Publications by authors named "Feng Liu"

4,175 Publications

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The prevalence of psychological disorders among cancer patients during the COVID-19 pandemic A meta-analysis.

Psychooncology 2022 Aug 11. Epub 2022 Aug 11.

Department of Clinical Spiritual Care, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan Province, P.R. China, 410013.

Purpose: We aimed to assess the prevalence rate (PR) of depression, anxiety, posttraumatic stress disorder (PTSD), insomnia, distress, and fear of cancer progression/recurrence among patients with cancer during the COVID-19 pandemic.

Methods: Studies that reported the PR of six psychological disorders among cancer patients during the COVID-19 pandemic were searched in PubMed, Embase, PsycINFO, and Web of Science databases, from January 2020 up to 31 January 2022. Meta-analysis results were merged using PR and 95% confidence intervals (CI), and heterogeneity among studies was evaluated using I and Cochran's Q test. Publication bias was examined using funnel plots and Egger's tests. All data analyses were performed using Stata14.0 software.

Results: Forty studies with 27,590 participants were included. Pooled results showed that the PR of clinically significant depression, anxiety, PTSD, distress, insomnia, and fear of cancer progression/recurrence among cancer patients were 32.5%, 31.3%, 28.2%, 53.9%, 23.2%, and 67.4%, respectively. Subgroup analysis revealed that patients with head and neck cancer had the highest PR of clinically significant depression (74.6%) and anxiety (92.3%) symptoms. Stratified analysis revealed that patients with higher education levels had higher levels of clinically significant depression (37.2%). A higher level of clinically significant PTSD was observed in employed patients (47.4%) or female with cancer (27.9%).

Conclusion: This meta-analysis evaluated the psychological disorders of cancer patients during the COVID-19 outbreak. Therefore, it is necessary to develop psychological interventions to improve the mental health of cancer patients during the pandemic. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/pon.6012DOI Listing
August 2022

[Ga]Ga-FAPI PET/CT Improves the T Staging of Patients with Newly Diagnosed Nasopharyngeal Carcinoma: A Comparison with [F]F-FDG.

Mol Imaging Biol 2022 Aug 9. Epub 2022 Aug 9.

Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian Province, China.

Purpose: This study aimed to explore the value of [Ga]Ga-labelled fibroblast activation protein inhibitor ([Ga]Ga-FAPI) positron emission tomography/computed tomography (PET/CT) in the initial staging of patients with newly diagnosed nasopharyngeal carcinoma (NPC), compared with 2-deoxy-2[F]fluoro-D-glucose ([F]F-FDG) PET/CT.

Materials And Methods: Forty-seven treatment-naïve patients with newly diagnosed NPC underwent magnetic resonance imaging (MRI), [Ga]Ga-DOTA-FAPI-04 PET/CT and [F]F-FDG PET/CT within 1 week. The diagnostic efficiency of all imaging modalities for evaluating primary tumour extension was compared from the two aspects of soft tissue and bony structure involvement. The accuracy of two PET/CT methods for diagnosing cervical lymph node (CLN) metastases was compared, and MRI served as the standard reference. T and N stages were assessed by MRI, [Ga]Ga-FAPI PET/CT and [F]F-FDG PET/CT. Immunohistochemical (IHC) staining for FAP was conducted in 22 of the patients.

Results: [Ga]Ga-FAPI PET/CT outperformed [F]F-FDG PET/CT in the assessment of primary tumour invasion in the cavernous sinus (10 vs. 1, p < 0.001) and bony structures (207 vs. 177, p < 0.001). Compared with MRI, [Ga]Ga-FAPI PET/CT upgraded and underestimated T stage in 13 and 2 patients, while [F]F-FDG PET/CT upgraded and underestimated T stage in 5 and 13 patients. However, [Ga]Ga-FAPI PET/CT was inferior to [F]F-FDG PET/CT in diagnosing positive CLNs based on the analyses of patients, neck sides, neck levels and individual nodes. [Ga]Ga-FAPI PET/CT changed therapeutic schedules in 8 patients because of stage group changes. The presence of FAP with high quantity and intensity in cancer-associated fibroblasts (CAFs) was confirmed in all tumour specimens.

Conclusion: [Ga]Ga-FAPI PET/CT outperformed [F]F-FDG PET/CT in detecting the cavernous sinus and bony structure involvement of primary NPC tumours, suggesting its value in improving T staging and therapeutic regimen selection. However, the performance of [Ga]Ga-FAPI PET/CT is less promising for N staging because it detected fewer positive CLNs than [F]F-FDG PET/CT.
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http://dx.doi.org/10.1007/s11307-022-01748-8DOI Listing
August 2022

Observation of a State X(2600) in the π^{+}π^{-}η' System in the Process J/ψ→γπ^{+}π^{-}η'.

Phys Rev Lett 2022 Jul;129(4):042001

Institute of High Energy Physics, Beijing 100049, People's Republic of China.

Based on (10087±44)×10^{6}  J/ψ events collected with the BESIII detector, the process J/ψ→γπ^{+}π^{-}η^{'} is studied using two largest decay channels of the η^{'} meson, η^{'}→γπ^{+}π^{-} and η^{'}→ηπ^{+}π^{-}, η→γγ. A new resonance, which we denote as the X(2600), is observed with a statistical significance larger than 20σ in the π^{+}π^{-}η^{'} invariant mass spectrum, and it has a connection to a structure around 1.5  GeV/c^{2} in the π^{+}π^{-} invariant mass spectrum. A simultaneous fit on the π^{+}π^{-}η^{'} and π^{+}π^{-} invariant mass spectra with the two η^{'} decay modes indicates that the mass and width of the X(2600) state are 2618.3±2.0_{-1.4}^{+16.3}  MeV/c^{2} and 195±5_{-17}^{+26}  MeV, where the first uncertainties are statistical, and the second systematic.
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http://dx.doi.org/10.1103/PhysRevLett.129.042001DOI Listing
July 2022

Cardiac Arrhythmia classification based on 3D recurrence plot analysis and deep learning.

Front Physiol 2022 22;13:956320. Epub 2022 Jul 22.

School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, QLD, Australia.

Artificial intelligence (AI) aided cardiac arrhythmia (CA) classification has been an emerging research topic. Existing AI-based classification methods commonly analyze electrocardiogram (ECG) signals in lower dimensions, using one-dimensional (1D) temporal signals or two-dimensional (2D) images, which, however, may have limited capability in characterizing lead-wise spatiotemporal correlations, which are critical to the classification accuracy. In addition, existing methods mostly assume that the ECG data are linear temporal signals. This assumption may not accurately represent the nonlinear, nonstationary nature of the cardiac electrophysiological process. In this work, we have developed a three-dimensional (3D) recurrence plot (RP)-based deep learning algorithm to explore the nonlinear recurrent features of ECG and Vectorcardiography (VCG) signals, aiming to improve the arrhythmia classification performance. The 3D ECG/VCG images are generated from standard 12 lead ECG and 3 lead VCG signals for neural network training, validation, and testing. The superiority and effectiveness of the proposed method are validated by various experiments. Based on the PTB-XL dataset, the proposed method achieved an average F1 score of 0.9254 for the 3D ECG-based case and 0.9350 for the 3D VCG-based case. In contrast, recently published 1D and 2D ECG-based CA classification methods yielded lower average F1 scores of 0.843 and 0.9015, respectively. Thus, the improved performance and visual interpretability make the proposed 3D RP-based method appealing for practical CA classification.
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http://dx.doi.org/10.3389/fphys.2022.956320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352947PMC
July 2022

Overlapping and segregated changes of functional hubs in melancholic depression and non-melancholic depression.

J Psychiatr Res 2022 Jul 31;154:123-131. Epub 2022 Jul 31.

Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China; Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, 528000, China; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China. Electronic address:

Background: Previous research found associations between neuropsychiatric disorders and patterns of highly connected "hub" nodes, which are crucial in coordinating brain functions. Melancholic depression is considered a relatively distinct and homogenous subtype of major depressive disorder (MDD), which responds better to pharmacological treatments than placebos or psychotherapies. Accordingly, melancholic depression probably has distinct neuropathological underpinnings. This study aims to examine the overlapping and segregated changes of functional hubs in melancholic and non-melancholic MDD.

Methods: Thirty-one melancholic patients, 28 non-melancholic patients, and 32 healthy controls were included. Resting-state functional imaging data were analyzed using global functional connectivity.

Results: Both melancholic and non-melancholic patients had increased GFC in the bilateral insula and decreased GFC in the PCC/precuneus compared to HCs. The distinction was that melancholic patients showed increased GFC in the bilateral thalamus, right inferior parietal lobule (IPL), and left cerebellum Crus I and decreased GFC in the left temporal lobe, whereas non-melancholic patients showed increased GFC in the left superior parietal lobe. Additionally, compared with non-melancholic patients, melancholic individuals displayed significant increases of GFC in the left IPL and cerebellum.

Conclusion: Increased GFC of the insula and decreased GFC of the PCC and precuneus are the common abnormalities of melancholic and non-melancholic MDD. Hyperconnectivity of the IPL and cerebellum might be distinctive neuropathological features of melancholic MDD.
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http://dx.doi.org/10.1016/j.jpsychires.2022.07.043DOI Listing
July 2022

Superelastic graphene aerogel-based metamaterials.

Nat Commun 2022 Aug 5;13(1):4561. Epub 2022 Aug 5.

Key Laboratory of Organic Optoelectronics & Molecular Engineering, Ministry of Education, Department of Chemistry, Tsinghua University, 100084, Beijing, P. R. China.

Ultralight, ultrastrong, and supertough graphene aerogel metamaterials combining with multi-functionalities are promising for future military and domestic applications. However, the unsatisfactory mechanical performances and lack of the multiscale structural regulation still impede the development of graphene aerogels. Herein, we demonstrate a laser-engraving strategy toward graphene meta-aerogels (GmAs) with unusual characters. As the prerequisite, the nanofiber-reinforced networks convert the graphene walls' deformation from the microscopic buckling to the bulk deformation during the compression process, ensuring the highly elastic, robust, and stiff nature. Accordingly, laser-engraving enables arbitrary regulation on the macro-configurations of GmAs with rich geometries and appealing characteristics such as large stretchability of 5400% reversible elongation, ultralight specific weight as small as 0.1 mg cm, and ultrawide Poisson's ratio range from -0.95 to 1.64. Additionally, incorporating specific components into the pre-designed meta-structures could further achieve diversified functionalities.
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http://dx.doi.org/10.1038/s41467-022-32200-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355988PMC
August 2022

Copper-Catalyzed Nitrogen Atom Transfer to Isoquinolines via C-N Triple Bond Cleavage and Three-Component Cyclization.

Org Lett 2022 Aug 4. Epub 2022 Aug 4.

Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

A copper(I)-catalyzed tandem reaction of 2-bromoaryl ketones, terminal alkynes, and CHCN is developed, which combines N atom transfer and three-component [3 + 2 + 1] cyclization, and efficiently produces densely functionalized isoquinolines in a facile, highly selective, and general manner. In the reaction, the formation of aromatic C-N bonds along with the complete C-N triple bond cleavage is first realized; Cu(III)-acetylide species might serve as the intermediates, which allow highly selective 6-- cyclization.
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http://dx.doi.org/10.1021/acs.orglett.2c02257DOI Listing
August 2022

Pretracheal Lymph Node Subdivision in Predicting Contralateral Central Lymph Node Metastasis for Unilateral Papillary Thyroid Carcinoma: Preliminary Results.

Front Endocrinol (Lausanne) 2022 18;13:921845. Epub 2022 Jul 18.

Department of Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.

Background: The aims of this study were to assess the clinical value of pretracheal lymph node subdivision in identifying patients with contralateral central lymph node metastasis (CLNM) and risk factors for occult contralateral CLNM in unilateral PTC.

Methods: A total of 139 unilateral PTC patients with a clinically node-negative neck (cN0) who underwent bilateral central neck dissection (CND) were prospectively enrolled. Intraoperatively, the pretracheal region was further divided into ipsilateral and contralateral subregions. Ipsilateral and contralateral pretracheal lymph nodes (LNs) as well as other CLNs (prelaryngeal, ipsilateral paratracheal and contralateral paratracheal) were labeled separately and sent for pathological examination. Demographic and clinicopathologic variables were analyzed to identify factors predictive of contralateral CLNM.

Results: Of 139 patients, bilateral CLNM was present in 37 (26.6%) patients. Contralateral pretracheal LNM was significantly associated with contralateral CLNM. In multivariate analysis, prelaryngeal LNM ( = 0.004, odds ratio = 3.457) and contralateral pretracheal LNM ( = 0.006, odds ratio = 3.362) were identified as risk factors for contralateral CLNM. Neither neck recurrence nor distant metastasis was observed within the mean follow-up duration of 9.1 ± 1.8 months.

Conclusions: In most unilateral cN0 PTCs, performing ipsilateral CND is appropriate, while patients presenting with evident nodal disease intraoperatively or preoperatively in the contralateral central neck should undergo bilateral CND. Intraoperative re-evaluation of prelaryngeal and contralateral pretracheal LNs may be helpful in determining the extent of CND.
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http://dx.doi.org/10.3389/fendo.2022.921845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339796PMC
August 2022

Hypertension and Obesity: Risk Factors for Thyroid Disease.

Front Endocrinol (Lausanne) 2022 18;13:939367. Epub 2022 Jul 18.

Department of Data Science and AI, Faculty of Information Technology, Monash University, Melbourne, VIC, Australia.

Thyroid disease instances have rapidly increased in the past few decades; however, the cause of the disease remains unclear. Understanding the pathogenesis of thyroid disease will potentially reduce morbidity and mortality rates. Currently, the identified risk factors from existing studies are controversial as they were determined through qualitative analysis and were not further confirmed by quantitative implementations. Association rule mining, as a subset of data mining techniques, is dedicated to revealing underlying correlations among multiple attributes from a complex heterogeneous dataset, making it suitable for thyroid disease pathogenesis identification. This study adopts two association rule mining algorithms (i.e., Apriori and FP-Growth Tree) to identify risk factors correlated with thyroid disease. Extensive experiments were conducted to reach impartial findings with respect to knowledge discovery through two independent digital health datasets. The findings confirmed that gender, hypertension, and obesity are positively related to thyroid disease development. The history of I treatment and Triiodothyronine level can be potential factors for evaluating subsequent thyroid disease.
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http://dx.doi.org/10.3389/fendo.2022.939367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339634PMC
August 2022

Ancient DNA traces a Chinese 5400-year-old cat specimen as leopard cat (Prionailurus bengalensis).

J Genet Genomics 2022 Jul 31. Epub 2022 Jul 31.

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, 100044, China; University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2022.07.005DOI Listing
July 2022

miR-182-5p promotes hepatocyte-stellate cell crosstalk to facilitate liver regeneration.

Commun Biol 2022 Aug 1;5(1):771. Epub 2022 Aug 1.

National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.

A unique feature of the liver is its high regenerative capacity, which is essential to maintain liver homeostasis. However, key regulators of liver regeneration (LR) remain ill-defined. Here, we identify hepatic miR-182-5p as a key regulator of LR. Suppressing miR-182-5p, whose expression is significantly induced in the liver of mice post two-thirds partial hepatectomy (PH), abrogates PH-induced LR in mice. In contrast, liver-specific overexpression of miR-182-5p promotes LR in mice with PH. Overexpression of miR-182-5p failed to promote proliferation in hepatocytes, but stimulates proliferation when hepatocytes are cocultured with stellate cells. Mechanistically, miR-182-5p stimulates Cyp7a1-mediated cholic acid production in hepatocytes, which promotes hedgehog (Hh) ligand production in stellate cells, leading to the activation of Hh signaling in hepatocytes and consequent cell proliferation. Collectively, our study identified miR-182-5p as a critical regulator of LR and uncovers a Cyp7a1/cholic acid-dependent mechanism by which hepatocytes crosstalk to stellate cells to facilitate LR.
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http://dx.doi.org/10.1038/s42003-022-03714-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343643PMC
August 2022

Abnormal spontaneous neural activity in hippocampal-cortical system of patients with obsessive-compulsive disorder and its potential for diagnosis and prediction of early treatment response.

Front Cell Neurosci 2022 15;16:906534. Epub 2022 Jul 15.

Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.

Early brain functional changes induced by pharmacotherapy in patients with obsessive-compulsive disorder (OCD) in relation to drugs or because of the impact of such drugs on the improvement of OCD remain unclear. Moreover, no neuroimaging biomarkers are available for diagnosis of OCD and prediction of early treatment response. We performed a longitudinal study involving 34 patients with OCD and 36 healthy controls (HCs). Patients with OCD received 5-week treatment with paroxetine (40 mg/d). Resting-state functional magnetic resonance imaging (fMRI), regional homogeneity (ReHo), support vector machine (SVM), and support vector regression (SVR) were applied to acquire and analyze the imaging data. Compared with HCs, patients with OCD had higher ReHo values in the right superior temporal gyrus and bilateral hippocampus/parahippocampus/fusiform gyrus/cerebellum at baseline. ReHo values in the left hippocampus and parahippocampus decreased significantly after treatment. The reduction rate (RR) of ReHo values was positively correlated with the RRs of the scores of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and obsession. Abnormal ReHo values at baseline could serve as potential neuroimaging biomarkers for OCD diagnosis and prediction of early therapeutic response. This study highlighted the important role of the hippocampal-cortical system in the neuropsychological mechanism underlying OCD, pharmacological mechanism underlying OCD treatment, and the possibility of building models for diagnosis and prediction of early treatment response based on spontaneous activity in the hippocampal-cortical system.
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http://dx.doi.org/10.3389/fncel.2022.906534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334680PMC
July 2022

Effects of stand condition and root density on fine-root dynamics across root functional groups in a subtropical montane forest.

J For Res (Harbin) 2022 Jul 23:1-11. Epub 2022 Jul 23.

CAS Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074 People's Republic of China.

Fine roots play key roles in belowground C cycling in terrestrial ecosystems. Based on their distinct functions, fine roots are either absorptive fine roots (AFRs) or transport fine roots (TFRs). However, the function-based fine root dynamics of trees and their responses to forest stand properties remain unclear. Here, we studied the dynamics of AFRs and TFRs and their responses to stand conditions and root density in a subtropical montane mixed forest based on a 2-a root window experiment. Mean (± SE) annual production, mortality, and turnover rate of AFRs were 7.87 ± 0.17 m m a, 8.13 ± 0.20 m m aand 2.96 ± 0.24 a, respectively, compared with 7.09 ± 0.17 m m a, 4.59 ± 0.17 m m a, and 2.01 ± 0.22 a, respectively, for TFRs. The production and mortality of fine roots were significantly higher in high root-density sites than in low-root density sites, whereas the turnover of fine roots was faster in the low root-density sites. Furthermore, root density had a larger positive effect than other environmental factors on TFR production but had no obvious impact on AFR production. Tree species diversity had an apparent positive effect on AFR production and was the crucial driver of AFR production, probably due to a complementary effect, but had no evident impact on TFR. Both tree density and tree species diversity were positively correlated with the mortality of AFRs and negatively related to the turnover of TFRs, suggesting that higher root density caused stronger competition for rooting space and that plants tend to reduce maintenance costs by decreasing TFR turnover. These findings illustrated the importance of root functional groups in understanding root dynamics and their responses to changes in environmental conditions.

Supplementary Information: The online version contains supplementary material available at 10.1007/s11676-022-01514-0.
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http://dx.doi.org/10.1007/s11676-022-01514-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307969PMC
July 2022

A New Strategy for Highly Efficient Separation between Monovalent Cations by Applying Opposite-Oriented Pressure and Electric Fields.

Small 2022 Jul 30:e2203396. Epub 2022 Jul 30.

State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing, 100871, China.

Biological ion channels exhibit excellent ion selectivity, but it has been challenging to design their artificial counterparts, especially for highly efficient separation of similar ions. Here, a new strategy to achieve high selectivity between alkali metal ions with artificial nanostructures is reported. Molecular dynamics (MD) simulations and experiments are combined to study the transportation of monovalent cations through graphene oxide (GO) nanoslits by applying pressure or/and electric fields. It is found that the ionic transport selectivity under the pressure driving reverses compared with that under the electric field driving. Moreover, MD simulations show that different monovalent cations can be separated with unprecedentedly high selectivity by applying opposite-oriented pressure and electric fields. This highly efficient separation originates from two distinctive ionic transporting modes, that is, hydration shells drive ions under pressure, but drag ions under the electric field. Hence, ions with different hydration strengths can be efficiently separated by tuning the net mobility induced by the two types of driving forces when the selected ions are kept moving while the other ones are immobilized. And nanoconfinement is confirmed to enhance the separation efficacy. This discovery paves a new avenue for separating similar ions without elaborately designing biomimetic nanostructures.
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http://dx.doi.org/10.1002/smll.202203396DOI Listing
July 2022

Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China.

BMJ Open 2022 07 29;12(7):e062239. Epub 2022 Jul 29.

School of Medicine, Nankai University, Tianjin, China

Objectives: We aimed to assess the associations between night-time sleep duration and fasting glucose (FG), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and body mass index (BMI) among adults free of type 2 diabetes (T2D) or without diagnosed T2D.

Design: Cross-sectional study.

Setting: Medical examination centres at six hospitals in Beijing-Tianjin-Hebei region, China.

Participants: Participants were recruited via multistage, stratified cluster sampling. We included adults free of T2D or without diagnosed T2D who attended for physical examination and completed the validated questionnaire. 32 497 participants were included in the study, of whom 52.50% were men.

Primary And Secondary Outcome Measures: FG, TG, HDL-C, height and weight were measured.

Results: Overall, 12.80% and 9.67% reported night sleep duration <7 hours and ≥9 hours, respectively; 6.91% had elevated FG and 3.57% had undiagnosed T2D. Sleep duration had an independent, U-shaped associated with FG (β (linear term)=-0.111, p=0.047; β (quadratic term)=0.008, p=0.026) with 6.9 hours of sleep associated with the lowest FG and a negative association with BMI (β=-0.154, p<0.001). BMI mediated a U-shaped association of sleep duration with TG/HDL-C (β=-0.040, p=0.017; β=0.003, p=0.023).

Conclusions: Both short and long night-time sleep was associated with elevated FG, and short sleep duration was associated with increased BMI. BMI mediated a U-shaped association between sleep duration and TG/HDL-C.
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http://dx.doi.org/10.1136/bmjopen-2022-062239DOI Listing
July 2022

Synthesis of Ladder-Type 9,9'-Bifluorenylidene-Based Conjugated Oligomers via a Pd-Catalyzed Tandem Suzuki Coupling/Heck Cyclization Approach.

Org Lett 2022 Aug 29;24(31):5851-5854. Epub 2022 Jul 29.

College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China.

For new ladder-type oligomers and polymers with versatile and robust synthetic strategies, in this study, four fully conjugated ladder-type overcrowded 9,9'-bifluorenylidene-based compounds and oligomers (, , , and ) were synthesized via a Pd-catalyzed tandem Suzuki coupling/Heck cyclization reaction. By monomer screening and route optimization, the target products were obtained in high yields and characterized by H and C NMR spectroscopy and high resolution mass spectroscopy.
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http://dx.doi.org/10.1021/acs.orglett.2c02418DOI Listing
August 2022

Facile Access to Far-Red Fluorescent Probes with Through-Space Charge Transfer Effect for In Vivo Two-Photon Microscopy of Mouse Cerebrovascular System.

Angew Chem Int Ed Engl 2022 Jul 28. Epub 2022 Jul 28.

The Chinese University of Hong Kong, Shenzhen, School of Science and Engineering, 2001 Longxiang Boulevard, Longgang District, 518172, Shenzhen, CHINA.

Many efforts have been devoted to obtain fluorescent probes via synthetic approaches. In this communication, we developed a facile strategy to construct far-red fluorescent probes based on the through-space charge transfer of the acceptors with the donors in the complexes and their "twist + twist" interactions. Due to their rare two-photon excitation property, we for the first time presented their utility in in vivo imaging of mouse cerebrovascular system.
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http://dx.doi.org/10.1002/anie.202209590DOI Listing
July 2022

An in-plane supercapacitor obtained by facile template method with high performance Mn-Co sulfide-based oxide electrode.

Nanotechnology 2022 Jul 28. Epub 2022 Jul 28.

Lanzhou University, Tianshui south road no.222, Lanzhou, 730000, CHINA.

Designing in-plane supercapacitors with high electrode materials selectivity is an indispensable approach to improve electrochemical performance. In this work, a facile template method was employed to fabricate in-plane supercapacitors. This template method could select any electrochemical active materials as electrode materials of in-plane supercapacitors. Hence, a high electrochemical performance material Mn-Co LDO-2S with optimized metal-sulfur bonds proportion and abundant sulfur vacancies was employed as electrode material of symmetrical in-plane supercapacitor (SPS). SPS exhibits excellent electrochemical performance finally, and has considerable area energy density 55.0 Wh cm-2 with an area power density of 0.7 mW cm-2. As a result, introducing sulfur atoms and sulfur vacancies are efficient approaches to improve electrode materials' electrochemical performance, and template method that proposed in this work is a promising approach to widen selectivity of in-plane supercapacitors' electrode materials.
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http://dx.doi.org/10.1088/1361-6528/ac84e2DOI Listing
July 2022

Correction: Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven.

Stem Cell Res Ther 2022 Jul 27;13(1):362. Epub 2022 Jul 27.

Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.

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http://dx.doi.org/10.1186/s13287-022-03078-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327333PMC
July 2022

A reconfigurable and magnetically responsive assembly for dynamic solar steam generation.

Nat Commun 2022 Jul 27;13(1):4335. Epub 2022 Jul 27.

Key Laboratory of Organic Optoelectronics & Molecular Engineering, Ministry of Education, Department of Chemistry & State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, People's Republic of China.

Interfacial solar vapor generation is a promising technique to efficiently get fresh water from seawater or effluent. However, for the traditional static evaporation models, further performance improvement has encountered bottlenecks due to the lack of dynamic management and self-regulation on the evolving water movement and phase change in the evaporation process. Here, a reconfigurable and magnetically responsive evaporator with conic arrays is developed through the controllable and reversible assembly of graphene wrapped FeO nanoparticles. Different from the traditional structure-rigid evaporation architecture, the deformable and dynamic assemblies could reconfigure themselves both at macroscopic and microscopic scales in response to the variable magnetic field. Thus, the internal water transportation and external vapor diffusion are greatly promoted simultaneously, leading to a 23% higher evaporation rate than that of static counterparts. Further, well-designed hierarchical assembly and dynamic evaporation system can boost the evaporation rate to a record high level of 5.9 kg m h. This proof-of-concept work demonstrates a new direction for development of high performance water evaporation system with the ability of dynamic reconfiguration and reassembly.
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http://dx.doi.org/10.1038/s41467-022-32051-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329472PMC
July 2022

Au-Stabilized Nanoporous PdCuAu Alloys Exhibiting Outstanding Catalytic Activity and Durability for the Formic Acid Oxidation Reaction.

ACS Appl Mater Interfaces 2022 Aug 27;14(31):35466-35476. Epub 2022 Jul 27.

Tianjin Key Laboratory of Advanced Functional Porous Materials, Institute for New Energy Materials and Low-Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China.

Metallic Pd is widely recognized as an efficient electrocatalyst for the formic acid oxidation reaction (FAOR), which unfortunately suffers from poor durability owing to Pd dissolution and CO poisoning. The present work describes an effective method to enhance Pd durability by alloying with Cu and Au. Cu could provide surface OH at low potentials to remove poisonous CO for improved CO resistance. Au, the most inert metal, was added to reduce Pd and Cu dissolution. Moreover, alloying with Cu and Au could also modulate the electronic structure of Pd which is just profitable for the FAOR. The constructed PdCuAu with a nanoporous structure exhibits a specific activity of 14.9 mA cm and a Pd mass activity of 6012 A g, which is ∼15 times and ∼14 times higher than those of commercial Pd/C. While these two electrocatalysts were used as fuel cell anodes, the maximum power density of the PdCuAu anode (Pd loading 10 μg cm) is 93.2 mW cm and the value of the Pd/C anode (Pd loading 1.2 mg cm) is 60.3 mW cm. The power efficiency of Pd has been notably increased by 185 times in this home-made nanoporous PdCuAu ternary alloy electrocatalyst.
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http://dx.doi.org/10.1021/acsami.2c04350DOI Listing
August 2022

Simple Detection of DNA Methyltransferase with an Integrated Padlock Probe.

Biosensors (Basel) 2022 Jul 26;12(8). Epub 2022 Jul 26.

State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China.

DNA methyltransferases (MTases) can be regarded as biomarkers, as demonstrated by many studies on genetic diseases. Many researchers have developed biosensors to detect the activity of DNA MTases, and nucleic acid amplification, which need other probe assistance, is often used to improve the sensitivity of DNA MTases. However, there is no integrated probe that incorporates substrates and template and primer for detecting DNA MTases activity. Herein, we first designed a padlock probe (PP) to detect DNA MTases, which combines target detection with rolling circle amplification (RCA) without purification or other probe assistance. As the substrate of MTase, the PP was methylated and defended against HpaII, lambda exonuclease, and ExoI cleavage, as well as digestion, by adding MTase and the undestroyed PP started RCA. Thus, the fluorescent signal was capable of being rapidly detected after adding SYBR Gold to the RCA products. This method has a detection limit of approximately 0.0404 U/mL, and the linear range was 0.5-110 U/mL for M.SssI. Moreover, complex biological environment assays present prospects for possible application in intricacy environments. In addition, the designed detection system can also screen drugs or inhibitors for MTases.
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http://dx.doi.org/10.3390/bios12080569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332213PMC
July 2022

LGCCT: A Light Gated and Crossed Complementation Transformer for Multimodal Speech Emotion Recognition.

Entropy (Basel) 2022 Jul 21;24(7). Epub 2022 Jul 21.

Institute of Artificial Intelligence and Change Management, Shanghai University of International Business and Economics, Shanghai 200062, China.

Semantic-rich speech emotion recognition has a high degree of popularity in a range of areas. Speech emotion recognition aims to recognize human emotional states from utterances containing both acoustic and linguistic information. Since both textual and audio patterns play essential roles in speech emotion recognition (SER) tasks, various works have proposed novel modality fusing methods to exploit text and audio signals effectively. However, most of the high performance of existing models is dependent on a great number of learnable parameters, and they can only work well on data with fixed length. Therefore, minimizing computational overhead and improving generalization to unseen data with various lengths while maintaining a certain level of recognition accuracy is an urgent application problem. In this paper, we propose LGCCT, a light gated and crossed complementation transformer for multimodal speech emotion recognition. First, our model is capable of fusing modality information efficiently. Specifically, the acoustic features are extracted by CNN-BiLSTM while the textual features are extracted by BiLSTM. The modality-fused representation is then generated by the cross-attention module. We apply the gate-control mechanism to achieve the balanced integration of the original modality representation and the modality-fused representation. Second, the degree of attention focus can be considered, as the uncertainty and the entropy of the same token should converge to the same value independent of the length. To improve the generalization of the model to various testing-sequence lengths, we adopt the length-scaled dot product to calculate the attention score, which can be interpreted from a theoretical view of entropy. The operation of the length-scaled dot product is cheap but effective. Experiments are conducted on the benchmark dataset CMU-MOSEI. Compared to the baseline models, our model achieves an 81.0% F1 score with only 0.432 M parameters, showing an improvement in the balance between performance and the number of parameters. Moreover, the ablation study signifies the effectiveness of our model and its scalability to various input-sequence lengths, wherein the relative improvement is almost 20% of the baseline without a length-scaled dot product.
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http://dx.doi.org/10.3390/e24071010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316084PMC
July 2022

Comparative Physiological and Transcriptomic Analyses Reveal Mechanisms of Exogenous Spermidine-Induced Tolerance to Low-Iron Stress in L.

Antioxidants (Basel) 2022 Jun 27;11(7). Epub 2022 Jun 27.

College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.

Iron (Fe) deficiency in plants is a major problem in agriculture. Therefore, we investigated both the physiological features and molecular mechanisms of plants' response to low-Fe (LF) stress along with the mitigation of LF with exogenous spermidine (Spd) in tomato plants. The results showed that exogenous Spd foliar application relieved the suppressing effect of LF stress on tomato plants by regulating the photosynthetic efficiency, chlorophyll metabolism, antioxidant levels, organic acid secretion, polyamine metabolism and osmoregulatory systems. Analysis of transcriptomic sequencing results revealed that the differentially expressed genes of iron-deficiency stress were mainly enriched in the pathways of phytohormone signaling, starch and sucrose metabolism and phenyl propane biosynthesis in both leaves and roots. Moreover, Spd-induced promotion of growth under LF stress was associated with upregulation in the expression of some transcription factors that are related to growth hormone response in leaves (, , ) and ethylene-related signaling factors in roots (, ). We propose that traits associated with changes in low-iron-tolerance genes can potentially be used to improve tomato production. The study provides a theoretical basis for dealing with the iron deficiency issue to develop efficient nutrient management strategies in protected tomato cultivation.
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http://dx.doi.org/10.3390/antiox11071260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312307PMC
June 2022

ASCL2 Maintains Stemness Phenotype through ATG9B and Sensitizes Gliomas to Autophagy Inhibitor.

Adv Sci (Weinh) 2022 Jul 26:e2105938. Epub 2022 Jul 26.

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, 400038, China.

Autophagy is a highly conserved process that is vital for tumor progression and treatment response. Although autophagy is proposed to maintain the stemness phenotype in adult diffuse glioma, the molecular basis of the link between autophagy and stemness is poorly understood, which makes it impossible to effectively screen for the population that will benefit from autophagy-targeted treatment. Here, ATG9B as essential for self-renewal capacity and tumor-propagation potential is identified. Notably, ASCL2 transcriptionally regulates the expression of ATG9B to maintain stemness properties. The ASCL2-ATG9B axis is an independent prognostic biomarker and indicator of autophagic activity. Furthermore, the highly effective blood-brain barrier (BBB)-permeable autophagy inhibitor ROC-325, which can significantly inhibit the progression of ASCL2-ATG9B axis gliomas as a single agent is investigated. These data demonstrate that a new ASCL2-ATG9B signaling axis is crucial for maintaining the stemness phenotype and tumor progression, revealing a potential autophagy inhibition strategy for adult diffuse gliomas.
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http://dx.doi.org/10.1002/advs.202105938DOI Listing
July 2022

(-Bu)NBr-Promoted N Splitting to Molybdenum Nitride.

J Am Chem Soc 2022 Aug 26;144(31):14071-14078. Epub 2022 Jul 26.

Department of Chemistry, Fudan University, Shanghai 200438, China.

Splitting of N via six-electron reduction and further functionalization to value-added products is one of the most important and challenging chemical transformations in N fixation. However, most N splitting approaches rely on strong chemical or electrochemical reduction to generate highly reactive metal species to bind and activate N, which is often incompatible with functionalizing agents. Catalytic and sustainable N splitting to produce metal nitrides under mild conditions may create efficient and straightforward methods for N-containing organic compounds. Herein, we present that a readily available and nonredox (-Bu)NBr can promote N-splitting with a Mo(III) platform. Both experimental and theoretical mechanistic studies suggest that simple X (X = Br, Cl, etc.) anions could induce the disproportionation of Mo[N()Ar] at the early stage of the catalysis to generate a catalytically active {Mo[N()Ar]} species. The quintet Mo species prove to be more favorable for N fixation kinetically and thermodynamically, compared with the quartet Mo counterpart. Especially, computational studies reveal a distinct heterovalent {Mo-N-Mo} dimeric intermediate for the N≡N triple bond cleavage.
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http://dx.doi.org/10.1021/jacs.2c01507DOI Listing
August 2022

Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation.

Hepatology 2022 Jul 26. Epub 2022 Jul 26.

Institute of Molecular Medicine, State Key Laboratory of Natural and Biomimetic Drugs, MOE Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University, Beijing, China.

Background And Aims: Cell fate can be directly reprogrammed from accessible cell types (e.g., fibroblasts) into functional cell types by exposure to small molecule stimuli. However, no chemical reprogramming method has been reported to date that successfully generates functional hepatocyte-like cells that can repopulate liver tissue, casting doubt over the feasibility of chemical reprogramming approaches to obtain desirable cell types for therapeutic applications.

Approach And Results: Here, through chemical induction of phenotypic plasticity, we provide a proof-of-concept demonstration of the direct chemical reprogramming of mouse fibroblasts into functional hepatocyte-like cells using exposure to small molecule cocktails in culture medium to successively stimulate endogenous expression of master transcription factors (TFs) associated with hepatocyte development, such as Hnf4a, Nr1i2, and Nr1h4. RNA sequencing (RNA-seq) analysis, metabolic assays, and in vivo physiological experiments show that chemically-induced hepatocytes (CiHeps) exhibit comparable activity and function to primary hepatocytes, especially in liver repopulation to rescue liver failure in Fah Rag2 Il2rg (FRG) mice in vivo. Single-cell RNA-seq further revealed that gastrointestinal-like and keratinocyte-like cells were induced along with CiHeps, resembling the activation of an intestinal program within hepatic reprogramming as described in transgenic approaches.

Conclusions: Our findings show that direct chemical reprogramming can generate hepatocyte-like cells with high-quality physiological properties, providing a paradigm for establishing hepatocyte identity in fibroblasts, and demonstrating the potential for chemical reprogramming in organ/tissue repair and regeneration therapies.
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http://dx.doi.org/10.1002/hep.32686DOI Listing
July 2022

Fabrication of Gold-Based "Sphere-on-Plate" Hybrid Nanostructures with Dual Plasmonic Absorptions Covering Visible and Near-Infrared II Windows the Volmer-Weber Growth Mode.

Langmuir 2022 Aug 25;38(31):9669-9677. Epub 2022 Jul 25.

School of Chemistry, Chemical Engineering, and Materials, Jining University, Qufu 273155, Shandong, China.

We report a synthetic strategy to create gold(Au)-based "sphere-on-plate" hybrid nanostructures (SPHNSs). The surface doping of plate-like Au seeds with Pt/Ag atoms is found to be crucial to increase the lattice spacing, inducing island-like deposition of Au atoms the Volmer-Weber growth mode. The resulting products are featured with the morphology that quasi-spherical nanoparticles are scattered over the nanoplates. Due to the presence of two distinctly dimensioned particles in one entity, the current Au-based SPHNSs exhibit unique dual plasmonic absorptions, where the visible absorbance centered at 546 nm is related to the size of the anchored particles. Arising from such a plasmonic advantage, the Au-based SPHNSs exhibit enhancement in photothermal conversion under laser irradiations at the wavelengths of both 808 and 1064 nm. The current work offers a feasible route to fabricate noble metal hybrid nanostructures involving zero-dimensional (0D) and two-dimensional (2D) structures, which could work as promising materials for photothermal conversion.
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http://dx.doi.org/10.1021/acs.langmuir.2c01289DOI Listing
August 2022

Phase interface engineering of metal selenides heterostructure for enhanced lithium-ion storage and electrocatalysis.

J Colloid Interface Sci 2022 Jul 2;627:716-729. Epub 2022 Jul 2.

School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, PR China.

Biphasic or multiphase heterostructures hold attractive prospects in engineering advanced electrode materials for energy-related applications owing to the appealing synergistic effect; however, they still suffer from unsatisfied electrochemical activity and reaction kinetics. Herein, guided by density functional theory calculation, a well-engineered selenides heterostructure with high-density NiSe-NiSe biphasic interfaces that fastened in N, O-codoped carbon matrix, was developed for high-performance lithium storage and electrocatalysis. By controlled selenylation of metal-organic framework (MOF), a series of [email protected] hybrids ([email protected], NiSe/[email protected], NiSe/[email protected], and [email protected]) with tunable biphasic components and grain sizes were prepared. Abundant two-phase interfaces with higher interface density are generated inside the NiSe/NiSe-1 induced by much smaller nanograins in comparison with the NiSe/NiSe-2, so that significant charge redistribution and faster electrons/Li ions transfer kinetics are achieved within the selenides, which are proved by the mutual verification of experiment and theoretical analysis. Benefitting from this optimized heterointerfaces, the NiSe/[email protected] electrode manifests reduced polarization, superior rate capability, and prolonged cyclic stability (621.3 mAh g at 1 A g for 1000 cycles; 362.3 mAh g at 4 A g for 2000 cycles) with respect to the NiSe/[email protected], as well as excellent performance in LiCoO//NiSe/[email protected] full cell. Detailed electrochemical analysis confirmed rapid electrons/Li diffusion rates and more pseudocapacitive energy for the NiSe/[email protected] Therefore, the NiSe/[email protected] showcases superior hydrogen evolution reaction (HER) and lithium storage performance. This work demonstrates the significance of interface modulation to boost the electrochemical performance of multiphase heterostructures for energy storage and conversion.
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http://dx.doi.org/10.1016/j.jcis.2022.06.177DOI Listing
July 2022

Highly Efficient Organic Solar Cells Enabled by the Incorporation of a Sulfonated Graphene Doped PEDOT:PSS Interlayer.

ACS Appl Mater Interfaces 2022 Aug 25;14(30):34814-34821. Epub 2022 Jul 25.

Frontiers Science Center for Transformative Molecules, Center of Hydrogen Science, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

An interface modification layer plays an important role in improving the performance of organic solar cells (OSCs). The structure design or doping of electrode interlayer materials can effectively inhibit interfacial carrier recombination and improve ohmic contact between the active layer and the electrodes, which is desirable for realizing high power conversion efficiencies (PCEs). Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) has been extensively used as a hole-transport layer (HTL) in OSCs. Here, a modification of PEDOT:PSS is proposed using sulfonated graphene (SG) as a secondary dopant for improving the surface morphology and conductivity. The incorporation of the SG-doped PEDOT:PSS as the HTLs in OSCs leads to the increased charge extraction and shows the best PCEs of 17.48% for PM6:Y6 devices and 18.56% for PM6:L8-BO devices. The significant improvement in device performance suggests that SG-PEDOT:PSS is a promising interfacial layer for efficient charge transport and extraction toward high-efficiency OSCs.
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http://dx.doi.org/10.1021/acsami.2c10407DOI Listing
August 2022
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