Publications by authors named "Feng Peng"

477 Publications

Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods.

Chem Sci 2021 Jul 19;12(26):9031-9036. Epub 2021 May 19.

Department of Process Research and Development, Merck & Co., Inc. Rahway New Jersey 07065 USA

An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of several synthetic methods: (1) complexation-driven selective acyl migration/oxidation; (2) BSA-mediated cyclization to anhydrouridine; (3) hydrochlorination using FeCl/TMDSO; (4) dynamic stereoselective phosphoramidation using a chiral nucleophilic catalyst. The new route improves the yield of uprifosbuvir 50-fold over the previous manufacturing process and expands the tool set available for synthesis of antiviral nucleotides.
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http://dx.doi.org/10.1039/d1sc01978cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261776PMC
July 2021

Design, Synthesis and Antibacterial Activity of Novel Pyrimidine-Containing 4H-Chromen-4-One Derivatives*.

Chem Biodivers 2021 Jun 22. Epub 2021 Jun 22.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, 550025, P. R. China.

A series of pyrimidine-containing 4H-chromen-4-one derivatives were designed and synthesized by combining bioactive substructures. Preliminary biological activity results showed that most of the compounds displayed significant inhibitory activities in vitro against Xanthomonas axonopodis pv. Citri (X. axonopodis), Xanthomonas oryzae pv. oryzae (X. oryzae) and Ralstonia solanacearum (R. solanacearum). In particular, compound 2-[(3-{[5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy}propyl)sulfanyl]-4-(4-methylphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile (4c) demonstrated a good inhibitory effect against X. axonopodis and X. oryzae, with the half-maximal effective concentration (EC ) values of 15.5 and 14.9 μg/mL, respectively, and compound 2-[(3-{[5,7-Dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy}propyl)sulfanyl]-4-(3-fluorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile (4h) showed the best antibacterial activity against R. solanacearum with an EC value of 14.7 μg/mL. These results were better than commercial reagents bismerthiazol (BT, 51.7, 70.1 and 52.7 μg/mL, respectively) and thiodiazole copper (TC, 77.9, 95.8 and 72.1 μg/mL, respectively). In vivo antibacterial activity results indicated that compound 4c displayed better curative (42.4 %) and protective (49.2 %) activities for rice bacterial leaf blight than BT (35.2, 39.1 %) and TC (30.8, 27.3 %). The mechanism of compound 4c against X. oryzae was analyzed through scanning electron microscopy (SEM). These results indicated that pyrimidine-containing 4H-chromen-4-one derivatives have important value in the research of new agrochemicals.
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http://dx.doi.org/10.1002/cbdv.202100186DOI Listing
June 2021

Low shifts in salinity determined assembly processes and network stability of microeukaryotic plankton communities in a subtropical urban reservoir.

Microbiome 2021 06 3;9(1):128. Epub 2021 Jun 3.

Aquatic Ecohealth Group, Fujian Key Laboratory of Watershed Ecology, Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.

Background: Freshwater salinization may result in significant changes of microbial community composition and diversity, with implications for ecosystem processes and function. Earlier research has revealed the importance of large shifts in salinity on microbial physiology and ecology, whereas studies on the effects of smaller or narrower shifts in salinity on the microeukaryotic community in inland waters are scarce. Our aim was to unveil community assembly mechanisms and the stability of microeukaryotic plankton networks at low shifts in salinity.

Results: Here, we analyzed a high-resolution time series of plankton data from an urban reservoir in subtropical China over 13 consecutive months following one periodic salinity change ranging from 0 to 6.1‰. We found that (1) salinity increase altered the community composition and led to a significant decrease of plankton diversity, (2) salinity change influenced microeukaryotic plankton community assembly primarily by regulating the deterministic-stochastic balance, with deterministic processes becoming more important with increased salinity, and (3) core plankton subnetwork robustness was higher at low-salinity levels, while the satellite subnetworks had greater robustness at the medium-/high-salinity levels. Our results suggest that the influence of salinity, rather than successional time, is an important driving force for shaping microeukaryotic plankton community dynamics.

Conclusions: Our findings demonstrate that at low salinities, even small increases in salinity are sufficient to exert a selective pressure to reduce the microeukaryotic plankton diversity and alter community assembly mechanism and network stability. Our results provide new insights into plankton ecology of inland urban waters and the impacts of salinity change in the assembly of microbiotas and network architecture. Video abstract.
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http://dx.doi.org/10.1186/s40168-021-01079-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176698PMC
June 2021

Non Noble-Metal Copper-Cobalt Bimetallic Catalyst for Efficient Catalysis of the Hydrogenolysis of 5-Hydroxymethylfurfural to 2,5-Dimethylfuran under Mild Conditions.

ACS Omega 2021 Apr 16;6(16):10910-10920. Epub 2021 Apr 16.

School of Chemistry & Chemical Engineering, Guangzhou University, Guangzhou 510006, Guangdong, China.

The efficient catalysis of the hydrogenation of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF) over non noble-metal catalysts has received great attention in recent years. However, the reaction usually requires harsh conditions, such as high reaction temperature and excessively long reaction time, which limits the application of the non noble-metal catalysts. In this work, a bimetallic Co [email protected] catalyst was prepared via the pyrolysis of MOFs, and an 85% DMF yield was achieved under a reaction temperature and time of 160 °C and 3 h, respectively. The results of X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray spectroscopy (EDX) mapping, and other characterization techniques showed that the synthesis method in this paper realized the in situ loading of cobalt into the copper catalyst. The reaction mechanism studies revealed that the cobalt doping effectively enhanced the hydrogenation activity of the copper-based catalyst on the C-O bond at a low temperature. Moreover, the bimetallic Co [email protected] catalyst exhibited superior reusability without any loss in the activity when subjected to five testing rounds.
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http://dx.doi.org/10.1021/acsomega.1c00676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153901PMC
April 2021

Segmenting lung lesions of COVID-19 from CT images via pyramid pooling improved Unet.

Biomed Phys Eng Express 2021 05 20;7(4). Epub 2021 May 20.

Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Chongqing 400044, People's Republic of China.

Segmenting lesion regions of Coronavirus Disease 2019 (COVID-19) from computed tomography (CT) images is a challenge owing to COVID-19 lesions characterized by high variation, low contrast between infection lesions and around normal tissues, and blurred boundaries of infections. Moreover, a shortage of available CT dataset hinders deep learning techniques applying to tackling COVID-19. To address these issues, we propose a deep learning-based approach known as PPM-Unet to segmenting COVID-19 lesions from CT images. Our method improves an Unet by adopting pyramid pooling modules instead of the conventional skip connection and then enhances the representation of the neural network by aiding the global attention mechanism. We first pre-train PPM-Unet on COVID-19 dataset of pseudo labels containing1600 samples producing a coarse model. Then we fine-tune the coarse PPM-Unet on the standard COVID-19 dataset consisting of 100 pairs of samples to achieve a fine PPM-Unet. Qualitative and quantitative results demonstrate that our method can accurately segment COVID-19 infection regions from CT images, and achieve higher performance than other state-of-the-art segmentation models in this study. It offers a promising tool to lay a foundation for quantitatively detecting COVID-19 lesions.
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http://dx.doi.org/10.1088/2057-1976/ac008aDOI Listing
May 2021

transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma.

Transl Lung Cancer Res 2021 Mar;10(3):1383-1396

Department of Thoracic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: transmembrane domain (TMD) mutation has been reported as a rare driver mutation associated with advanced stage disease and a poor prognosis in patients with lung adenocarcinoma (LUAD). We aimed to comprehensively profile the genetic landscape and treatment response information of TMD-mutant LUAD.

Methods: An in-house database of 7,812 LUAD patients was screened for mutation prevalence. A multi-center cohort of 16 V659E-mutant patients and an external cohort of 38 -mutant patients from cBioPortal with overall survival (OS) data were analyzed. Eight patients from the in-house cohort were included in the real-world study of treatment response. Molecular docking simulation and binding affinity prediction were performed.

Results: In Chinese LUAD, the prevalence of TMD mutation was 0.18% (14/7,812), and 0.14% (11/7,812) for the V659E mutation. The most recurrent co-alteration was mutation (n=4, 25%) and amplification (n=2, 12.5%). TMD-mutant patients were diagnosed at more advance stages (P<0.001) and had poorer OS (median OS 10.0 61.6 months, HR =7.9, 95% CI: 1.0-61.0, P<0.001) than non-TMD mutations. The overall response rate of targeted therapy, chemo-based therapy, and immunotherapy was 57.1%, 22.2%, and 0%, respectively. We postulated to challenge the resistance of tyrosine kinase inhibitor (TKI) with another with stronger binding energy to HER2 and supported the conclusion with a successful case. Additionally, we demonstrated a three-month response to the off-label use of pyrotinib in fifth-line therapy.

Conclusions: Comapred with non-TMD mtuations, TMD mutation is a rare driver mutation with poorer prognosis in LUAD. Targeted therapy is the dominant choice for patients harboring this targetable mutation and longer OS could possibly be achieved through rechallenge with TKI of stronger binding affinity. Response to fifth-line pyrotinib was observed.
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http://dx.doi.org/10.21037/tlcr-21-107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044484PMC
March 2021

Impact of Percutaneous Transhepatic Biliary Drainage on Clinical Outcomes of Patients with Malignant Obstructive Jaundice Undergoing Laparoscopic Pancreaticoduodenectomy.

Curr Med Sci 2021 Apr 20;41(2):375-380. Epub 2021 Apr 20.

Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Preoperative biliary drainage may increase the morbidity and mortality of pancreaticoduodenectomy. Studies on percutaneous transhepatic biliary drainage (PTBD) before laparoscopic pancreaticoduodenectomy (LPD), however, are scarce. The aim of this study was to examine the impact of PTBD on clinical outcomes of patients with malignant obstructive jaundice undergoing LPD. Clinical data of 172 patients who had malignant obstructive jaundice and underwent LPD from 2014 to 2017 in our hospital were retrospectively analyzed. Demographics, catheter-related complications, postoperative complications, and oncological outcomes were collected and analyzed. Propensity score matching was performed to minimize selection bias associated with the comparison of data between patients who underwent PTBD and then LPD (PTBD group), and those given LPD alone (LPD group). The results showed that, in the PTBD group relative to the LPD group, the operating time was significantly shortened (250.28±69.95 vs. 278.58±86.51 min, P=0.0196), the intraoperative blood loss was markedly reduced (271.96±403.47 vs. 429.72±482.47 mL, P=0.022), and overall rates of complications (16.33% vs. 36.49%, P=0.0025) including postoperative haemorrhage (2.04% vs. 12.16%, P=0.0072) and delayed gastric emptying (4.08% vs. 13.51%, P=0.0251) were greatly decreased. The propensity score-matched analysis, with 48 patients enrolled in each group, revealed no statistically significant differences in operating duration (262.71±68.64 vs. 280.25±83.52 min, P=0.264), intraoperative blood loss (290.21±407.71 vs. 373.75±422.33 mL, P=0.327) and delayed gastric emptying (4.17% vs. 12.50%, P=0.1396). PTBD group had lower incidences in overall complications (22.92% vs. 39.58%, P=0.0481) and postoperative haemorrhage (2.08% vs. 12.50%, P=0.0497) than LPD group. In conclusion, patients with malignant obstructive jaundice may benefit from PTBD procedure before LPD in terms of perioperative outcomes.
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http://dx.doi.org/10.1007/s11596-021-2357-7DOI Listing
April 2021

Molybdenum-catalyzed hydrogenolysis of herbaceous biomass: A procedure integrated lignin fragmentation and components fractionation.

Bioresour Technol 2021 Aug 19;333:124977. Epub 2021 Mar 19.

Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, People's Republic of China. Electronic address:

In this work, a low-cost MoO/C catalyst was prepared for the reductive catalytic fractionation (RCF) of various herbaceous biomass feedstocks (Miscanthus, Triarrhena, Floridulus, Sorghum stem and Corncob). Phenolic monomers from the hydrogenolysis of lignin component were obtained in up to 26.4 wt%, with high selectivity towards methyl coumarate (33%) and methyl ferulate (24%). The RCF left solid carbohydrate pulps with high retentions (up to 87%), which were suitable for enzymatic hydrolysis. The reaction conditions, including temperature, time, H pressure, and sawdust size were examined in terms of monophenols yield, selectivity, delignification and sugar retention. This study showed that MoO/C could function as an excellent catalyst for lignin fragmentation as well as the fractionation of herbaceous biomass components.
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http://dx.doi.org/10.1016/j.biortech.2021.124977DOI Listing
August 2021

Corrosion Behavior and Biocompatibility of Diamond-like Carbon-Coated Zinc: An In Vitro Study.

ACS Omega 2021 Apr 2;6(14):9843-9851. Epub 2021 Apr 2.

Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Owing to the desirable degradation rate and good biocompatibility, zinc (Zn) and Zn alloys are promising biodegradable implant metals in orthopedic and cardiovascular applications. Surface modification, such as deposition of coatings, is frequently implemented to further enhance their biological properties. In this study, diamond-like carbon (DLC) films are deposited on Zn by magnetron sputtering. The DLC films do not change the surface morphology of Zn but alter the hydrophobic properties with a contact angle of approximately 90°. Electrochemical and in vitro immersion tests reveal that the corrosion resistances of the DLC-coated Zn decrease unexpectedly, which is possibly due to galvanic corrosion between the DLC film and Zn substrate. Furthermore, the uncoated and coated Zn samples show hemolysis ratios less than 1%. The cells cultured in the Zn extract exhibit higher viability than those cultured in the extract of the DLC-coated Zn, suggesting that the DLC films decrease the cytocompatibility of Zn. The lower corrosion resistance has little influence on the hemolysis ratio, suggesting that hemolysis is not an obstacle for the design of Zn-based biomaterials. Our results show that the traditional concept of protection with DLC films may not be applicable universally and decreased corrosion resistance and cytocompatibility are actually observed in DLC-coated Zn.
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http://dx.doi.org/10.1021/acsomega.1c00531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047653PMC
April 2021

In vitro and in vivo analysis of metabolites involved in the TCA cycle and glutamine metabolism associated with cisplatin resistance in human lung cancer.

Expert Rev Proteomics 2021 Mar 19;18(3):233-240. Epub 2021 Apr 19.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P. R. China.

Elucidating the dysregulated metabolic pathways in cancer cells and their relevance to cisplatin resistance could yield new insights into cancer therapy. We previously reported that eight metabolites involved in the tricarboxylic acid (TCA) cycle and glutamine metabolism were associated with platinum-based chemotherapy efficacy in human lung cancer. Here, we investigated the metabolic differences upon cisplatin treatment in lung cancer in vitro and in vivo. A simple and partially validated standard addition method was applied for the quantification of five metabolites involved in the TCA cycle and glutamine metabolism using amide hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS). The present study investigated the levels of these biomarkers in A549 cells and the cisplatin-resistant A549-DDP cells, as well as in the plasma before and after cisplatin treatment in A549 xenograft mice. Levels of five metabolites, including 2-hydroxyglutaric acid (2-HG), α-ketoglutarate (α-KG), succinate, glutamine, and glutamate, showed a decreasing trend in A549-DDP cells. In addition, 2-HG and glutamine were the most significantly altered metabolites in cisplatin-treated A549 xenograft mice. These data indicate that the TCA cycle and glutamine metabolism play important roles in cisplatin-based chemotherapy resistance in lung cancer. Our results provide a new angle for exploring the molecular mechanisms underlying cisplatin resistance.
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http://dx.doi.org/10.1080/14789450.2021.1915775DOI Listing
March 2021

C + L band polarization rotator-splitter based on a compact S-bend waveguide mode demultiplexer.

Opt Express 2021 Mar;29(7):10949-10957

A novel high-fabrication-tolerance mode demultiplexer (MD) based on an S-bend waveguide is designed, which is used to split TE mode and TE mode, and convert the TE mode to TE mode. Based on the MD, a polarization-rotator-splitter (PRS) is demonstrated. The transmission losses of the fabricated PRS are lower than 0.5 dB and 0.6 dB for TE mode and TM mode, respectively, in the wavelength span of 1520-1630 nm. And the corresponding polarization extinction ratios are larger than 19.5 dB and 17.6 dB, respectively. This MD has the most compact size comparing with other experimentally demonstrated MDs used in PRS.
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http://dx.doi.org/10.1364/OE.412992DOI Listing
March 2021

Quantum and Classical Proton Diffusion in Superconducting Clathrate Hydrides.

Phys Rev Lett 2021 Mar;126(11):117002

Departments of Physics and Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

The discovery of near room temperature superconductivity in clathrate hydrides has ignited the search for both higher temperature superconductors and deeper understanding of the underlying physical phenomena. In a conventional electron-phonon mediated picture for the superconductivity for these materials, the high critical temperatures predicted and observed can be ascribed to the low mass of the protons, but this also poses nontrivial questions associated with how the proton dynamics affect the superconductivity. Using clathrate superhydride Li_{2}MgH_{16} as an example, we show through ab initio path integral simulations that proton diffusion in this system is remarkably high, with a diffusion coefficient, for example, reaching 6×10^{-6}  cm^{2}/s at 300 K and 250 GPa. The diffusion is achieved primarily through proton transfer among interstitial voids within the otherwise rigid Li_{2}Mg sublattice at these conditions. The findings indicate the coexistence of proton quantum diffusion together with hydrogen-induced superconductivity, with implications for other very-high-temperature superconducting hydrides.
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http://dx.doi.org/10.1103/PhysRevLett.126.117002DOI Listing
March 2021

[Progress of the application research of acupuncture anesthesia in thyroid surgery].

Zhen Ci Yan Jiu 2021 Feb;46(2):168-71

Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.

This article reviews the clinical studies on the application of acupuncture anesthesia in thyroid surgery over the past 5 years. Starting from the principle of acupuncture anesthesia, the authors explore the application of acupuncture anesthesia in thyroid surgery, its advantages and development. The summarized findings showed that acupuncture anesthesia has a better analgesic effect in thyroid surgery, which can reduce the occurrence of stress reactions, adverse reactions and complications, and is conducive to postoperative recovery. However, there is a lack of standardized operations. In the future, standardized operations can make acupuncture anesthesia more widely used and popularized.
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http://dx.doi.org/10.13702/j.1000-0607.200283DOI Listing
February 2021

OPA Interacting Protein 5 Antisense RNA 1 Expedites Cell Migration and Invasion Through FOXM1/ Wnt/β-Catenin Pathway in Pancreatic Cancer.

Dig Dis Sci 2021 Mar 29. Epub 2021 Mar 29.

Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No 1095 Jiefang Avenue, Wuhan, 430030, China.

Background: Pancreatic cancer (PC) is a digestive tract malignancy with poor prognosis. Long noncoding RNA (lncRNA) OPA interacting protein 5 antisense RNA 1 (OIP5-AS1) was regarded to be correlated with human malignancy, working as tumor suppressor or promoter on the basis of tumor types. However, the function of OIP5-AS1 in PC remained unclear.

Aims: The study focused on the function and regulatory mechanism of OIP5-AS1 in PC.

Methods: OIP5-AS1 expression was assessed by the quantitative reverse transcription PCR (RT-qPCR) in tumor tissues and PC cell lines. 5-ethynyl-2'-deoxyuridine (EdU) incorporation and cell counting kit-8 (CCK-8) assays were applied to detect cell proliferation ability. Through wound healing and transwell assays, cell migration and invasion capacities were estimated. Flow cytometry analysis was performed to examine apoptosis capability of PC cells.

Results: OIP5-AS1 downregulating inhibited cell proliferation, migration, and invasion capacities, while promoting cell apoptosis rates. As a competing endogenous RNA (ceRNA), OIP5-AS1 competed with Forkhead Box M1 (FOXM1) for the binding sites on microRNA-320b (miR-320b). OIP5-AS1 was able to upregulate FOXM1 expression via silencing miR-320b. Furthermore, FOXM1 served as an activator of Wnt/β-catenin pathway and mediated the effect of OIP5-AS1 on Wnt/β-catenin pathway.

Conclusion: OIP5-AS1 expedites the proliferative, migrated, and invasive capability of PC cells, while repressing cell apoptosis through regulating miRNA-320b/FOXM1 axis and FOXM1/Wnt/β-catenin pathway in PC. OIP5-AS1 regulation on FOXM1/Wnt/β-catenin pathway may offer novel efficient markers for PC treatments.
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http://dx.doi.org/10.1007/s10620-021-06919-1DOI Listing
March 2021

Natural Polymer Rubber: A Novel Material.

J Agric Food Chem 2021 Apr 24;69(13):3797-3821. Epub 2021 Mar 24.

College of Life Sciences, Northwest A&F University, Yangling 712100, China.

As the second natural rubber resource, rubber (EUR) from Oliver is mainly composed of 1,4-polyisoprene, which is the isomer of natural rubber -1,4-polyisoprene from . In the past few years, the great potential application of EUR has received increasing attention, and there is a growing awareness that the natural polymer EUR could become an emerging research topic in field of the novel materials due to its unique and excellent duality of both rubber and plastic. To gain insight into its further development, in this review, the extraction, structure, physicochemical properties, and modification of EUR are discussed in detail. More emphasis on the potential applications in the fields of the environment, agriculture, engineering, and biomedical engineering is summarized. Finally, some insights into the challenges and perspectives of EUR are also suggested.
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http://dx.doi.org/10.1021/acs.jafc.0c07560DOI Listing
April 2021

[Emission Inventory of Air pollutants for the Harmless Treatment of Municipal Solid Waste].

Huan Jing Ke Xue 2021 Mar;42(3):1333-1342

College of Resource Environment and Tourism, Capital Normal University, Beijing 100048, China.

In order to comprehensively assess the emission status of air pollutes from domestic waste treatment plants in mainland China, the basic statistical information of 31 provinces and cities in China was systematically collected and collated. The emission factor method was adopted to establish the 2016 list of air pollutants for the harmless treatment of domestic garbage in mainland China. The results showed that in 2016, the total amount of CH, VOCs, NH, TSP, PM, and PM gaseous pollutants discharged from domestic waste landfills was 3472084.50, 185117.10, 66.45, 54.94, 25.99, and 3.92 t, respectively. The total amount of CH, SO, NO, NH, VOCs, CO, TSP, PM,PM, and BC of gaseous pollutants discharged from incineration facilities was 25389.10, 6419.30, 70923.84, 221.36, 435.33, 3025.19, 221.36, 221.36, 2.21, and 2.86 t, respectively. Through the analysis of solid waste treatment sources, partial, and temporal distribution characteristics of air pollutants, and the proportion of incineration plants in the provinces and municipalities to the number of household harmless waste treatment plants, it was determined that the total amount of gaseous pollutants discharged from domestic waste incineration sources and landfill sources had an upward trend during the period 2010-2016. In 2016, domestic landfill treatment was the most important waste treatment method in China, and mainly concentrated in areas with moderate population density and large land resources, such as central and western regions. Domestic waste incineration treatment facilities are mainly concentrated in developed cities in the Yangtze River Delta, Pearl River Delta, and the Beijing-Tianjin-Hebei Region.
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http://dx.doi.org/10.13227/j.hjkx.202006177DOI Listing
March 2021

Zn-contained mussel-inspired film on Mg alloy for inhibiting bacterial infection and promoting bone regeneration.

Regen Biomater 2021 Feb 30;8(1):rbaa044. Epub 2020 Sep 30.

Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.

Infection and insufficient osteointegration are the main causes of orthopedic implant failure. Furthermore, activating favorable inflammation response is vital to the fast osteointegration of implants. Therefore, endowing the implants with multifunctions (antibacterial, anti-inflammation, and pro-osteointegration) is a promising strategy to improve the performance of orthopedic implants. In this study, a Zn-contained polydopamine (PDA) film was fabricated on AZ31 alloy. The film possessed a stable Zn ion release in 14 days. The results of electrochemical analysis implied the favorable corrosion protection of the film, and thus, leading to a suitable hemolysis ratio (below 1%). The antibacterial assessment revealed that the film exhibited excellent resistance against (nearly 100%), which can be ascribed to the release of Zn ions. The cell-culture evaluation revealed that the extract of Zn-contained PDA-coated sample can activate RAW264.7 polarization to an anti-inflammatory phenotype, as well as enhance the osteogenic differentiation ability of MC3T3-E1. Additionally, the femoral osteomyelitis model indicated that the as-prepared film had a high antibacterial capability at early stage of the implantation, and showed better osteogenesis and osteointegration after 8 weeks of implantation. With favorable antibacterial, anti-inflammation, and pro-osteogenesis abilities, the novel designed Zn-contained PDA film is promising to be used in Mg-based orthopedic implants.
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http://dx.doi.org/10.1093/rb/rbaa044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947588PMC
February 2021

Enhanced osteogenesis of titanium with nano-Mg(OH) film and a mechanism study via whole genome expression analysis.

Bioact Mater 2021 Sep 13;6(9):2729-2741. Epub 2021 Feb 13.

Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China.

Titanium (Ti) has been the most widely used orthopedic implant in the past decades. However, their inert surface often leads to insufficient osteointegration of Ti implant. To solve this issue, two bioactive Mg(OH) films were developed on Ti surfaces using hydrothermal treatment (Ti-M1# and Ti-M2#). The Mg(OH) films showed nano-flake structures: sheets on Ti-M1# with a thickness of 14.7 ± 0.7 nm and a length of 131.5 ± 2.9 nm, and on Ti-M2# with a thickness of 13.4 ± 2.2 nm and a length of 56.9 ± 5.6 nm. Both films worked as Mg ions releasing platforms. With the gradual degradation of Mg(OH) films, weakly alkaline microenvironments will be established surrounding the modified implants. Benefiting from the sustained release of Mg ions, nanostructures, and weakly alkaline microenvironments, the as-prepared nano-Mg(OH) coated Ti showed better and osteogenesis. Notably, Ti-M2# showed better osteogenesis than Ti-M1#, which can be ascribed to its smaller nanostructure. Moreover, whole genome expression analysis was applied to study the osteogenic mechanism of nano-Mg(OH) films. For both coated samples, most of the genes related to ECM-receptor interaction, focal adhesion, and TGF-β pathways were upregulated, indicating that these signaling pathways were activated, leading to better osteogenesis. Furthermore, cells cultured on Ti-M2# showed markedly upregulated BMP-4 gene expression, suggesting that the nanostructure with Mg ion release ability can better activate BMP-4 related signaling pathways, resulting in better osteogenesis. Nano-Mg(OH) films demonstrated a superior osteogenesis and are promising surface modification strategy for orthopedic applications.
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http://dx.doi.org/10.1016/j.bioactmat.2021.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895731PMC
September 2021

Thermosensitive -hydrogel-coated titania nanotubes with controlled drug release and immunoregulatory characteristics for orthopedic applications.

Mater Sci Eng C Mater Biol Appl 2021 Mar 13;122:111878. Epub 2021 Jan 13.

School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China.

Although Ti is widely used in orthopedic implants, its bio-inert characteristics and poor antibacterial activity may result in implant failure. To counter this problem, in this study, we loaded simvastatin, a bioactive compound that promotes osteogenesis, in TiO nanotubes and a thermosensitive chitosan-glycerin-hydroxypropyl methyl cellulose hydrogel (CGHH) was then layered on top of these nanotubes. At normal human-body temperature (37 °C), CGHH was present in a sol state, thus facilitating the controlled release of simvastatin to enhance differentiation in MC3T3-E1 osteoblasts. In vitro cell-culture studies suggested that CGHH in a gel state would induce macrophage polarization to the pro-inflammatory M1 phenotype. In vitro testing against Escherichia coli and Staphylococcus aureus indicated no antibacterial activity in CGHH in both sol and gel states. However, the results of subcutaneous infection animal models suggested that CGHH showed excellent in vivo antibacterial activity, which can be explained by the fact at high temperatures induced by an infection, CGHH transitioned into a gel state and released large amounts of glycerin. Such a high glycerin dosage induced an acute inflammatory reaction and antibacterial activity. Thus, due to their enhanced osteogenesis capacity at normal body temperature and antibacterial characteristics in the presence of infection, the newly designed simvastatin-loaded CGHH-encapsulated TiO nanotubes are promising materials for application in orthopedic implants.
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http://dx.doi.org/10.1016/j.msec.2021.111878DOI Listing
March 2021

Direct Epitaxial Approach to Achieve a Monolithic On-Chip Integration of a HEMT and a Single Micro-LED with a High-Modulation Bandwidth.

ACS Appl Electron Mater 2021 Jan 14;3(1):445-450. Epub 2021 Jan 14.

Department of Electronic and Electrical Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom.

Visible light communications (VLC) require III-nitride visible micro-light-emitting diodes (μLEDs) with a high-modulation bandwidth. Such μLEDs need to be driven at a high injection current density on a kA/cm scale, which is about 2 orders of magnitude higher than those for normal visible LED operation. μLEDs are traditionally fabricated by dry-etching techniques where dry-etching-induced damages are unavoidable, leading to both a substantial reduction in performance and a great challenge to viability at a high injection current density. Furthermore, conventional biasing (which is simply applied across a p-n junction) is good enough for normal LED operation but generates a great challenge for a single μLED, which needs to be modulated at a high injection current density and at a high frequency. In this work, we have proposed a concept for an epitaxial integration and then demonstrated a completely different method that allows us to achieve an epitaxial integration of a single μLED with a diameter of 20 μm and an AlGaN/GaN high-electron-mobility transistor (HEMT), where the emission from a single μLED is modulated by tuning the gate voltage of its HEMT. Furthermore, such a direct epitaxial approach has entirely eliminated any dry-etching-induced damages. As a result, we have demonstrated an epitaxial integration of monolithic on-chip μLED-HEMT with a record modulation bandwidth of 1.2 GHz on industry-compatible -plane substrates.
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http://dx.doi.org/10.1021/acsaelm.0c00985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885730PMC
January 2021

The novel GLP-1/GIP dual agonist DA3-CH is more effective than liraglutide in reducing endoplasmic reticulum stress in diabetic rats with cerebral ischemia-reperfusion injury.

Nutr Metab Cardiovasc Dis 2021 01 12;31(1):333-343. Epub 2020 Sep 12.

Second Hospital, Neurology Department, Shanxi Medical University, Taiyuan 030001, Shanxi province, PR China; Research and Experimental Center, Henan University of Chinese Medicine, Zhengzhou 450046, Henan province, PR China.

Background And Aims: Diabetes is one of the most important risk factors and comorbidities of ischemic stroke. Endoplasmic reticulum stress (ERS) is considered to be the major injury mechanism of ischemic stroke with diabetes. Studies have found that incretin can inhibit ERS in ischemia-reperfusion injury of the liver and heart. We aimed to explore the effects of GLP-1/GIP double agonist DA3-CH and GLP-1 single agonist liraglutide on ERS and apoptosis in diabetic rats with cerebral ischemia-reperfusion injury.

Methods And Results: 72 Sprague-Dawley (SD) male rats were randomly divided into 4 groups: ① blank group (Sham group, n = 18); model group (Saline group, n = 18); DA3 treatment group (DA3 group, n = 18); liraglutide treatment group (Lir group, n = 18). The Sham group was not given any treatment and was only raised in the same environment as the other groups. The remaining 3 groups used STZ-induced diabetes models. After the successful membrane formation of diabetes, DA3-CH and liraglutide (10 mmol/kg, once-daily for 14 days) were injected intraperitoneally. Thereafter, rats were subjected to middle cerebral artery occlusion followed by 24-h reperfusion. Animals were evaluated for neurologic deficit score, infarct volume, and biomarker analyses of the brain after ischemia. The DA3-CH-treated and liraglutide-treated groups showed significantly reduced scores of neurological dysfunction and cerebral infarction size, and reduced the expression of ERS markers GRP78, CHOP and Caspase-12, and the expression of apoptosis marker bax. Anti-apoptotic markers bcl-2 and neuronal numbers increased significantly.

Conclusions: DA3-CH and liraglutide have obvious neuroprotective effects in a rat model of cerebral ischemia-reperfusion injury with diabetes, which can reduce the infarct size and the neurological deficit score. Their exert neuroprotective effects in a rat model of cerebral ischemia-reperfusion injury with diabetes by inhibiting endoplasmic reticulum stress and thereby reducing apoptosis. DA3 is better than liraglutide.
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http://dx.doi.org/10.1016/j.numecd.2020.09.002DOI Listing
January 2021

Changes of Brain Structure in Patients With Metastatic Non-Small Cell Lung Cancer After Long-Term Target Therapy With EGFR-TKI.

Front Oncol 2020 6;10:573512. Epub 2021 Jan 6.

Department of Thoracic Oncology and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Purpose: Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy is the routine treatment for patients with metastatic non-small cell lung cancer (NSCLC) harboring positive EGFR mutations. Patients who undergo such treatment have reported cognitive decline during follow-up. This study, therefore, aimed to evaluate brain structural changes in patients receiving EGFR-TKI to increase understanding of this potential symptom.

Method: The medical records of 75 patients with metastatic NSCLC (without brain metastasis or other co-morbidities) who received EGFR-TKI therapy from 2010 to 2017 were reviewed. The modified Scheltens Visual Scale and voxel-based morphometry were used to evaluate changes in white matter lesions (WML) and gray matter volume (GMV), respectively.

Results: The WML scores were higher at the 12-month [8.65 ± 3.86; 95% confidence interval (CI), 1.60-2.35; p < 0.001] and 24-month follow-ups (10.11 ± 3.85; 95% CI, 2.98-3.87; p < 0.001) compared to baseline (6.68 ± 3.64). At the 24-month follow-up, the visual scores were also significantly higher in younger patients (3.89 ± 2.04) than in older patients (3.00 ± 1.78; p = 0.047) and higher in female patients (3.80 ± 2.04) than in male patients (2.73 ± 1.56; p = 0.023). Additionally, significant GMV loss was observed in sub-regions of the right occipital lobe (76.71 voxels; 95% CI, 40.740-112.69 voxels), left occipital lobe (93.48 voxels; 95% CI, 37.48-149.47 voxels), and left basal ganglia (37.57 voxels; 95% CI, 21.58-53.57 voxels) (all p < 0.005; cluster-level false discovery rate < 0.05).

Conclusions: An increase in WMLs and loss of GMV were observed in patients with metastatic NSCLC undergoing long-term EGFR-TKI treatment. This might reflect an unknown side-effect of EGFR-TKI treatment. Further prospective studies are necessary to confirm our findings.
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http://dx.doi.org/10.3389/fonc.2020.573512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815525PMC
January 2021

Fabrication of flexible composite film based on xylan from pulping process for packaging application.

Int J Biol Macromol 2021 Mar 21;173:285-292. Epub 2021 Jan 21.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, China; Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China. Electronic address:

To realize the application of xylan based film in food and drug packaging, the poor mechanical property and film-forming property of xylan based film must be overcome. Herein, a good oxygen barrier composite film with desired mechanical properties was prepared based on carboxymethly xylan (CMX), chitosan (CS), and graphene oxide (GO). The results of scanning electron microscope revealed the composite film had a dense and continuous structure, which will endow the composite film with excellent mechanical property. As expected, the composite film with the 0.5% mass fraction of GO exhibited best mechanical property, among which the tensile stress, tensile strain, and Young's modulus of the composite film reached 50.81 MPa, 47.61%, and 1.39 GPa, respectively. The oxygen barrier properties of the composite films significantly increased with the addition of graphene oxide due to the dense, stacked multilayer structure. In addition, these composite films exhibited good antibacterial properties. Therefore, these films show great promise in the field of food packaging and wound dressing due to their excellent mechanical, oxygen barrier and antibacterial properties.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.01.128DOI Listing
March 2021

Distribution and therapeutic outcomes of intergenic sequence-ALK fusion and coexisting ALK fusions in lung adenocarcinoma patients.

Lung Cancer 2021 02 9;152:104-108. Epub 2021 Jan 9.

Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China. Electronic address:

Introduction: Patients with ALK rearranged non-small-cell lung cancer (NSCLC) show survival benefits from tyrosine-kinase inhibitor (TKI). Widely application of DNA sequencing revealed various rearrangement pattern in addition to single EML4-ALK fusion. Here, we retrospectively analyzed the distribution and coexistence of ALK rearrangement and therapeutic outcome of patients with ALK rearranged NSCLC.

Method: ALK positive NSCLC patients were screened at West China Hospital. NGS was performed on pre-treatment samples. Clinical characteristics and therapeutic outcomes were collected to retrospectively analyzed.

Results: Among the 89 patients with 22 ALK rearrangements, fusions of intergenic sequences with ALK were found in 15 (16.85 %). Non-EML4-ALK fusions were present in 18 patients (20.22 %). Coexistence of rearrangements were present in 16 patients (17.98 %). Intergenic sequence-ALK and non-EML4-ALK fusions occurred at higher rates in patients with at least two fusions (62.5 % versus 6.85 % for intergenic sequence-ALK, 62.5 % versus 10.96 % for non-EML4-ALK). There were 40 ALK-rearranged NSCLC patients receiving the first-line crizotinib. The median progression-free survival (PFS) was 9.7 months when excluding three lost patients. In the seven patients who had at least two fusions, the median PFS was 11.9 months, compared with 9.0 months among those with single (p = 0.336). No significant difference in median PFS was found between patients with and without intergenic-ALK fusion (12.0 months versus 9.6 months, p = 0.989). The median PFS was 9.0 months in patients harboring a single EML4-ALK fusion versus 13.0 months in those with other ALK alterations (P = 0.890). The PFS of patients with single intergenic sequence-ALK fusion reached to 2.9 months, 27 months, and 28.9 months respectively.

Conclusion: Our study reports the distribution of intergenic sequence-ALK and coexisting fusions in ALK-rearranged NSCLC. Intergenic sequence-ALK and non-EML4-ALK are prone to coexist with other fusions. Neither intergenic sequence-ALK nor coexistence of fusions had a significant effect on the therapeutic benefit of treatment with crizotinib.
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http://dx.doi.org/10.1016/j.lungcan.2020.12.018DOI Listing
February 2021

Impact of Inductively Coupled Plasma Etching Conditions on the Formation of Semi-Polar ( 11 2 ¯ 2 ) and Non-Polar ( 11 2 ¯ 0 ) GaN Nanorods.

Nanomaterials (Basel) 2020 Dec 20;10(12). Epub 2020 Dec 20.

Department of Electrical & Electronic Engineering, University of Bath, Bath BA2 7AY, UK.

The formation of gallium nitride (GaN) semi-polar and non-polar nanostructures is of importance for improving light extraction/absorption of optoelectronic devices, creating optical resonant cavities or reducing the defect density. However, very limited studies of nanotexturing via dry etching have been performed, in comparison to wet etching. In this paper, we investigate the formation and morphology of semi-polar (112¯2) and non-polar (112¯0) GaN nanorods using inductively coupled plasma (ICP) etching. The impact of gas chemistry, pressure, temperature, radio-frequency (RF) and ICP power and time are explored. A dominant chemical component is found to have a significant impact on the morphology, being impacted by the polarity of the planes. In contrast, increasing the physical component enables the impact of crystal orientation to be minimized to achieve a circular nanorod profile with inclined sidewalls. These conditions were obtained for a small percentage of chlorine (Cl) within the Cl + argon (Ar) plasma combined with a low pressure. Damage to the crystal was reduced by lowering the direct current (DC) bias through a reduction of the RF power and an increase of the ICP power.
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http://dx.doi.org/10.3390/nano10122562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766584PMC
December 2020

Constructing a new polymer acceptor enabled non-halogenated solvent-processed all-polymer solar cell with an efficiency of 13.8.

Chem Commun (Camb) 2021 Jan;57(7):935-938

Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China.

A new polymer acceptor, PS1, was developed by connecting the non-fullerene acceptor building block of dithienothiophen[3,2-b]pyrrolobenzotriazole capped with 3-(dicyanomethylidene)-indan-1-one through a thiophene spacer. The solubilizing alkyl side groups in the central unit enabled PS1 to be readily dissolved in non-chlorinated solvents. By using 2-methyltetrahydrofuran as the processing solvent, the all-polymer solar cell (all-PSC) containing PS1 and a polymer donor PTzBI-oF in the light-harvesting layer exhibited an impressively high power conversion efficiency of 13.8%.
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http://dx.doi.org/10.1039/d0cc07213cDOI Listing
January 2021

Phosphatase and Tensin Homolog Mutation in Immune Cell Infiltration and Clinicopathological Features of Low-Grade Gliomas.

Front Mol Biosci 2020 10;7:562416. Epub 2020 Dec 10.

Xi'an Medical University, Xi'an, China.

The mutation of phosphatase and tensin homolog () genes frequently occur in low-grade gliomas (LGGs) and are deeply associated with a poor prognosis and survival rate. In order to identify the crucial signaling pathways and genes associated with the mutation, we performed bioinformatics analysis on the RNA sequencing results, which were obtained from The Cancer Genome Atlas database. A total of 352 genes were identified as differentially expressed genes (DEGs). The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested that the DEGs were significantly enriched in categories associated with cell division and multiple metabolic progressions. The histological stage was significantly associated with expression levels. In addition, the mutation was associated with an abundance of cells, neutrophils, macrophages, dendritic cells, and cells during tumor infiltration. The results showed that patients with LGGs harboring the mutation had a poor prognosis and more serious immune cell infiltration occurred depending on the mRNA expression level. These results demonstrated that multiple genes and signaling pathways play a key role in LGG from low grade to high grade, and are associated with mutations. In this study, we outlined an approach to assess the influence of mutations on prognosis, overall survival, and messenger RNA (mRNA) expression. Our results provided alternative strategies for the personalized treatment of patients with LGGs harboring the mutation.
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http://dx.doi.org/10.3389/fmolb.2020.562416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758504PMC
December 2020

Copper Thiocyanate as an Anode Interfacial Layer for Efficient Near-Infrared Organic Photodetector.

ACS Appl Mater Interfaces 2021 Jan 22;13(1):1027-1034. Epub 2020 Dec 22.

Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.

Interfacial modification between the electrode and the overlying organic layer has significant effects on the charge injection and collection and thus the device performance of organic photodetectors. Here, we used copper(I) thiocyanate (CuSCN) as the anode interfacial layer for organic photodetector, which was inserted between the anode and an organic light-sensitive layer. The CuSCN layer processed with ethyl sulfide solution presented similar optical properties to the extensively used anode interlayer of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), while the relatively shallow conduction band of CuSCN resulted in a much higher electron-injection barrier from the anode and shunt resistance than those of PEDOT:PSS. Moreover, the CuSCN-based device also exhibited an increased depletion width for the PEDOT:PSS-based device, as indicated by the Mott-Schottky analysis. These features lead to the dramatically reduced dark current density of 2.7 × 10 A cm and an impressively high specific detectivity of 4.4 × 10 cm Hz W under -0.1 V bias and a working wavelength of 870 nm. These findings demonstrated the great potential of using CuSCN as an anode interfacial layer for developing high-performance near-infrared organic photodetectors.
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http://dx.doi.org/10.1021/acsami.0c18260DOI Listing
January 2021

Predicting severe or critical symptoms in hospitalized patients with COVID-19 from Yichang, China.

Aging (Albany NY) 2020 12 9;13(2):1608-1619. Epub 2020 Dec 9.

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.

Objectives: We aimed to identify potential risk factors for severe or critical coronavirus disease 2019 (COVID-19) and establish a prediction model based on significant factors.

Methods: A total of 370 patients with COVID-19 were consecutively enrolled at The Third People's Hospital of Yichang from January to March 2020. COVID-19 was diagnosed according to the COVID-19 diagnosis and treatment plan released by the National Health and Health Committee of China. Effect-size estimates are summarized as odds ratio (OR) and 95% confidence interval (CI).

Results: 326 patients were diagnosed with mild or ordinary COVID-19, and 44 with severe or critical COVID-19. After propensity score matching and statistical adjustment, eight factors were significantly associated with severe or critical COVID-19 ( <0.05) relative to mild or ordinary COVID-19. Due to strong pairwise correlations, only five factors, including diagnostic delay (OR, 95% CI, : 1.08, 1.02 to 1.17, 0.048), albumin (0.82, 0.75 to 0.91, <0.001), lactate dehydrogenase (1.56, 1.14 to 2.13, 0.011), white blood cell (1.27, 1.08 to 1.50, 0.004), and neutrophil (1.40, 1.16 to 1.70, <0.001), were retained for model construction and performance assessment. The nomogram model based on the five factors had good prediction capability and accuracy (C-index: 90.6%).

Conclusions: Our findings provide evidence for the significant contribution of five independent factors to the risk of severe or critical COVID-19, and their prediction was reinforced in a nomogram model.
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http://dx.doi.org/10.18632/aging.202261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880337PMC
December 2020