Publications by authors named "Felix Ratjen"

100Publications

Designing Clinical Trials for Anti-Inflammatory Therapies in Cystic Fibrosis.

Front Pharmacol 2020 11;11:576293. Epub 2020 Sep 11.

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2020.576293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516261PMC
September 2020

Aerosolized lancovutide in adolescents (≥12 years) and adults with cystic fibrosis - a randomized trial.

J Cyst Fibros 2020 Sep 1. Epub 2020 Sep 1.

Division of Respiratory Medicine, Department of Pediatrics, Translational Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2020.08.014DOI Listing
September 2020

Projecting the impact of delayed access to elexacaftor/tezacaftor/ivacaftor for people with Cystic Fibrosis.

J Cyst Fibros 2020 Aug 5. Epub 2020 Aug 5.

University of Toronto, Canada; Adult Cystic Fibrosis Program, Division of Respirology, St. Michael's Hospital, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2020.07.017DOI Listing
August 2020

Paediatric reproducibility limits for the forced expiratory volume in 1 s.

Thorax 2020 Oct 11;75(10):891-896. Epub 2020 Aug 11.

Translational Medicine, SickKids Research Institute, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2020-214817DOI Listing
October 2020

Clinical Outcomes Associated with Complex Infection in Patients with Cystic Fibrosis.

Ann Am Thorac Soc 2020 Jul 17. Epub 2020 Jul 17.

University of Toronto/ Hospital for Sick Children, Infectious Disease, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.202003-204OCDOI Listing
July 2020

Clinical Effectiveness of Lumacaftor/Ivacaftor in Cystic Fibrosis Patients Homozygous for F508del-CFTR.

Ann Am Thorac Soc 2020 Jul 9. Epub 2020 Jul 9.

University of Alabama at Birmingham, Medicine, Cystic Fibrosis Center, Birmingham, Alabama, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.202002-144OCDOI Listing
July 2020

The Remaining Barriers to Normalcy in CF: Advances in Assessment of CF Lung Disease.

Pediatr Pulmonol 2020 Jun 26. Epub 2020 Jun 26.

Division of Pediatric Pulmonology, Allergy, and Sleep Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24929DOI Listing
June 2020

Comparison of Functional Free-Breathing Pulmonary H and Hyperpolarized Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis.

Acad Radiol 2020 Jun 10. Epub 2020 Jun 10.

Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.acra.2020.05.008DOI Listing
June 2020

Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis.

Cochrane Database Syst Rev 2020 06 10;6:CD010004. Epub 2020 Jun 10.

Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD010004.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389742PMC
June 2020

Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis.

Cochrane Database Syst Rev 2020 06 10;6:CD009528. Epub 2020 Jun 10.

Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD009528.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388933PMC
June 2020

Changes in LCI in F508del/F508del patients treated with lumacaftor/ivacaftor: Results from the prospect study.

J Cyst Fibros 2020 Jun 6. Epub 2020 Jun 6.

Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada; Translational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2020.05.010DOI Listing
June 2020

Evaluation of a multiple breath nitrogen washout system in children.

Pediatr Pulmonol 2020 08 28;55(8):2108-2114. Epub 2020 May 28.

Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24862DOI Listing
August 2020

Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis.

Cochrane Database Syst Rev 2020 05 15;5:CD006961. Epub 2020 May 15.

Department of Pediatrics, Division of Infectious Diseases, Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD006961.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387858PMC
May 2020

Lung compartment analysis assessed from N multiple-breath washout in children with cystic fibrosis.

Pediatr Pulmonol 2020 07 16;55(7):1671-1680. Epub 2020 Apr 16.

Pediatric Pulmonary Service, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24773DOI Listing
July 2020

Bronchodilator responsiveness in children with cystic fibrosis and allergic bronchopulmonary aspergillosis.

Eur Respir J 2020 Aug 27;56(2). Epub 2020 Aug 27.

Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00175-2020DOI Listing
August 2020

Persistent ventilation inhomogeneity after an acute exacerbation in preschool children with recurrent wheezing.

Pediatr Allergy Immunol 2020 08 13;31(6):608-615. Epub 2020 Apr 13.

Division of Respiratory Medicine, Department of Paediatrics, Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13245DOI Listing
August 2020

Changes in the parent cystic fibrosis questionnaire-revised (CFQ-R) with respiratory symptoms in preschool children with cystic fibrosis.

J Cyst Fibros 2020 May 2;19(3):492-498. Epub 2020 Mar 2.

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; Translational Medicine Program, SickKids Research Institute, Toronto, Canada; Department of Paediatrics, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2020.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329610PMC
May 2020

The utility of moment ratios and abbreviated endpoints of the multiple breath washout test in preschool children with cystic fibrosis.

Pediatr Pulmonol 2020 03 3;55(3):649-653. Epub 2020 Jan 3.

Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24618DOI Listing
March 2020

Integrating the multiple breath washout test into international multicentre trials.

J Cyst Fibros 2020 Jul 24;19(4):602-607. Epub 2019 Nov 24.

Translational Medicine, Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2019.11.006DOI Listing
July 2020

Assessing the feasibility of hyperpolarized Xe multiple-breath washout MRI in pediatric cystic fibrosis.

Magn Reson Med 2020 07 25;84(1):304-311. Epub 2019 Nov 25.

Translational Medicine Program, Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mrm.28099DOI Listing
July 2020

Anti-inflammatories and mucociliary clearance therapies in the age of CFTR modulators.

Pediatr Pulmonol 2019 11;54 Suppl 3:S46-S55

Division of Respiratory Medicine, The Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24364DOI Listing
November 2019

Antimicrobial resistance in cystic fibrosis: A Delphi approach to defining best practices.

J Cyst Fibros 2020 May 31;19(3):370-375. Epub 2019 Oct 31.

Departments of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2019.10.006DOI Listing
May 2020

Long-term effect of CFTR modulator therapy on airway nitric oxide.

Eur Respir J 2020 01 9;55(1). Epub 2020 Jan 9.

Division of Respiratory Medicine, Dept of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01113-2019DOI Listing
January 2020

Proteomic Profiling to Identify Blood Biomarkers Predictive of Response to Azithromycin in Children and Adolescents With Cystic Fibrosis.

Chest 2019 10 12;156(4):667-673. Epub 2019 Jun 12.

Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2019.05.017DOI Listing
October 2019

Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial.

Lancet Respir Med 2019 09 6;7(9):802-809. Epub 2019 Jun 6.

Division of Pulmonary Medicine, Seattle Children's Hospital, Seattle, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(19)30187-0DOI Listing
September 2019

Blood biomarkers to predict short-term pulmonary exacerbation risk in children and adolescents with CF: A pilot study.

J Cyst Fibros 2020 01 5;19(1):49-51. Epub 2019 Jun 5.

Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada; Prevention Of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2019.05.020DOI Listing
January 2020

Incidence and risk factors of paediatric cystic fibrosis-related diabetes.

J Cyst Fibros 2019 11 6;18(6):874-878. Epub 2019 May 6.

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatrics, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15691993193007
Publisher Site
http://dx.doi.org/10.1016/j.jcf.2019.04.015DOI Listing
November 2019

Lavage lipidomics signatures in children with cystic fibrosis and protracted bacterial bronchitis.

J Cyst Fibros 2019 11 25;18(6):790-795. Epub 2019 Apr 25.

Hauner Children's Hospital, Ludwig Maximilians University, German Center for Lung Research (DZL), Lindwurmstr. 4a, D-80337 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15691993183086
Publisher Site
http://dx.doi.org/10.1016/j.jcf.2019.04.012DOI Listing
November 2019

A two-center analysis of hyperpolarized Xe lung MRI in stable pediatric cystic fibrosis: Potential as a biomarker for multi-site trials.

J Cyst Fibros 2019 09 25;18(5):728-733. Epub 2019 Mar 25.

Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054852PMC
September 2019

Oral Azithromycin and Response to Pulmonary Exacerbations Treated with Intravenous Tobramycin in Children with Cystic Fibrosis.

Ann Am Thorac Soc 2019 07;16(7):861-867

3 Division of Infectious Diseases, Department of Pediatrics, Hospital for Sick Children, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.201811-774OCDOI Listing
July 2019

Growth of Pulmonary Arteriovenous Malformations in Pediatric Patients with Hereditary Hemorrhagic Telangiectasia.

J Pediatr 2019 May 8;208:279-281. Epub 2019 Mar 8.

Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada; Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2018.12.069DOI Listing
May 2019

Hyperpolarised Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis.

Eur Respir J 2019 05 2;53(5). Epub 2019 May 2.

Division of Respiratory Medicine, Dept of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.02188-2018DOI Listing
May 2019

Does the multiple-breath washout test need to be measured before spirometry?

ERJ Open Res 2019 Feb 4;5(1). Epub 2019 Feb 4.

Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/23120541.00230-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360208PMC
February 2019

Lung clearance index is elevated in young children with symptom-controlled asthma.

Health Sci Rep 2018 Aug 19;1(8):e58. Epub 2018 Jun 19.

Division of Respiratory Medicine, Department of Pediatrics Hospital for Sick Children and Research Institute Toronto Ontario Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hsr2.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266588PMC
August 2018

A theory for polymicrogyria and brain arteriovenous malformations in HHT.

Neurology 2019 01;92(1):34-42

From the Department of Medical Imaging (J.M.K., L.C., S.M., T.K.), Division of Respirology (M.E.F.) and Department of Paediatrics (F.R.), Department of Medicine, and Division of Neurosurgery (T.K.), Department of Surgery, University of Toronto; Division of Neuroradiology (J.M.K., L.C., S.M., T.K.), Toronto Western Hospital, University Health Network, Canada; Departments of Radiology and Pathology (J.M.), University of Utah School of Medicine, Salt Lake City; Toronto HHT Centre, Division of Respirology, Department of Medicine, and Li Ka Shing Knowledge Institute (M.E.F.), St. Michael's Hospital, Toronto; and Division of Respiratory Medicine (F.R.), the Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336165PMC
January 2019

Letting It All Out: Neutrophils in Early Cystic Fibrosis Airway Inflammation.

Am J Respir Crit Care Med 2019 Apr;199(7):816-817

1 Division of Respiratory Medicine The Hospital for Sick Children Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201810-1951EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444667PMC
April 2019

The lung clearance index as a monitoring tool in cystic fibrosis: ready for the clinic?

Curr Opin Pulm Med 2018 11;24(6):579-585

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCP.0000000000000515DOI Listing
November 2018

Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease.

Acad Radiol 2019 03 5;26(3):344-354. Epub 2018 Aug 5.

Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10766332183027
Publisher Site
http://dx.doi.org/10.1016/j.acra.2018.04.024DOI Listing
March 2019

Ventilation inhomogeneity in infants with recurrent wheezing.

Thorax 2018 10 15;73(10):936-941. Epub 2018 Jun 15.

Division of Respiratory Medicine and Translational Medicine, Department of Pediatrics & Physiology, Hospital for Sick Children & University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2017-211351DOI Listing
October 2018

Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants.

Pediatr Pulmonol 2018 07 23;53(7):907-916. Epub 2018 May 23.

Division of Respiratory Medicine, Department of Pediatrics, and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24063DOI Listing
July 2018

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

J Cyst Fibros 2019 01 10;18(1):35-43. Epub 2018 Oct 10.

Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2018.03.013DOI Listing
January 2019

Early detection using qPCR of Pseudomonas aeruginosa infection in children with cystic fibrosis undergoing eradication treatment.

J Cyst Fibros 2018 11 7;17(6):723-728. Epub 2018 Mar 7.

Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto M5G 1X8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2018.02.008DOI Listing
November 2018

Comparison of facemask and mouthpiece interfaces for multiple breath washout measurements.

J Cyst Fibros 2018 07 2;17(4):511-517. Epub 2018 Mar 2.

Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Physiology and Experimental Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2018.01.003DOI Listing
July 2018

Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis.

Thorax 2018 05 15;73(5):451-458. Epub 2018 Feb 15.

Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2017-210979DOI Listing
May 2018

The effects of 100% oxygen on breathing pattern are not limited to young children.

Eur Respir J 2018 01 4;51(1). Epub 2018 Jan 4.

Translational Medicine, Hospital for Sick Children, Toronto, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.02055-2017DOI Listing
January 2018

Echocardiography Grading for Pulmonary Arteriovenous Malformation Screening in Children with Hereditary Hemorrhagic Telangiectasia.

J Pediatr 2018 04 20;195:288-291.e1. Epub 2017 Dec 20.

University of Toronto, Toronto, Ontario, Canada; Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2017.11.047DOI Listing
April 2018

Elucidating progression of early cystic fibrosis lung disease.

Eur Respir J 2017 11 9;50(5). Epub 2017 Nov 9.

Paediatric Respiratory Medicine, Inselspital, University of Bern, Bern, Switzerland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01916-2017DOI Listing
November 2017

Correcting for tissue nitrogen excretion in multiple breath washout measurements.

PLoS One 2017 11;12(10):e0185553. Epub 2017 Oct 11.

Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636099PMC
October 2017

Inter-test reproducibility of the lung clearance index measured by multiple breath washout.

Eur Respir J 2017 10 5;50(4). Epub 2017 Oct 5.

Division of Respiratory Medicine, Dept of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00433-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898949PMC
October 2017

Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis.

Cochrane Database Syst Rev 2017 10 5;10:CD009528. Epub 2017 Oct 5.

Department of Pediatrics, Division of Infectious Diseases, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/14651858.CD009528.pub4
Publisher Site
http://dx.doi.org/10.1002/14651858.CD009528.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485918PMC
October 2017

Another Brick in the Wall: Lung Clearance Index and Lower Airways Pathology in Preschool Cystic Fibrosis.

Ann Am Thorac Soc 2017 09;14(9):1389-1390

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.201706-432EDDOI Listing
September 2017

Changes in magnetic resonance imaging scores and ventilation inhomogeneity in children with cystic fibrosis pulmonary exacerbations.

Eur Respir J 2017 08 24;50(2). Epub 2017 Aug 24.

Labatt Family Heart Centre, Dept of Pediatrics and Dept of Diagnostic Imaging, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00244-2017DOI Listing
August 2017

Chronic Hypoxemia in a 2-Year-Old Boy.

Ann Am Thorac Soc 2017 08;14(8):1348-1352

1 Division of Respiratory Medicine, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.201701-069CCDOI Listing
August 2017

Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis.

Cochrane Database Syst Rev 2017 06 19;6:CD006961. Epub 2017 Jun 19.

Department of Pediatrics, Division of Infectious Diseases, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD006961.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481487PMC
June 2017

Clinical Outcomes Associated with Achromobacter Species Infection in Patients with Cystic Fibrosis.

Ann Am Thorac Soc 2017 Sep;14(9):1412-1418

4 Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://www.atsjournals.org/doi/10.1513/AnnalsATS.201701-071O
Publisher Site
http://dx.doi.org/10.1513/AnnalsATS.201701-071OCDOI Listing
September 2017

Psychosocial Response to Uncertain Newborn Screening Results for Cystic Fibrosis.

J Pediatr 2017 05 6;184:165-171.e1. Epub 2017 Mar 6.

Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; Health System Planning & Evaluation Research Program, Institute for Clinical Evaluative Sciences, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2017.01.049DOI Listing
May 2017

Pilot trial of tobramycin inhalation powder in cystic fibrosis patients with chronic Burkholderia cepacia complex infection.

J Cyst Fibros 2017 Jul 3;16(4):492-495. Epub 2017 Mar 3.

Division of Respirology and Keenan Research Centre of Li Ka Shing Knowledge Institute, Department of Medicine, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto M5B 1W8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2017.02.008DOI Listing
July 2017

Effectiveness of a stepwise Pseudomonas aeruginosa eradication protocol in children with cystic fibrosis.

J Cyst Fibros 2017 May 9;16(3):395-400. Epub 2017 Feb 9.

Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto M5G 1X8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2017.01.007DOI Listing
May 2017

Validation of multiple breath washout devices.

J Cyst Fibros 2017 11 7;16(6):e22-e23. Epub 2017 Feb 7.

Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2017.01.011DOI Listing
November 2017

How Best to Capture Early Cystic Fibrosis Lung Disease?

Authors:
Felix Ratjen

Am J Respir Crit Care Med 2017 02;195(3):283-284

1 Hospital for Sick Children University of Toronto Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201609-1836EDDOI Listing
February 2017

Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis.

Cochrane Database Syst Rev 2016 12 19;12:CD010004. Epub 2016 Dec 19.

Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1XB.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD010004.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464024PMC
December 2016

Clinimetric Properties of the Lung Clearance Index in Adults and Children With Cystic Fibrosis.

Chest 2016 12;150(6):1412-1413

Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2016.08.1478DOI Listing
December 2016

Constrictive Bronchiolitis: A Distinct Phenotype of Cystic Fibrosis Lung Disease?

Ann Am Thorac Soc 2016 12;13(12):2111-2112

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.201609-701EDDOI Listing
December 2016

Lumacaftor/Ivacaftor in Patients Aged 6-11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR.

Am J Respir Crit Care Med 2017 04;195(7):912-920

4 Pulmonary and Sleep Medicine, Seattle Children's Hospital, Seattle, Washington; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201608-1754OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440888PMC
April 2017

Special considerations for the treatment of pulmonary exacerbations in children with cystic fibrosis.

Expert Rev Respir Med 2016 Nov 20;10(11):1221-1228. Epub 2016 Oct 20.

b Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children , University of Toronto , Toronto , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2017.1246963DOI Listing
November 2016

Effect of pulmonary exacerbations treated with oral antibiotics on clinical outcomes in cystic fibrosis.

Thorax 2017 04 18;72(4):327-332. Epub 2016 Aug 18.

Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2016-208450DOI Listing
April 2017

Parent Experience With False-Positive Newborn Screening Results for Cystic Fibrosis.

Pediatrics 2016 09 2;138(3). Epub 2016 Aug 2.

Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada; Institute of Health Policy, Management and Evaluation, Departments of Pediatrics and Pediatric Medicine, and Institute for Clinical Evaluative Sciences, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2016-1052DOI Listing
September 2016

Longitudinal study of Stenotrophomonas maltophilia antibody levels and outcomes in cystic fibrosis patients.

J Cyst Fibros 2017 01 23;16(1):58-63. Epub 2016 Jun 23.

Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Canada M5G 1X8. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2016.06.007DOI Listing
January 2017

Physiologic endpoints for clinical studies for cystic fibrosis.

J Cyst Fibros 2016 07 15;15(4):416-23. Epub 2016 Jun 15.

Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2016.05.014DOI Listing
July 2016

Pulmonary artery hypertension: an underrated disease manifestation in cystic fibrosis?

Authors:
Felix Ratjen

Lancet Respir Med 2016 08 10;4(8):596-598. Epub 2016 Jun 10.

Division of Respiratory Medicine, Department of Pediatrics, Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(16)30107-2DOI Listing
August 2016

Utility of MDCT MIP Postprocessing Reconstruction Images in Children With Hereditary Hemorrhagic Telangiectasia.

J Comput Assist Tomogr 2016 May-Jun;40(3):375-9

From *The Department of Diagnostic Imaging, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain; †Chest Division, The Department of Pediatrics, The Hospital for Sick Children; ‡The Department of Diagnostic Imaging, The Hospital for Sick Children; and §The Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RCT.0000000000000385DOI Listing
January 2017

Lung clearance index response in patients with CF with class III CFTR mutations.

Thorax 2016 May 4;71(5):476-7. Epub 2016 Mar 4.

Division of Respiratory Medicine, Department of Pediatrics, Toronto, Ontario, Canada Physiology & Experimental Medicine, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Pediatrics, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2015-207894DOI Listing
May 2016