Publications by authors named "Feng Zhou"

1,313 Publications

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Scalable Production of Boron Quantum Dots for Broadband Ultrafast Nonlinear Optical Performance.

Nanomaterials (Basel) 2021 Mar 9;11(3). Epub 2021 Mar 9.

International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Institute of Microscale Optoelectronics (IMO), Shenzhen University, Shenzhen 518060, China.

A simple and effective approach based on the liquid phase exfoliation (LPE) method has been put forward for synthesizing boron quantum dots (BQDs). By adjusting the interactions between bulk boron and various solvents, the average diameter of produced BQDs is about 7 nm. The nonlinear absorption (NLA) responses of as-prepared BQDs have been systematically studied at 515 nm and 1030 nm. Experimental results prove that BQDs possess broadband saturable absorption (SA) and good third-order nonlinear optical susceptibility, which are comparable to graphene. The fast relaxation time and slow relaxation time of BQDs at 515 nm and 1030 nm are about 0.394-5.34 ps and 4.45-115 ps, respectively. The significant ultrafast nonlinear optical properties can be used in optical devices. Here, we successfully demonstrate all-optical diode application based on BQDs/ReS tandem structure. The findings are essential for understanding the nonlinear optical properties in BQDs and open a new pathway for their applications in optical devices.
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http://dx.doi.org/10.3390/nano11030687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001285PMC
March 2021

Combat COVID-19 infodemic using explainable natural language processing models.

Inf Process Manag 2021 Jul 6;58(4):102569. Epub 2021 Mar 6.

Industrial and Manufacturing Systems Engineering, University of Michigan-Dearborn, 4901 Evergreen Road, Dearborn, MI 48128, United States of America.

Misinformation of COVID-19 is prevalent on social media as the pandemic unfolds, and the associated risks are extremely high. Thus, it is critical to detect and combat such misinformation. Recently, deep learning models using natural language processing techniques, such as BERT (Bidirectional Encoder Representations from Transformers), have achieved great successes in detecting misinformation. In this paper, we proposed an explainable natural language processing model based on DistilBERT and SHAP (Shapley Additive exPlanations) to combat misinformation about COVID-19 due to their efficiency and effectiveness. First, we collected a dataset of 984 claims about COVID-19 with fact-checking. By augmenting the data using back-translation, we doubled the sample size of the dataset and the DistilBERT model was able to obtain good performance (accuracy: 0.972; areas under the curve: 0.993) in detecting misinformation about COVID-19. Our model was also tested on a larger dataset for AAAI2021 - COVID-19 Fake News Detection Shared Task and obtained good performance (accuracy: 0.938; areas under the curve: 0.985). The performance on both datasets was better than traditional machine learning models. Second, in order to boost public trust in model prediction, we employed SHAP to improve model explainability, which was further evaluated using a between-subjects experiment with three conditions, i.e., text (T), text+SHAP explanation (TSE), and text+SHAP explanation+source and evidence (TSESE). The participants were significantly more likely to trust and share information related to COVID-19 in the TSE and TSESE conditions than in the T condition. Our results provided good implications for detecting misinformation about COVID-19 and improving public trust.
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http://dx.doi.org/10.1016/j.ipm.2021.102569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980090PMC
July 2021

Cervical HSIL Involving the Endometrium and Adenomyosis: A Case Report and Literature Review.

J Coll Physicians Surg Pak 2021 Mar;31(3):337-339

Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Cervical squamous cell carcinoma (SCC) spreading superficially to the inner surface of the uterus and replacing the endometrial lining cells with carcinoma cells is called superficial spreading SCC. We, hereby report a 53-year postmenopausal woman who had a history of cervical SCC in situ/high grade squamous intraepithelial lesion (HSIL). Ultrasonography revealed an enlarged uterus measuring 9.0×6.5×5.0 cm with dilatation of the uterine cavity and the cervical canal. Subsequently, she underwent total abdominal hysterectomy (TAH) and bilateral salpingo-ophorectomy with a diagnosis of cervical HSIL involving the endometrium and adenomyosis. This a very rare phenomenon, as the endometrial involvement may be caused by direct extension of the cervical lesion, and occur mainly in postmenopausal women, and should be deligently searched during pathological examination. Key Words: HSIL, Cervix, Endometrium, Adenomyosis.
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http://dx.doi.org/10.29271/jcpsp.2021.03.337DOI Listing
March 2021

The Impacts of the Occupants on the Bacterial Communities of Classrooms.

Curr Microbiol 2021 Mar 25. Epub 2021 Mar 25.

College of Engineering, Peking University, Beijing, 100871, China.

In modern societies, people spend most of their time in the built environment which harbors unique microbial assemblages with the potential to influence human health. However, how the occupants of buildings influence indoor microbial communities remains under-researched. Here, we investigated the diversities of the bacterial communities of a typical Chinese middle school to demonstrate the effects of occupant activities on bacterial communities inside classrooms. The results showed that samples taken from classrooms exhibited higher microbial diversity compared to samples collected from public areas such as gym and restaurant, suggesting the occupant activities could increase the diversities of the indoor microbial communities. Moreover, we also found that the duration of occupation strongly influence the presence/absence of phylogenetic lineages of the bacterial communities, the type of occupants, on the other hand, affect the relative abundances of bacterial taxa. In addition, samples taken from classrooms with longer occupation time exhibited a better fit to the Sloan Neutral Community Model for Prokaryotes, suggesting that room occupation influences the assembly process of microbial communities. In conclusion, our study demonstrates that the duration of occupation and the type of occupants influence the microbiome of the built environment.
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http://dx.doi.org/10.1007/s00284-021-02451-7DOI Listing
March 2021

Catalytic Enantioselective Transfer Hydrogenation-Carboxylative Cyclization to 4-Fluoroalkyl 2-Oxazolidinone with CO as the C1 Synthon.

Org Lett 2021 Apr 24;23(7):2726-2730. Epub 2021 Mar 24.

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032, China.

We report a sequential catalytic asymmetric transfer hydrogenation-carboxylative cyclization for the facile construction of chiral 4-fluoroalkyl 2-oxazolidinones with high enantioselectivity. The resulting 2-oxazolidinones can be easily elaborated to synthetic useful chiral β-fluoroalkyl β-amino alcohols. This research also represents a rare example of catalytic asymmetric sequential reactions using CO as a C1 synthon as well as carboxylative cyclization of α-fluoroalkyl propargylamines.
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http://dx.doi.org/10.1021/acs.orglett.1c00632DOI Listing
April 2021

Manipulating Electrical Properties of Silica-Based Materials via Atomic Oxygen Irradiation.

ACS Appl Mater Interfaces 2021 Apr 24;13(13):15344-15352. Epub 2021 Mar 24.

Center of Advanced Lubrication and Seal Materials, Northwestern Polytechnical University, Xi'an 710072, P. R. China.

Regulated triboelectrification has attracted considerable research attention due to its potential applications in harvesting energy and importance in antistatic protection. Irradiation is an effective and stable modification method due to its adjustable and uniform irradiation parameters. Moreover, atomic oxygen (AO) irradiation is an important component in the low earth orbit, which is a considerable factor for promoting triboelectric nanogenerators (TENGs) in the outer space. AO irradiation was utilized to manipulate the surface structure and chemical composition to regulate electrical properties. AO irradiation can increase electron-donating groups and enhance electrical positivity of polydimethylsiloxane (PDMS) films due to the transition from Si-C bonds to Si-O bonds. Therefore, different trends of polytetrafluoroethylene (PTFE) and polystyrene (PS) were caused by their TENG composition with irradiated PDMS. Tribocharge cross-over polarity and charge generation were prevented completely in PS- and PDMS-based TENGs by adjusting the irradiation time to 4.1 h. Short-circuit current enhanced from 5 to 22 μA and the output voltage increased from 160 to 760 V when PDMS films in PTFE- and PDMS-based TENGs were subjected to AO irradiation for 6 h. This study demonstrated that AO irradiation can manipulate triboelectric properties of silica-based materials, which are potential components for harvesting energy and preventing electrostatic hazard in the outer space.
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http://dx.doi.org/10.1021/acsami.1c02259DOI Listing
April 2021

Ethyl acetate subfractions from ethanol extracts of fermented oats ( L.) exert anti-cancer properties and through G2/M and S Phase arrest and apoptosis.

J Cancer 2021 30;12(7):1853-1866. Epub 2021 Jan 30.

Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Cancer is a major public problem and poses a long-term impact on patients' life, work, and study. Oats are widely recognized as healthy food and fermented oats were rich in the higher contents of polyphenols. However, the role of fermented oats in cancer remains elusive. The effect of ethyl acetate subfractions (EASs) from ethanol extracts of oats fermented by 3.2751 on cancer cells was verified by series experiments and . The cell viability, colony formation, cell cycle, apoptosis, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and western blot were determined . The toxicity of EASs and xenograft mouse model were performed . MTT assay indicated that EASs interference suppressed the proliferation of four human cancer cells in a dose-dependent manner without a significant impact on two normal cells. EASs (0.2, 0.4, and 0.8 μg/mL) resulted in the G2/M and S phase arrest, apoptosis, depolarization of MMP, and ROS generation in HepG2 cells by flow cytometry. p53, JNK, caspase-9, and caspase-3 were activated and the expression of Bax was promoted, while the expression of Bcl-2 was reduced in HepG2 cells exposed to EASs via western blot. Furthermore, the study using a xenograft mouse model demonstrated that EASs attenuated the tumor growth with low systemic toxicity. EASs exhibited anti-cancer activities and via cell cycle arrest and apoptosis. This finding suggests that polyphenol-enriched composition from fermented oats might become a promising candidate for impeding the development and progression of liver cancer.
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http://dx.doi.org/10.7150/jca.48993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974531PMC
January 2021

Variations of root-associated bacterial cooccurrence relationships in paddy soils under chlorantraniliprole (CAP) stress.

Sci Total Environ 2021 Mar 5;779:146247. Epub 2021 Mar 5.

MOE Laboratory for Earth Surface Processes, College of Urban & Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:

Root-associated microbiomes are beneficial for plant development and health. However, the assembly of root-associated bacterial communities and their feedback under chlorantraniliprole (CAP) stress are unclear. This study investigated the response of root-associated bacterial microbiota to CAP dosage during the two developmental phases of rice. The results showed that CAP application had little effect on the bacterial diversity of bulk and rhizosphere soils, whereas that of the endosphere samples demonstrated a large variability. Moreover, the CAP stress exhibited less influence than the plant compartment and developmental stage contributing to microbiome variation. The core bacterial co-occurrence relationships also changed with the CAP application, especially, in the endosphere of the roots. These results further elucidate the impacts of CAP application on root-associated bacterial communities in intensive agricultural ecosystems and provide new insights for CAP ecological risk assessments.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146247DOI Listing
March 2021

[Heavy Metal Ion Adsorption Properties and Stability of Amine-sulfur Modified Biochar in Aqueous Solution].

Huan Jing Ke Xue 2021 Feb;42(2):874-882

College of Environment, Hohai University, Nanjing 210098, China.

A novel biochar was prepared by modification with corn straw, ethylene triamine, and carbon disulfide, and its adsorption properties and stability with respect to heavy metal ions in single and mixed systems (Pb, Ni, and Cd) were investigated. Characterization analysis confirmed the successful modification of an amine-sulfur double group on the surface of the biochar, which had abundant functional groups with a large specific surface area. Adsorption experiments under the single system indicated that the adsorption equilibrium time was 4 h and the optimum dosages were 1, 0.8, and 1.2 g·L. The adsorption met the conditions of the quasi-second-order kinetic equation. Under the ternary system, the adsorption equilibrium time was reduced to 1.5 h, the optimum dosages were 0.4, 1.6, and 0.8 g·L, and the adsorption sequence was Pb > Cd > Ni. The total amount of adsorption was 0.67 mmol·g, which was higher than that of single heavy metal ions, indicating that amine-sulfur modified straw biochar (BC-SN) has an improved treatment effect on polluted water under the coexistence of three heavy metal ions. The Pb and Cd adsorbed by the biochar was stably bound in the form of heavy metal sulfide and a chelated amino group. In contrast, the adsorption of Ni was via the mixed adsorption of various functional groups. When Pb and Cd compete for adsorption, the binding energy is higher and adsorption stability is more reliable.
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http://dx.doi.org/10.13227/j.hjkx.202006182DOI Listing
February 2021

A risk score based on baseline risk factors for predicting mortality in COVID-19 patients.

Curr Med Res Opin 2021 Mar 17. Epub 2021 Mar 17.

Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China.

Background: To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources.

Methods: 6,415 patients from seven hospitals in Wuhan city were assigned to the training and testing cohorts. A total of 6,351 patients from another three hospitals in Wuhan, 2,169 patients from outside of Wuhan, and 553 patients from Milan, Italy were assigned to three independent validation cohorts. A total of 64 candidate clinical variables at hospital admission were analyzed by random forest and least absolute shrinkage and selection operator (LASSO) analyses.

Results: Eight factors, namely, xygen saturation, blood rea nitrogen, espiratory rate, admission before the date the national aximum number of daily new cases was reached, ge, rocalcitonin, -reactive protein (CRP), and absolute eutrophil counts, were identified as having significant associations with mortality in COVID-19 patients. A composite score based on these eight risk factors, termed the OURMAPCN-score, predicted the risk of mortality among the COVID-19 patients, with a C-statistic of 0.92 (95% confidence interval [CI] 0.90-0.93). The hazard ratio for all-cause mortality between patients with OURMAPCN-score >11 compared with those with scores ≤11 was 18.18 (95% CI 13.93-23.71; P < 0.0001). The predictive performance, specificity, and sensitivity of the score were validated in three independent cohorts.

Conclusions: The OURMAPCN score is a risk assessment tool to determine the mortality rate in COVID-19 patients based on a limited number of baseline parameters. This tool can assist physicians in optimizing the clinical management of COVID-19 patients with limited hospital resources.
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http://dx.doi.org/10.1080/03007995.2021.1904862DOI Listing
March 2021

A randomized trial in the investigation of anxiety and depression in patients with coronavirus disease 2019 (COVID-19).

Ann Palliat Med 2021 Feb;10(2):2167-2174

Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: In March 2020, the World Health Organization (WHO) declared COVID-19 a public health emergency of international concern. A small proportion of patients infected with COVID-19 go on to develop pneumonia. We speculated that COVID-19 may be likely to result in psychological disorders such as anxiety and depression. In this study, we conducted an investigation of anxiety and depression in patients with COVID-19.

Methods: Sixty-five COVID-19 patients were randomly enrolled into this study. Anxiety and depression among participants were measured through the completion of anonymous Chinese-language Zung self-rating anxiety scale and self-rating depression scale questionnaires. Data were analyzed using independent samples t-tests, Mann-Whitney U-tests, and χ2 tests.

Results: The questionnaire results showed that 26.15% and 41.54% of participants suffered from anxiety and depression, respectively, although there was no significantly statistical difference between the proportions of COVID-19 patients with anxiety and depression. Statistically significant differences in employment status, partial pressure of oxygen, and corticosteroid application existed between moderate- and severe COVID-19 patients (P<0.05). In particular, the partial pressure of oxygen was significantly lower in severe COVID-19 patients than in their moderate counter parts (71.31±23.54 vs. 101.06±34.43, U=156, P=0.006). Total lymphocytes was lower in severe group than in moderate group [1.659±0.643 vs. 0.745 (0.645, 0.928), U=109, P=0.000]. Also, a higher proportion of female than male patients had anxiety (χ2=5.388, P=0.02). COVID-19 patients who received antiviral medications also displayed a higher rate of anxiety (χ2=4.481, P=0.034). Total lymphocytes between the non-anxiety and anxiety had statistical difference (U=321, P=0.019). Meanwhile, total lymphocytes between the non-depression and depression also had statistical difference (U=389.5, P=0.01).

Conclusions: Among patients with COVID-19, females and those treated with antiviral medications were more likely to experience anxiety. In addition, our findings reflected the effect of anxiety and depression on immune system.
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http://dx.doi.org/10.21037/apm-21-212DOI Listing
February 2021

Substrate Topography Regulates Differentiation of Annulus Fibrosus-Derived Stem Cells via CAV1-YAP-Mediated Mechanotransduction.

ACS Biomater Sci Eng 2021 03 30;7(3):862-871. Epub 2020 Mar 30.

Department of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Medical College, Soochow University, Suzhou, Jiangsu 215007, China.

Regeneration of annulus fibrosus (AF) through tissue engineering techniques shows promise as a treatment for patients with degenerative disc disease (DDD). Yet, it remains challenging because of the intrinsic heterogeneity of AF tissue and shortage of in-depth knowledge of its structure-function correlation. In the current study, we fabricated fibrous poly(ether carbonate urethane)urea (PECUU) scaffolds with various fiber sizes to mimic the microstructural feature of native AF and aimed to regulate the differentiation of AF-derived stem cells (AFSCs) by controlling the topographical cues of the scaffold. We found that the morphology of AFSCs varied significantly on scaffolds with various fiber sizes. Meanwhile, the expression of the phenotypic marker genes of outer AF was up-regulated on scaffolds with large fibers. Meanwhile, enhanced expression of the phenotypic marker genes of inner AF was seen on scaffolds with small fibers. Such topography-dependent gene expression in AFSCs approximated the biochemical profile of AF tissue in various zones. Moreover, cell spreading and nucleus translocation of Yes-associated protein (YAP) were facilitated with increased fiber size. Formation and maturation of focal adhesions of AFSCs were also promoted. We also found that Caveolin-1 (CAV1) positively modulated the mechano-responses of YAP in response to substrate topography. In conclusion, depending on the activation of the CAV1-YAP mechanotransduction axis, tuning the fiber size of scaffolds can effectively induce changes in cell shape, adhesions, and extracellular matrix expression. This work may therefore provide new insights in the design of novel materials toward AF tissue regeneration.
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http://dx.doi.org/10.1021/acsbiomaterials.9b01823DOI Listing
March 2021

Significance of expression of AIM2, IL1β, and IL18 in plasma of patients with acute cerebral infarction.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Feb;46(2):149-155

Department of Neurology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208.

Objectives: Inflammation especially the overexpression of inflammasome and inflammatory cytokines, is one of the important reasons that affect the occurrence and development of acute cerebral infarction, including the initiation of cerebral infarction, the progress and recovery of post-infarction injury. This study aims to explore expressions of absent in melanoma 2 (AIM2), interleukin-1β (IL-1β), and interleukin-18 (IL-18) in plasma of patients with acute cerebral infarction and its significance.

Methods: A total of 85 patients with acute cerebral infarction were enrolled in the cerebral infarction group. They were assigned into mild, moderate, and severe groups according to the severity of neurological deficits. They were assigned into small, middle, and large cerebral infarction groups according to the area of cerebral infarction. They were assigned into a good prognosis group and a poor prognosis group according to the Modified Rankin Scale (mRS) score on the 90th day after the onset. A total of 85 healthy controls were selected as a control group. The levels of AIM2, IL-1β, and IL-18 in plasma of the cerebral group and the control group were detected by enzyme-linked immunosorbent assay (ELISA).

Results: The levels of plasma AIM2, IL-1β, and IL-18 in the cerebral infarction group were significantly higher than those in the control group (all <0.001). In the cerebral infarction group, the expression levels of plasma AIM2, IL-1β, and IL-18 were as follows: The severe neurological deficitc group>the moderate group>the mild group, the large area of cerebral infarction group>the middle area group>the small area group, and the poor prognosis group> the good prognosis group (all <0.05). The levels of plasma AIM2 were positively correlated with National Institute of Health Stroke Scale (NIHSS) score, the cerebral infarction area, and the mRS score (=0.791, =0.710, =0.763, respectively, all <0.001). The levels of plasma IL-1β were positively correlated with the NIHSS score, the cerebral infarction area, and the mRS score (=0.716, =0.690, =0.688, respectively, all <0.001). The levels of plasma IL-18 were positively correlated with the NIHSS score, the cerebral infarction area, and the mRS score (=0.714, =0.638, =0.653, respectively, all <0.001). The level of plasma AIM2 was positively correlated with that of IL-1β and IL-18 (=0.828, =0.751, both <0.001).

Conclusions: Expressions of AIM2, IL-1β, and IL-18 are up-regulated in the plasma of patients with acute cerebral infarction, and they are closely related to the severity of neurological deficit, cerebral infarction area, and prognosis in patients with acute cerebral infarction, suggesting that AIM2, IL-1β, and IL-18 may play an important role in the occurrence and development of acute cerebral infarction.
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http://dx.doi.org/10.11817/j.issn.1672-7347.2021.190662DOI Listing
February 2021

Impact of a Telephone Intervention on Bowel Preparation Quality for Colonoscopy in the Elderly.

Gastroenterol Nurs 2021 Mar-Apr 01;44(2):92-97

Chun-Jiu Hu, MD, Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.

Bowel preparation is the basis of colonoscopy, and adequate bowel preparation is essential to the success of colonoscopy. Studies have been reported that telephone intervention can improve the quality of bowel preparation, while it remains unclear regarding effectiveness with the elderly. The purpose of this study was to evaluate the effect of telephone intervention on the quality of bowel preparation for colonoscopy in elderly outpatients. In total, 162 outpatients older than 65 years were enrolled and randomly divided into a control group and a study group. Patients in the study group were re-educated through telephone by a specific nurse 2 days before colonoscopy, whereas participants in the control group received education only on the day of appointment. The Ottawa score was used to evaluate the quality of bowel preparation between the two groups. In this study, no significant differences were observed in age, gender, body mass index, educational level, smoking and/or alcohol drinking, waiting time to colonoscopy, reasons for colonoscopy, and colonoscopic findings between the control group and the study group. Participants in the study group had higher adequate bowel preparation and compliance than the control group (83.1% vs. 59.5%, p = .03; 96.4% vs. 74.7%, p < .001). Univariate analysis showed that only noncompliance with start time was significantly associated with satisfactory bowel preparation in elderly patients. In conclusion, telephone intervention 2 days before colonoscopy can improve the quality of bowel preparation in the elderly.
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http://dx.doi.org/10.1097/SGA.0000000000000573DOI Listing
March 2020

Di-(2-ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice.

Environ Toxicol 2021 Mar 4. Epub 2021 Mar 4.

Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, China.

Di-(2-ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it is widely applied in various plastic products. DEHP is an endocrine-disrupting chemical (EDC) that has been shown to disrupt the function of reproductive system in females. Although many studies have shown that DEHP potentially causes female reproductive toxicity, including depletion of the primordial follicle and decreased sex hormone production, the specific mechanisms by which DEHP affects female reproduction remain unknown. In recent years, research focused on the intestinal flora has provided an idea to eliminate our confusion, and gut bacterial dysbiosis may contribute to female reproductive toxicity. In the present study, the feces of DEHP-exposed mice were collected and analyzed using 16S rRNA amplicon sequencing and untargeted global metabolite profiling of metabolomics. DEHP obviously causes reproductive toxicity, including the ovarian organ coefficient, estradiol level, histological features of the ovary and estrus. Furthermore, DEHP exposure alters the structure of the intestinal microbiota community and fecal metabolite profile in mice, suggesting that the reproductive toxicity may be caused by gut bacterial dysbiosis and altered metabolites, such as changes in the levels of short-chain fatty acid (SCFA). Additionally, it is well known that changes in gut microbiota and fecal metabolites cause inflammation and tissue oxidative stress, expectedly, we found oxidative stress in the ovary and systemic inflammation in DEHP exposed mice. Thus, based on our findings, DEHP exposure may cause gut bacterial dysbiosis and altered metabolite profiles, particularly SCFA profiles, leading to oxidative stress in the ovary and systemic inflammation to ultimately induce female reproductive toxicity.
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http://dx.doi.org/10.1002/tox.23121DOI Listing
March 2021

Robust Hybrid Omniphobic Surface for Stain Resistance.

ACS Appl Mater Interfaces 2021 Mar 4;13(12):14562-14568. Epub 2021 Mar 4.

State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, PR China.

Inspired by natural living surfaces, researchers have developed many excellent anti-smudge coatings, but there remain some critical challenges such as complex or expensive fabrications, poor long-term stability, non-transparency, etc., which may limit their large-area application. In this work, we designed a robust and transparent omniphobic coating with a one-step dip coating method. The perfluoropolyether chains were grafted on a smooth glass surface, and the coating surface not only presented good liquid repellency and stain resistance but also owned excellent mechanical wear resistance. The stain resistance property and wettability have barely changed after hundreds of thousands of friction cycles in air or even in an organic solvent surrounding. The robust hybrid coating possesses simple preparation, an excellent property, and durability, which may bring a widespread interest in the engineering application field.
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http://dx.doi.org/10.1021/acsami.0c22834DOI Listing
March 2021

Confusion about the definition of imported cases in the early stage of the epidemic.

Int J Infect Dis 2021 Feb 27;105:413. Epub 2021 Feb 27.

Department of Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2021.02.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910701PMC
February 2021

[Study on time-toxicity relationship and mechanism of Gardeniae Fructus extract on hepatoxicity in rats based on proteomics].

Zhongguo Zhong Yao Za Zhi 2021 Jan;46(1):162-170

Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology Nanchang 330004, China.

To study the time-toxicity relationship and mechanism of Gardeniae Fructus extract on the hepatoxicity in rats. Rats were randomly divided into C group(0 day), D5 group(5 days), D12 group(12 days), D19 group(19 days), and D26 group(7 days recovery after 19 days of administration). The rats in normal group received normal saline through intragastric administration, and the rats in other groups received 10 g·kg~(-1 )Gardeniae Fructus extract through intragastric administration. After the final administration, the livers were collected. Hematoxylin-eosin staining was used to observe the histopathological changes in the liver tissue. Total liver proteins were extracted for proteomic analysis, detected by the Nano-ESI liquid-mass spectrometry system and identified by Protein Disco-very software. SIEVE software was used for relative quantitative and qualitative analysis of proteins. The protein-protein interaction network was constructed based on STRING. Cytoscape software was used for cluster analysis of differential proteins. Kyoto encyclopedia of genes and genomes(KEGG) database was used to perform enrichment signal pathway analysis. Pearson correlation analysis was performed for the screened differential protein expression and liver pathology degree score. The results showed that the severity of liver injury in D5, D12 and D19 groups was significantly higher than that in group C. The degree of liver damage in D5 group was slightly higher than that in D12 and D19 groups, with no significant difference between group D26 and group C. Totally 147 key differential proteins have been screened out by proteomics and mainly formed 6 clusters, involving in drug metabolism pathways, retinol metabolism pathways, proteasomes, amino acid biosynthesis pathways, and glycolysis/gluconeogenesis pathways. The results of Pearson correlation analysis indicated that differential protein expressions had a certain temporal relationship with the change of liver pathological degree. The above results indicated that the severity of liver damage caused by Gardeniae Fructus extract did not increase with time and would recover after drug with drawal. The above pathways may be related to the mechanism of liver injury induced by Gardeniae Fructus extract.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200901.402DOI Listing
January 2021

Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization.

Mol Pain 2021 Jan-Dec;17:1744806921996520

Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.

Microglia activation and subsequent pro-inflammatory responses play a key role in the development of neuropathic pain. The process of microglia polarization towards pro-inflammatory phenotype often occurs during neuroinflammation. Recent studies have demonstrated an active role for the gut microbiota in promoting microglial full maturation and inflammatory capabilities via the production of Short-Chain Fatty Acids (SCFAs). However, it remains unclear whether SCFAs is involved in pro-inflammatory/anti-inflammatory phenotypes microglia polarization in the neuropathic pain. In the present study, chronic constriction injury (CCI) was used to induce neuropathic pain in mice, the mechanical withdrawal threshold, thermal hyperalgesia were accomplished. The levels of microglia markers including ionized calcium-binding adaptor molecule 1 (Iba1), cluster of differentiation 11b (CD11b), pro-inflammatory phenotype markers including CD68, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and anti-inflammatory phenotype markers including CD206, IL-4 in the hippocampus and spinal cord were determined on day 21 after CCI. The results showed that CCI produced mechanical allodynia and thermal hyperalgesia, and also increased the expressions of microglia markers (Iba1, CD11b) and pro-inflammatory phenotype markers (CD68, IL-1β, and TNF-α), but not anti-inflammatory phenotype marker (CD206, IL-4) in the hippocampus and spinal cord, accompanied by increased SCFAs in the gut. Notably, antibiotic administration reversed these abnormalities, and its effects was also bloked by SCFAs administration. In conclusion, data from our study suggest that CCI can lead to mechanical and thermal hyperalgesia, while SCFAs play a key role in the pathogenesis of neuropathic pain by regulating microglial activation and subsequent pro-inflammatory phenotype polarization. Antibiotic administration may be a new treatment for neuropathic pain by reducing the production of SCFAs and further inhibiting the process of microglia polarization.
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http://dx.doi.org/10.1177/1744806921996520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925956PMC
February 2021

Global irrigation contribution to wheat and maize yield.

Nat Commun 2021 02 23;12(1):1235. Epub 2021 Feb 23.

Sino-French Institute of Earth System Sciences, Peking University, 100871, Beijing, China.

Irrigation is the largest sector of human water use and an important option for increasing crop production and reducing drought impacts. However, the potential for irrigation to contribute to global crop yields remains uncertain. Here, we quantify this contribution for wheat and maize at global scale by developing a Bayesian framework integrating empirical estimates and gridded global crop models on new maps of the relative difference between attainable rainfed and irrigated yield (ΔY). At global scale, ΔY is 34 ± 9% for wheat and 22 ± 13% for maize, with large spatial differences driven more by patterns of precipitation than that of evaporative demand. Comparing irrigation demands with renewable water supply, we find 30-47% of contemporary rainfed agriculture of wheat and maize cannot achieve yield gap closure utilizing current river discharge, unless more water diversion projects are set in place, putting into question the potential of irrigation to mitigate climate change impacts.
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http://dx.doi.org/10.1038/s41467-021-21498-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902844PMC
February 2021

Prevalence and determinants of potentially inappropriate medications prescribing in elderly patients in Chinese communities.

Ann Palliat Med 2021 Feb 11;10(2):2072-2079. Epub 2021 Feb 11.

The First Affiliated Hospital of Soochow University, Department of Pharmacy, Suzhou, China; China Pharmaceutical University, Nanjing, China.

Background: To assess the prevalence and associated risk of potentially inappropriate medications (PIMs) prescribing in community-dwelling elderly patients in China and to examine the most frequently used PIMs. This will provide a reference for the formulation of medication manuals for the community-dwelling elderly and further standardize the use of medications in elderly patients.

Methods: We conducted a cross-sectional retrospective study from April 1, 2020 to April 30, 2020. Data from elderly patients aged ≥65 years were collected from the Hengjie (N=2,294), Loujiang (N=3,972), and Tongxing communities (N=1,969) in Suzhou. The frequency of PIMs was detected using the 2019 Beers criteria and the 2017 Chinese criteria. Chi-square (for categorical variables), ANOVA (for continuous variables as applicable), and logistic regression were used to describe and identify potential predictors of PIMs.

Results: A total of 8,235 elderly patients were examined. Using the Chinese criteria, the prevalence of PIMs was 37.07%, which was slightly higher than that found using the 2019 Beers criteria (32.16%). The most prescribed PIMs were estazolam (21.53%) and insulin (4.60%) based on the Chinese criteria. Logistic regression analysis showed that advanced age, polypharmacy, and comorbid disease of patients were associated with a high risk of PIMs. Furthermore, the educational background and professional title of physicians were also associated with PIMs.

Conclusions: Given the high prevalence of PIMs in the Chinese community-dwelling elderly population, the implementation of evidence-based interventions to promote rational clinical drug use could improve their quality of life.
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http://dx.doi.org/10.21037/apm-21-32DOI Listing
February 2021

The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke.

J Neuroinflammation 2021 Feb 20;18(1):51. Epub 2021 Feb 20.

Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.

Background And Purpose: To investigate the association of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) with post-thrombolysis early neurological outcomes including early neurological improvement (ENI) and early neurological deterioration (END) in patients with acute ischemic stroke (AIS).

Methods: AIS patients undergoing intravenous thrombolysis were enrolled from April 2016 to September 2019. Blood cell counts were sampled before thrombolysis. Post-thrombolysis END was defined as the National Institutes of Health Stroke Scale (NIHSS) score increase of ≥ 4 within 24 h after thrombolysis. Post-thrombolysis ENI was defined as NIHSS score decrease of ≥ 4 or complete recovery within 24 h. Multinomial logistic regression analysis was performed to explore the relationship of NLR, PLR, and LMR to post-thrombolysis END and ENI. We also used receiver operating characteristic curve analysis to assess the discriminative ability of three ratios in predicting END and ENI.

Results: Among 1060 recruited patients, a total of 193 (18.2%) were diagnosed with END and 398 (37.5%) were diagnosed with ENI. Multinomial logistic model indicated that NLR (odds ratio [OR], 1.385; 95% confidence interval [CI] 1.238-1.551, P = 0.001), PLR (OR, 1.013; 95% CI 1.009-1.016, P = 0.001), and LMR (OR, 0.680; 95% CI 0.560-0.825, P = 0.001) were independent factors for post-thrombolysis END. Moreover, NLR (OR, 0.713; 95% CI 0.643-0.791, P = 0.001) served as an independent factor for post-thrombolysis ENI. Area under curve (AUC) of NLR, PLR, and LMR to discriminate END were 0.763, 0.703, and 0.551, respectively. AUC of NLR, PLR, and LMR to discriminate ENI were 0.695, 0.530, and 0.547, respectively.

Conclusions: NLR, PLR, and LMR were associated with post-thrombolysis END. NLR and PLR may predict post-thrombolysis END. NLR was related to post-thrombolysis ENI.
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http://dx.doi.org/10.1186/s12974-021-02090-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896410PMC
February 2021

Subchondral Trabecular Microstructure and Articular Cartilage Damage Variations Between Osteoarthritis and Osteoporotic Osteoarthritis: A Cross-sectional Cohort Study.

Front Med (Lausanne) 2021 2;8:617200. Epub 2021 Feb 2.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Osteoporotic osteoarthritis (OP-OA) is a specific type of OA. In this study, we aimed to assess the subchondral plate and rod microstructural differences between OA and OP-OA patients by using an individual trabeculae segmentation (ITS) system and to analyze the relationships between subchondral microstructures and cartilage damage in OA and OP-OA patients. Overall, 31 femoral heads were included in this study, which included 11 samples with OA and 13 samples with OP-OA; the normal control (NC) group contained 7 healthy femoral heads. ITS was performed to segment the subchondral trabecular bone into plate and rod trabeculae based on microcomputed tomography (micro-CT) images. We compared the plate and rod trabeculae of the subchondral trabecular bone between OA and OP-OA patients. The Osteoarthritis Research Society International (OARSI) score was employed to evaluate cartilage damage based on histological observations. Pearson's correlation coefficient and linear regression analysis were applied to analyze the relationships between subchondral microstructures and articular cartilage damage. Results showed that several microstructural parameters, including bone volume fraction (BV/TV), plate bone volume fraction (pBV/TV), rod bone volume fraction (rBV/TV), plate trabecular number (pTb.N), rod trabecular number (rTb.N), junction density between rod and plate (R-P Junc.D), and junction density between plate and plate (P-P Junc.D), were significantly decreased in patients with OP-OA compared with those in patients with OA ( < 0.05). Histological observations indicated that cartilage damage was more serious in patients with OP-OA than that in patients with OA ( < 0.05). Moreover, BV/TV, pBV/TV, pTb.N, and pTb.Th were significantly related to the OARSI score in both OA and OP-OA patients. These results indicated that there were differences in the subchondral rod and plate trabeculae between OA and OP-OA patients. Subchondral decreased plate trabeculae (pBV/TV, pTb.N, and pTb.Th) might account for cartilage damage in the progression of OP-OA. This study provided new insights to research OA when it is combined with OP.
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http://dx.doi.org/10.3389/fmed.2021.617200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884461PMC
February 2021

Mental health status among Chinese healthcare-associated infection control professionals during the outbreak of coronavirus disease 2019: A national cross-sectional survey.

Medicine (Baltimore) 2021 Feb;100(5):e24503

Infection Control Center, Xiangya Hospital, Central South University.

Abstract: Recently, the coronavirus disease 2019 (COVID-19) epidemic has greatly threatened global public health. The responsibility of healthcare-associated infection control professionals (ICPs) is to prevent and control the nosocomial infections. The mental health status of ICPs deserves more attention, however, the correlational research is still lacking. This study aims to investigate the incidence and risk factors of mental health status among ICPs in China during the outbreak of COVID-19.A national cross-sectional survey was performed. The online questionnaire was completed by 9228 ICPs from 3776 hospitals throughout China. Data collection tools were used, including demographics data questionnaire, the Chinese version of the 12-item general health questionnaire (GHQ-12) and the Chinese version of the psychological capital questionnaire (PCQ) for medical staff. Univariate and multivariable analyses were conducted.The total score of mental health of Chinese ICPs was 3.45 ± 2.57. 5608 (60.77%) ICPs might have mental health problems. The psychological capital was in the upper-middle level with an average score of 3.72 ± 0.38. An increased mental health problem risk was associated with the greater self-efficacy and working in the public hospital; a significantly lower risk was obtained by working in the second-class hospital rather than in the third-class hospitals. Besides, mental health problem risk of ICPs working in hospitals of the western economic region or northeast economic region was more significant than that in hospitals of the central economic region. However, a lower risk was caused by the unmarried than married, and working years in department ≤1 year contributed to the lower risk than that >20 years. Moreover, fewer working hours per week, higher values of hope, and optimism each were contributed to a lower risk.Chinese healthcare-associated ICPs were under different levels of mental health problems in fighting against COVID-19. More importantly, we should actively deal with the mental health problem of ICPs and help them get rid of psychological disorders.
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http://dx.doi.org/10.1097/MD.0000000000024503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870200PMC
February 2021

Acute hepatotoxicity and nephrotoxicity risk assessment of the Tibetan medicine 25 flavors of the turquoise pill based on H-NMR metabonomics.

J Ethnopharmacol 2021 Feb 8:113916. Epub 2021 Feb 8.

Beijing Hospital of Tibetan Medicine, China Tibetology Research Center, Beijing 100029, China. Electronic address:

Ethnopharmacological Relevance: 25 flavors of the turquoise pill, a traditional Tibetan medicine for the treatment of various types of hepatitis, has not been investigated on its safety, especially the component mineral turquoise, which is believed to be essential but worried for its potential toxicity.

Aim Of The Study: To explore the potential acute toxicity and function of 25 flavors of the turquoise pill and turquoise, the possible mechanism of the effects of turquoise and 25 flavors of the turquoise pill were systematically studied based on H NMR metabolomics.

Materials And Methods: The rats were administered with turquoise and 25 flavors of the turquoise pill by gavage for 7 days, and samples of serum, liver, and kidney were collected. The potential toxicity and function of turquoise and 25 flavors of the turquoise pill on the liver and kidney of SD rats were evaluated by H NMR metabonomics, histopathology, and biochemical indexes.

Results: The results demonstrated that 25 flavors of the turquoise pill could scavenge free oxygen radicals, strengthen aerobic respiration and inhibit glycolysis in the liver. It did not cause oxidative stress in the kidney with no obvious damage. By modulation of branched-chain amino acids (BCAAs), 25 flavors of the turquoise pill can improve the utilization of glucose and promote aerobic respiration of the kidney.

Conclusion: Considering the high dosage and short duration used in this study relative to their typical clinical usage, administration of 25 flavors of the turquoise pill and its component mineral turquoise are safe to livers and kidneys.
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http://dx.doi.org/10.1016/j.jep.2021.113916DOI Listing
February 2021

In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing.

Transl Psychiatry 2021 Feb 4;11(1):94. Epub 2021 Feb 4.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611054, China.

Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed as a potential therapeutic intervention in psychiatric disorders. However, following intranasal administration, oxytocin could penetrate directly into the brain or influence its activity via increased peripheral concentrations crossing the blood-brain barrier or influencing vagal projections. In the current randomized, placebo-controlled, pharmaco-imaging clinical trial we investigated effects of 24IU oral (lingual) oxytocin spray, restricting it to peripherally mediated blood-borne and vagal effects, on responses to face emotions in 80 male subjects and compared them with 138 subjects treated intranasally with 24IU. Oral, but not intranasal oxytocin administration increased both arousal ratings for faces and associated brain reward responses, the latter being partially mediated by blood concentration changes. Furthermore, while oral oxytocin increased amygdala and arousal responses to face emotions, after intranasal administration they were decreased. Thus, oxytocin can produce markedly contrasting motivational effects in relation to socioemotional cues when it influences brain function via different routes. These findings have important implications for future therapeutic use since administering oxytocin orally may be both easier and have potentially stronger beneficial effects by enhancing responses to emotional cues and increasing their associated reward.
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http://dx.doi.org/10.1038/s41398-021-01241-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862637PMC
February 2021

Genetic variants in gene and clinical outcomes of resectable non-small-cell lung cancer.

Future Oncol 2021 Mar 5;17(7):795-805. Epub 2021 Feb 5.

Department of Physiology & Pathophysiology, The Fourth Military Medical University, Xi'an, 710032, China.

A series of studies have demonstrated that plays a critical role in the development and progression of several cancers. However, the association between genetic variants in the  gene and the clinical outcome of patients with non-small-cell lung cancer (NSCLC) has not been investigated. Six functional SNPs in  were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 484 Chinese NSCLC patients undergoing surgery. Multivariate Cox proportional hazards model were used for the prognosis analysis. We found that SNP rs2305158 exhibited a significant association with overall survival of NSCLC patients in the dominant model (hazard ratio [HR]: 0.68; 95% CI: 0.49-0.95; p = 0.02). Lymph node metastasis was significantly associated with increased death risk (HR: 1.73; 95% CI: 1.24-2.40; p = 0.001) in patients with the homozygous wildtype (WW) genotype of rs2305158. However, no significant association was observed between them in patients carrying a heterozygous variant (WV) or homozygous variant (VV) genotype of rs2305158. Finally, in the joint and interaction analysis, the patients carrying homozygous wildtype (WW) genotype and lymph node metastasis from N1 to N3 conferred a significant increased effect on death (HR: 2.29; 95% CI: 1.40-3.76; p = 0.001). Our results suggest that  polymorphisms may serve as an independent prognostic marker for NSCLC patients.
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http://dx.doi.org/10.2217/fon-2020-0211DOI Listing
March 2021

Hypersensitive C-reactive protein-albumin ratio predicts symptomatic intracranial hemorrhage after endovascular therapy in acute ischemic stroke patients.

BMC Neurol 2021 Feb 1;21(1):47. Epub 2021 Feb 1.

Department of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, P.R. China.

Background: Approximately 10% of patients would develop symptomatic intracranial hemorrhage (sICH) after endovascular therapy. The aim of our study was to explore the ability of hypersensitive C-reactive protein-albumin ratio (HAR) in predicting sICH after endovascular therapy.

Methods: From April 2016 to December 2018, 334 consecutive patients with anterior circulation infarction undergoing endovascular therapy were enrolled in our study. sICH was defined using Heidelberg bleeding classification after endovascular therapy. Multiple regression analysis was used to investigate the potential risk factors of sICH after endovascular therapy. We used receiver operating characteristic curve analysis and nomogram analysis to assess the overall discriminative ability of the HAR in predicting sICH after endovascular therapy.

Results: Among these 334 patients enrolled, 37 (11.1%) patients with anterior circulation infarction were identified with sICH after endovascular therapy. Univariate logistic regression analysis demonstrated that patients with higher levels of HAR may be inclined to develop sICH (odds ratio, 10.994; 95% confidence interval, 4.567-26.463; P = 0.001). This association remained significant even after adjustment for potential confounders. Also, a cutoff value of 0.526× 10 for HAR was detected in predicting sICH (area under curve, 0.763). Furthermore, nomogram analysis also suggested that HAR was an indicator of sICH (c-index was 0.890, P< 0.001).

Conclusions: This study showed that high levels of HAR could predict sICH after endovascular therapy.
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http://dx.doi.org/10.1186/s12883-021-02066-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849085PMC
February 2021

Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients.

Med (N Y) 2021 Jan 8. Epub 2021 Jan 8.

Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: To develop a sensitive risk score predicting the risk of mortality in patients with coronavirus disease 2019 (COVID-19) using complete blood count (CBC).

Methods: We performed a retrospective cohort study from a total of 13,138 inpatients with COVID-19 in Hubei, China, and Milan, Italy. Among them, 9,810 patients with 2 CBC records from Hubei were assigned to the training cohort. CBC parameters were analyzed as potential predictors for all-cause mortality and were selected by the generalized linear mixed model (GLMM).

Findings: Five risk factors were derived to construct a composite score (PAWNN score) using the Cox regression model, including platelet counts, age, white blood cell counts, neutrophil counts, and neutrophil:lymphocyte ratio. The PAWNN score showed good accuracy for predicting mortality in 10-fold cross-validation (AUROCs 0.92-0.93) and subsets with different quartile intervals of follow-up and preexisting diseases. The performance of the score was further validated in 2,949 patients with only 1 CBC record from the Hubei cohort (AUROC 0.97) and 227 patients from the Italian cohort (AUROC 0.80). The latent Markov model (LMM) demonstrated that the PAWNN score has good prediction power for transition probabilities between different latent conditions.

Conclusions: The PAWNN score is a simple and accurate risk assessment tool that can predict the mortality for COVID-19 patients during their entire hospitalization. This tool can assist clinicians in prioritizing medical treatment of COVID-19 patients.

Funding: This work was supported by National Key R&D Program of China (2016YFF0101504, 2016YFF0101505, 2020YFC2004702, 2020YFC0845500), the Key R&D Program of Guangdong Province (2020B1111330003), and the medical flight plan of Wuhan University (TFJH2018006).
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http://dx.doi.org/10.1016/j.medj.2020.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831644PMC
January 2021

Application of ultrasound-guided intranodal lymphangiography and embolisation in cancer patients with postoperative lymphatic leakage.

World J Surg Oncol 2021 Jan 30;19(1):32. Epub 2021 Jan 30.

Department of Intervention, The Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Suzhou, Jiangsu, 215004, People's Republic of China.

Background: Traumatic lymphatic leakage is a rare but potentially life-threatening complication. The purpose of this study was to introduce ultrasound-guided intranodal lymphangiography and embolisation techniques for postoperative lymphatic leakage in patients with cancer.

Methods: From January 2018 through June 2020, seven cancer patients (three males, four females, aged 59-75 years [mean 67.57 ± 6.11 years]) developed lymphatic leakage after abdominal or pelvic surgery, with drainage volumes ranging from 550 to 1200 mL per day. The procedure and follow-up of ultrasound-guided intranodal lymphangiography and embolisation were recorded. This study retrospectively analysed the technical success rate, operative time, length of hospital stay, clinical efficacy, and complications.

Results: The operation was technically successful in all patients. Angiography revealed leakage, and embolisation was performed in all seven patients (7/7, 100%). The operative time of angiography and embolisation was 41 to 68 min, with an average time of 53.29 ± 10.27 min. The mean length of stay was 3.51 ± 1.13 days. Lymph node embolisation was clinically successful in five patients (5/7, 71.43%), who had a significant reduction in or disappearance of chylous ascites. The other two patients received surgical treatment 2 weeks later due to poor results after embolisation. All patients were followed for 2 weeks. No serious complications or only minor complications were found in all the patients.

Conclusions: Ultrasound-guided intranodal lymphangiography and embolisation were well tolerated by the patients, who experienced a low incidence of complications. Early intervention is recommended for cancer patients with postoperative lymphatic leakage.
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http://dx.doi.org/10.1186/s12957-021-02144-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847140PMC
January 2021