Felix Hausch

Felix Hausch

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Felix Hausch

Felix Hausch

Publications by authors named "Felix Hausch"

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FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.

PLoS One 2019 6;14(9):e0221926. Epub 2019 Sep 6.

Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730887PMC
September 2019

Structural and Dynamical Basis of G Protein Inhibition by YM-254890 and FR900359: An Inhibitor in Action.

J Chem Inf Model 2019 Sep 26. Epub 2019 Sep 26.

Clemens Schöpf Institute for Organic Chemistry and Biochemistry , Darmstadt University of Technology , Alarich-Weiss-Strasse 4 , 64287 Darmstadt , Germany.

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http://dx.doi.org/10.1021/acs.jcim.9b00433DOI Listing
September 2019

Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States.

Angew Chem Int Ed Engl 2019 Jul 5;58(28):9429-9433. Epub 2019 Jun 5.

Lehrstuhl für Biomolekulare NMR-Spektroskopie, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany.

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http://dx.doi.org/10.1002/anie.201902994DOI Listing
July 2019

The selective FKBP51 inhibitor SAFit2 reduces alcohol consumption and reinstatement of conditioned alcohol effects in mice.

Addict Biol 2019 Jun 7:e12758. Epub 2019 Jun 7.

Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.

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http://dx.doi.org/10.1111/adb.12758DOI Listing
June 2019

Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in M145.

MBio 2019 05 21;10(3). Epub 2019 May 21.

Department of Microbiology and Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Tübingen, Germany

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http://dx.doi.org/10.1128/mBio.00326-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529630PMC
May 2019

The Many Faces of FKBP51.

Biomolecules 2019 01 21;9(1). Epub 2019 Jan 21.

Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany.

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http://www.mdpi.com/2218-273X/9/1/35
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http://dx.doi.org/10.3390/biom9010035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359276PMC
January 2019

FKBP Ligands-Where We Are and Where to Go?

Front Pharmacol 2018 5;9:1425. Epub 2018 Dec 5.

Department of Chemistry, Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Darmstadt, Germany.

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http://dx.doi.org/10.3389/fphar.2018.01425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290070PMC
December 2018

Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.

J Med Chem 2018 04 5;61(8):3660-3673. Epub 2018 Apr 5.

Department of Translational Research in Psychiatry , Max Planck Institute of Psychiatry , 80804 Munich , Germany.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00137
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http://dx.doi.org/10.1021/acs.jmedchem.8b00137DOI Listing
April 2018

Cryo-EM Structures of Class B GPCR Reveal the Activation Mechanism.

Authors:
Felix Hausch

Angew Chem Int Ed Engl 2017 10 18;56(41):12412-12414. Epub 2017 Aug 18.

Clemens-Schöpf-Institute of Organic Chemistry and Biochemistry, Technical University Darmstadt, 64289, Darmstadt, Germany.

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http://doi.wiley.com/10.1002/anie.201707200
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http://dx.doi.org/10.1002/anie.201707200DOI Listing
October 2017

Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues.

Chemistry 2017 Mar 7;23(13):3178-3183. Epub 2017 Feb 7.

Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1002/chem.201605362DOI Listing
March 2017

Recent Progress in FKBP Ligand Development.

Curr Mol Pharmacol 2015 ;9(1):27-36

Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.

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October 2016

Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51.

J Med Chem 2016 Mar 8;59(6):2410-22. Epub 2016 Mar 8.

Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry , Kraepelinstrasse 2, 80804 Munich, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01355DOI Listing
March 2016

FKBPs and their role in neuronal signaling.

Authors:
Felix Hausch

Biochim Biophys Acta 2015 Oct 20;1850(10):2035-40. Epub 2015 Jan 20.

Max Planck Institute of Psychiatry, 80804 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2015.01.012DOI Listing
October 2015

Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands.

J Med Chem 2015 Oct 30;58(19):7796-806. Epub 2015 Sep 30.

Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry , Kraepelinstrasse 2, 80804 Munich, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00785DOI Listing
October 2015

FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma.

Nucleic Acids Res 2015 Aug 22;43(14):6983-93. Epub 2015 Jun 22.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/nar/gkv615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538817PMC
August 2015

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice.

Psychoneuroendocrinology 2015 May 26;55:128-43. Epub 2015 Feb 26.

Max Planck Institute of Psychiatry, Department of Stress Neurobiology and Neurogenetics, 80804 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2015.02.016DOI Listing
May 2015

Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.

J Neurosci 2015 Apr;35(17):6639-53

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain, School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom, and

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4364-14.2
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http://dx.doi.org/10.1523/JNEUROSCI.4364-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412889PMC
April 2015

Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs).

Angew Chem Int Ed Engl 2015 Jan 20;54(1):345-8. Epub 2014 Nov 20.

Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich (Germany).

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http://dx.doi.org/10.1002/anie.201408776DOI Listing
January 2015

Stereoselective construction of the 5-hydroxy diazabicyclo[4.3.1]decane-2-one scaffold, a privileged motif for FK506-binding proteins.

Org Lett 2014 Oct 6;16(20):5254-7. Epub 2014 Oct 6.

Max Planck Institute of Psychiatry , Kraepelinstr. 2, 80804 München, Germany.

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http://dx.doi.org/10.1021/ol5023195DOI Listing
October 2014

A polymorphism in the Crhr1 gene determines stress vulnerability in male mice.

Endocrinology 2014 Jul 28;155(7):2500-10. Epub 2014 Apr 28.

Max Planck Institute of Psychiatry (C.L., C.K., J.H., C.D., A.A, P.W., J.A., C.Q., K.V.W., S.H.S., L.C., R.W-A., J.B., R.L., F.H., M.U., F.H., E.B.B., M.V.S.), 80804 Munich, Germany; Lundbeck Research USA (K.A.J.), Paramus, New Jersey 07652; and Johannes Gutenberg University Medical Center (M.B.M.), 55131 Mainz, Germany.

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http://dx.doi.org/10.1210/en.2013-1986DOI Listing
July 2014

Snapshot of antidepressants at work: the structure of neurotransmitter transporter proteins.

Angew Chem Int Ed Engl 2014 May 11;53(20):5008-9. Epub 2014 Apr 11.

AG Chemical Genomics, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, Munich (Germany) http://www.mpipsykl.mpg.de/en/research/groups/hausch/index.html.

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http://dx.doi.org/10.1002/anie.201310567DOI Listing
May 2014

Structures of class B G protein-coupled receptors: prospects for drug discovery.

Authors:
Felix Hausch

Angew Chem Int Ed Engl 2013 Dec 11;52(49):12783-5. Epub 2013 Oct 11.

AG Chemical Genomics, Max Planck Institute of Psychiatry, Kraepelinstr. 2, München (Germany) http://www.mpipsykl.mpg.de/en/research/groups/hausch/index.html.

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http://dx.doi.org/10.1002/anie.201307542DOI Listing
December 2013

Crystal structures of the free and ligand-bound FK1-FK2 domain segment of FKBP52 reveal a flexible inter-domain hinge.

J Mol Biol 2013 Nov 8;425(22):4134-44. Epub 2013 Aug 8.

Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2013.07.041DOI Listing
November 2013

InterAKTions with FKBPs--mutational and pharmacological exploration.

PLoS One 2013 28;8(2):e57508. Epub 2013 Feb 28.

Research Group Chemical Genomics, Max Planck Institute of Psychiatry, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057508PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585324PMC
September 2013

FKBPs and the Akt/mTOR pathway.

Cell Cycle 2013 Aug 1;12(15):2366-70. Epub 2013 Jul 1.

Max Planck Institute of Psychiatry; Munich, Germany.

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http://dx.doi.org/10.4161/cc.25508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841315PMC
August 2013

Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.

J Med Chem 2013 May 6;56(10):3922-35. Epub 2013 May 6.

AG Chemical Genomics, Max Planck Institute of Psychiatry , Kraepelinstraße 2, 80804 Munich, Germany.

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http://dx.doi.org/10.1021/jm400087kDOI Listing
May 2013

Large FK506-binding proteins shape the pharmacology of rapamycin.

Mol Cell Biol 2013 Apr 28;33(7):1357-67. Epub 2013 Jan 28.

Max Planck Institute of Psychiatry, Department of Chemical Genomics, Munich, Germany.

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http://mcb.asm.org/content/early/2013/01/25/MCB.00678-12.ful
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http://mcb.asm.org/cgi/doi/10.1128/MCB.00678-12
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http://dx.doi.org/10.1128/MCB.00678-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624267PMC
April 2013

The seven pillars of molecular pharmacology: GPCR research honored with Nobel Prize for chemistry.

Angew Chem Int Ed Engl 2012 Dec 5;51(49):12172-5. Epub 2012 Nov 5.

Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany.

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http://dx.doi.org/10.1002/anie.201208565DOI Listing
December 2012

Structural biology: Snapshot of an activated peptide receptor.

Nature 2012 Oct 10;490(7421):492-3. Epub 2012 Oct 10.

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http://www.nature.com/doifinder/10.1038/nature11634
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http://dx.doi.org/10.1038/nature11634DOI Listing
October 2012

The prospect of FKBP51 as a drug target.

ChemMedChem 2012 Aug 13;7(8):1351-9. Epub 2012 May 13.

Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich (Germany).

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http://doi.wiley.com/10.1002/cmdc.201200137
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http://dx.doi.org/10.1002/cmdc.201200137DOI Listing
August 2012

Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52.

J Med Chem 2012 May 19;55(9):4123-31. Epub 2012 Apr 19.

Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany.

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http://pubs.acs.org/doi/10.1021/jm201747c
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http://dx.doi.org/10.1021/jm201747cDOI Listing
May 2012

Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52.

J Med Chem 2012 May 19;55(9):4114-22. Epub 2012 Apr 19.

Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany.

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http://pubs.acs.org/doi/10.1021/jm201746x
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http://dx.doi.org/10.1021/jm201746xDOI Listing
May 2012

Biomimetic screening of class-B G protein-coupled receptors.

J Am Chem Soc 2011 Jun 23;133(23):8927-33. Epub 2011 May 23.

Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany.

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http://dx.doi.org/10.1021/ja200160sDOI Listing
June 2011

Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.

Acta Crystallogr D Biol Crystallogr 2011 Jun 17;67(Pt 6):549-59. Epub 2011 May 17.

Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1107/S0907444911013862DOI Listing
June 2011

Corticotropin releasing factor receptor antagonists for major depressive disorder.

Expert Opin Investig Drugs 2011 Apr;20(4):519-35

Max Planck Institute of Psychiatry, Kraepelinsr, Munich, Germany.

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http://dx.doi.org/10.1517/13543784.2011.565330DOI Listing
April 2011

Facile synthesis of a fluorescent cyclosporin a analogue to study cyclophilin 40 and cyclophilin 18 ligands.

ACS Med Chem Lett 2010 Dec 25;1(9):536-9. Epub 2010 Aug 25.

AG Chemical Genomics, Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 München, Germany.

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http://dx.doi.org/10.1021/ml1001272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007835PMC
December 2010

XAP2 inhibits glucocorticoid receptor activity in mammalian cells.

FEBS Lett 2009 May 16;583(9):1493-8. Epub 2009 Apr 16.

Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany.

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http://dx.doi.org/10.1016/j.febslet.2009.03.072DOI Listing
May 2009

Fluorescent probes to characterise FK506-binding proteins.

Chembiochem 2009 May;10(8):1402-10

Chemical Genomics Research Group, Max Planck Institute for Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany.

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http://dx.doi.org/10.1002/cbic.200800806DOI Listing
May 2009

EMBL conference on Chemical Biology 2008.

Chembiochem 2008 Dec;9(18):3083-6

Chemical Genomics Research Group, Max Planck Institute of Psychiatry, Munich, Germany.

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http://dx.doi.org/10.1002/cbic.200800711DOI Listing
December 2008

Betablockers at work: the crystal structure of the beta2-adrenergic receptor.

Authors:
Felix Hausch

Angew Chem Int Ed Engl 2008 ;47(18):3314-6

Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany.

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http://doi.wiley.com/10.1002/anie.200705971
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http://dx.doi.org/10.1002/anie.200705971DOI Listing
May 2008

Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase.

Biol Chem 2004 Jun;385(6):481-5

ESBATech AG, CH-8952 Zürich-Schlieren, Switzerland.

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http://dx.doi.org/10.1515/BC.2004.056DOI Listing
June 2004

Internal 32P-labeling of L-deoxyoligonucleotides.

Nucleic Acids Res 2003 Apr;31(7):e34

NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, D-10589 Berlin, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152819PMC
http://dx.doi.org/10.1093/nar/gng034DOI Listing
April 2003

Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase.

Chem Biol 2003 Mar;10(3):225-31

Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

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March 2003

Intestinal digestive resistance of immunodominant gliadin peptides.

Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G996-G1003

Department of Chemical Engineering, Stanford University, Stanford, California 94305-5025, USA.

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http://www.physiology.org/doi/10.1152/ajpgi.00136.2002
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http://dx.doi.org/10.1152/ajpgi.00136.2002DOI Listing
October 2002

Structural basis for gluten intolerance in celiac sprue.

Science 2002 Sep;297(5590):2275-9

Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5025, USA.

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http://dx.doi.org/10.1126/science.1074129DOI Listing
September 2002