Publications by authors named "Feng Pan"

814 Publications

Protein DEK and DTA Aptamers: Insight Into the Interaction Mechanisms and the Computational Aptamer Design.

Front Mol Biosci 2022 19;9:946480. Epub 2022 Jul 19.

School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.

By blocking the DEK protein, DEK-targeted aptamers (DTAs) can reduce the formation of neutrophil extracellular traps (NETs) to reveal a strong anti-inflammatory efficacy in rheumatoid arthritis. However, the poor stability of DTA has greatly limited its clinical application. Thus, in order to design an aptamer with better stability, DTA was modified by methoxy groups (DTA_OMe) and then the exact DEK-DTA interaction mechanisms were explored through theoretical calculations. The corresponding 2'-OCH-modified nucleotide force field was established and the molecular dynamics (MD) simulations were performed. It was proved that the 2'-OCH-modification could definitely enhance the stability of DTA on the premise of comparative affinity. Furthermore, the electrostatic interaction contributed the most to the binding of DEK-DTA, which was the primary interaction to maintain stability, in addition to the non-specific interactions between positively-charged residues (e.g., Lys and Arg) of DEK and the negatively-charged phosphate backbone of aptamers. The H-bond network analysis reminded that eight bases could be mutated to probably enhance the affinity of DTA_OMe. Therein, replacing the 29th base from cytosine to thymine of DTA_OMe was theoretically confirmed to be with the best affinity and even better stability. These research studies imply to be a promising new aptamer design strategy for the treatment of inflammatory arthritis.
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http://dx.doi.org/10.3389/fmolb.2022.946480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345330PMC
July 2022

Potential pollution assessment of labile trace metals in Xixi River estuary sediments in Xiamen, China.

J Contam Hydrol 2022 Jul 28;250:104055. Epub 2022 Jul 28.

College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, PR China. Electronic address:

The release of trace metals caused by industrial effluents and anthropogenic activities has been recorded in the Xixi River estuary, southern China. However, a thorough understanding of the behavior of trace heavy metals in Xixi River sediments is lacking. A total of 12 sediment cores were collected in June and December in the upper estuary section and mouth of the estuary. Here, an in situ high-resolution sampling technique, namely, diffusive gradients in thin films (DGT), was employed to acquire profiles of trace element concentrations and the release of bioavailable metals from sediments in different seasons. A three-step Community Bureau of Reference (BCR) sequential extraction method was used to explore the chemical speciation of trace metals in different seasons and to thereby assess the release potential of trace elements in sediments. The BCR sequential extraction results showed that the trace metals Fe, Mn, Co and Pb were mainly in the residual fraction, which rarely influences living organisms. The total mobile fractions (F1 + F2 + F3) of all trace metals were higher in winter than in summer, suggesting that accumulation occurred from summer to winter. DGT measurements showed that the intensity of sulfate reduction was higher in summer than in winter because of the high temperatures and high organic matter in summer. The intensity of sulfate and Mn(III/IV) reduction increased from the upper estuary section to the lower estuary. Fe(III) reduction decreased in summer but increased slowly in winter. The Pearson correlation results showed that the release of DGT-labile Co in pore water was related to Mn(III/IV) reduction, while the release of DGT-labile Pb was basically not controlled by the Fe-Mn-S redox transition. Abnormally high DGT-labile Pb concentrations were observed at the sampling station (XR3) closest to the estuary in winter, which might have been caused by the high Pb content in the local micro-sediments.
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http://dx.doi.org/10.1016/j.jconhyd.2022.104055DOI Listing
July 2022

Effects of fiddler crab bioturbation on the geochemical migration and bioavailability of heavy metals in coastal wetlands.

J Hazard Mater 2022 09 15;437:129380. Epub 2022 Jun 15.

State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, PR China.

Fiddler crabs, found in coastal wetlands worldwide, function as ecosystem engineers. Their burrowing activity can significantly alter biogeochemistry at the local scale, however, the mobility of heavy metals (HMs) in burrow sediments remains unclear. Here, we used diffusive gradients in thin-film probes to obtain bioavailable Fe and HMs (Cu, Zn, Ni, Cd, Pb, Co, and Mo) in crab burrows from coastal wetlands (mudflats, salt marshes, and mangroves). The depth-profile results showed that most HMs were enriched at shallow and deep depths but deficient at middle depths. We highlighted that bioturbation improved oxic conditions, enhanced HM concentrations, and favored dissolved HM retention in burrow sediments, which served as a sink for overlying water HMs via burrow flushing but a potential source of particle HMs via enhanced resuspension. In deep anoxic layers, Fe(III) reduction drove the remobilization of HMs, except Cu and Mo, leading to the co-release of HMs with Fe. This Fe-HM coupling/decoupling was verified using enhanced two-dimensional high-resolution imaging, which revealed highly spatial heterogeneity of multiple HMs. Moreover, the hydrological conditions regulating bioturbation effects on HM behavior varied across different coastal wetlands. With coastal environmental changes, the key role of ubiquitous bioturbation in HM migration and bioavailability should be reconsidered.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129380DOI Listing
September 2022

Bipolar charge collecting structure enables overall water splitting on ferroelectric photocatalysts.

Nat Commun 2022 Jul 22;13(1):4245. Epub 2022 Jul 22.

State Key Laboratory of Catalysis, Dalian National Laboratory for Clean Energy, iChEM, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

Ferroelectrics are considered excellent photocatalytic candidates for solar fuel production because of the unidirectional charge separation and above-gap photovoltage. Nevertheless, the performance of ferroelectric photocatalysts is often moderate. A few studies showed that these types of photocatalysts could achieve overall water splitting. This paper proposes an approach to fabricating interfacial charge-collecting nanostructures on positive and negative domains of ferroelectric, enabling water splitting in ferroelectric photocatalysts. The present study observes efficient accumulations of photogenerated electrons and holes within their thermalization length (~50 nm) around Au nanoparticles located in the positive and negative domains of a BaTiO single crystal. Photocatalytic overall water splitting is observed on a ferroelectric BaTiO single crystal after assembling oxidation and reduction cocatalysts on the positively and negatively charged Au nanoparticles, respectively. The fabrication of bipolar charge-collecting structures on ferroelectrics to achieve overall water splitting offers a way to utilize the energetic photogenerated charges in solar energy conversion.
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http://dx.doi.org/10.1038/s41467-022-32002-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307613PMC
July 2022

Establishing a Resilient Conductive Binding Network for Si-Based Anodes via Molecular Engineering.

Acc Chem Res 2022 Aug 22;55(15):2088-2102. Epub 2022 Jul 22.

School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China.

ConspectusSilicon-based anode materials have become a research hot spot as the most promising candidates for next-generation high-capacity lithium-ion batteries. However, the irreversible degradation of the conductive network in the anode and the resultant dramatic capacity loss have become two ultimate challenges that stem from inherent characteristics of the Si-based materials, including poor conductivity and massive volume changes (up to 300%) during cycling. Apart from optimization of the active materials, one effective way to stabilize high-capacity Si-based anodes is by designing polymeric binders to reinforce the conductive networks during repeated charge and discharge processes. As an inactive component in the electrode, the binder not only holds other components (e.g., active materials, conductive agents, and current collectors) together to maintain the mechanical integrity of the electrode but also serves as a thickener to facilitate the homogeneous distribution of particles. Therefore, binders play a key role in Si-based anodes by maintaining the integrity of conductive networks in the electrode.In this Account, on the basis of the extensive binder-related work on Si-based anodes since the 2000s, efforts made on maintaining the conductive network can be categorized into two main strategies: (1) stabilization of the primary conductive network (which generally refers to conductive agents) by enhancing the binding strength and resilience of the binding between electrode components (i.e., Si particles, conducting agents, and current collectors) via various interactions (e.g., dipolar interactions and covalent bonds) and (2) construction of the secondary conductive network by employing conductive binders, which serve as a molecular-level conductive layer on active materials. In this sense, functional groups in binders can be divided into two categories: mechanical structural units and conductive structural units. On the one hand, functional groups with strong polarities (e.g., -OH, -COOH, -NH and -CONH-) generally serve as binding structural units because of their bonding tendencies; on the other hand, exhibiting high electronic conductivity, conjugated functional groups (e.g., -CHOS-, -CH, -CH-, and -CHN-) are commonly found in conductive binders. Through establishing the correlation between structural units and their corresponding properties, we systematically summarize the optimization strategies and design principles of binders to achieve a robust conductive network in Si-based anodes. In addition, integration of desirable mechanical properties and high conductivity into the binder in order to achieve a multidimensionally stable conductive network is proposed. Through an insightful retrospective and prospective on binders, a key electrode component, we hope to provide a fresh perspective on performance optimization of Si-based anodes.
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http://dx.doi.org/10.1021/acs.accounts.2c00259DOI Listing
August 2022

High-accuracy virtual testing of air conditioner's digital twin focusing on key material's deformation and fracture behavior prediction.

Sci Rep 2022 Jul 20;12(1):12432. Epub 2022 Jul 20.

Shanghai ShareFEA Engineering Technology Co., Ltd., Shanghai, China.

The concept of digital twin has been introduced for some time, yet one fundamental element of digital twin, digital material, has not been thoroughly studied. To interact with the physical product, the digital twin should always truthfully reflect the responses under various stimuli. In this paper, the deformation and fracture behavior of high impact polystyrene (HIPS) under the influencing factors of strain rate and stress triaxiality are studied to construct the material's digital model. A digital twin of air conditioner product is further built and tested under virtual drop test. Comparing to experimental results, the acceleration curve, crazing induced whitening and the fracture events can all be captured by the digital twin. Our work demonstrates the importance of material characterization as an essential step to construct an accurate digital twin and shows a promising future of digital twin in virtual testing to replace traditional "trial and error" experiments.
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http://dx.doi.org/10.1038/s41598-022-16511-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300695PMC
July 2022

Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy.

Biomaterials 2022 Jul 8;287:121673. Epub 2022 Jul 8.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China. Electronic address:

Vitamin C (VitC) has shown great promise to promote cancer immunotherapy, however, its high hydrophilicity makes it quickly excreted, leading to limited therapeutic efficiency even with frequent high-dose administration. Herein, we provide a pioneering report about the employment of VitC amphiphile self-assembled nanofiber hydrogels for enhanced cancer immunotherapy. Specifically, driven by hydrogen bonding and hydrophobic interactions, the synthesized VitC amphiphile, consisting of a hydrophilic VitC headgroup and a hydrophobic alkyl chain, could self-assemble into an injectable nanofiber hydrogel with self-healing properties. The formed VitC hydrogel not only serves as a reservoir for VitC but also acts as an effective delivery platform for stimulator of interferon genes (STING) agonist-4 (SA). Interestingly, the VitC hydrogel itself exhibits antitumor effects by upregulating genes related to interferon (IFN) signaling, apoptotic signaling and viral recognition and defense. Moreover, the SA-encapsulated VitC hydrogel ([email protected] hydrogel) synergistically activated the immune system to inhibit the progression of both local and abscopal tumors.
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http://dx.doi.org/10.1016/j.biomaterials.2022.121673DOI Listing
July 2022

[Forecasting of Emission Co-reduction of Greenhouse Gases and Pollutants for the Road Transport Sector in Lanzhou Based on the LEAP Model].

Huan Jing Ke Xue 2022 Jul;43(7):3386-3395

College of Atmospheric Science, Lanzhou University, Lanzhou 730000, China.

With the continuous increase in transportation activities, the transportation sector has become an important source of global greenhouse gases. In 2019, road vehicles accounted for nearly three-quarters of the CO emissions of the entire transportation sector and will be the key to achieving carbon peaks in the transportation sector. At the same time, air pollutants emitted by road vehicles are also one of the threats to the environment and human health. Based on the long-range energy alternatives planning system (LEAP) model, we constructed the baseline (BAU) scenario, low-carbon (LC) scenario, and enhanced low-carbon (ELC) scenario for the development of the road transport sector in Lanzhou from 2015 to 2040 and simulated energy consumption and emission co-reduction of greenhouse gases and pollutants under policies and measures. The results showed that the energy consumption and CO emissions of the LC scenario will peak in 2026, whereas those in the ELC scenario will peak in 2020. In these two scenarios, pollutant emissions such as NO, CO, HC, PM, and PM began to decline sharply between 2015 and 2017, and the downward trend will slow down gradually around 2023. Based on the feasibility of measures and the cost of abatement, the LC scenario can be used as a road vehicle carbon peak scenario in Lanzhou. In this scenario, the reduction rates of energy consumption, CO, NO, CO, HC, PM, and PM emissions will reach -24.17%, -26.57%, -55.38%, -65.91%, -72.87%, -76.66%, and -77.18% compared with those under the BAU scenario by 2040. At present, the road vehicles in Lanzhou City should focus on structural optimization measures such as clean-energy use of public transportation, electrification of small passenger cars, and phasing out old cars, as well as vigorously promoting low-carbon travel and improving energy efficiency accompanying the development of automotive technology. These efforts will effectively control CO and pollutant emissions by road vehicles, and carbon peaks will be achieved as soon as possible. In addition, it is necessary to pay attention to the changes in vehicle types during the implementation of these measures, which most contribute CO and various pollutants, in order to make the measures more targeted by changing the number or the market share of new energy of focused vehicle types.
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http://dx.doi.org/10.13227/j.hjkx.202109119DOI Listing
July 2022

Strategies and characterization methods for achieving high performance PEO-based solid-state lithium-ion batteries.

Chem Commun (Camb) 2022 Jul 21;58(59):8182-8193. Epub 2022 Jul 21.

School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.

Polyethylene oxide (PEO) based polymer electrolytes have been widely used in solid-state lithium batteries (SSBs) owing to the high solubility of lithium salt, favourable ionic conductivity, flexibility for improved interfacial contact and scalable processing. In this work, we summarize the main limitations remaining to be solved before the large-scale commercialization of PEO-based SSBs, including (1) improving ionic conductivity toward high-rate performance and lower operating temperature, (2) enhancing mechanical strength for improved lithium dendrite resistance and large-scale processing, (3) strengthening electrochemical stability to match high energy density electrodes with high voltage, and (4) achieving high thermal stability toward safe operation. Meanwhile, the characterization methods to investigate the ion transportation mechanism, lithium dendrite growth and decomposition reaction are also discussed.
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http://dx.doi.org/10.1039/d2cc02306gDOI Listing
July 2022

Prospective dietary polyunsaturated fatty acid intake is associated with trajectories of fatty liver disease: an 8 year follow-up study from adolescence to young adulthood.

Eur J Nutr 2022 Jul 3. Epub 2022 Jul 3.

Nutritional Epidemiology, Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.

Background And Aim: Dietary fat intake has long been associated with fatty liver. Our study aimed to determine the effect of dietary fats on longitudinal fatty liver index (FLI) trajectories from adolescence to young adulthood.

Methods: Nine hundred eighty-five participants in the Raine Study, Perth, Western Australia, Australia, had cross-sectional assessments at ages 14, 17, 20 and 22 years, during which anthropometric measurements and blood tests were obtained. FLI trajectories were derived from the longitudinal FLI results. Dietary fat intake was measured with a semi-quantitative food frequency questionnaire at 14 years and log multinominal regression analyses were used to estimate relative risks.

Results: Three FLI trajectories were identified and labelled as stable-low (79.1%, N = 782), low-to-high (13.9%, N = 132), and stable-high (7%, N = 71). The low-to-high group associated with an increased intake of the long-chain polyunsaturated fatty acids EPA, DPA and DHA (RR 1.27, 95% CI 1.10-1.48) relative to the stable-low group. Compared to the stable-low group, omega-6 and the ratio of omega-6 to omega-3 in the stable-high group were associated with an increased relative risk of 1.34 (95% CI 1.02-1.76) and 1.10 (95% CI 1.03-1.16), respectively.

Conclusion: For those at high risk of fatty liver in early adolescence, high omega-6 fatty acid intake and a high ratio of omega-6 to omega-3 fatty acids are associated with increased risk of fatty liver. There should be caution in assuming these associations are causal due to possible undetected and underestimated confounding factors.
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http://dx.doi.org/10.1007/s00394-022-02934-8DOI Listing
July 2022

Orthogonal interlayer coupling in an all-antiferromagnetic junction.

Nat Commun 2022 Jun 28;13(1):3723. Epub 2022 Jun 28.

Key Laboratory of Advanced Materials (MOE), School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

In conventional ferromagnet/spacer/ferromagnet sandwiches, noncollinear couplings are commonly absent because of the low coupling energy and strong magnetization. For antiferromagnets (AFM), the small net moment can embody a low coupling energy as a sizable coupling field, however, such AFM sandwich structures have been scarcely explored. Here we demonstrate orthogonal interlayer coupling at room temperature in an all-antiferromagnetic junction FeO/CrO/FeO, where the Néel vectors in the top and bottom FeO layers are strongly orthogonally coupled and the coupling strength is significantly affected by the thickness of the antiferromagnetic CrO spacer. From the energy and symmetry analysis, the direct coupling via uniform magnetic ordering in CrO spacer in our junction is excluded. The coupling is proposed to be mediated by the non-uniform domain wall state in the spacer. The strong long-range coupling in an antiferromagnetic junction provides an unexplored approach for designing antiferromagnetic structures and makes it a promising building block for antiferromagnetic devices.
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http://dx.doi.org/10.1038/s41467-022-31531-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240048PMC
June 2022

A Systematic Analysis Reveals the Prognostic and Immunological Role of Reptin/RUVBL2 in Human Tumors.

Front Genet 2022 8;13:911223. Epub 2022 Jun 8.

Department of Clinical Laboratory, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Reptin/RUVBL2 is involved in the remodeling of chromatin, DNA damage repair, and regulation of the cell cycle, all of which help to play essential roles in cancer. However, relevant pan-cancer analysis of Reptin is lacking. This study first investigated the potential oncogenic roles of Reptin and revealed a relationship between Reptin with clinicopathological characteristics and immune infiltration based on big data. Here, we showed that Reptin is overexpressed in many cancers. A significant association exists between the expression of Reptin and the prognosis of cancer cases. Reptin had a meaningful interaction with the immune infiltration of CD4 Th1 cells and immune modulator genes in multiple cancer types. And negative correlation exists between Reptin and cancer-associated fibroblasts in BRCA, PRAD, TGCT, and THYM. A significant negative association exists between Reptin and regulatory T cells in TGCT and THCA. Moreover, Reptin is significantly associated with genomic heterogeneity, DNA mismatch repair genes, methyltransferase, and RNA modification genes in specific cancer types. Spliceosome, Hippo signaling pathway, DNA replication pathway, and acetyltransferase activity-associated functions were observed in the effect of Reptin on the tumor. This systematic analysis highlights Reptin as a vital cancer regulator among numerous genes and proved its potential prognosticator value and therapeutic target role for specific tumor types.
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http://dx.doi.org/10.3389/fgene.2022.911223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213802PMC
June 2022

[Eating out of home of urban adults in eighteen provinces (autonomous regions, municipalities) of China in 2017].

Wei Sheng Yan Jiu 2022 May;51(3):397-427

China National Center for Food Safety Risk Assessment, Beijing 100022, China.

Objective: To analyze the eating out of home behavior of urban adults in China.

Methods: Samples were chosen from China Food Consumption Survey in 2017. A total of 17 234 participants aged 18 and above were included in the final analysis. The food frequency questionnaire were used to collect eating out of home status in the past week. χ~2 test was used to compare the difference in the rate of eating out of home and dining places among different groups. Non-parametric test was used to compare the differences in dining out times.

Results: The overall prevalence of eating out of home was 55.6% in urban adults aged in 2017. The average number of eating out of home was 2.8 times. The proportion of eating in hotels and restaurants was 36.0%. The proportion of eating in the canteen of school, workplace and other places was 19.8%. The rate of eating out of home and dining out times were higher among male, 18-44 years old, people with higher educational level and higher household income. The proportion of students eating in canteen was higher. The proportion of professional technicians and service staff eating in hotels and restaurants were higher.

Conclusion: Eating out of home is more common among urban adults aged 18 and above in China. Young people aged 18-44 years old eat out more often in the past week. The proportion of people eating in hotels and restaurants is higher.
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http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2022.03.009DOI Listing
May 2022

Effect of Psychological Intervention-Assisted Comfort Nursing Based on PERMA Model on Stress and Psychological Changes of Patients after Breast Cancer Surgery.

Comput Math Methods Med 2022 7;2022:1853754. Epub 2022 Jun 7.

Department of Hospital Infection-Control Department, People's Hospital of Dongxihu District, Wuhan, Hubei 430040, China.

Objective: To investigate the emotional response, stress and psychological changes of patients with breast cancer after surgery for psychological intervention-assisted comfort nursing based on the PERMA model.

Methods: A total of 100 postoperative breast cancer patients admitted to our hospital from March 2019 to June 2021 were selected as prospective research objects. According to a random number table, they were divided into a control group and an observation group with 50 cases each. Among them, the control group implemented routine nursing care, and the observation group implemented psychological intervention-assisted comfort care based on the PERMA model on the basis of the control group. The differences in compliance behavior, self-care ability, emotional response, stress response changes, and pain scores of the two groups of breast cancer patients before and after nursing were compared.

Results: After nursing, the mental behavior scores, exercise scores, medication scores, and balanced diet scores of the two groups of breast cancer patients after surgery were significantly improved. The observation group's compliance behavior scores were significantly higher than those of the control group. In the two groups of breast cancer patients, postoperative anxiety, depression, fatigue, and anger of the patients were significantly improved, and the emotional response score of the observation group was significantly lower than that of the control group. The self-care skill score, self-responsibility score, health knowledge score, and self-concept score of the observation group were excellent compared with those of the control group; the difference was significant by the above statistics ( < 0.05). The HR and MAP of the control group during the operation were higher than those 1 day before the start of the operation and decreased at the end of the operation, but still higher than the level 1 day before the start of the operation; the change trend of the observation group was the same as that of the control group, but there were differences between the time points. There was no significant significance ( > 0.05). The HR and MAP of the observation group during the operation were lower than those of the control group, and the MAP at the end of the operation was lower than that of the control group. This difference was statistically significant ( < 0.05). In the control group, the values increased at the time point during the operation and decreased at the end of the operation, but still higher than the level 1 day before the operation. The difference was statistically significant ( < 0.05). The change trend of the observation group was the same as that of the control group; and the values during and at the end of the operation were all lower than those of the control group. This difference was statistically significant ( < 0.05). The pain scores of the two groups of patients at different time points were significantly improved, and the observation group was significantly less than the control group. This difference was statistically significant ( < 0.05).

Conclusion: Psychological intervention-assisted comfort nursing can effectively enhance the compliance behavior of patients after breast cancer surgery, improve the emotional response, stress response, and pain of patients, and have certain reference value for the nursing of patients after breast cancer surgery.
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http://dx.doi.org/10.1155/2022/1853754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197632PMC
June 2022

Sleep deprivation altered encoding of basolateral amygdala on fear acquisition.

Cereb Cortex 2022 Jun 14. Epub 2022 Jun 14.

Faculty of Psychology, Southwest University, Chongqing 400715, China.

Sleep deprivation (SD) may lead to the development of fear- and anxiety-related emotional disorders. However, the neural mechanisms underlying the effects of SD on fear acquisition are unclear. Here, we tested whether and how SD influences the behavioral and neural manifestations of fear acquisition. We found that subjective fear ratings and objective fear indices (skin conductance response [SCR]) in the SD group were greater than those in the control group during fear acquisition, suggesting that SD facilitated fear acquisition (nSD = 18 and ncontrol = 23 for self-reported rating analysis; nSD = 10 and ncontrol = 10 for SCR analysis). Neuroimaging data showed that the SD group exhibited stronger activity in the left basolateral amygdala (BLA) and left superficial amygdala (SFA). Moreover, the left BLA activity, which positively correlated with the objective fear indices, significantly mediated the effect of SD on fear acquisition. Together, the present findings indicate that SD facilitates fear acquisition by augmenting threat-specific encoding in the BLA, which may be a potential biomarker of the risk of developing fear-related disorders under traumatic and distressing situations.
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http://dx.doi.org/10.1093/cercor/bhac233DOI Listing
June 2022

Graph-based discovery and analysis of atomic-scale one-dimensional materials.

Natl Sci Rev 2022 Jun 26;9(6):nwac028. Epub 2022 Feb 26.

School of Advanced Materials, Peking University, Shenzhen Graduate School, Shenzhen 518055, China.

Recent decades have witnessed an exponential growth in the discovery of low-dimensional materials (LDMs), benefiting from our unprecedented capabilities in characterizing their structure and chemistry with the aid of advanced computational techniques. Recently, the success of two-dimensional compounds has encouraged extensive research into one-dimensional (1D) atomic chains. Here, we present a methodology for topological classification of structural blocks in bulk crystals based on graph theory, leading to the identification of exfoliable 1D atomic chains and their categorization into a variety of chemical families. A subtle interplay is revealed between the prototypical 1D structural motifs and their chemical space. Leveraging the structure graphs, we elucidate the self-passivation mechanism of 1D compounds imparted by lone electron pairs, and reveal the dependence of the electronic band gap on the cationic percolation network formed by connections between structure units. This graph-theory-based formalism could serve as a source of stimuli for the future design of LDMs.
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http://dx.doi.org/10.1093/nsr/nwac028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170357PMC
June 2022

Origin of structural degradation in Li-rich layered oxide cathode.

Nature 2022 06 8;606(7913):305-312. Epub 2022 Jun 8.

Chemical Sciences and Engineering Division, Argonne National Laboratory, Lemont, IL, USA.

Li- and Mn-rich (LMR) cathode materials that utilize both cation and anion redox can yield substantial increases in battery energy density. However, although voltage decay issues cause continuous energy loss and impede commercialization, the prerequisite driving force for this phenomenon remains a mystery Here, with in situ nanoscale sensitive coherent X-ray diffraction imaging techniques, we reveal that nanostrain and lattice displacement accumulate continuously during operation of the cell. Evidence shows that this effect is the driving force for both structure degradation and oxygen loss, which trigger the well-known rapid voltage decay in LMR cathodes. By carrying out micro- to macro-length characterizations that span atomic structure, the primary particle, multiparticle and electrode levels, we demonstrate that the heterogeneous nature of LMR cathodes inevitably causes pernicious phase displacement/strain, which cannot be eliminated by conventional doping or coating methods. We therefore propose mesostructural design as a strategy to mitigate lattice displacement and inhomogeneous electrochemical/structural evolutions, thereby achieving stable voltage and capacity profiles. These findings highlight the significance of lattice strain/displacement in causing voltage decay and will inspire a wave of efforts to unlock the potential of the broad-scale commercialization of LMR cathode materials.
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http://dx.doi.org/10.1038/s41586-022-04689-yDOI Listing
June 2022

Corrigendum: Preliminary Exploration of Transpedal Lymphangiography With High-Dose Ethiodized Oil Application in the Treatment of Postoperative Chylothorax.

Front Med (Lausanne) 2022 19;9:929540. Epub 2022 May 19.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

[This corrects the article DOI: 10.3389/fmed.2021.754781.].
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http://dx.doi.org/10.3389/fmed.2022.929540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161287PMC
May 2022

Intercalation-driven ferroelectric-to-ferroelastic conversion in a layered hybrid perovskite crystal.

Nat Commun 2022 Jun 3;13(1):3104. Epub 2022 Jun 3.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.

Two-dimensional (2D) organic-inorganic hybrid perovskites have attracted intense interests due to their quantum well structure and tunable excitonic properties. As an alternative to the well-studied divalent metal hybrid perovskite based on Pb, Sn and Cu, the trivalent metal-based (eg. Sb with ns2 outer-shell electronic configuration) hybrid perovskite with the AMX formula (A = monovalent cations, M = trivalent metal, X = halide) offer intriguing possibilities for engineering ferroic properties. Here, we synthesized 2D ferroelectric hybrid perovskite (TMA)SbCl with measurable in-plane and out-of-plane polarization. Interestingly, (TMA)SbCl can be intercalated with FeCl ions to form a ferroelastic and piezoelectric single crystal, (TMA)-Fe(iii)Cl-SbCl. Density functional theory calculations were carried out to investigate the unusual mechanism of ferroelectric-ferroelastic crossover in these crystals.
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http://dx.doi.org/10.1038/s41467-022-30822-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166815PMC
June 2022

Elastic Lattice Enabling Reversible Tetrahedral Li Storage Sites in a High-Capacity Manganese Oxide Cathode.

Adv Mater 2022 Jul 23;34(30):e2202745. Epub 2022 Jun 23.

School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China.

The key to breaking through the capacity limitation imposed by intercalation chemistry lies in the ability to harness more active sites that can reversibly accommodate more ions (e.g., Li ) and electrons within a finite space. However, excessive Li-ion insertion into the Li layer of layered cathodes results in fast performance decay due to the huge lattice change and irreversible phase transformation. In this study, an ultrahigh reversible capacity is demonstrated by a layered oxide cathode purely based on manganese. Through a wealth of characterizations, it is clarified that the presence of low-content Li MnO domains not only reduces the amount of irreversible O loss; but also regulates Mn migration in LiMnO domains, enabling elastic lattice with high reversibility for tetrahedral sites Li-ion storage in Li layers. This work utilizes bulk cation disorder to create stable Li-ion-storage tetrahedral sites and an elastic lattice for layered materials, with a reversible capacity of 600 mA h g , demonstrated in th range 0.6-4.9 V versus Li/Li at 10 mA g . Admittedly, discharging to 0.6 V might be too low for practical use, but this exploration is still of great importance as it conceptually demonstrates the limit of Li-ions insertion into layered oxide materials.
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http://dx.doi.org/10.1002/adma.202202745DOI Listing
July 2022

Piezoelectric Strain-Controlled Magnon Spin Current Transport in an Antiferromagnet.

Nano Lett 2022 Jun 18;22(12):4646-4653. Epub 2022 May 18.

Key Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

As the core of spintronics, the transport of spin aims at a low-dissipation data process. The pure spin current transmission carried by magnons in antiferromagnetic insulators is natively endowed with superiority such as long-distance propagation and ultrafast speed. However, the traditional control of magnon transport in an antiferromagnet via a magnetic field or temperature variation adds critical inconvenience to practical applications. Controlling magnon transport by electric methods is a promising way to overcome such embarrassment and to promote the development of energy-efficient antiferromagnetic logic. Here, the experimental realization of an electric field-induced piezoelectric strain-controlled magnon spin current transmission through the antiferromagnetic insulator in the YFeO/CrO/Pt trilayer is reported. An efficient and nonvolatile manipulation of magnon propagation/blocking is achieved by changing the relative direction between the Néel vector and spin polarization, which is tuned by ferroelastic strain from the piezoelectric substrate. The piezoelectric strain-controlled antiferromagnetic magnon transport opens an avenue for the exploitation of antiferromagnet-based spin/magnon transistors with ultrahigh energy efficiency.
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http://dx.doi.org/10.1021/acs.nanolett.2c00405DOI Listing
June 2022

A survival analysis based volatility and sparsity modeling network for student dropout prediction.

PLoS One 2022 5;17(5):e0267138. Epub 2022 May 5.

Department of Personnel, Shenyang Polytechnic College, Shenyang, Liaoning, China.

Student Dropout Prediction (SDP) is pivotal in mitigating withdrawals in Massive Open Online Courses. Previous studies generally modeled the SDP problem as a binary classification task, providing a single prediction outcome. Accordingly, some attempts introduce survival analysis methods to achieve continuous and consistent predictions over time. However, the volatility and sparsity of data always weaken the models' performance. Prevailing solutions rely heavily on data pre-processing independent of predictive models, which are labor-intensive and may contaminate authentic data. This paper proposes a Survival Analysis based Volatility and Sparsity Modeling Network (SAVSNet) to address these issues in an end-to-end deep learning framework. Specifically, SAVSNet smooths the volatile time series by convolution network while preserving the original data information using Long-Short Term Memory Network (LSTM). Furthermore, we propose a Time-Missing-Aware LSTM unit to mitigate the impact of data sparsity by integrating informative missingness patterns into the model. A survival analysis loss function is adopted for parameter estimation, and the model outputs monotonically decreasing survival probabilities. In the experiments, we compare the proposed method with state-of-the-art methods in two real-world MOOC datasets, and the experiment results show the effectiveness of our proposed model.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267138PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071151PMC
May 2022

Tuning the exposure of BiVO-{010} facets to enhance the N photofixation performance.

RSC Adv 2021 Aug 27;11(46):28908-28911. Epub 2021 Aug 27.

School of Advanced Materials, Peking University, Shenzhen Graduate School Shenzhen China

Effective separation of photoexcited carriers and chemisorption of the N molecule are two key issues to efficient nitrogen photofixation. The spatial charge separation of BiVO with anisotropic exposed facets, namely the transfer of photoexcited electrons and holes to {010} and {110} facets, respectively, helps to enhance the separation ability of photogenerated carriers. Theoretical calculation results predict that a surface oxygen vacancy is easier to form on the (010) facet than on the (110) facet of BiVO. Accordingly, in this study, enhanced N photofixation performance has been achieved for the first time by tuning the exposure of {010} facets of BiVO.
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http://dx.doi.org/10.1039/d1ra02739eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038164PMC
August 2021

Association Between Obesity and Poor Prognosis in Patients Receiving Anlotinib for Advanced Non-Small Cell Lung Cancer.

Front Pharmacol 2022 30;13:812555. Epub 2022 Mar 30.

Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Anlotinib is a novel anti-angiogenesis drug. In non-small cell lung cancer (NSCLC), high body mass index (BMI) was not associated with worse survival in patients treated with bevacizumab compared with those with normal or low BMI. However, it remains unknown whether such an association still exists in NSCLC patients receiving anlotinib therapy. Hence, we conducted this study to investigate whether BMI is associated with clinical outcomes in patients treated with anlotinib for advanced NSCLC. Data of 554 patients from the ALTER-0302 and the ALTER-0303 trials were analyzed in this study. The patients were classified into non-obesity (BMI <28 kg/m) and obesity (BMI ≥28 kg/m) subgroups. The primary endpoint was overall survival (OS). The secondary endpoints included progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR). OS was defined as the interval between the first drug administration and death. PFS was defined as the time span from the date of initiating the treatment to the first documented progression or death from any cause, whichever occurred first. ORR included complete response (CR) and partial response (PR). There were 354 patients (63.9%) who received anlotinib in this study. Restricted cubic spline model showed a U-shaped relation between BMI and the risk of death in the anlotinib group. In a multivariable Cox regression model, a trend of worse overall survival was observed in obese patients who received anlotinib compared with placebo (HR, 2.33; 95% CI, 0.77-7.06; = 0.136). The interaction between BMI stratification and treatment was significant for OS (P for interaction = 0.038). Our results revealed a U-shaped relationship between BMI and risk of death in patients receiving anlotinib for advanced NSCLC. More importantly, obesity (BMI ≥28 kg/m) might be a potential predictor of use of anlotinib in advanced NSCLC.
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http://dx.doi.org/10.3389/fphar.2022.812555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005904PMC
March 2022

Quantitative Trait Locus Analysis and Identification of Candidate Genes Affecting Seed Size and Shape in an Interspecific Backcross Inbred Line Population of × .

Front Plant Sci 2022 22;13:837984. Epub 2022 Mar 22.

Zhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, China.

Seed size and shape are key agronomic traits affecting seedcotton yield and seed quality in cotton ( spp.). However, the genetic mechanisms that regulate the seed physical traits in cotton are largely unknown. In this study, an interspecific backcross inbred line (BIL) population of 250 BCF lines, derived from the recurrent parent Upland CRI36 () and Hai7124 (), was used to investigate the genetic basis of cotton seed physical traits via quantitative trait locus (QTL) mapping and candidate gene identification. The BILs were tested in five environments, measuring eight seed size and shape-related traits, including 100-kernel weight, kernel length width and their ratio, kernel area, kernel girth, kernel diameter, and kernel roundness. Based on 7,709 single nucleotide polymorphic (SNP) markers, a total of 49 QTLs were detected and each explained 2.91-35.01% of the phenotypic variation, including nine stable QTLs mapped in at least three environments. Based on pathway enrichment, gene annotation, genome sequence, and expression analysis, five genes encoding starch synthase 4, transcription factor PIF7 and MYC4, ubiquitin-conjugating enzyme E27, and THO complex subunit 4A were identified as candidate genes that might be associated with seed size and shape. Our research provides valuable information to improve seed physical traits in cotton breeding.
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http://dx.doi.org/10.3389/fpls.2022.837984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981304PMC
March 2022

Serum NSE is Early Marker of Transformed Neuroendocrine Tumor After EGFR-TKI Treatment of Lung Adenocarcinoma.

Cancer Manag Res 2022 30;14:1293-1302. Epub 2022 Mar 30.

Pulmonary and Critical Care Medicine, Shanghai Jiao Tong University, Shanghai Chest Hospital, Shanghai, People's Republic of China.

Background: Transformation to a lung neuroendocrine tumor (LNET) is a mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). Serum neuron-specific enolase (NSE) is a useful marker in the detection of LNET. Therefore, we explored the clinical significance of serum NSE levels in the detection of transformed neuroendocrine tumors after EGFR-TKI therapy.

Methods: We report a cohort of 5 cases in our treatment group. The characteristics of the patients, pathological diagnoses, immunohistochemistry with molecular detection, laboratory examination, and treatment histories are analyzed. The tumor markers of serum NSE were analyzed. Additionally, we reviewed the publications reporting the tumor markers before and after LNET transformation during EGFR-TKI therapy.

Results: Most patients are female (3/5), aged <60 years old (4/5), nonsmokers (4/5) and harbor the EGFR 19 exon deletion (4/5). The median time of LNET transformation was 19 months (range: 12-31 months). The clinical characteristics were similar to those reported in previous studies. Laboratory examination revealed an increased NSE level before the LNET is defined. Sixteen publications were reviewed. Of those, 86.67% (13/15) publications showed an increased level of NSE when the LNET transformation was defined.

Conclusion: Adenocarcinoma tumors in non-smokers, young patients harboring the EGFR 19 exon deletion tended to transform to LNETs after EGFR-TKI therapy. Combining our findings and a review of the literature, we suggest that serum NSE may be a useful tumor marker to predict neuroendocrine tumor transformation.
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http://dx.doi.org/10.2147/CMAR.S349082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978576PMC
March 2022

Longitudinal Association of Infrapatellar Fat Pad Signal Intensity Alteration with Biochemical Biomarkers in Knee Osteoarthritis.

Rheumatology (Oxford) 2022 Apr 6. Epub 2022 Apr 6.

Menzies Institute for Medical Research,University of Tasmania, Hobart, Australia.

Objective: To explore the longitudinal association of quantitative infrapatellar fat pad (IPFP) signal intensity alteration with osteoarthritis (OA)-related biomarkers.

Method: Eighteen OA-related biochemical biomarkers of 600 knee OA participants in the Foundation for the National Institutes of Health OA Biomarkers Consortium (FNIH) study were extracted. The quantitative IPFP signal intensity measures was acquired based on magnetic resonance imaging, including mean value [Mean (IPFP)] and standard deviation [sDev (IPFP)] of the whole IPFP, median value [Median (H)] and upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity to volume of whole IPFP [Percentage (H)] and Clustering factor (H). The linear mixed-effect model was applied to determine the longitudinal associations between IPFP signal intensity alteration and biochemical biomarkers over 2 years.

Results: All IPFP measures except for Clustering factor (H) were positively associated with urine collagenase-cleaved type II collagen neoepitope (uC2C), urine C-terminal cross-linked telopeptide of type II collagen (uCTX-II), urine C-terminal cross-linked telopeptide of type I collagen-α (uCTX-Iα) and urine N-terminal cross-linked telopeptide of type I collagen (uNTX-I). Mean (IPFP), Median (H) and Percentage (H) were positively associated with nitrated form of an epitope located in the triple helix of type II collagen (Coll2-1 NO2). Mean (IPFP), Median (H) and UQ (H) were positively associated with sCTX-I and uCTX-Iβ. Positive associations between sDev (IPFP), Percentage (H) and serum hyaluronic acid (sHA) were found.

Conclusion: Our results suggest a role of IPFP signal intensity alteration in joint tissue remodelling on a molecular level.
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http://dx.doi.org/10.1093/rheumatology/keac214DOI Listing
April 2022

Enhanced Ferroelectric and Piezoelectric Properties in Graphene-Electroded Pb(Zr,Ti)O Thin Films.

ACS Appl Mater Interfaces 2022 Apr 5;14(15):17987-17994. Epub 2022 Apr 5.

Institute for Quantum Science and Engineering and Department of Physics, Southern University of Science and Technology of China, Shenzhen 518055, China.

While using ferroelectric polarization to tune the functional properties of 2D materials has been extensively studied recently, the effects of 2D materials on the ferroelectricity and piezoelectricity of ferroelectrics are much less explored. In this work, we report markedly enhanced ferroelectric and piezoelectric properties of graphene/Pb(ZrTi)O/SrRuO (GR/PZT/SRO) capacitors. Compared with conventional metal-electroded ferroelectric capacitors, the GR/PZT/SRO capacitors exhibit more abrupt polarization switching, larger switchable polarization, lower leakage current, and smaller coercive voltage. Moreover, with graphene electrodes, the ferroelectric properties of PZT capacitors are much more stable against aging. The enhanced ferroelectric behaviors in GR/PZT/SRO capacitors can be attributed to an improved interface with fewer defects and inhibited growth of defective interfacial layer resulting from the graphene protection. Because of the atomic thickness and extraordinary mechanical flexibility of graphene, the piezoelectric response in PZT with graphene electrode is about four times larger than the one with an Au electrode. Our findings on the enhanced ferroelectric and piezoelectric properties of PZT with 2D electrodes advance the understanding of the 2D/PZT interface and provide solutions for developing high-performance ferroelectrics devices.
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http://dx.doi.org/10.1021/acsami.2c02277DOI Listing
April 2022

Integrated Metabolomics and Proteomics Analysis of Urine in a Mouse Model of Posttraumatic Stress Disorder.

Front Neurosci 2022 11;16:828382. Epub 2022 Mar 11.

Biomedical Analysis Center, Army Medical University, Chongqing, China.

Posttraumatic stress disorder (PTSD) is a serious stress disorder that occurs in individuals who have experienced major traumatic events. The underlying pathological mechanisms of PTSD are complex, and the related predisposing factors are still not fully understood. In this study, label-free quantitative proteomics and untargeted metabolomics were used to comprehensively characterize changes in a PTSD mice model. Differential expression analysis showed that 12 metabolites and 27 proteins were significantly differentially expressed between the two groups. Bioinformatics analysis revealed that the differentiated proteins were mostly enriched in: small molecule binding, transporter activity, extracellular region, extracellular space, endopeptidase activity, zymogen activation, hydrolase activity, proteolysis, peptidase activity, sodium channel regulator activity. The differentially expressed metabolites were mainly enriched in Pyrimidine metabolism, D-Glutamine and D-glutamate metabolism, Alanine, aspartate and glutamate metabolism, Arginine biosynthesis, Glutathione metabolism, Arginine, and proline metabolism. These results expand the existing understanding of the molecular basis of the pathogenesis and progression of PTSD, and also suggest a new direction for potential therapeutic targets of PTSD. Therefore, the combination of urine proteomics and metabolomics explores a new approach for the study of the underlying pathological mechanisms of PTSD.
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http://dx.doi.org/10.3389/fnins.2022.828382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963102PMC
March 2022

Lipidomic Profiling Identifies Serum Lipids Associated with Persistent Multisite Musculoskeletal Pain.

Metabolites 2022 Feb 25;12(3). Epub 2022 Feb 25.

Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS 7000, Australia.

Lipid mediators have been suggested to have a role in pain sensitivity and response; however, longitudinal data on lipid metabolites and persistent multisite musculoskeletal pain (MSMP) are lacking. This study was to identify lipid metabolic markers for persistent MSMP. Lipidomic profiling of 807 lipid species was performed on serum samples of 536 participants from a cohort study. MSMP was measured by a questionnaire and defined as painful sites ≥4. Persistent MSMP was defined as having MSMP at every visit. Logistic regression was used with adjustment for potential confounders. The Benjamini-Hochberg method was used to control for multiple testing. A total of 530 samples with 807 lipid metabolites passed quality control. Mean age at baseline was 61.54 ± 6.57 years and 50% were females. In total, 112 (21%) of the participants had persistent MSMP. Persistent MSMP was significantly associated with lower levels of monohexosylceramide (HexCer)(d18:1/22:0 and d18:1/24:0), acylcarnitine (AC)(26:0) and lysophosphatidylcholine (LPC)(18:1 [sn1], 18:2 [sn1], 18:2 [sn2], and 15-MHDA[sn1] [104_sn1]) after controlling for multiple testing. After adjustment for age, sex, body mass index, comorbidities, and physical activity, HexCer(d18:1/22:0 and d18:1/24:0) and LPC(15-MHDA [sn1] [104_sn1]) were significantly associated with persistent MSMP [Odds Ratio (OR) ranging from 0.25-0.36]. Two lipid classes-HexCer and LPC-were negatively associated with persistent MSMP after adjustment for covariates (OR = 0.22 and 0.27, respectively). This study identified three novel lipid signatures of persistent MSMP, suggesting that lipid metabolism is involved in the pathogenesis of persistent pain.
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http://dx.doi.org/10.3390/metabo12030206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953175PMC
February 2022
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