Publications by authors named "Feng Jin"

841 Publications

Metabolome and Transcriptome Profiling Unveil the Mechanisms of Polyphenol Synthesis in the Developing Endopleura of Walnut ( L.).

Int J Mol Sci 2022 Jun 14;23(12). Epub 2022 Jun 14.

State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of the State Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China.

Walnut ( L.) is an important woody nut tree species, and its endopleura (the inner coating of a seed) is rich in many polyphenols. Thus far, the pathways and essential genes involved in polyphenol biosynthesis in developing walnut endopleura remain largely unclear. We compared metabolite differences between endopleura and embryo in mature walnuts, and analyzed the changes of metabolites in endopleura at 35, 63, 91, 119, and 147 days after pollination (DAP). A total of 760 metabolites were detected in the metabolome, and the polyphenol contents in endopleura were higher than those in embryos. A total of 15 types of procyanidins, 10 types of kaempferol glycosides, and 21 types of quercetin glycosides that accumulated during endopleura development were identified. The analysis of the phenylpropane metabolic pathway showed that phenylalanine was gradually transformed into proanthocyanidins and other secondary metabolites with the development of endopleura. A total of 49 unigenes related to polyphenol synthesis were identified by transcriptome analysis of endopleura. The expression patterns of , , , , , , , and were similar, and their expression levels were highest in endopleura at maturity. Transcriptome and metabolome analysis showed that endopleura rapidly synthesized and accumulated polyphenols during maturation. Moreover, the transcription factor MYB111 played an important role in synthesizing polyphenols in endopleura, and its expression pattern was positively correlated with the accumulation pattern of quercetin, kaempferol, and proanthocyanidins. was co-expressed with , , , and other genes related to cell senescence and abiotic stress response. Our study analyzed the composition and molecular synthesis mechanism of polyphenols in walnut endopleura, and provided new perspectives and insights regarding the nutritional research of walnut nuts.
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http://dx.doi.org/10.3390/ijms23126623DOI Listing
June 2022

Hypoxia- and Inflammation-Related Transcription Factor SP3 May Be Involved in Platelet Activation and Inflammation in Intracranial Hemorrhage.

Front Neurol 2022 2;13:886329. Epub 2022 Jun 2.

Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China.

The purpose of this study was to identify the biomarkers implicated in the development of intracranial hemorrhage (ICH) and potential regulatory pathways. In the transcriptomic data for patients with ICH, we identified DEmiRNAs and DEmRNAs related to hypoxia, inflammation, and their transcription factors (TFs). An ICH-based miRNA-TF-mRNA regulatory network was thus constructed, and four biomarkers (, and ) were screened for their association with inflammation or hypoxia by machine learning. Following this, SP3 was found to be a transcription factor involved in hypoxia and inflammation, which regulates and . From the constructed miRNA-TF-mRNA regulatory network, we identified three axes, hsa-miR-940/RUNX1/TIMP1, hsa-miR-571/SP3/TIMP1, and hsa-miR-571/SP3/PLAUR, which may be involved in the development of ICH. Upregulated and were validated in an independent clinical cohort 3 days after ICH onset. According to Gene Set Enrichment Analysis (GSEA), SP3 was discovered to be important in interleukin signaling and platelet activation for hemostasis. Transcription factor SP3 associated with hypoxia or inflammation plays an important role in development of ICH. This study provides potential targets for monitoring the severity of inflammation and hypoxia in patients with ICH.
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http://dx.doi.org/10.3389/fneur.2022.886329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201407PMC
June 2022

Final Overall Survival Analysis of Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma: A Multicenter, Randomized Phase III Trial.

J Clin Oncol 2022 Jun 16:JCO2200327. Epub 2022 Jun 16.

Department of Head and Neck Oncology, The Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.

JCO We previously reported significantly improved failure-free survival using gemcitabine plus cisplatin induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma. Here, we present the final overall survival (OS) analysis. In this multicenter, randomized trial, patients were assigned to be treated with concurrent chemoradiotherapy alone (standard therapy, n = 238) or gemcitabine and cisplatin induction chemotherapy before concurrent chemoradiotherapy (n = 242). With a median follow-up of 69.8 months, the induction chemotherapy group had a significantly higher 5-year OS (87.9% 78.8%, hazard ratio, 0.51 [95% CI 0.34 to 0.78]; = .001) and a comparable risk of late toxicities (≥ grade 3, 11.3% 11.4%). Notably, the depth of the tumor response to induction chemotherapy correlated significantly and positively with survival (complete response partial response stable/progressive disease, 5-year OS, 100% 88.4% 61.5%, = .005). Besides, patients with a low pretreatment cell-free Epstein-Barr virus DNA load (< 4,000 copies/mL) might not benefit from induction chemotherapy (5-year OS, 90.6% 91.4%, = .77). In conclusion, induction chemotherapy before concurrent chemoradiotherapy improved OS significantly in patients with locally advanced nasopharyngeal carcinoma, without increasing the risk of late toxicities. Tumor response to induction chemotherapy and pretreatment cell-free Epstein-Barr virus DNA might be useful to guide individualized treatment.
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http://dx.doi.org/10.1200/JCO.22.00327DOI Listing
June 2022

Adsorption Behaviors of Cationic Methylene Blue and Anionic Reactive Blue 19 Dyes onto Nano-Carbon Adsorbent Carbonized from Small Precursors.

Nanomaterials (Basel) 2022 May 25;12(11). Epub 2022 May 25.

Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, China.

In this work, an innovative nano-carbon material (N-CM) adsorbent was reported for exploring its adsorption behaviors toward cationic methylene blue (MB) and anionic reactive blue 19 (RB19) pollutants. The proposed N-CM was synthesized by a one-step solvothermal treatment of citric acid and zinc gluconate small precursors. N-CM consists of nanosheets that have an advantageous specific surface area, large sp/sp hybridized domains, and abundant nitrogen/oxygen-containing surface functional groups. The synergistic effects of these features are conducive to the MB and RB19 adsorption. Different from anionic RB19 adsorption (79.54 mg/g) by the cooperative π-π stacking and hydrogen bonding, cationic MB adsorbed onto N-CM mainly by the electrostatic attraction at the natural pH solution (> pH), with an adsorption capacity up to 118.98 mg/g. Interestingly, both MB and RB19 adsorption conformed to the pseudo-second order kinetic (R ≥ 0.995) and Langmuir isothermal (R ≥ 0.990) models, accompanied by similar maximum monolayer adsorption capacities of 120.77 and 116.01 mg/g, respectively. Their adsorption processes exhibited spontaneously endothermic characteristics. Moreover, N-CM showed superior selective capability toward MB in different mixed dye systems, with high removal efficiencies of 73-89%. These results demonstrate that the high-performance carbon adsorbent prepared from small precursors via low-temperature carbonization shows great potentials in wastewater treatment.
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http://dx.doi.org/10.3390/nano12111814DOI Listing
May 2022

Lysosome lipid signalling from the periphery to neurons regulates longevity.

Nat Cell Biol 2022 Jun 9;24(6):906-916. Epub 2022 Jun 9.

Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.

Lysosomes are key cellular organelles that metabolize extra- and intracellular substrates. Alterations in lysosomal metabolism are implicated in ageing-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to regulate ageing remains unclear. Here we report a fat-to-neuron lipid signalling pathway induced by lysosomal metabolism and its longevity-promoting role in Caenorhabditis elegans. We discovered that induced lysosomal lipolysis in peripheral fat storage tissue upregulates the neuropeptide signalling pathway in the nervous system to promote longevity. This cell-non-autonomous regulation is mediated by a specific polyunsaturated fatty acid, dihomo-γ-linolenic acid, and LBP-3 lipid chaperone protein transported from the fat storage tissue to neurons. LBP-3 binds to dihomo-γ-linolenic acid, and acts through NHR-49 nuclear receptor and NLP-11 neuropeptide in neurons to extend lifespan. These results reveal lysosomes as a signalling hub to coordinate metabolism and ageing, and lysosomal signalling mediated inter-tissue communication in promoting longevity.
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http://dx.doi.org/10.1038/s41556-022-00926-8DOI Listing
June 2022

An Empirical Study on the Inequality in Health and Healthcare in China's Medical Reform.

J Environ Public Health 2022 26;2022:5789118. Epub 2022 May 26.

School of International Trade and Economics, University of International Business and Economics, Beijing 100029, China.

To make clear what role the Urban and Rural Residents Basic Medical Insurance (URRBMI) plays in the inequality in health and healthcare, this article combines the time-varying DID method with the concentration index to conduct an empirical study. We find that the URRBMI improves health but expands health inequality among different income groups, with its contribution growing over time. Besides, the URRBMI significantly promotes healthcare utilization, reduces the medical burden, and narrows the gap among different income groups, though this effect is generally downward. These findings help clarify what deserves more attention to enlarge benefits and reduce inequality in this medical reform and provide policy implications for policymakers. Increasing investment in medical resources and constructing the hierarchical medical system and medical treatment combination may make a difference.
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http://dx.doi.org/10.1155/2022/5789118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162853PMC
June 2022

Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway.

Biomed Pharmacother 2022 Jun 29;150:113040. Epub 2022 Apr 29.

Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China.

Objective: Several metabolites from the kynurenine pathway of tryptophan metabolism play a critical role in vascular function and vascular wall remodeling. This study aimed to test whether metabolite kynurenic acid (KYNA) from the kynurenine pathway relaxes blood vessels.

Approach And Results: We employed histological staining, in vitro cell culture, Western blotting, real-time PCR, and nitric oxide detection to validate kynurenine aminotransferase (KAT) localization in the vasculature as well as KYNA action on endothelial cells. We also detected vascular reactivity by organ chamber and monitored blood pressure by telemetry to investigate the regulation effect of KYNA on vascular tone. The results presented that perivascular adipose tissue (PVAT) from mice thoracic aorta had robust staining of anti-KAT1 and KYNA than PVAT from the abdominal aorta and mesenteric artery, which is consistent with the expression profile of brown adipocyte marker uncoupling protein 1. KYNA, metabolized from kynurenine by KAT, relaxed pre-contracted both aortic ring and mesenteric artery. In addition, KYNA derived from KAT in PVAT participates in the cross-talk between PVAT and vessel by mediating PVAT inhibition on agonist-induced thoracic aorta contraction. Furthermore, intraperitoneal injection of KYNA in mice reduced blood pressure. The vessel relaxation effect of KYNA was through the endothelium-dependent PI3K-Akt-eNOS pathway. Finally, the high-fat diet decreased KAT1 expression in perithoracic aortic fat and led to KYNA reduction in blood.

Conclusions: Our research identified KYNA generated by KAT as a novel perivascular brown adipocyte-derived vascular relaxation factor and suggests that KYNA reduction is a critical event in vascular dysfunction under obese condition.
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http://dx.doi.org/10.1016/j.biopha.2022.113040DOI Listing
June 2022

Evaluation of the Effects on Uninfected Pregnant Women and Their Pregnancy Outcomes During the COVID-19 Pandemic in Beijing, China.

Front Med (Lausanne) 2022 11;9:842826. Epub 2022 May 11.

Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.

Background: People's lifestyles may have changed during the COVID-19 pandemic, which may have a profound impact on pregnant women and newborns. This study aims to assess the effects of the COVID-19 pandemic on uninfected pregnant women and their newborns, including potential environmental factors.

Methods: We retrospectively analyzed the pregnancy complications of 802 cases in the pandemic group and 802 controls in the pre-pandemic group in a matched nested case-control study, and evaluated the association with sociodemographic features, lifestyles, and other factors in 311 pregnant women with adverse pregnancy outcomes.

Results: Compared to the pre-pandemic group, the rates of anemia, vaginitis, shoulder dystocia, and adverse pregnancy outcomes such as preterm birth were increased in the pandemic group. After controlling for the covariates, we observed a higher risk of adverse pregnancy outcomes in the pandemic group. Pregnant women with adverse pregnancy outcomes had an increased rate of anemia and vaginal candidiasis.

Conclusion: COVID-19 pandemic has profound effects on adverse pregnancy outcomes, suggesting the importance of ensuring regular prenatal checkups and keeping a healthy lifestyle.
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http://dx.doi.org/10.3389/fmed.2022.842826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131041PMC
May 2022

The E484K Substitution in a SARS-CoV-2 Spike Protein Subunit Vaccine Resulted in Limited Cross-Reactive Neutralizing Antibody Responses in Mice.

Viruses 2022 04 21;14(5). Epub 2022 Apr 21.

State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially emerging variants, poses an increased threat to global public health. The significant reduction in neutralization activity against the variants such as B.1.351 in the serum of convalescent patients and vaccinated people calls for the design of new potent vaccines targeting the emerging variant. However, since most vaccines approved and in clinical trials are based on the sequence of the original SARS-CoV-2 strain, the immunogenicity and protective efficacy of vaccines based on the B.1.351 variant remain largely unknown. In this study, we evaluated the immunogenicity, induced neutralization activity, and protective efficacy of wild-type spike protein nanoparticle (S-2P) and mutant spike protein nanoparticle (S-4M-2P) carrying characteristic mutations of B.1.351 variant in mice. Although there was no significant difference in the induction of spike-specific IgG responses in S-2P- and S-4M-2P-immunized mice, neutralizing antibodies elicited by S-4M-2P exhibited noteworthy, narrower breadth of reactivity with SARS-CoV-2 variants compared with neutralizing antibodies elicited by S-2P. Furthermore, the decrease of induced neutralizing antibody breadth at least partly resulted from the amino acid substitution at position 484. Moreover, S-4M-2P vaccination conferred insufficient protection against live SARS-CoV-2 virus infection, while S-2P vaccination gave definite protection against SARS-CoV-2 challenge in mice. Together, our study provides direct evidence that the E484K substitution in a SARS-CoV-2 subunit protein vaccine limited the cross-reactive neutralizing antibody breadth in mice and, more importantly, draws attention to the unfavorable impact of this mutation in spike protein of SARS-CoV-2 variants on the induction of potent neutralizing antibody responses.
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http://dx.doi.org/10.3390/v14050854DOI Listing
April 2022

Electrolyte additive strategy enhancing the electrochemical performance of a soft-packed LiCoO//graphite full cell.

Dalton Trans 2022 Jun 7;51(22):8723-8732. Epub 2022 Jun 7.

MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry, The Key Lab of Low-Carbon Chemistry & Energy Conservation of Guangdong Province, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.

During the development of high-capacity, ultra-stable battery electrode materials, battery performance, and safety issues are proved to be related to the properties of the electrolyte used. The employment of electrolyte additives is to improve the battery electrolyte properties. Representative commercial two-electrode LiCoO//graphite pouch cells are used to study electrolyte additives represented by fluoroethylene carbonate (FEC) to improve the electrochemical stability of a commercial pouch full cell. The study reveals that a 1.5% FEC electrolyte additive has the best stability in the voltage range of 3.0-4.2 V.
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http://dx.doi.org/10.1039/d2dt01088gDOI Listing
June 2022

A novel nomogram and risk classification system for predicting lymph node metastasis of breast mucinous carcinoma: A SEER-based study.

Cancer Med 2022 May 22. Epub 2022 May 22.

Department of Surgical Oncology and Breast Surgery, the First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Mucinous breast cancer (MBC) is a rare disease, and patients with lymph node metastasis (LNM) have a poor prognosis. We aimed to explore the predictive factors of LNM and to construct a nomogram for predicting the risk of LNM and to identify the suitable axillary surgery for patients with diverse risks.

Patients And Methods: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Chi-square and rank-sum tests were used to analyze the differences between groups. Survival analysis was performed with Kaplan-Meier curves and log-rank tests. Independent factor identification and nomogram construction were performed with logistic regression analysis. The nomogram was qualified with a discrimination and calibration plot. Propensity score matching was performed to balance the disparities between groups.

Results: Patients with metastatic lymph nodes have a worse prognosis. Univariate and multivariate analyses indicated that tumor size, grade, and age were independent risk factors for LNM. The nomogram constructed with these three factors can predict the risk of LNM with high accuracy (AUC: 0.767, 95% CI: 0.697-0.838) and good calibration. Based on the nomogram, a risk classification system satisfactorily stratified the patients into 3 groups with diverse risks of LNM. In the low-risk group, there were no significant differences between sentinel lymph node biopsy and no axillary surgery. In the middle- and high-risk groups, both SLNB and axillary lymph node dissection were superior to no axillary surgery, with similar survival benefits.

Conclusions: The nomogram based on tumor size, grade, and age could conveniently and accurately predict the risk of LNM in MBC and assist clinicians in optimizing surgical strategies.
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http://dx.doi.org/10.1002/cam4.4804DOI Listing
May 2022

Effects of magnolol and honokiol blend on performance, egg quality, hepatic lipid metabolism, and intestinal morphology of hens at late laying cycle.

Animal 2022 Jun 13;16(6):100532. Epub 2022 May 13.

Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Animal Embryo and Molecular Breeding, Nanhu Road, No. 1 of Nanhuyaoyuan, 430064 Wuhan, China. Electronic address:

Magnolol and its isomer honokiol are polyphenols with anti-oxidative and anti-inflammatory activities. We evaluated the effects of magnolol and honokiol supplementation alone or in combination with hen diets during the late laying cycle. A total of 540 Jingfen pink-shell laying hens (50 weeks old) were randomly assigned to six treatments: a control diet and diets supplemented with 300 mg/kg magnolol (M), honokiol (H), or 300 mg/kg total phenols with a magnolol/honokiol ratio of 2:1 (MH), 1:2 (MH), and 1:1 (MH). Compared with that of the control, all supplementation groups had higher laying rates and the M, MH, and MH groups showed comparatively lower feed conversion ratios. Magnolol and honokiol supplementation increased the Haugh units of fresh eggs at week 62 and alleviated the decline of the Haugh units of eggs stored for 14 days. Compared with that of the control group, the serum total antioxidant capacity of the MH and MH groups significantly increased, and all supplementation groups had higher total antioxidant capacity and lower malondialdehyde content in the liver. With respect to lipid metabolism, the MH and MH groups had lower total and relative liver weights compared with those of the control and H groups. The mRNA expression levels of CCAAT enhancer binding protein alpha, sterol regulatory element binding protein-1, fatty acid synthase and stearyl coenzyme A desaturase 1 involved in lipogenesis; microsomal triglyceride transfer protein and apolipoprotein B involved in fatty acid transport; and the proinflammatory cytokine interleukin-1 beta were lower in all supplementation groups compared with those in the control. With respect to gut health, the heights of the jejunum and ileum villi significantly increased in all supplementation groups compared with those of the control, and the jejunum villus heights of the M and MH groups were higher than those of the H and MH groups. The H and MH groups had higher mRNA expression levels of zonula occludens-1 in the ileum compared with those in the control and M groups, whereas all supplementation groups had higher mRNA levels of claudin-1 than that of the control group. In conclusion, magnolol and honokiol improved hen performance and the albumen quality of fresh and stored eggs by improving the antioxidant capacity, liver lipid metabolism, and intestinal health of laying hens. The combination of magnolol and honokiol at a 1:1 ratio may be an optimal choice for hen diet supplementation.
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http://dx.doi.org/10.1016/j.animal.2022.100532DOI Listing
June 2022

Correction: Angiotensin-Converting Enzyme (ACE) 2 Overexpression Ameliorates Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition.

Mol Med 2022 May 4;28(1):53. Epub 2022 May 4.

Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China.

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http://dx.doi.org/10.1186/s10020-022-00482-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069746PMC
May 2022

Association between platelets and in-hospital mortality in critically ill patients with tumours: a retrospective cohort study.

BMJ Open 2022 04 27;12(4):e053691. Epub 2022 Apr 27.

Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, China

Objectives: Platelet count is an independent predictor of mortality in patients with cancer. It remains unknown whether the platelet count is related to in-hospital mortality in severely ill patients with tumours.

Design: A retrospective study based on a dataset from a multicentre cohort.

Setting: This was a secondary analysis of data from one Electronic Intensive Care Unit Collaborative Research Database survey cycle (2014-2015).

Participants: The data pertaining to severely ill patients with tumours were collected from 208 hospitals located across the USA. This study initially a total of 200 859 participants. After the population was limited to patients with combined tumours and platelet deficiencies, the remaining 2628 people were included in the final data analysis.

Primary And Secondary Outcome Measures: The main measure was the platelet count, and the main outcome was in-hospital mortality.

Results: After adjustment for the covariates, the platelet count had a curvilinear relationship with in-hospital mortality (p<0.001). The first inflection point was 18.4 (per 10 change). On the left side of the first inflection point (platelet count ≤184 'x10ˆ9/L), an increase of 10 in the platelet count was negatively associated with in-hospital mortality (OR 0.92, 95% CI 0.89 to 0.95, p<0.001). The second inflection point was 44.5 (per 10 change). Additional increases of 10 in the platelet count thereafter were positively associated with hospital mortality (OR 1.13, 95% CI 1.00 to 1.28, p=0.0454). The baseline platelet count was in the range of 184 'x10ˆ9/L-445 'x10ˆ9/L(p=0.0525), and the hospital mortality was lower than the baseline platelet count in other ranges.

Conclusions: The relationship between platelet count and in-hospital mortality in critically ill patients with tumours was curvilinear. The lowest in-hospital mortality was associated with platelet count between 184 'x10ˆ9/Land 445 'x10ˆ9/L. This indicates that both high and low platelet count should receive attention in clinical practice.
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http://dx.doi.org/10.1136/bmjopen-2021-053691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047744PMC
April 2022

The relationship among psychosocial adaptation, medication adherence and quality of life in breast cancer women with adjuvant endocrine therapy.

BMC Womens Health 2022 04 27;22(1):135. Epub 2022 Apr 27.

Department of Breast Oncology, The First Affiliated Hospital of China Medical University, No. 155, North Street, Heping District,, Shenyang, 110001, Liaoning Province, China.

Background: Patients undergoing endocrine therapy for breast cancer often suffer from poor psychosocial adaptation, low compliance with endocrine therapy and poor quality of life. However, the relationship among the three is not completely clear. The aims of this study were to investigate the status of psychosocial adaptation (PSA), medication adherence and quality of life (QOL) in breast cancer women with adjuvant endocrine therapy (AET), and to analyze the influencing factors of QOL and explore the relationship among them.

Methods: 346 breast cancer women were selected who underwent endocrine therapy after surgery, and data collected by the general information questionnaire, the PSA questionnaire among breast cancer women with AET, Morisky Medication Adherence Scale and The Functional Assessment of Cancer Therapy-Breast (FACT-B). The relationship among the variables was investigated by univariate analysis, multiple stepwise regression analysis and mediating effect analysis.

Results: The scores of PSA, medication adherence and QOL were slightly above the medium level. Univariate analysis showed that there were significant differences in QOL among breast cancer women of AET with different types of exercise, medical payment methods, discomfort symptoms (headache, hypomnesis, arthralgia, perturbation), type of discomfort symptoms, medication adherence and PSA; Multi-factor analysis showed that PSA and medication adherence were the influential factors of QOL; mediating effect showed that medication adherence played a partial mediating role in PSA and QOL.

Conclusion: The QOL of breast cancer women with AET will be directly affected by PSA. Medication compliance has a weak mediating effect in the indirect impact of PSA on the QOL. In the future, clinical nursing work should take targeted measures to improve the PSA level of patients, and effectively improve the compliance of patients with medication, so as to better improve the QOL of breast cancer women.
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http://dx.doi.org/10.1186/s12905-022-01722-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044832PMC
April 2022

Comparison of low-dose morphine intrathecal analgesia and sufentanil PCIA in elderly patients with hip fracture undergoing single spinal anesthesia - a randomized clinical trial.

BMC Anesthesiol 2022 04 27;22(1):124. Epub 2022 Apr 27.

Department of Anesthesiology, Gaoyou T.C.M. Hospital, 225600, Jiang Su, P. R. China.

Background: The complications of postoperative pain, such as hypertension, hypermetabolism, irritability, and postoperative cognitive dysfunction, significantly affect the postoperative rehabilitation of elderly patients. Intrathecal morphine prolongs analgesia after surgery, but has been implicated in nausea and vomiting, pruritus, postoperative respiratory depression, or apneic episodes. The present study explored the effect and safety of low-dose morphine used adjunctively with bupivacaine during single spinal anesthesia or sufentanil patient-controlled intravenous analgesia (PCIA) in elderly patients with hip fracture surgery. Since elderly patients often need anticoagulant therapy in the early postoperative period, single spinal anesthesia was involved in completing the operation in this study.

Methods: Eighty elderly patients aged 70-85 years who underwent elective hip fracture surgery with single spinal anesthesia were divided into two groups, 12.5 mg of 0.5% hyperbaric bupivacaine with 100 µg of morphine (morphine group, group M) and 12.5 mg of 0.5% hyperbaric bupivacaine with 100 µg of sufentanil PCIA (sufentanil group, group S). The analgesia scores using the visual analogue scale (VAS), the Brinell comfort scale (BCS) were evaluated at 6, 12, 24, and 48 h after operation, and adverse reactions were recorded such as nausea and vomiting, pruritus, sedation, respiratory depression, and POD (postoperative delirium) with Delirium Rating Scale-r 98.

Results: Within 24 h after operation, the analgesic and BCS scores of group M were better than those of group S (P < 0.05). Group M had higher frequency of skin pruritus than group S within 24 h, and the difference was statistically significant. The incidence of POD in group M (2 cases) was lower than that in group S (6 cases) (5.71% vs 18.18%) (P < 0.05) with the DRS-r 98 scores. No significant difference was observed in nausea and vomiting between the two groups, and the difference of severe respiratory depression was not found in both groups.

Conclusion: Compared with sufentanil PCIA, low-dose intrathecal morphine has a satisfactory analgesic effect, and little effect on the patient's cognitive function with low medical cost. Under effective respiratory monitoring, it can be used safely and effectively in elderly patients with hip fracture.

Trial Registration: Registered with the Chinese Clinical Trial Registry under ChiCTR2100042706 . 26/01/2021.
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http://dx.doi.org/10.1186/s12871-022-01677-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044775PMC
April 2022

Scalable Strategy to Directly Prepare 2D and 3D Liquid Metal Circuits Based on Laser-Induced Selective Metallization.

ACS Appl Mater Interfaces 2022 May 25;14(17):20000-20013. Epub 2022 Apr 25.

State Key Laboratory of Polymer Materials Engineering of China, Polymer Research Institute, Sichuan University, Chengdu 610065, China.

Selective wetting of a gallium-based liquid metal on copper circuits is one of the ways to prepare liquid metal circuits. However, the complex fabrication processes of an adhesion layer between copper circuits (or patterns) and substrates were still inevitable, limiting scalable applications. Our work developed a facile way to directly prepare 2D and 3D liquid metal circuits by combining laser-induced selective metallization and selective wetting for the first time. The copper template was obtained on elastomers using laser-induced selective metallization, and high-resolution liquid metal circuits were fabricated by brushing Galinstan on the copper template in the alkali solution. The distribution of Cu element not only was on the top surface but also extended to the interior of the elastomer substrate. This revealed that the Cu layer prepared by laser-induced selective metallization is born to firmly embed into the substrate, which endowed the circuits with strong adhesion, reaching the highest 5B level. Moreover, the prepared liquid metal circuits (or patterns) had a typical layered structure. The liquid metal circuits exhibit good flexibility, stretchability, self-healing ability, and acid-alkaline resistance. Compared with the traditional methods of patterning liquid metals, fabricating liquid metal circuits based on laser-induced selective metallization has irreplaceable advantages, such as strong adhesion between circuits and substrate, fabricating 3D circuits, good acid-alkaline resistance, cost-effectiveness, maskless use, time savings, arbitrary design of patterns, and convenient operation, which endow this method with great application prospect.
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http://dx.doi.org/10.1021/acsami.2c01201DOI Listing
May 2022

Pyrotinib-Containing Neoadjuvant Therapy in Patients With HER2-Positive Breast Cancer: A Multicenter Retrospective Analysis.

Front Oncol 2022 7;12:855512. Epub 2022 Apr 7.

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Pyrotinib, a small-molecule tyrosine kinase inhibitor, has been investigated as a component of neoadjuvant therapy in phase 2 trials of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This study aimed to evaluate the effectiveness and safety of pyrotinib-containing neoadjuvant therapy for patients with HER2-positive early or locally advanced breast cancer in the real-world setting.

Methods: Data of 97 patients with HER2-positive breast cancer from 21 centers across China treated with pyrotinib-containing neoadjuvant therapy were reviewed. Neoadjuvant therapy consisted of taxane/carboplatin/trastuzumab plus pyrotinib (TCbH+Py, 30 [30.9%]), anthracycline/cyclophosphamide followed by taxane/trastuzumab plus pyrotinib (AC-TH+Py) or taxane followed by anthracycline/cyclophosphamide/trastuzumab plus pyrotinib (T-ACH+Py, 29 [29.9%]), taxane/trastuzumab plus pyrotinib (TH+Py, 23 [23.7%]), and other pyrotinib-containing neoadjuvant treatment (15 [15.5%]). The primary outcome was breast pathological complete response (bpCR, ypT0/is) rate. Secondary outcomes included total pathological complete response (tpCR, ypT0/is ypN0) rate, objective response rate (ORR), and the incidence of preoperative adverse events.

Results: The ORR of pyrotinib-containing neoadjuvant therapy was 87.6% (85/97). The bpCR and tpCR rates were 54.6% (95% confidence interval [CI], 44.2%-64.7%) and 48.5% [95% CI, 38.2%-58.8%], respectively. The most common grade 3 or 4 treatment-related adverse events included diarrhea (15 [15.5%]), decreased hemoglobin (nine [9.3%]), and decreased neutrophil count (eight [8.2%]). No treatment-related deaths occurred.

Conclusion: Pyrotinib-containing neoadjuvant therapy for patients with HER2-positive early or locally advanced breast cancer shows favorable effectiveness with manageable toxicity in the real-world setting. Trastuzumab plus pyrotinib may be a novel option of dual HER2-targeted blockade.
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http://dx.doi.org/10.3389/fonc.2022.855512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021502PMC
April 2022

Room temperature all-solid-state lithium batteries based on a soluble organic cage ionic conductor.

Nat Commun 2022 Apr 19;13(1):2031. Epub 2022 Apr 19.

i-Lab, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou, 215123, China.

All solid-state lithium batteries (SSLBs) are poised to have higher energy density and better safety than current liquid-based Li-ion batteries, but a central requirement is effective ionic conduction pathways throughout the entire cell. Here we develop a catholyte based on an emerging class of porous materials, porous organic cages (POCs). A key feature of these Li conducting POCs is their solution-processibility. They can be dissolved in a cathode slurry, which allows the fabrication of solid-state cathodes using the conventional slurry coating method. These Li conducting cages recrystallize and grow on the surface of the cathode particles during the coating process and are therefore dispersed uniformly in the slurry-coated cathodes to form a highly effective ion-conducting network. This catholyte is shown to be compatible with cathode active materials such as LiFePO, LiCoO and LiNiCoMnO, and results in SSLBs with decent electrochemical performance at room temperature.
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http://dx.doi.org/10.1038/s41467-022-29743-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018795PMC
April 2022

[Corrigendum] MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1.

Oncol Rep 2022 Jun 13;47(6). Epub 2022 Apr 13.

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, P.R. China.

Subsequently to the publication of the above article, an interested reader drew to the authors' attention that the data panel for the MDA‑MB‑231/migration/NC experiment in Fig. 2B on p. 1428 was strikingly similar to the data shown for the MDA‑MB‑231/invasion/Blank experiment in Fig. 2C, such that these data appeared to have been derived from the same original source. The authors have referred back to their original data, and realize that the data panel was selected incorrectly for Fig. 2B. The corrected version of Fig. 2, showing the correct data for the MDA‑MB‑231/migration/NC experiment in Fig. 2B, is shown on the next page. The authors regret the error that was made during the preparation of this figure, and can confirm that the error in the assembly of this figure did not adversely affect the conclusions reported in the study. The authors are grateful to the Editor of for allowing them the opportunity to publish a Corrigendum, and all the authors agree to this Corrigendum. Furthermore, they apologize to the readership for any inconvenience caused. [the original article was published in Oncology Reports 35: 1425‑1432, 2016; DOI: 10.3892/or.2015.4502].
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http://dx.doi.org/10.3892/or.2022.8317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073415PMC
June 2022

Divergent and convergent imaging markers between bipolar and unipolar depression based on Machine Learning.

IEEE J Biomed Health Inform 2022 Apr 12;PP. Epub 2022 Apr 12.

Distinguishing bipolar depression (BD) from unipolar depression (UD) based on symptoms only is challenging. Brain functional connectivity (FC), especially dynamic FC, has emerged as a promising approach to identify possible imaging markers for differentiating BD from UD. However, most of such studies utilized conventional FC and group-level statistical comparisons, which may not be sensitive enough to quantify subtle changes in the FC dynamics between BD and UD. In this paper, we present a more effective individualized differentiation model based on machine learning and the whole-brain high-order functional connectivity (HOFC) network. The HOFC, capturing temporal synchronization among the dynamic FC time series, a more complex chronnectome metric compared to the conventional FC, was used to classify 52 BD, 73 UD, and 76 healthy controls (HC). We achieved a satisfactory accuracy (70.40%) in BD vs. UD differentiation. The resultant contributing features revealed the involvement of the coordinated flexible interactions among sensory (e.g., olfaction, vision, and audition), motor, and cognitive systems. Despite sharing common chronnectome of cognitive and affective impairments, BD and UD also demonstrated unique dynamic FC synchronization patterns. UD is more associated with abnormal visual-somatomotor inter-network connections, while BD is more related to impaired ventral attention-frontoparietal inter-network connections. Moreover, we found that the illness duration modulated the BD vs. UD separation, with the differentiation performance hampered by the secondary disease effects. Our findings suggest that BD and UD may have divergent and convergent neural substrates, which further expand our knowledge of the two different mental disorders.
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http://dx.doi.org/10.1109/JBHI.2022.3166826DOI Listing
April 2022

Enhanced rate capability and high-voltage cycling stability of single-crystal nickel-rich cathode by surface anchoring dielectric BaTiO.

J Colloid Interface Sci 2022 Aug 15;619:65-74. Epub 2022 Mar 15.

Research Center of Nanoscience and Nanotechnology, Shanghai University, Shanghai 200444, China. Electronic address:

The single-crystal Ni-rich Li(NiCoMn)O cathode (NCM) demonstrates better cycle performance, enhanced tap density and improved mechanical structure stability, compared with polycrystalline NCM.However, limited Li transports, (003) plane slips and microcracks in large single particles hinder rate capability and cycle performance. To overcome these shortcomings,single-crystal NCM cathodes have been modified by nanosized tetragonal BaTiO. Due to the dielectric properties, BaTiO particles induce electric field concentration at the BaTiO-NCM-electrolyte interface. Thus, a large amount of lithium vacancies can be formed, providing sufficient sites for the hopping diffusion of lithium ions, thereby significantly enhancing the diffusion coefficient of Li. Moreover, the redistribution of charges can inhibit the formation and accumulation of cathode-electrolyte-interface. Owing to the synergetic effect of BaTiO, the BT-modified single-crystal NCM with the optimized loading shows a remarkable initial discharge capacity of 138.5 mAh g and maintains 53.8% of its initial discharge capacity after 100 cycles under 5C at 4.5 V cut-off voltage. Overall, the proposed dielectric cathode-electrolyte-interface strategy can enhance Li ion transport and stabilize the interface structure, leading to improved rate performance. Meanwhile, the diffusion-induced state of charge gradient can also be inhibited, resulting in high structure stability of single-crystal NCMs under high rate and cut-off voltage cycling.
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http://dx.doi.org/10.1016/j.jcis.2022.03.064DOI Listing
August 2022

An Open-Framework Structured Material: [Ni(en)][Fe(CN)] as a Cathode Material for Aqueous Sodium- and Potassium-Ion Batteries.

ACS Appl Mater Interfaces 2022 Apr 1;14(14):16197-16203. Epub 2022 Apr 1.

School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.

Open-framework structured materials such as Prussian blue analogues and sodium superionic conductor (NASICON) materials have been regarded as promising electrode candidates for aqueous batteries. These materials exhibit outstanding long cycle stability and high rate capacity retention, due to their high ion diffusive rate in the crystal and the stable structure maintenance in the electrochemical reaction process. Herein, an open-framework structured material [Ni(en)][Fe(CN)] (NienHCF) is prepared and first used as a cathode material for aqueous sodium- and potassium-ion batteries. The resultant material exhibits a high output potential and outstanding cycle performance (93.4% after 500 cycles at 1 A g) in K-ion batteries. Meanwhile, the electrochemical reaction mechanism is investigated. After coupling with the activated carbon anode, the K-ion full cell has 91.5% capacity retention at 5 A g and retains 77.2% after 1000 cycles at 0.5 A g, exhibiting the potential as an electrode material for rechargeable aqueous K-ion and Na-ion batteries.
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http://dx.doi.org/10.1021/acsami.2c00143DOI Listing
April 2022

Breast adenoid cystic carcinoma: a report of seven cases and literature review.

BMC Surg 2022 Mar 24;22(1):113. Epub 2022 Mar 24.

Department of Breast Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Background: Primary adenoid cystic carcinoma (ACC) of breast is rarely seen clinically. It is a special subtype of triple-negative breast cancer characterized by low expression of Ki-67, low malignant potential, slow progression and favorable prognosis. To date, treatment for this disease is controversial and no consensus is reached. We analyzed clinical manifestations and pathological characteristics of seven primary breast ACC cases and reported in combination with literature review to promote understanding, diagnosis and treatment of this disease.

Case Presentation: We collected seven breast ACC cases pathologically diagnosed and treated in Department of breast surgery of the First Affiliated Hospital of China Medical University from January 2015 to December 2018. We organized and summarized the clinical, imaging, pathological and prognostic information and performed statistical analysis. The median age was 60 years (ranging from 54 to 64 years). Tumors of all patients were detected by immunohistochemistry. Molecular types were mostly triple negative (4/7), and Ki-67 expression was low (5/7). Lymph node metastases were absent in all patients received axillary lymph node surgery. Median follow-up time was 39 months (ranging from 25 to 68 months). There was no occurrence of relapse, distant metastasis or death.

Conclusion: Breast ACC is accompanied with favorable diagnosis, which is different from typical triple-negative breast cancer. Accurate diagnosis of ACC is particularly important.
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http://dx.doi.org/10.1186/s12893-022-01560-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953026PMC
March 2022

Raman and UVN+LWIR LIBS detection system for in-situ surface chemical identification.

MethodsX 2022 26;9:101647. Epub 2022 Feb 26.

Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, USA.

Laser Induced Breakdown Spectroscopy (LIBS) in the Ultra Violet/Visible/Near-IR (UVN) spectral range is a powerful analytical tool that facilitates the interpretation of Raman spectroscopic data by providing additional details in elemental chemistry. To acquire the complete information of molecular vibrations for more accurate and precise chemical bonding and structural analysis, an ideal optical sensing facility should be able to rapidly probe the broad vibrational dipole and polarizability responses of molecules by acquiring both Raman scattering and mid-IR emission spectroscopic signatures. Recently, the research team at Brimrose has developed a novel optical technology, Long-Wave IR (LWIR) LIBS. Critical experimental approaches were made to capture the infrared molecular emission signatures from vibrationally excited intact samples excited by laser-induced plasma in a LIBS event. LWIR LIBS is the only fieldable mid-IR emission spectroscopic technique to-date that that offers the same instrumental and analytical advantages of both UVN LIBS and Raman spectroscopy in in-situ stand-off field applications and can perform rapid and comprehensive molecular structure analysis without any sample-preparation.•A single excitation laser pulse is used to trigger both UVN and LWIR spectrometers simultaneously.•Time-resolved UVN-LWIR LIBS measurements showed the evolution of both atomic and molecular signature emissions of target compounds in the laser-induced plasma.•The technique was applied to the characterization of mineral and organic compounds in planetary analog samples.
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http://dx.doi.org/10.1016/j.mex.2022.101647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924681PMC
February 2022

A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPR axis.

Cell Death Differ 2022 Mar 17. Epub 2022 Mar 17.

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.

Hypoxic tumor microenvironment (TME) plays critical roles in induction of cancer stem cell-like phenotype in breast cancer and contribute to chemoresistance. However, the mechanism underlying stemness reprogramming of breast cancer cells (BCs) by hypoxic TME remains largely unknown. In the present study, we illustrated that HIF-2α, but not HIF-1α, induces stemness in BCs under hypoxia through SOD2-mtROS-PDI/GRP78-UPR pathway, linking mitochondrial metabolic state to endoplasmic reticulum (ER) response via mitochondrial reactive oxygen species (mtROS) level. HIF-2α activates endoplasmic reticulum unfolded protein response (UPR) in drug-sensitive MCF7 and T47D cells to induce drug-resistant stem-like phenotype. Genetic depletion or pharmacological inhibition (YQ-0629) of HIF-2α abolished hypoxia-induced stem-like phenotype in vitro and in vivo. Mechanistically, HIF-2α activates transcription of superoxide dismutase 2 (SOD2) under hypoxia and thereby decreases mtROS level. With less mtROS transported to endoplasmic reticulum, the expression and activity of protein disulfide isomerase (PDI) is suppressed, allowing glucose-regulated protein 78 (GRP78) to dissociate from receptor proteins of UPR and bind misfolded protein to activate UPR, which eventually confer chemoresistance and stem-like properties to BCs. Moreover, the increase in mtROS and PDI levels caused by HIF-2α knockdown and the subsequent UPR inhibition could be substantially rescued by mitoTEMPOL (a mtROS scavenger), 16F16 (a PDI inhibitor), or GRP78 overexpression. Overall, we reported the critical roles of HIF-2α-SOD2-mtROS-PDI/GRP78-UPR axis in mediating hypoxia-induced stemness in BCs, highlighting the interaction between organelles and providing evidence for further development of targeted HIF-2α inhibitor as a promising therapeutic strategy for chemoresistant breast cancer.
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http://dx.doi.org/10.1038/s41418-022-00963-8DOI Listing
March 2022

Pitaya-Structured Microspheres with Dual Laser Wavelength Responses for Polymer Laser Direct Writing.

ACS Appl Mater Interfaces 2022 Mar 17;14(12):14817-14833. Epub 2022 Mar 17.

State Key Laboratory of Polymer Materials Engineering of China, Polymer Research Institute, Sichuan University, Chengdu 610065, China.

A unique pitaya-structured graphene/[email protected] microsphere with dual laser wavelength responses is designed and prepared a facile approach of polymer melt blending. The graphene/TiO particles ("pitaya seeds") are homogeneously distributed in the polystyrene ("pitaya pulp") of the microspheres with an average size of 1.5 μm. The graphene in microspheres serves not only as a laser absorber that has responses to both 355 nm UV and 1064 nm NIR lasers but also as a reducing agent of TiO during laser direct writing (LDW). As expected, benefiting from the unique pitaya-structured structure, the graphene/[email protected] microsphere can remarkably improve the performance of both NIR and UV LDW of polymers. The results of characterizations reveal that the black color caused by NIR LDW is due to the generation of the amorphous carbon and the color change after UV LDW is owing to the formation of black sp/sp carbon compounds. Meanwhile, some TiO in microspheres is reduced into the black/gray titanium oxides of Ti and Ti after NIR and UV LDW, respectively. The above co-contribution endows the graphene/[email protected] microspheres with an outstanding color-changing ability. This pitaya-structured microsphere will have a profound effect on polymers' laser direct writing.
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http://dx.doi.org/10.1021/acsami.2c01454DOI Listing
March 2022

λ/30 inorganic features achieved by multi-photon 3D lithography.

Nat Commun 2022 Mar 15;13(1):1357. Epub 2022 Mar 15.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, 855 East Xingye Avenue, Panyu District, Guangzhou, 511443, P. R. China.

It's critically important to construct arbitrary inorganic features with high resolution. As an inorganic photoresist, hydrogen silsesquioxane (HSQ) has been patterned by irradiation sources with short wavelength, such as EUV and electron beam. However, the fabrication of three- dimensional nanoscale HSQ features utilizing infrared light sources is still challenging. Here, we demonstrate femtosecond laser direct writing (FsLDW) of HSQ through multi-photon absorption process. 26 nm feature size is achieved by using 780 nm fs laser, indicating super-diffraction limit photolithography of λ/30 for HSQ. HSQ microstructures by FsLDW possess nanoscale resolution, smooth surface, and thermal stability up to 600 °C. Furthermore, we perform FsLDW of HSQ to construct structural colour and Fresnel lens with desirable optical properties, thermal and chemical resistance. This study demonstrates that inorganic features can be flexibly achieved by FsLDW of HSQ, which would be prospective for fabricating micro-nano devices requiring nanoscale resolution, thermal and chemical resistance.
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http://dx.doi.org/10.1038/s41467-022-29036-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924217PMC
March 2022

Therapeutic effect of extracellular vesicles from different cell sources in traumatic brain injury.

Tissue Cell 2022 Jun 4;76:101772. Epub 2022 Mar 4.

Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, China. Electronic address:

Extracellular vesicles (EVs) are biologically active membrane vesicles secreted by many cells in the body. A variety of nucleic acids, proteins, and other biologically active substances in EVs can be used to exchange and transmit information between cells, thereby affecting the progression of various diseases. Numerous studies have demonstrated that EVs not only regulate changes in brain physiology but also regulate synaptic plasticity and neuronal regeneration in traumatic brain injury (TBI), which opens a new approach for the treatment of TBI. In view of the fact that most human cells can secrete EVs, and relevant experiments have proved that different doses of EVs have different therapeutic effects on TBI. To this end, this paper reviews the therapeutic effects of EVs from different cell sources and their doses on TBI.
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http://dx.doi.org/10.1016/j.tice.2022.101772DOI Listing
June 2022
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