503X.2016.05.017DOI Listing
October 2016

Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion.

Oncotarget 2016 Nov;7(47):78095-78109

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

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http://dx.doi.org/10.18632/oncotarget.12947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363646PMC
November 2016

ASXL1 plays an important role in erythropoiesis.

Sci Rep 2016 06 29;6:28789. Epub 2016 Jun 29.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1038/srep28789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926121PMC
June 2016

Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.

Stem Cell Reports 2016 06 26;6(6):914-925. Epub 2016 May 26.

Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911496PMC
June 2016

The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells.

Leukemia 2016 08 8;30(8):1784-1788. Epub 2016 Mar 8.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL.

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http://dx.doi.org/10.1038/leu.2016.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972674PMC
August 2016

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.

Blood 2016 05 4;127(19):2322-6. Epub 2016 Mar 4.

Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

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http://dx.doi.org/10.1182/blood-2015-11-677708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865589PMC
May 2016

Aberrant Myeloid Differentiation Contributes to the Development of Osteoporosis in Neurofibromatosis Type 1.

Curr Osteoporos Rep 2016 Feb;14(1):10-5

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, R. Bunn Gautier Building, 417 1011 NW 15th street, Locator R-629, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s11914-016-0298-zDOI Listing
February 2016

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.

Cell Rep 2015 Nov 12;13(8):1692-704. Epub 2015 Nov 12.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami, Miami, FL 33136, USA; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764044PMC
November 2015

Incidence and risk factors for myelofibrotic transformation among 272 Chinese patients with JAK2-mutated polycythemia vera.

Am J Hematol 2015 Dec 17;90(12):1116-21. Epub 2015 Nov 17.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.

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http://dx.doi.org/10.1002/ajh.24191DOI Listing
December 2015

Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis.

Mol Endocrinol 2015 Sep 5;29(9):1269-85. Epub 2015 Aug 5.

Department of Anatomy and Cell Biology (P.C., S.H.-B., D.H., A.G.R., M.R.A., J.P.B.), Indiana University School of Medicine, Indianapolis, Indiana 46202; Lilly Research Laboratories (K.R.S., J.K.M., Z.R.G., V.K.), Eli Lilly and Company, Indianapolis, Indiana 46202; Orthopaedic Surgery (M.B.A.), Indiana University School of Medicine; Department of Medical and Molecular Genetics (Z.W., Y.S., Y.L., J.P.B.), Indiana University School of Medicine; Center for Computational Biology and Bioinformatics (Z.W., Y.L.), Indiana University School of Medicine; Department of Pediatrics (Y.H., F.-C.Y.), Indiana University School of Medicine; Herman B Wells Center for Pediatric Research (Y.H., F.-C.Y.); Cellular and Integrative Physiology (F.M.P.); Center for Translational Musculoskeletal Research (S.J.W.), School of Health and Rehabilitation Sciences, Indiana University; and Department of Physical Therapy (S.J.W.), School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202.

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http://dx.doi.org/10.1210/me.2014-1406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552437PMC
September 2015

The TET2 interactors and their links to hematological malignancies.

IUBMB Life 2015 Jun 22;67(6):438-45. Epub 2015 Jun 22.

Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1002/iub.1389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765929PMC
June 2015

Dystrophic spinal deformities in a neurofibromatosis type 1 murine model.

PLoS One 2015 18;10(3):e0119093. Epub 2015 Mar 18.

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119093PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364663PMC
March 2016

[Anti-mouse CD122 antibody promotes the hematopoietic repopulating capacity of cord blood CD34⁺ cells in NOD/SCID mice].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2014 Dec;22(6):1673-7

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Scinces & Peking Union Medical College, Tianjin 300020, China.

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http://dx.doi.org/10.7534/j.issn.1009-2137.2014.06.032DOI Listing
December 2014

[Role of ASXL1 mutation in myeloid malignancies].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2014 Aug;22(4):1183-7

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. E-mail:

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http://dx.doi.org/10.7534/j.issn.1009-2137.2014.04.057DOI Listing
August 2014

Interleukin 8/KC enhances G-CSF induced hematopoietic stem/progenitor cell mobilization in Fancg deficient mice.

Stem Cell Investig 2014 31;1:19. Epub 2014 Oct 31.

1 Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA ; 2 State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China ; 3 Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.3978/j.issn.2306-9759.2014.10.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923645PMC
June 2016

The tumor suppressor CDKN3 controls mitosis.

J Cell Biol 2013 Jun 17;201(7):997-1012. Epub 2013 Jun 17.

Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://jcb.rupress.org/content/201/7/997.full.pdf
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http://www.jcb.org/cgi/doi/10.1083/jcb.201205125
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http://dx.doi.org/10.1083/jcb.201205125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691455PMC
June 2013

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model.

J Bone Miner Res 2013 Dec;28(12):2476-89

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1002/jbmr.1992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774615PMC
December 2013

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.

J Clin Invest 2013 Jan 10;123(1):329-34. Epub 2012 Dec 10.

Herman Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1172/JCI66167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533306PMC
January 2013

Nmp4/CIZ closes the parathyroid hormone anabolic window.

Crit Rev Eukaryot Gene Expr 2012 ;22(3):205-18

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586259PMC
http://dx.doi.org/10.1615/critreveukargeneexpr.v22.i3.40DOI Listing
April 2013

A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.

Exp Hematol 2013 Jan 11;41(1):56-66.e2. Epub 2012 Oct 11.

Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1016/j.exphem.2012.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764489PMC
January 2013

[Function of the present systematic evaluation in establishment of guidance for clinical practice].

Zhongguo Zhen Jiu 2012 Jul;32(7):649-52

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Acupuncture and Moxibustion Hospital, China Academy of Chinese Medical Sciences, Beijing 100700, China.

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July 2012

The plexiform neurofibroma microenvironment.

Cancer Microenviron 2012 Dec 24;5(3):307-10. Epub 2012 Jul 24.

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA,

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http://link.springer.com/10.1007/s12307-012-0115-x
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http://dx.doi.org/10.1007/s12307-012-0115-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460056PMC
December 2012

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster.

Nat Commun 2012 May 8;3:818. Epub 2012 May 8.

Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

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http://www.nature.com/articles/ncomms1826
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http://dx.doi.org/10.1038/ncomms1826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576573PMC
May 2012

Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression.

Annu Rev Pathol 2012 7;7:469-95. Epub 2011 Nov 7.

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1146/annurev-pathol-011811-132441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694738PMC
April 2013

Erk1 positively regulates osteoclast differentiation and bone resorptive activity.

PLoS One 2011 22;6(9):e24780. Epub 2011 Sep 22.

Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024780PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178550PMC
March 2012

The musculoskeletal phenotype of the RASopathies.

Am J Med Genet C Semin Med Genet 2011 May 14;157C(2):90-103. Epub 2011 Apr 14.

Division of Medical Genetics, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1002/ajmg.c.30296DOI Listing
May 2011

p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.

J Biol Chem 2011 Apr 15;286(15):13512-21. Epub 2011 Feb 15.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M110.187351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075697PMC
April 2011

Mast cells and the neurofibroma microenvironment.

Blood 2010 Jul 16;116(2):157-64. Epub 2010 Mar 16.

Department of Biochemistry, and Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-09-24
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http://dx.doi.org/10.1182/blood-2009-09-242875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910605PMC
July 2010

Mechanical stimulation suppresses phosphorylation of eIF2alpha and PERK-mediated responses to stress to the endoplasmic reticulum.

FEBS Lett 2010 Feb 22;584(4):745-52. Epub 2009 Dec 22.

Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.febslet.2009.12.028DOI Listing
February 2010

Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors.

Exp Hematol 2010 Feb 23;38(2):71-81. Epub 2009 Nov 23.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202-5122, USA.

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http://dx.doi.org/10.1016/j.exphem.2009.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815193PMC
February 2010

Ras dependent paracrine secretion of osteopontin by Nf1+/- osteoblasts promote osteoclast activation in a neurofibromatosis type I murine model.

Pediatr Res 2009 Jun;65(6):613-8

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1203/PDR.0b013e3181a1c607DOI Listing
June 2009

Novel method of murine embryonic stem cell-derived osteoclast development.

Stem Cells Dev 2009 Jan-Feb;18(1):195-200

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1089/scd.2008.0193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975428PMC
October 2010

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice.

Exp Hematol 2008 Sep 20;36(9):1084-90. Epub 2008 May 20.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0301472X0800130
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http://dx.doi.org/10.1016/j.exphem.2008.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877929PMC
September 2008

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.

Hum Mol Genet 2008 Apr 18;17(7):936-48. Epub 2007 Dec 18.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1093/hmg/ddm366DOI Listing
April 2008

Cul4A is required for hematopoietic stem-cell engraftment and self-renewal.

Blood 2007 Oct 6;110(7):2704-7. Epub 2007 Jul 6.

Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1182/blood-2006-12-064154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988932PMC
October 2007

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells.

J Immunol 2007 Feb;178(4):2527-34

Department Microbiology & Immunology, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.4049/jimmunol.178.4.2527DOI Listing
February 2007

Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.

Glia 2007 Apr;55(5):527-36

Department of Pediatrics, Herman B. Wells Center for Pediatric Cancer Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/glia.20482DOI Listing
April 2007

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.

J Clin Invest 2006 Nov 19;116(11):2880-91. Epub 2006 Oct 19.

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1172/JCI29092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616197PMC
November 2006

Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice.

Blood 2006 Dec 31;108(13):4283-7. Epub 2006 Aug 31.

Department of Microbiology and Immunology, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA.

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http://dx.doi.org/10.1182/blood-2006-03-007997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895443PMC
December 2006

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells.

Hum Mol Genet 2006 Oct 7;15(19):2837-45. Epub 2006 Aug 7.

Department of Pediatrics, Herman B. Wells Center for Pediatric Research and Indiana University School of Medicine, Cancer Research Institute, Indianapolis 46202, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddl208DOI Listing
October 2006

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.

Hum Mol Genet 2006 Aug 11;15(16):2421-37. Epub 2006 Jul 11.

Department of Pediatrics, and Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, Indianapolis, IN 46202, USA.

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http://academic.oup.com/hmg/article/15/16/2421/644093/Nf1-ma
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http://dx.doi.org/10.1093/hmg/ddl165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024714PMC
August 2006

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells.

Hum Mol Genet 2006 Jun 28;15(11):1858-69. Epub 2006 Apr 28.

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1093/hmg/ddl108DOI Listing
June 2006

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells.

Hum Mol Genet 2006 Jun 27;15(11):1921-30. Epub 2006 Apr 27.

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1093/hmg/ddl114DOI Listing
June 2006

Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.

Blood 2006 Feb 20;107(4):1375-82. Epub 2005 Oct 20.

Indiana University School of Medicine, Herman B. Wells Center for Pediatric Research, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1182/blood-2005-05-1985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895408PMC
February 2006

Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure.

Stem Cells 2005 Mar;23(3):335-46

Division of Experimental Hematology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45215, USA.

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http://dx.doi.org/10.1634/stemcells.2004-0216DOI Listing
March 2005