Publications

Metabolic profiling of nuciferine in rat urine, plasma, bile and feces after oral administration using ultra-high performance liquid chromatography-diode array detection-quadrupole time-of-flight mass spectrometry.
J Pharm Biomed Anal 2017 Jun 18;140:71-80. Epub 2017 Mar 18.
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China. Electronic address:

Formaldehyde and co-exposure with benzene induce compensation of bone marrow and hematopoietic stem/progenitor cells in BALB/c mice during post-exposure period.
Toxicol Appl Pharmacol 2017 Jun 31;324:36-44. Epub 2017 Mar 31.
Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China. Electronic address:

Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities.
Sci Rep 2017 Jun 22;7(1):4057. Epub 2017 Jun 22.
Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China.

Management of Chronic Total Coronary Occlusion in Stable Ischemic Heart Disease by Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting Versus Medical Therapy.
Am J Cardiol 2017 Jun 15. Epub 2017 Jun 15.
Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Institute for Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, Ontario, Canada. Electronic address:

Corrigendum to "Long-term clinical outcomes and predictors for survivors of out-of-hospital cardiac arrest" [Resuscitation 112 (2016) 59-64].
Resuscitation 2017 May 21;114:164. Epub 2017 Feb 21.
Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
J Pharm Biomed Anal 2017 May 27;139:73-86. Epub 2017 Feb 27.
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China. Electronic address:

Stress testing after percutaneous coronary interventions: a population-based study.
CMAJ Open 2017 May;5(2):E417-E423
Affiliations: Department of Medicine (Luca), University of Toronto; Institute for Clinical Evaluative Sciences (Koh, Qiu, Alter, Bhatia, Czarnecki, Wijeysundera, Ko); Toronto Rehabilitation Institute (Alter), University Health Network; Terrence Donnelly Heart Centre (Bagai, Goodman), St. Michael's Hospital, University of Toronto; Women's College Hospital Institute for Health Systems Solutions and Virtual Care (Bhatia); Schulich Heart Centre (Czarnecki, Lau, Wijeysundera, Ko), Sunnybrook Health Sciences Centre, University of Toronto; Canadian Heart Research Centre (Goodman), Toronto, Ont.

Comparison of Outcomes of Balloon-Expandable Versus Self-Expandable Transcatheter Heart Valves for Severe Aortic Stenosis.
Am J Cardiol 2017 Apr 5;119(7):1094-1099. Epub 2017 Jan 5.
Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Ontario, Canada.

Long-term clinical outcomes and predictors for survivors of out-of-hospital cardiac arrest.
Resuscitation 2017 Mar 16;112:59-64. Epub 2017 Jan 16.
Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

Metabolic profiles of physalin A in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci 2017 Mar 27;1046:102-109. Epub 2017 Jan 27.
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address:

(+)/(-)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors.
Sci Rep 2017 Mar 8;7:43576. Epub 2017 Mar 8.
School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, People's Republic of China.

LC-MS/MS method for simultaneous determination of flavonoids and physalins in rat plasma: Application to pharmacokinetic study after oral administration of Physalis alkekengi var. franchetii (Chinese lantern) extract.
Biomed Chromatogr 2017 Mar 8. Epub 2017 Mar 8.
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

A new eremophilane glycoside from the fruits of Physalis pubescens and its cytotoxic activity.
Nat Prod Res 2017 Mar 2:1-8. Epub 2017 Mar 2.
a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , People's Republic of China.

A novel withanolide with an unprecedented carbon skeleton from Physalis angulata.
Org Biomol Chem 2017 Feb;15(5):1110-1114
Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. and Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.


Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACE inhibitory activity.
Fitoterapia 2017 Jan 3;116:121-125. Epub 2016 Dec 3.
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China. Electronic address:

Locally and traditionally used Ligusticum species - A review of their phytochemistry, pharmacology and pharmacokinetics.
J Ethnopharmacol 2016 Dec 10;194:530-548. Epub 2016 Oct 10.
School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Effects of Polymorphisms in NR1H4, NR1I2, SLCO1B1, and ABCG2 on the Pharmacokinetics of Rosuvastatin in Healthy Chinese Volunteers.
J Cardiovasc Pharmacol 2016 Nov;68(5):383-390
*Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, China; †Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, China; ‡Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China; and §Shandong Luoxin Pharmaceutical Group Stock Co, Ltd, Linyi, China.

Withanolides from the stems and leaves of Physalis pubescens and their cytotoxic activity.
Steroids 2016 Nov 10;115:136-146. Epub 2016 Sep 10.
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, People's Republic of China. Electronic address:

Clinical Impact of Subsequent Depression in Patients With a New Diagnosis of Stable Angina: A Population-Based Study.
Circ Cardiovasc Qual Outcomes 2016 Nov 4;9(6):731-739. Epub 2016 Oct 4.
From the Schulich Heart Centre, Division of Cardiology, Department of Medicine, Sunnybrook Health Sciences Center (N.S., M.C.B., D.T.K., J.V.T., H.C.W.), Sunnybrook Research Institute (M.C.B., D.T.K., J.V.T., H.C.W.), Institute for Health Policy Management and Evaluation (D.T.K., J.V.T., P.K., H.C.W.), and Department of Psychiatry and Institute of Medical Science (P.K.), University of Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (F.Q., D.T.K., J.V.T., P.K., H.C.W.); and Social and Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (P.K.).

Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway.
Int J Oncol 2016 Nov 19;49(5):2075-2087. Epub 2016 Sep 19.
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China.

Combining Two-Photon-Activated Fluorescence Resonance Energy Transfer and Near-Infrared Photothermal Effect of Unimolecular Micelles for Enhanced Photodynamic Therapy.
ACS Nano 2016 Nov 3;10(11):10489-10499. Epub 2016 Nov 3.
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, People's Republic of China.

Relation between initial treatment strategy in stable coronary artery disease and 1-year costs in Ontario: a population-based cohort study.
CMAJ Open 2016 Jul-Sep;4(3):E409-E416. Epub 2016 Aug 8.
Division of Cardiology (Kang, Bennell, Ko, Wijeysundera), Sunnybrook Health Sciences Centre, Schulich Heart Centre, University of Toronto; Institute for Clinical Evaluative Sciences (Qiu, Austin, Ko, Wijeysundera), Toronto, Ont.; Libin Cardiovascular Institute of Alberta (Knudtson), University of Calgary, Calgary, Alta.; Institute of Health Policy, Management and Evaluation (Austin, Ko, Wijeysundera), University of Toronto, Toronto, Ont.

High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure.
EBioMedicine 2016 Aug 22;10:291-7. Epub 2016 Jun 22.
Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, Florida, United States. Electronic address:

Two pairs of farnesyl phenolic enantiomers as natural nitric oxide inhibitors from Ganoderma sinense.
Bioorg Med Chem Lett 2016 Jul 12;26(14):3342-5. Epub 2016 May 12.
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, People's Republic of China. Electronic address:

Factors associated with out-of-hospital cardiac arrest with pulseless electric activity: A population-based study.
Am Heart J 2016 Jul 30;177:129-37. Epub 2016 Apr 30.
Sunnybrook Health Sciences Centre; Rescu Keenan Research Centre, Li Ka Shing Knowledge Institute at St Michael's Hospital, Toronto, ON, Canada.

Tiliroside, the major component of Agrimonia pilosa Ledeb ethanol extract, inhibits MAPK/JNK/p38-mediated inflammation in lipopolysaccharide-activated RAW 264.7 macrophages.
Exp Ther Med 2016 Jul 28;12(1):499-505. Epub 2016 Apr 28.
Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education of China, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.

Predictors of Initial Revascularization Versus Medical Therapy Alone in Patients With Non-ST-Segment-Elevation Acute Coronary Syndrome Undergoing an Invasive Strategy.
Circ Cardiovasc Interv 2016 Jul;9(7)
From the Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre (H.C.W., M.C.B., D.T.K., J.V.T.) and Institute of Health Policy, Management and Evaluation (H.C.W., D.T.K., J.V.T.), University of Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Ontario, Canada (H.C.W., F.Q., D.T.K., J.V.T.); Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada (H.C.W.); Samuel S. Stratton VA Medical Center, Albany Medical Center, Albany Medical College, New York (M.S.S., W.E.B.); and Foothills Hospital, University of Calgary, Alberta, Canada (M.L.K.).

DASAF: An R Package for Deep Sequencing-Based Detection of Fetal Autosomal Abnormalities from Maternal Cell-Free DNA.
Biomed Res Int 2016 29;2016:2714341. Epub 2016 Jun 29.
Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Shanghai Center for Bioinformation Technology, Shanghai Industrial Technology Institute, Shanghai 200235, China; EG Information Technology Enterprise (EGI), Basepair Biotechonology. Co. Ltd., Suzhou 215123, China.

Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine.
Ther Drug Monit 2016 Jun;38(3):343-9
*The Translational Cancer Research Laboratory, School of Life Sciences, Jilin University, Changchun, China; †Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, China; and ‡Department of Neurology, First Hospital of Jilin University, Changchun, China.

Antiproliferative and Anti-inflammatory Withanolides from Physalis angulata.
J Nat Prod 2016 Jun 13;79(6):1586-97. Epub 2016 Jun 13.
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.

Elevated serum IL-35 and increased expression of IL-35-p35 or -EBI3 in CD4(+)CD25(+) T cells in patients with active tuberculosis.
Am J Transl Res 2016 15;8(2):623-33. Epub 2016 Feb 15.
Guangdong Provincial Key Laboratory of Medical Molecular DiagnosticsNo. 1 Xincheng Road, Dongguan 523808, China; Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical CollegeNo. 1 Xincheng Road, Dongguan 523808, China.

Association between publication of appropriate use criteria and the temporal trends in diagnostic angiography in stable coronary artery disease: A population-based study.
Am Heart J 2016 May 27;175:153-9. Epub 2016 Feb 27.
Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre, Ontario, Canada; University of Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Ontario, Canada. Electronic address:

Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway.
Mol Cell Biochem 2016 Apr 21;415(1-2):145-55. Epub 2016 Mar 21.
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, People's Republic of China.

Noninvasive diagnosis and monitoring of mutations by deep sequencing of circulating tumor DNA in esophageal squamous cell carcinoma.
Biochem Biophys Res Commun 2016 Mar 12;471(4):596-602. Epub 2016 Feb 12.
Hangzhou Cancer Institution, Hangzhou Cancer Hospital, Hangzhou, China. Electronic address:

Predictors and clinical outcomes of inpatient versus ambulatory management after an emergency department visit for atrial fibrillation: A population-based study.
Am Heart J 2016 Mar 17;173:161-9. Epub 2015 Dec 17.
University of Toronto, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, ON, Canada; Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Peter Munk Cardiac Centre of the University Health Network-Toronto General Hospital, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada. Electronic address:

An investigation of exciton behavior in type-II self-assembled GaSb/GaAs quantum dots.
Nanotechnology 2016 Feb 18;27(6):065602. Epub 2015 Dec 18.
National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, People's Republic of China. Institute of Optoelectronic Information Materials, Academy of Engineering and Technology, Yunnan University, Kunming 650091, People's Republic of China.

Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.
Bioorg Med Chem Lett 2016 Jan 17;26(2):662-6. Epub 2015 Nov 17.
Research and Development, Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543-4000, United States.

Association of prior β-blocker use and the outcomes of patients with out-of-hospital cardiac arrest.
Am Heart J 2015 Nov 26;170(5):1018-1024.e2. Epub 2015 Jul 26.
Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:


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