Publications by authors named "Feng Duan"

166 Publications

Qualitative and Quantitative Anatomy of the Deep Radioulnar Ligaments' Insertion on Ulna: Cadaveric, Histologic, and MRI Study.

J Hand Surg Am 2022 Aug 2. Epub 2022 Aug 2.

Department of Orthopaedic Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Purpose: To qualitatively and quantitatively analyze the anatomic features of the insertion of deep radioulnar ligaments (RULs) and provide an anatomic basis for further studies.

Methods: The anatomic features of deep RUL insertion were observed macroscopically in 26 cadaveric wrists, after which the size of the deep RUL footprint and distance from the center of the footprint to the ulnar-sided margin of articular cartilage of the ulnar head were each measured. Five specimens were analyzed histologically to examine the attachment of the RUL on the ulna. In addition, we evaluated 21 asymptomatic wrists from healthy volunteers using 3.0 T magnetic resonance imaging.

Results: The insertion of the deep RUL was located mainly on the radial aspect of the ulnar fovea from the foveal center to the articular cartilage. The footprint of the deep RUL appeared in 3 different shapes. The maximal width, length, and area of the footprint of the deep RUL were 3.7 (95% confidence interval [CI], 3.3-4.0) mm, 8.4 (95% CI, 7.9-8.9) mm, and 26.3 (95% CI, 23.4-29.1) mm, respectively. Histologic analyses showed the attachment of the deep RUL on the radial wall of the fovea exhibited a direct insertion with typical 4-layer structures. The deep RUL fibers formed an acute angle with the distal component of the triangular fibrocartilage complex.

Conclusions: The deep RUL was inserted on the radial side of the ulnar fovea and not the foveal center; it had direct insertion on the radial wall continuous with articular cartilage, and the fibers in the direct insertion formed an acute angle with the distal component of the triangular fibrocartilage complex.

Clinical Relevance: Understanding the quantitative anatomy of the deep RUL insertion may help guide surgeons to perform an anatomic foveal repair of the triangular fibrocartilage complex in its native footprint.
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http://dx.doi.org/10.1016/j.jhsa.2022.06.003DOI Listing
August 2022

An Oversampling Method of Unbalanced Data for Mechanical Fault Diagnosis Based on MeanRadius-SMOTE.

Sensors (Basel) 2022 Jul 10;22(14). Epub 2022 Jul 10.

School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China.

With the development of machine learning, data-driven mechanical fault diagnosis methods have been widely used in the field of PHM. Due to the limitation of the amount of fault data, it is a difficult problem for fault diagnosis to solve the problem of unbalanced data sets. Under unbalanced data sets, faults with little historical data are always difficult to diagnose and lead to economic losses. In order to improve the prediction accuracy under unbalanced data sets, this paper proposes MeanRadius-SMOTE based on the traditional SMOTE oversampling algorithm, which effectively avoids the generation of useless samples and noise samples. This paper validates the effectiveness of the algorithm on three linear unbalanced data sets and four step unbalanced data sets. Experimental results show that MeanRadius-SMOTE outperforms SMOTE and LR-SMOTE in various evaluation indicators, as well as has better robustness against different imbalance rates. In addition, MeanRadius-SMOTE can take into account the prediction accuracy of the overall and minority class, which is of great significance for engineering applications.
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http://dx.doi.org/10.3390/s22145166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324964PMC
July 2022

Graph Empirical Mode Decomposition-Based Data Augmentation Applied to Gifted Children MRI Analysis.

Front Neurosci 2022 1;16:866735. Epub 2022 Jul 1.

Department of Artificial Intelligence, Nankai University, Tianjin, China.

Gifted children and normal controls can be distinguished by analyzing the structural connectivity (SC) extracted from MRI data. Previous studies have improved classification accuracy by extracting several features of the brain regions. However, the limited size of the database may lead to degradation when training deep neural networks as classification models. To this end, we propose to use a data augmentation method by adding artificial samples generated using graph empirical mode decomposition (GEMD). We decompose the training samples by GEMD to obtain the intrinsic mode functions (IMFs). Then, the IMFs are randomly recombined to generate the new artificial samples. After that, we use the original training samples and the new artificial samples to enlarge the training set. To evaluate the proposed method, we use a deep neural network architecture called BrainNetCNN to classify the SCs of MRI data with and without data augmentation. The results show that the data augmentation with GEMD can improve the average classification performance from 55.7 to 78%, while we get a state-of-the-art classification accuracy of 93.3% by using GEMD in some cases. Our results demonstrate that the proposed GEMD augmentation method can effectively increase the limited number of samples in the gifted children dataset, improving the classification accuracy. We also found that the classification accuracy is improved when specific features extracted from brain regions are used, achieving 93.1% for some feature selection methods.
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http://dx.doi.org/10.3389/fnins.2022.866735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295389PMC
July 2022

Internal and external validation of machine learning-assisted prediction models for mechanical ventilation-associated severe acute kidney injury.

Aust Crit Care 2022 Jul 13. Epub 2022 Jul 13.

Department of Emergency, First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China; State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, General Hospital of People's Liberation Army, Beijing, 100853, China; National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

Background: Currently, very few preventive or therapeutic strategies are used for mechanical ventilation (MV)-associated severe acute kidney injury (AKI).

Objectives: We developed clinical prediction models to detect the onset of severe AKI in the first week of intensive care unit (ICU) stay during the initiation of MV.

Methods: A large ICU database Medical Information Mart for Intensive Care IV (MIMIC-IV) was analysed retrospectively. Data were collected from the clinical information recorded at the time of ICU admission and during the initial 12 h of MV. Using univariate and multivariate analyses, the predictors were selected successively. For model development, two machine learning algorithms were compared. The primary goal was to predict the development of AKI stage 2 or 3 (AKI-23) and AKI stage 3 (AKI-3) in the first week of patients' ICU stay after initial 12 h of MV. The developed models were externally validated using another multicentre ICU database (eICU Collaborative Research Database, eICU) and evaluated in various patient subpopulations.

Results: Models were developed using data from the development cohort (MIMIC-IV: 2008-2016; n = 3986); the random forest algorithm outperformed the logistic regression algorithm. In the internal (MIMIC-IV: 2017-2019; n = 1210) and external (eICU; n = 1494) validation cohorts, the incidences of AKI-23 were 154 (12.7%) and 119 (8.0%), respectively, with areas under the receiver operator characteristic curve of 0.78 (95% confidence interval [CI]: 0.74-0.82) and 0.80 (95% CI: 0.76-0.84); the incidences of AKI-3 were 81 (6.7%) and 67 (4.5%), with areas under the receiver operator characteristic curve of 0.81 (95% CI: 0.76-0.87) and 0.80 (95% CI: 0.73-0.86), respectively.

Conclusions: Models driven by machine learning and based on routine clinical data may facilitate the early prediction of MV-associated severe AKI. The validated models can be found at: https://apoet.shinyapps.io/mv_aki_2021_v2/.
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http://dx.doi.org/10.1016/j.aucc.2022.06.001DOI Listing
July 2022

Cerebral cortex layer segmentation using diffusion magnetic resonance imaging in vivo with applications to laminar connections and working memory analysis.

Hum Brain Mapp 2022 Jul 1. Epub 2022 Jul 1.

College of Artificial Intelligence, Nankai University, Tianjin, China.

Understanding the laminar brain structure is of great help in further developing our knowledge of the functions of the brain. However, since most layer segmentation methods are invasive, it is difficult to apply them to the human brain in vivo. To systematically explore the human brain's laminar structure noninvasively, the K-means clustering algorithm was used to automatically segment the left hemisphere into two layers, the superficial and deep layers, using a 7 Tesla (T) diffusion magnetic resonance imaging (dMRI)open dataset. The obtained layer thickness was then compared with the layer thickness of the BigBrain reference dataset, which segmented the neocortex into six layers based on the von Economo atlas. The results show a significant correlation not only between our automatically segmented superficial layer thickness and the thickness of layers 1-3 from the reference histological data, but also between our automatically segmented deep layer thickness and the thickness of layers 4-6 from the reference histological data. Second, we constructed the laminar connections between two pairs of unidirectional connected regions, which is consistent with prior research. Finally, we conducted the laminar analysis of the working memory, which was challenging to do in the past, and explained the conclusions of the functional analysis. Our work successfully demonstrates that it is possible to segment the human cortex noninvasively into layers using dMRI data and further explores the mechanisms of the human brain.
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http://dx.doi.org/10.1002/hbm.25998DOI Listing
July 2022

Long-term outcomes of transarterial embolization with lipiodol-bleomycin emulsion plus polyvinyl alcohol particles versus the particles alone for large symptomatic focal nodular hyperplasia: a propensity score-matched analysis.

Eur Radiol 2022 Jun 28. Epub 2022 Jun 28.

The First Health Care Department, The Second Medical Center & National Clinical Research Center for Geriatric disease, Chinese PLA general Hospital, Beijing, 100853, People's Republic of China.

Objectives: To compare the efficacy of transarterial embolization (TAE) with polyvinyl alcohol (PVA) particles alone and lipiodol-bleomycin emulsion (LBE) plus PVA particles for patients with unresectable large symptomatic focal nodular hyperplasia (FNH).

Methods: We performed a retrospective analysis of patients who underwent TAE either with PVA particles alone (group A, n = 46) or LBE plus PVA particles (group B, n = 35) for large (≥ 7 cm) symptomatic FNH between January 2002 and February 2019. Propensity score matching (PSM) (1:1) was performed to adjust for potential baseline confounders. Technical success, adverse events (AEs), symptom relief, and changes in the lesion size after TAE were evaluated. Statistical analysis included Wilcoxon rank sum test and χ test.

Results: After PSM, no significant differences in baseline characteristics were found between the groups (31 in group A and 31 in group B, with a mean age of 31 years). Technical success was achieved in all patients (100%), without major AEs in both groups. Complete resolution of the abdominal symptoms was reported in 77.4% in group A and 100% in group B (p = 0.037) during a mean follow-up period of 72 months; complete resolution (CR) of the FNH rate was significantly higher in group B than in group A (93.6% vs. 67.7%; p = 0.019).

Conclusion: Compared with the use PVA particles alone, TAE with LBE plus PVA particles in the treatment of patients with large symptomatic FNH had a significantly higher rates of CR of the FNH and complete relief of the symptoms.

Key Points: • Transarterial embolization (TAE) with lipiodol-bleomycin emulsion (LBE) plus PVA particles for the large symptomatic FNH yielded better results than with PVA particles alone, in terms of complete resolution of FNH lesions (93.6% vs 67.7%) and complete relief of the abdominal symptoms (100% vs 77.4%) during a mean follow-up period of 72 months (38-170 months). • No major complications were recorded in both groups, and no significant difference in the incidence of postembolization syndrome were observed between the two groups.
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http://dx.doi.org/10.1007/s00330-022-08972-4DOI Listing
June 2022

A Robust 3D-Convolutional Neural Network-Based Electroencephalogram Decoding Model for the Intra-Individual Difference.

Int J Neural Syst 2022 Jul 21;32(7):2250034. Epub 2022 Jun 21.

Department of Systems Life Engineering, Maebashi Institute of Technology, Meabashi 3710132, Japan.

The convolutional neural network (CNN) has emerged as a powerful tool for decoding electroencephalogram (EEG), which owns the potential use in the event-related potential-based brain-computer interface (ERP-BCI). However, the intra-individual difference of ERP makes the traditional learning models trained on static EEG data hard to decode when the EEG features vary along the time, which limits the long-time performance of the model. Addressing this problem, this study proposes a three-dimension CNN (3D-CNN)-based model to decode the ERPs dynamically. As input, the EEG is transformed into a brain topographic map stream along time. Then the 3D-CNN applies three-dimension kernels to capture the dynamical characteristic of spatial feature at several time points. Ten subjects participated in a cross-time task for 6 or 12[Formula: see text]h. The 3D-CNN shows higher accuracies and shorter computational cost than the baseline models of the 2D-CNN, the long short term memory (LSTM), the back propagation (BP), and the fisher linear discriminant analysis (FLDA) when detecting the ERPs. In addition, four schemes of the 3D-CNN are compared to explore the influence of the structure on the performance. This result demonstrates advanced robustness of the 3D-CNN kernel to the intra-individual EEG difference, helping to launch a more practical EEG decoding model for a long-time use.
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http://dx.doi.org/10.1142/S0129065722500344DOI Listing
July 2022

Study on the Collection Efficiency of Bioaerosol Nanoparticles by Andersen-Type Impactors.

J Biomed Nanotechnol 2022 Feb;18(2):319-326

Beijing Institute of Metrology, Beijing, 100029, China.

Airborne transmission is much more common than previously thought. Based on our knowledge about SARS-COV-2 (COVID-19) infection, the aerosol transmission routes for all respiratory infections must be reassessed. Thus far, the COVID-19 outbreak has caused catastrophic public health and economic crises, posing a serious threat to the lives and health of people around the world and directing public attention toward the airborne transmission of pathogens. The novel coronavirus transmission in the form of nanoaerosols in a wider range hinders prevention and early warning efforts. As a classical bioaerosol sampler, the Andersen six-stage sampler is widely used in the collection and research of aerosol particles. In this study, the physical and biological collection efficiency of the six-stage sampler was explored by qPCR and colony counting method. Results showed that the physical collection efficiency reached more than 50% when the particle size was larger than 0.75 m. However, the overall biological collection efficiency was only 0.25%. In addition, fluorescence microscopy and flow cytometry were used to detect the microbial state after sampling, and the results showed that the proportion of the collected live bacteria was less than 15% of the total. This result is of great significance not only for the application of the Andersen six-stage sampler in collecting nanosized bioaerosols, but also provides reference for the selection of subsequent detection technologies for effective collection.
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http://dx.doi.org/10.1166/jbn.2022.3276DOI Listing
February 2022

Heparin-bonded stent graft placement for treatment of massive epistaxis from ruptured radiation-induced internal carotid artery pseudoaneurysm: A case report.

Radiol Case Rep 2022 Jun 12;17(6):2129-2132. Epub 2022 Apr 12.

Departments of Interventional Radiology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, P.R. China.

Rupture of an internal carotid artery (ICA) pseudoaneurysm is a rare but life-threatening complication of irradiation therapy for a nasopharyngeal carcinoma (NPC). A 36-year-old man had a history of NPC treated with radiotherapy 8 years previously. He was admitted to the hospital because of severe repetitive epistaxis with hemodynamically instablility. An emergent angiography showed the left ICA pseudoaneurysm at the petrous portion (C2 segment). The patient was successfully treated by a new-generation heparin-bonded stent graft without any complication. Emergent stent graft placement is effective in stopping hemorrhage and is therefore a life-saving intervention. Long-term follow-up is necessary to look out for delayed post-treatment complications.
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http://dx.doi.org/10.1016/j.radcr.2022.03.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024372PMC
June 2022

Metal recovery and heavy metal migration characteristics of ferritic stainless steel pickling sludge reduced by municipal sludge.

Waste Manag 2022 May 18;144:57-66. Epub 2022 Mar 18.

School of Energy and Environment, Anhui University of Technology, Ma'anshan 243000, China. Electronic address:

A new method for recovering metals from ferritic stainless steel pickling sludge using municipal sludge as a reducing agent is proposed. The effects of temperature, municipal sludge blending ratio, and reaction atmosphere on the recovery characteristics were studied. The migration characteristics of heavy metals (HMs) at different temperatures were also investigated. The results showed that municipal sludge can be used as a reducing agent for metal recovery from pickling sludge. Under optimized conditions (temperature of 650 °C and blending ratio of 5%), the recovery fractions of Fe, Cr, and Ni were 70.1, 53.7, and 60.3%, respectively. The CO atmosphere was beneficial for increasing the recovery fraction of the pickling sludge. The migration fractions of Cr, Mn, and Ni were approximately 10%. The migration fractions of Zn, Cu, and Pb, which are semi-volatile HMs, varied significantly with temperature. The migration fractions of Cd and As, which are volatile HMs, could exceed 70%.
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http://dx.doi.org/10.1016/j.wasman.2022.03.010DOI Listing
May 2022

Prostate arterial chemoembolization for treatment of refractory hematuria and urinary retention in patients with localized advanced prostate cancer.

Prostate Cancer Prostatic Dis 2022 Mar 5. Epub 2022 Mar 5.

Department of Interventional Radiology, Tianjin Nankai Hospital, Tianjin, 300193, China.

Objectives: To evaluate the safety and efficacy transcatheter arterial chemoembolization (TACE) for the treatment of refractory gross hematuria (RGH) and urinary retention (UR) secondary to localized advanced prostate cancer (PCa).

Patients And Methods: Thirty-two patients (mean age 72.5 years, range 60-89) with advanced PCa-related RGH that failed conventional therapy were included. Twenty-two of these patients had catheter-dependent due to PCa-related UR. TACE was performed with epirubicin (EPI)-eluting HepaSpheres (HS) plus intra-arterial (IA) infusion of docetaxel. Technical success, adverse events (AEs), overall survival (OS), control of RGH, removal of indwelling catheters, and local disease control, were evaluated.

Results: Technical success was achieved in 100% without major AEs. Mean follow up post-TACE was 27 months (range 8-56 months) with a mean OS of 30 months. GRH stopped within 5 days after TACE in all patients, 26 (86.7%) of these patients exhibited good bleeding control during a mean follow-up of 24 months; 17 (77.3%) of the 22 patients with UR had recovered spontaneous urination, 15 (88.2%) patients were catheter-free at their last follow-up with a mean of 24 months. BS was obtained in 73.3% (22/30) of patients at a mean follow-up of 29 months. At the last visit, 22 patients had a mean of 36 months follow-up and the mean percentage reduction in prostate volume was 55.5%, with a statistically different from baseline (P = 0.022). Negative biopsy results were obtained in 84.2% (16/19) of the patients at 12-47 months after TACE. Compared with baseline values, there was a significant improvements in IPSS, QoL, Q, and PVR (all P < 0.05).

Conclusions: TACE using EPI-eluting HS plus IA infusion of docetaxel is a safe and effective treatment option for the advanced PCa patients with GRH and UR, and it could be considered as an alternative if there was no other therapeutic choice.
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http://dx.doi.org/10.1038/s41391-022-00516-7DOI Listing
March 2022

Long noncoding RNA SNHG1 silencing accelerates hepatocyte-like cell differentiation of bone marrow-derived mesenchymal stem cells to alleviate cirrhosis via the microRNA-15a/SMURF1/UVRAG axis.

Cell Death Discov 2022 Feb 22;8(1):77. Epub 2022 Feb 22.

Department of Interventional Radiology, the First Medical Center, Chinese PLA General Hospital, Beijing, 100853, P.R. China.

Bone marrow-derived mesenchymal stem cells (BMSCs) can differentiate into hepatocyte-like cells (HLCs) to attenuate cirrhosis. Long noncoding RNA (lncRNA) SNHG1 has been demonstrated to orchestrate BMSC differentiation, whereas its role in cirrhosis remains elusive. Therefore, this study was performed to figure out whether lncRNA SNHG1 was involved in cirrhosis by affecting HLC differentiation of BMSCs. Mouse BMSCs were isolated, and the BMSC differentiation into HLCs was induced by hepatocyte growth factor (HGF). A cirrhotic mouse model was established using carbon tetrachloride and phenobarbital, followed by intravenous injection of BMSCs with manipulated expression of lncRNA SNHG1, microRNA (miR)-15a, and SMURF1. Subsequent to HGF induction, expression of hepatocyte-related genes, albumin secretion, and glycogen accumulation was increased in BMSCs, suggesting the differentiation of BMSCs into HLCs. Mechanistically, lncRNA SNHG1 bound to miR-15a that targeted SMURF1, and SMURF1 diminished ATG5 and Wnt5a expression by enhancing the ubiquitination of UVRAG. LncRNA SNHG1 or SMURF1 silencing or miR-15a overexpression promoted differentiation of BMSCs into HLCs and repressed cirrhosis of mice by upregulating ATG5 and Wnt5a via UVRAG. Conclusively, lncRNA SNHG1 silencing might facilitate HLC differentiation from mouse BMSCs and alleviate cirrhosis via the miR-15a/SMURF1/UVRAG/ATG5/Wnt5a axis.
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http://dx.doi.org/10.1038/s41420-022-00850-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863836PMC
February 2022

The role of the microRNA regulatory network in Alzheimer's disease: a bioinformatics analysis.

Arch Med Sci 2022 18;18(1):206-222. Epub 2021 Mar 18.

Department of Neurology, PLA Navy General Hospital, Haidian District, Beijing, China.

Introduction: Alzheimer's disease (AD) is a neurodegenerative disease which presents with an earlier age of onset and increased symptom severity. The objective of this study was to evaluate the relationship between regulation of miRNAs and AD.

Material And Methods: We completed a bioinformatic analysis of miRNA-AD studies through multiple databases such as TargetScan, Database for Annotation, Visualization and Integrated Discovery (DAVID), FunRich and String and assessed which miRNAs are commonly elevated or decreased in brain tissues, cerebrospinal fluid (CSF) and blood of AD patients. All identified articles were assessed using specific inclusion and exclusion criteria.

Results: MiRNAs related to AD of twenty-eight studies were assessed in this study. A wide range of miRNAs were up-regulated or down-regulated in tissues of AD patients' brain, blood and CSF. Twenty-seven differentially dysregulated miRNAs involved in amyloidogenesis, inflammation, tau phosphorylation, apoptosis, synaptogenesis, neurotrophism, neuron degradation, and activation of cell cycle entry were identified. Additionally, our bioinformatics analysis identified the top ten functions of common miRNAs in candidate studies. The functions of common up-regulated miRNAs primarily target the nucleus and common down-regulated miRNAs primarily target transcription, DNA-templated.

Conclusions: Comprehensive analysis of all miRNA studies reveals cooperation in miRNA signatures whether in brain tissues or in CSF and peripheral blood. More and more studies suggest that miRNAs may play crucial roles as diagnostic biomarkers and/or as new therapeutic targets in AD. According to biomarkers, we can identify the preclinical phase early, which provides an important time window for therapeutic intervention.
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http://dx.doi.org/10.5114/aoms/80619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826944PMC
March 2021

A Fast Approach to Removing Muscle Artifacts for EEG with Signal Serialization Based Ensemble Empirical Mode Decomposition.

Entropy (Basel) 2021 Sep 6;23(9). Epub 2021 Sep 6.

College of Artificial Intelligence, Nankai University, Tianjin 300350, China.

An electroencephalogram (EEG) is an electrophysiological signal reflecting the functional state of the brain. As the control signal of the brain-computer interface (BCI), EEG may build a bridge between humans and computers to improve the life quality for patients with movement disorders. The collected EEG signals are extremely susceptible to the contamination of electromyography (EMG) artifacts, affecting their original characteristics. Therefore, EEG denoising is an essential preprocessing step in any BCI system. Previous studies have confirmed that the combination of ensemble empirical mode decomposition (EEMD) and canonical correlation analysis (CCA) can effectively suppress EMG artifacts. However, the time-consuming iterative process of EEMD may limit the application of the EEMD-CCA method in real-time monitoring of BCI. Compared with the existing EEMD, the recently proposed signal serialization based EEMD (sEEMD) is a good choice to provide effective signal analysis and fast mode decomposition. In this study, an EMG denoising method based on sEEMD and CCA is discussed. All of the analyses are carried out on semi-simulated data. The results show that, in terms of frequency and amplitude, the intrinsic mode functions (IMFs) decomposed by sEEMD are consistent with the IMFs obtained by EEMD. There is no significant difference in the ability to separate EMG artifacts from EEG signals between the sEEMD-CCA method and the EEMD-CCA method ( > 0.05). Even in the case of heavy contamination (signal-to-noise ratio is less than 2 dB), the relative root mean squared error is about 0.3, and the average correlation coefficient remains above 0.9. The running speed of the sEEMD-CCA method to remove EMG artifacts is significantly improved in comparison with that of EEMD-CCA method ( < 0.05). The running time of the sEEMD-CCA method for three lengths of semi-simulated data is shortened by more than 50%. This indicates that sEEMD-CCA is a promising tool for EMG artifact removal in real-time BCI systems.
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http://dx.doi.org/10.3390/e23091170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465074PMC
September 2021

Recognizing Missing Electromyography Signal by Data Split Reorganization Strategy and Weight-Based Multiple Neural Network Voting Method.

IEEE Trans Neural Netw Learn Syst 2022 05 2;33(5):2070-2079. Epub 2022 May 2.

Surface electromyography (sEMG) signals have been applied widely in prosthetic hand controlling. In the sEMG signal acquisition, wireless devices bring convenience, but also introduce signal missing due to interference or failure during data transmission. The missing signal may only last for tens of milliseconds, but have a great impact on the recognition. Researchers have employed various methods to complete missing sEMG data, but the completed signal may not totally fit the origins, and more extra calculation time will be spent. When recognizing hand gestures by sEMG from few sensors, to recognize the slightly or not serious signal missing, this study proposed a data split reorganization (DSR) strategy and a weight-based multiple neural network voting (WMV) method. To validate the proposed methods, controllable missing sEMG signals are generated artificially. Three time domain features are extracted based on non-overlapping sliding windows. The DSR is employed to make full use of the features, and then the WMV is utilized to recognize them. Nine subjects participated in the experiments, and the results indicate that the accuracy of the proposed methods is higher. For 5%, 10%, and 15% data missing ratios, the accuracy is 93.66%, 92.55%, and 91.19%, respectively. The Wilcoxon signed-rank test also demonstrates that these results are significantly superior to the situations in which the proposed methods are not applied. In the future, we will optimize the proposed methods to recognize the seriously missing sEMG signal.
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http://dx.doi.org/10.1109/TNNLS.2021.3105595DOI Listing
May 2022

Comparison of long-term outcomes of balloon angioplasty with or without stent placement for hepatic vein type Budd-Chiari syndrome.

Eur J Gastroenterol Hepatol 2021 12;33(1S Suppl 1):e843-e850

School of Medicine, Nankai University, Tianjin.

Purpose: To compare percutaneous transluminal balloon angioplasty (PTBA) alone with PTBA plus stent placement for Budd-Chiari syndrome (BCS) patients with short-segmental obstruction of hepatic vein.

Methods: Between May 2001 and December 2010, 91 hepatic vein type BCS patients (mean age, 32.8 ± 10.8; M:F ratio 50:41) were included and divided into two groups (PTBA alone, as group A, n = 48; PTBA plus stent, as group B, n = 43). The incidence of restenosis, long-term patency, and survival were evaluated.

Results: All 91 patients were successfully treated with hepatic vein recanalization. During follow-up period (median 161 months, range: 84-234), group B had a significantly higher proportion of hepatic vein restenosis (56%, 24/43) than group A (33%, 16/48; P < 0.05). Cumulative primary patency rates at 1, 5, 10, 15 years were 96%, 81%, 69%, 65% and 91%, 60%, 47%, 47% in group A and group B, respectively (log-rank P < 0.05). Secondary technical success rates of target hepatic vein were 93% and 57% in group A and group B, respectively (P < 0.05). Clinical complete response rates were 94% and 86% in group A and group B, respectively (P > 0.05). The 15-year cumulative survival rates were 98% and 95% in group A and group B, respectively (P > 0.05). Major procedure-related complications occurred in 3 (3%) patients (1 in group A, 2 in group B).

Conclusions: Hepatic vein recanalization is safe and efficient for hepatic vein type BCS patients with hepatic vein short segmental obstruction. Restenosis after hepatic vein stenting is more common and difficult to manage than that after hepatic vein balloon angioplasty alone.
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http://dx.doi.org/10.1097/MEG.0000000000002277DOI Listing
December 2021

A Study of the Brain Network Connectivity in Visual-Word Pairing Associative Learning and Episodic Memory Reactivating Task.

Comput Intell Neurosci 2021 8;2021:5579888. Epub 2021 Jul 8.

Computational Engineering Applications Unit, Head Office for Information Systems and Cybersecurity, RIKEN, Wako-Shi, Japan.

Episodic memory allows a person to recall and mentally reexperience specific episodes from one's personal past. Studies of episodic memory are of great significance for the diagnosis and the exploration of the mechanism of memory generation. Most of the current studies focus on certain brain regions and pay less attention to the interrelationship between multiple brain regions. To explore the interrelationship in the brain network, we use an open fMRI dataset to construct the brain functional connectivity and effective connectivity network. We establish a binary directed network of the memory when it is reactivated. The binary directed network shows that the occipital lobe and parietal lobe have the most causal connections. The number of edges starting from the superior parietal lobule is the highest, with 49 edges, and 31 of which are connected to the occipital cortex. This means that the interaction between the superior parietal lobule and the occipital lobe plays the most important role in episodic memory, and the superior parietal lobule plays a more causal role in causality. In addition, memory regions such as the precuneus and fusiform also have some edges. The results show that the posterior parietal cortex plays an important role of hub node in the episodic memory network. From the brain network model, more information can be obtained, which is conducive to exploring the brain's changing pattern in the whole memory process.
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http://dx.doi.org/10.1155/2021/5579888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285180PMC
July 2021

Uterine Artery Embolization with Small-Sized Particles for the Treatment of Symptomatic Adenomyosis: A 42-Month Clinical Follow-Up.

Int J Gen Med 2021 15;14:3575-3581. Epub 2021 Jul 15.

Medical School of Chinese PLA, Beijing, 100853, People's Republic of China.

Purpose: To assess the long-term outcome of performing uterine artery embolization (UAE) using small particles in women with symptomatic adenomyosis (AD).

Methods: Twenty-seven consecutive women (median age 42 years, range 29-53 years) with AD, in eight cases AD combined with fibroids, who underwent UAE between February 2015 and January 2019, were retrospectively analyzed. The embolization was performed using small-sized polyvinyl alcohol particles (100 μm and 300 μm). The patients completed the Uterine Fibroid Symptom and Quality of Life questionnaire at baseline and at a 42-month follow-up (range 24-71). The junction zone (JZ) thickness and uterine volume were also calculated at baseline and at a three-month follow-up.

Results: The total symptom severity score (SSS) decreased from a median of 59 (range 34-78) at baseline to a median of 9 (range 3-47) at the end of this study; the health-related quality of life score (HRQOL) increased from a median of 38 (range 23-49) at baseline to a median of 84 (range 46-97) at 42 months. Twenty of the 27 patients were asymptomatic. The clinical response of the remaining seven women was little improvement in their symptoms, and one of the seven women underwent a hysterectomy at 35 months. Twenty-six of the 27 (96%) patients had a preserved uterus at the 42-month follow-up. There was no difference after UAE in SSS, HRQOL, junction zone (JZ) thickness, and uterus volume between patients with pure AD and those with AD combined with fibroids ( = 0.729, 0.710, 0.973, and > 0.99). There was no difference in the JZ thickness and uterus volume at baseline between the asymptomatic women and the women with an insufficient response ( = 0.854 and 0.253), and there were no major complications afterwards.

Conclusion: From the long-term follow-ups, it could be seen that UAE using small particles is safe and effective in treating AD, especially in preserving the uterus. There is no relationship between the clinical outcomes and the initial presence of AD, with or without fibroids, and the JZ thickness at baseline does not seem to be a predictor for the long-term outcome of UAE.
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http://dx.doi.org/10.2147/IJGM.S312618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289687PMC
July 2021

Efficacy and Safety of Surgical Ligation versus Endovascular Embolization for Type II Congenital Extrahepatic Portosystemic Shunt.

Biomed Res Int 2021 31;2021:9951393. Epub 2021 May 31.

Institution of Oncology, Chinese PLA General Hospital, Beijing 100853, China.

Objective: To evaluate the safety and efficacy of surgical ligation and endovascular embolization for the treatment of type II congenital extrahepatic portosystemic shunt CEPS).

Methods: In this retrospective study, 23 patients diagnosed with type II CEPS between March 2011 and April 2019 were divided into either a surgical group ( = 13; 41.5 ± 19.9 years) or the interventional group ( = 10; 44.9 ± 19.7 years). The surgical group underwent laparoscopic surgical ligation of the shunt alone or ligation of the shunt and splenic artery and/or vein. The interventional group underwent endovascular embolization using microcoils, detachable coils, and vascular plug.

Results: All 23 patients received a one-step shunt closure, and their clinical symptoms were significantly improved within 3-month postprocedure and without recurrence during follow-up. The serum ammonia levels in both groups decreased after the procedure and dropped to normal level at 6- to 12-month postprocedure. Compared with baseline, the portal vein diameter in interventional group increased significantly at 3-, 6-, 12-, and 36-month postocclusion ( = 0.01 for all). The procedure time was shorter in the interventional group (127.0 ± 43.2 minutes) than the surgical group (219.8 ± 56.7 minutes; < 0.001). The intraoperative blood loss in the interventional group (32.0 ± 62.5 mL) was less than that in the surgical group (238.5 ± 396.9 mL; = 0.001).

Conclusion: Both surgical ligation and endovascular embolization are effective in the treatment of type II CEPS. Endovascular embolization has the advantages of shorter procedure time and less intraoperative blood loss. The ligation of the portosystemic shunt and splenic artery and vein is feasible with apparent safety, and it could avoid a second surgical treatment.
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http://dx.doi.org/10.1155/2021/9951393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187072PMC
October 2021

Functional conservation and divergence of SEPALLATA-like genes in the development of two-type florets in marigold.

Plant Sci 2021 Aug 15;309:110938. Epub 2021 May 15.

Key Laboratory of Horticultural Plant Biology, Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Shizishan Street No. 1, Wuhan, 430070, China; Key Laboratory of Urban Agriculture in Central China (Pilot Run), Ministry of Agriculture, Wuhan, 430070, China. Electronic address:

Marigold (Tagetes erecta), as one member of Asteraceae family, bears a typical capitulum with two morphologically distinct florets. The SEPALLATA genes are involved in regulating the floral meristem determinacy, organ identity, fruit maturation, seed formation, and plant architecture. Here, five SEP-like genes were cloned and identified from marigold. Sequence alignment and phylogenetic analysis demonstrated that TeSEP3-1, TeSEP3-2, and TeSEP3-3 proteins were grouped into SEP3 clade, and TeSEP1 and TeSEP4 proteins were clustered into SEP1/2/4 clade. Quantitative real-time PCR analysis revealed that TeSEP1 and TeSEP3-3 were broadly expressed in floral organs, and that TeSEP3-2 and TeSEP4 were mainly expressed in pappus and corollas, while TeSEP3-1 was mainly expressed in two inner whorls. Ectopic expression of TeSEP1, TeSEP3-2, TeSEP3-3, and TeSEP4 in arabidopsis and tobacco resulted in early flowering. However, overexpression of TeSEP3-1 in arabidopsis and tobacco caused no visible phenotypic changes. Notably, overexpression of TeSEP4 in tobacco decreased the number of petals and stamens. Overexpression of TeSEP1 in tobacco led to longer sepals and simpler inflorescence architecture. The comprehensive pairwise interaction analysis suggested that TeSEP proteins had a broad interaction with class A, C, D, E proteins to form dimers. The yeast three-hybrid analysis suggested that in ternary complexes, class B proteins interacted with TeSEP3 by forming heterodimer TePI-TeAP3-2. The regulatory network analysis of MADS-box genes in marigold further indicated that TeSEP proteins played a "glue" role in regulating floral organ development, implying functional conservation and divergence of MADS box genes in regulating two-type floret developments. This study provides an insight into the formation mechanism of floral organs of two-type florets, thus broadening our knowledge of the genetic basis of flower evolution.
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http://dx.doi.org/10.1016/j.plantsci.2021.110938DOI Listing
August 2021

Long-term outcomes of individualized interventional treatment for primary Budd-Chiari syndrome complicated by inferior vena cava thrombosis.

Eur J Gastroenterol Hepatol 2021 12;33(1S Suppl 1):e642-e649

School of Medicine, Nankai University, Tianjin.

Background: Various endovascular treatments were used for Budd-Chiari syndrome (BCS) patients complicated by inferior vena cava (IVC) thrombosis. The best treatment for this disease remains unknown. To evaluate safety and efficacy of individualized interventional treatment for primary BCS with IVC thrombosis.

Methods: Forty-seven consecutive patients with IVC involvement BCS complicated by IVC thrombosis between June 2002 and August 2020 were analyzed retrospectively. They were treated with individualized interventional treatment based on thrombus type and size. Agitation thrombolysis, transcatheter thrombus aspiration, and catheter-directed thrombolysis were initially used for fresh and mixed thrombus (n = 20), then stent implantation for compressing thrombus and IVC recanalization were performed according to the size of the residual thrombus. Direct balloon angioplasty was used for old thrombus (n = 27).

Results: Median follow-up duration was 109 (5-223) months (average 114 ± 60 months). IVC recanalization were attempted in forty patients and failed in one. The technical successful rate of IVC recanalization was 97.5%. Thrombus was completely lysed in eight patients with fresh thrombus (40%, 8/20), partially lysed in 11 patients with mixed thrombus (55%, 11/20), and no response in one patient with mixed thrombus (5%, 1/20). Thrombolytic-related complications occurred in one patient (5%, 1/20). No symptomatic pulmonary embolism occurred. Among the 11 patients with thrombus partially lysed, five patients underwent stent implantation for compressing thrombus, six patients received conservative treatment. Old thrombus was completely lysed in 15 patients (55.6%, 15/27) during follow-up. Restenosis occurred in six patients (15.4%, 6/39). Primary patency rates at 1, 5, 10 and 15 years were 92, 92, 86 and 80%, respectively. Hepatocellular carcinoma (HCC) occurred in four patients (8.5%, 4/47). One patient died of HCC. The survival rate was 97.9%.

Conclusions: The individualized interventional treatment based on thrombus type and size for primary BCS complicated by IVC thrombosis patients is safe and effective with long-term patency and survival.
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http://dx.doi.org/10.1097/MEG.0000000000002191DOI Listing
December 2021

Endovascular Double-Layer Bare Stent Placement in the Treatment of Posttraumatic Pseudoaneurysm.

Biomed Res Int 2021 11;2021:5575173. Epub 2021 Mar 11.

Department of Interventional Radiology, The General Hospital of Chinese People's Liberation Army, Beijing 100853, China.

Objective: To investigate the efficacy and safety of endovascular double-layer bare stent placement for the treatment of traumatic false aneurysm (TFA).

Methods: This is a retrospective review of five patients with TFA undergone double-layer bare stent placement in our center between February 2011 and August 2020. There are 2 males and 3 females aged 29-65 years, with an average age of 43 years. One case suffered from common carotid artery pseudoaneurysm, and four cases suffered superficial femoral artery pseudoaneurysm.

Results: The endovascular interventional treatment was successful in all 5 patients, and the pseudoaneurysms disappeared after treatment. No TFA recurrence and no complications such as instent stenosis, stent migration, stent fracture, endoleak, and infection were observed during the 3-99-month follow-up period.

Conclusion: For the treatment of TFA, endovascular interventional therapy with double-layer bare stent was minimally invasive, safe, and effective with fewer complications. It could preserve all branches of parent artery and had the advantage of lower cost. It can be used in the treatment of TFA in selected cases. However, further clinical researches with larger cohorts are needed before its long-term efficacy can be completely clarified.
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http://dx.doi.org/10.1155/2021/5575173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972842PMC
May 2021

Dried sludge reburning blended with calcium magnesium acetate addition in a fluidized bed combustor.

Waste Manag 2021 Mar 11;123:120-130. Epub 2021 Feb 11.

Anhui Province Key Laboratory of Metallurgical Engineering & Resources Recycling (Anhui University of Technology), School of Energy and Environment, Anhui University of Technology, Ma'anshan 243002, Anhui Province, China. Electronic address:

The combustion and pollutant emission characteristics of the dried sludge in a fluidized bed combustor (FBC) were studied. The sludge reburning technology was employed for the first time in FBC. A scheme for using the dried sludge reburning blended with calcium magnesium acetate (CMA) to reduce pollutants simultaneously was also proposed, and the effect of the CMA addition was investigated. Results showed that fluidized bed reburning technology can be used to effectively treat the sewage sludge with lower calorific values. As the secondary fuel mass percentage increases, the unburned carbon content in fly ash and the CO emission increase, resulting in lower combustion efficiency. However, the de-NO ratio increases from 37.1% to 53.7%, and the de-SO ratio only increased from 1.6% to 7.6% as the secondary fuel mass percentage increase from 10% of 25%. For dried sludge blended with CMA, the minimum emissions of SO and NO significantly decrease to 254 mg/Nm and 70.9 mg/Nm at Ca/S ratio of 2, respectively. Results of main gaseous pollutant emissions from the sludge combustion in an FBC using different pollutant removal methods were compared under well-defined conditions. Fuel reburning blended with CMA addition has the smallest SO and NO emissions.
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http://dx.doi.org/10.1016/j.wasman.2021.01.028DOI Listing
March 2021

General versus local anesthesia for percutaneous radiofrequency ablation of hepatocellular carcinoma at unusual regions.

J Cancer Res Ther 2020 ;16(7):1686-1690

Department of Interventional Radiology, The First Medical Centre of Chinese PLA General Hospital, Beijing, China.

Aims: The aim of this study is to compare the efficacy and safety of percutaneous radiofrequency ablation (RFA) under general anesthesia or local anesthesia plus intraoperative analgesia in the treatment of hepatocellular carcinoma (HCC) at unusual regions.

Subjects And Methods: From July 2012 to October 2019, 83 consecutive patients with 107 HCC lesions were treated with interventional radiology therapy. The lesions were located at some unusual regions such as diaphragmatic surface, hepatic hilum, hepatic subcapsular region, tissues near inferior vena cava, and tissues near the colon. General anesthesia was applied in 57 cases (general anesthesia group) and local anesthesia plus intraoperative analgesia was used in 26 cases (local anesthesia group). All patients were treated with transcatheter arterial chemoembolization, followed immediately by RFA. The rate of tumor inactivation, time used for placing RF needles to the scheduled sites, pain score, and complications were analyzed.

Statistical Analysis Used: All continuous variables were tested for the normal/nonnormal distribution by Kolmogorov-Smirnov test. The t-test was used to analyze the normal distribution variables; the Mann-Whitney U-test was used to measure nonnormal distribution variables; and the Chi-square test for categorical variables. P < 0.05 was considered statistically significant.

Results: The treatments were successful in all patients, including 51 cases of complete response (CR) and 6 cases of partial response (PR) in the general anesthesia group and 18 cases of CR and 8 cases of PR in the local anesthesia group (P = 0.049). The time used for placing the needles to the scheduled sites was 1-5 min (mean 2 min) in the general anesthesia group and 2-9 min (mean 4 min) in the local analgesia group (P < 0.001). The pain scores ranged from 0 to 2 points (mean 1 point) in the general anesthesia group and 2-9 points (mean 5 points) in the local anesthesia group (P < 0.001). With regard to complications, seven cases had pneumothorax and four cases had slight hepatic subcapsular hemorrhage in the general anesthesia group and four cases of pneumothorax and three cases of slight hepatic subcapsular hemorrhage in the local anesthesia group, and the difference was not statistically significant between the two groups (P = 0.715).

Conclusions: For HCC located at unusual regions, general anesthesia is superior to local anesthesia plus intraoperative analgesia in percutaneous RFA in reducing the difficulty of the procedure and improving the safety of RFA.
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http://dx.doi.org/10.4103/jcrt.JCRT_1187_20DOI Listing
October 2021

Wireless Epidural Electrical Stimulation in Combination With Serotonin Agonists Improves Intraspinal Metabolism in Spinal Cord Injury Rats.

Neuromodulation 2021 Apr 30;24(3):416-426. Epub 2020 Dec 30.

Department of Neurosurgery, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: The combination of epidural electrical stimulation (EES) and serotonin agonists (5-HTA) effectively restores rhythmic lower-limb movements and improves intraspinal hemodynamics after spinal cord injury (SCI). Nonetheless, whether EES + 5-HTA improves intraspinal metabolism remains unclear. The present study aimed to evaluate the effects of EES + 5-HTA on intraspinal metabolism in SCI rats.

Materials And Methods: Wireless EES (WEES) implantation with complete T8 transection was performed in SCI rats. Electrodes were placed at the T12 and L2 vertebral levels. After rest for a week, the SCI rats received 11 weeks of WEES + 5-HTA treatment and treadmill training. WEES was switched off after each daily training. Locomotor function was evaluated by motion capture at week 12. Positron emission tomography-computed tomography was conducted to evaluate basal metabolism when WEES was switched off and assess task metabolism when WEES was switched on.

Results: With locomotor recovery after training for 11 weeks, WEES + 5-HTA conjointly improved basal metabolism (vs. each intervention alone; p < 0.05) and linearly modulated task metabolism in a frequency-dependent manner (R = 0.8901). Furthermore, 60 Hz of WEES was identified as the threshold for the extensive activation of the spinal cord's task metabolism below the transection plane (p < 0.05).

Conclusions: WEES + 5-HTA could conjointly restore basal metabolism to a healthy level and modulate task metabolism by adjusting the stimulation frequency.
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http://dx.doi.org/10.1111/ner.13344DOI Listing
April 2021

Nanoparticle-free and self-healing amphiphobic membrane for anti-surfactant-wetting membrane distillation.

J Environ Sci (China) 2021 Feb 14;100:298-305. Epub 2020 Aug 14.

Key Laboratory of Green Process and Engineering, Chinese Academy of Sciences, Beijing 100049, China; University of Chinese Academy of Sciences, Beijing 100190, China. Electronic address:

In membrane distillation (MD), complicated feed water with amphiphilic contaminants induces fouling/wetting of the MD membrane and can even lead to process failure. This study reports a facile approach to fabricate robust and self-healing hybrid amphiphobic membranes for anti-surfactant-wetting MD based on the ultra-low surface energy of fluorinated polyhedral oligomeric silsesquioxanes (F-POSS) and its thermal induced motivation and rotation. The thermal treatment makes the membranes achieving amphiphobicity at a very low cost of F-POSS (13.04 wt.%), which is about 1/3 of without thermal treatment. The prepared membrane exhibits excellent amphiphobicity, i.e. ethanol contact angle of 120.3°, without using environmentally toxic fluorinated nanoparticles. Robust MD performance was observed for the amphiphobic membrane in concentrated sodium dodecyl sulfate (SDS) feed solutions. Furthermore, the fabricated membrane exhibited stable amphiphobicity even in extreme environments, including strong acid or alkaline solutions. In the event of a damaged or abraded membrane surface where the F-POSS can be removed, the amphiphobic membrane exhibits self-healing ability with additional thermal treatment. This simple approach without the use of nanoparticles provides an environmentally friendly way for fabrication of amphiphobic membranes for anti-surfactant-wetting membrane distillation.
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http://dx.doi.org/10.1016/j.jes.2020.04.044DOI Listing
February 2021

Feasibility of Augmented Reality-Guided Transjugular Intrahepatic Portosystemic Shunt.

J Vasc Interv Radiol 2020 Dec;31(12):2098-2103

Department of Interventional Radiology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, China. Electronic address:

Purpose: To investigate an augmented reality (AR)-guided endovascular puncture to facilitate successful transjugular intrahepatic portosystemic shunt (TIPS).

Materials And Methods: An AR navigation system for TIPS was designed. Three-dimensional (3D) liver models including portal and hepatic vein anatomy were extracted from preoperative CT images. The 3D models, intraoperative subjects, and electromagnetic tracking information of the puncture needles were integrated through the system calibration. In the AR head-mounted display, the 3D models were overlaid on the subjects, which was a liver phantom in the first phase and live beagle dogs in the second phase. One life-size liver phantom and 9 beagle dogs were used in the experiments. Imaging after puncture was performed to validate whether the needle tip accessed the target hepatic vein successfully.

Results: Endovascular punctures of the portal vein of the liver phantom were repeated 30 times under the guidance of the AR system, and the puncture needle successfully accessed the target vein during each attempt. In the experiments of live canine subjects, the punctures were successful in 2 attempts in 7 beagle dogs and in 1 attempt in the remaining 2 dogs. The puncture time of needle from hepatic vein to portal vein was 5-10 s in the phantom experiments and 10-30 s in the canine experiments.

Conclusions: The feasibility of AR-based navigation facilitating accurate and successful portal vein access in preclinical models of TIPS was validated.
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http://dx.doi.org/10.1016/j.jvir.2020.07.025DOI Listing
December 2020

Markerless Rat Behavior Quantification With Cascade Neural Network.

Front Neurorobot 2020 27;14:570313. Epub 2020 Oct 27.

Department of Neurosurgery, China International Neurological Institute, Xuanwu Hospital, Capital Medical University, Beijing, China.

Quantifying rat behavior through video surveillance is crucial for medicine, neuroscience, and other fields. In this paper, we focus on the challenging problem of estimating landmark points, such as the rat's eyes and joints, only with image processing and quantify the motion behavior of the rat. Firstly, we placed the rat on a special running machine and used a high frame rate camera to capture its motion. Secondly, we designed the cascade convolution network (CCN) and cascade hourglass network (CHN), which are two structures to extract features of the images. Three coordinate calculation methods-fully connected regression (FCR), heatmap maximum position (HMP), and heatmap integral regression (HIR)-were used to locate the coordinates of the landmark points. Thirdly, through a strict normalized evaluation criterion, we analyzed the accuracy of the different structures and coordinate calculation methods for rat landmark point estimation in various feature map sizes. The results demonstrated that the CCN structure with the HIR method achieved the highest estimation accuracy of 75%, which is sufficient to accurately track and quantify rat joint motion.
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http://dx.doi.org/10.3389/fnbot.2020.570313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652788PMC
October 2020

Electroencephalography Symmetry in Power, Waveform and Power Spectrum in Major Depression.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:5280-5283

Depression is a harmful disease with high incidence. However, no effective method based on physiological information detection has been published to diagnose depression. Electroencephalography (EEG) has been used as a tool to detect physiological information of depressed patients and the symmetry of EEG receives much attention. This research focused on the symmetry of EEG in left and right homologous brain regions. 22 healthy volunteers and 41 volunteers of major depression were tested and three methods, average power ratio, waveform correlation and power spectral correlation, were adopted to measure the symmetry in all frequency bands and all brain regions. After t-test, homologous site pairs in particular frequency bands with significant differences between major depressed patients and controls were found out. Then sample entropy analysis was adopted, trying to figure out further connections between EEG symmetry and major depression. The accuracy tests were also taken and the average accuracy of some tests could reach 93.7%. The result of this research can hopefully serve as a theoretical basis for pattern recognition in the diagnosis of depression. The accuracy of pattern recognition based on multiple processing methods and sites will increase dramatically.
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http://dx.doi.org/10.1109/EMBC44109.2020.9176462DOI Listing
July 2020

Coupling-oxidation process promoted ring-opening degradation of 2-mecapto-5-methyl-1,3,4-thiadizaole in wastewater.

Water Res 2020 Nov 1;186:116362. Epub 2020 Sep 1.

Beijing Engineering Research Center of Process Pollution Control, Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing 100190, China.

As an important raw material and intermediate of widely used antibiotics cefazolin and cefazedone, 2-mecapto-5-methyl-1,3,4-thiadizaole (MMTD) in antibiotic wastewater is hardly decyclized during wastewater treatment, posing great risk to the environment. This work proposed a green "coupling-oxidation" process to enhance ring-opening of MMTD during antibiotic wastewater treatment. In particular, the significant role of humic substances (HS) as pre-coupling reagent was emphasized. Real HS and different model HS, especially quinones, not only efficiently pre-coupled MMTD (>95%) but also promoted the MMTD removal by MnO (from 72.4% to 92.4%). Mass spectrometric analysis indicated that MMTD pre-coupled to HS would be oxidized with ring opening to environmental-friendly sulfonated HS, while direct oxidation of MMTD produced MMTD dimers or sulfonated MMTD that would not undergo ring opening. Theoretical calculations indicated that pre-coupling to HS enabled the ring-opening oxidation by increasing the nucleophilicity and decreasing ring-opening barrier of thiadiazole. Based on the density function theory (DFT), the global nucleophilicity index (Nu) followed the trend of HS-MMTD > MMTD dimer > sulfonated MMTD, while the ring-opening barrier followed the trend of HS-MMTD (274 kJ/mol) < first ring of MMTD dimers (286 kJ/mol) < MMTD (338 kJ/mol). Theoretical calculations further confirmed that the cross-coupled HS-MMTD intermediate was more likely to be decyclized than intermediates from direct oxidation. Moreover, nitrogen, acetaldehyde group, sulfate and CO were the products of thiadiazole ring degradation. Pre-coupling of MMTD with HS provides a new idea and strategy in developing a green and sustainable scheme for wastewater treatment.
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http://dx.doi.org/10.1016/j.watres.2020.116362DOI Listing
November 2020
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