Felix Carvalho

Felix Carvalho

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Felix Carvalho

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Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells.

Neurotoxicology 2019 12 29;75:158-173. Epub 2019 Aug 29.

UCIBIO, REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Portugal; FP-ENAS (Unidade de Investigação UFP em Energia, Ambiente e Saúde), CEBIMED (Centro de Estudos em Biomedicina), Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2019.08.009DOI Listing
December 2019

Metabolic signature of methylone in primary mouse hepatocytes, at subtoxic concentrations.

Arch Toxicol 2019 Nov 7;93(11):3277-3290. Epub 2019 Sep 7.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-019-02566-8DOI Listing
November 2019

Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.

Toxicol Lett 2019 Nov 12;319:129-137. Epub 2019 Nov 12.

UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2019.11.004DOI Listing
November 2019

Hepatic Metabolic Derangements Triggered by Hyperthermia: An In Vitro Metabolomic Study.

Metabolites 2019 Oct 15;9(10). Epub 2019 Oct 15.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.3390/metabo9100228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835778PMC
October 2019

Biodistribution and metabolic profile of 3,4-dimethylmethcathinone (3,4-DMMC) in Wistar rats through gas chromatography-mass spectrometry (GC-MS) analysis.

Toxicol Lett 2019 Oct 18. Epub 2019 Oct 18.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal.

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http://dx.doi.org/10.1016/j.toxlet.2019.10.003DOI Listing
October 2019

The new psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone) induces oxidative stress, apoptosis, and autophagy in primary rat hepatocytes at human-relevant concentrations.

Arch Toxicol 2019 Sep 29;93(9):2617-2634. Epub 2019 Aug 29.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-019-02539-xDOI Listing
September 2019

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

Authors:
Christina Fitzmaurice Degu Abate Naghmeh Abbasi Hedayat Abbastabar Foad Abd-Allah Omar Abdel-Rahman Ahmed Abdelalim Amir Abdoli Ibrahim Abdollahpour Abdishakur S M Abdulle Nebiyu Dereje Abebe Haftom Niguse Abraha Laith Jamal Abu-Raddad Ahmed Abualhasan Isaac Akinkunmi Adedeji Shailesh M Advani Mohsen Afarideh Mahdi Afshari Mohammad Aghaali Dominic Agius Sutapa Agrawal Ayat Ahmadi Elham Ahmadian Ehsan Ahmadpour Muktar Beshir Ahmed Mohammad Esmaeil Akbari Tomi Akinyemiju Ziyad Al-Aly Assim M AlAbdulKader Fares Alahdab Tahiya Alam Genet Melak Alamene Birhan Tamene T Alemnew Kefyalew Addis Alene Cyrus Alinia Vahid Alipour Syed Mohamed Aljunid Fatemeh Allah Bakeshei Majid Abdulrahman Hamad Almadi Amir Almasi-Hashiani Ubai Alsharif Shirina Alsowaidi Nelson Alvis-Guzman Erfan Amini Saeed Amini Yaw Ampem Amoako Zohreh Anbari Nahla Hamed Anber Catalina Liliana Andrei Mina Anjomshoa Fereshteh Ansari Ansariadi Ansariadi Seth Christopher Yaw Appiah Morteza Arab-Zozani Jalal Arabloo Zohreh Arefi Olatunde Aremu Habtamu Abera Areri Al Artaman Hamid Asayesh Ephrem Tsegay Asfaw Alebachew Fasil Ashagre Reza Assadi Bahar Ataeinia Hagos Tasew Atalay Zerihun Ataro Suleman Atique Marcel Ausloos Leticia Avila-Burgos Euripide F G A Avokpaho Ashish Awasthi Nefsu Awoke Beatriz Paulina Ayala Quintanilla Martin Amogre Ayanore Henok Tadesse Ayele Ebrahim Babaee Umar Bacha Alaa Badawi Mojtaba Bagherzadeh Eleni Bagli Senthilkuimar Balakrishnan Abbas Balouchi Till Winfried Bärnighausen Robert J Battista Masoud Behzadifar Meysam Behzadifar Bayu Begashaw Bekele Yared Belete Belay Yaschilal Muche Belayneh Kathleen Kim Sachiko Berfield Adugnaw Berhane Eduardo Bernabe Mircea Beuran Nickhill Bhakta Krittika Bhattacharyya Belete Biadgo Ali Bijani Muhammad Shahdaat Bin Sayeed Charles Birungi Catherine Bisignano Helen Bitew Tone Bjørge Archie Bleyer Kassawmar Angaw Bogale Hunduma Amensisa Bojia Antonio M Borzì Cristina Bosetti Ibrahim R Bou-Orm Hermann Brenner Jerry D Brewer Andrey Nikolaevich Briko Nikolay Ivanovich Briko Maria Teresa Bustamante-Teixeira Zahid A Butt Giulia Carreras Juan J Carrero Félix Carvalho Clara Castro Franz Castro Ferrán Catalá-López Ester Cerin Yazan Chaiah Wagaye Fentahun Chanie Vijay Kumar Chattu Pankaj Chaturvedi Neelima Singh Chauhan Mohammad Chehrazi Peggy Pei-Chia Chiang Tesfaye Yitna Chichiabellu Onyema Greg Chido-Amajuoyi Odgerel Chimed-Ochir Jee-Young J Choi Devasahayam J Christopher Dinh-Toi Chu Maria-Magdalena Constantin Vera M Costa Emanuele Crocetti Christopher Stephen Crowe Maria Paula Curado Saad M A Dahlawi Giovanni Damiani Amira Hamed Darwish Ahmad Daryani José das Neves Feleke Mekonnen Demeke Asmamaw Bizuneh Demis Birhanu Wondimeneh Demissie Gebre Teklemariam Demoz Edgar Denova-Gutiérrez Afshin Derakhshani Kalkidan Solomon Deribe Rupak Desai Beruk Berhanu Desalegn Melaku Desta Subhojit Dey Samath Dhamminda Dharmaratne Meghnath Dhimal Daniel Diaz Mesfin Tadese Tadese Dinberu Shirin Djalalinia David Teye Doku Thomas M Drake Manisha Dubey Eleonora Dubljanin Eyasu Ejeta Duken Hedyeh Ebrahimi Andem Effiong Aziz Eftekhari Iman El Sayed Maysaa El Sayed Zaki Shaimaa I El-Jaafary Ziad El-Khatib Demelash Abewa Elemineh Hajer Elkout Richard G Ellenbogen Aisha Elsharkawy Mohammad Hassan Emamian Daniel Adane Endalew Aman Yesuf Endries Babak Eshrati Ibtihal Fadhil Vahid Fallah Mahbobeh Faramarzi Mahdieh Abbasalizad Farhangi Andrea Farioli Farshad Farzadfar Netsanet Fentahun Eduarda Fernandes Garumma Tolu Feyissa Irina Filip Florian Fischer James L Fisher Lisa M Force Masoud Foroutan Marisa Freitas Takeshi Fukumoto Neal D Futran Silvano Gallus Fortune Gbetoho Gankpe Reta Tsegaye Gayesa Tsegaye Tewelde Gebrehiwot Gebreamlak Gebremedhn Gebremeskel Getnet Azeze Gedefaw Belayneh K Gelaw Birhanu Geta Sefonias Getachew Kebede Embaye Gezae Mansour Ghafourifard Alireza Ghajar Ahmad Ghashghaee Asadollah Gholamian Paramjit Singh Gill Themba T G Ginindza Alem Girmay Muluken Gizaw Ricardo Santiago Gomez Sameer Vali Gopalani Giuseppe Gorini Bárbara Niegia Garcia Goulart Ayman Grada Maximiliano Ribeiro Guerra Andre Luiz Sena Guimaraes Prakash C Gupta Rahul Gupta Kishor Hadkhale Arvin Haj-Mirzaian Arya Haj-Mirzaian Randah R Hamadeh Samer Hamidi Lolemo Kelbiso Hanfore Josep Maria Haro Milad Hasankhani Amir Hasanzadeh Hamid Yimam Hassen Roderick J Hay Simon I Hay Andualem Henok Nathaniel J Henry Claudiu Herteliu Hagos D Hidru Chi Linh Hoang Michael K Hole Praveen Hoogar Nobuyuki Horita H Dean Hosgood Mostafa Hosseini Mehdi Hosseinzadeh Mihaela Hostiuc Sorin Hostiuc Mowafa Househ Mohammedaman Mama Hussen Bogdan Ileanu Milena D Ilic Kaire Innos Seyed Sina Naghibi Irvani Kufre Robert Iseh Sheikh Mohammed Shariful Islam Farhad Islami Nader Jafari Balalami Morteza Jafarinia Leila Jahangiry Mohammad Ali Jahani Nader Jahanmehr Mihajlo Jakovljevic Spencer L James Mehdi Javanbakht Sudha Jayaraman Sun Ha Jee Ensiyeh Jenabi Ravi Prakash Jha Jost B Jonas Jitendra Jonnagaddala Tamas Joo Suresh Banayya Jungari Mikk Jürisson Ali Kabir Farin Kamangar André Karch Narges Karimi Ansar Karimian Amir Kasaeian Gebremicheal Gebreslassie Kasahun Belete Kassa Tesfaye Dessale Kassa Mesfin Wudu Kassaw Anil Kaul Peter Njenga Keiyoro Abraham Getachew Kelbore Amene Abebe Kerbo Yousef Saleh Khader Maryam Khalilarjmandi Ejaz Ahmad Khan Gulfaraz Khan Young-Ho Khang Khaled Khatab Amir Khater Maryam Khayamzadeh Maryam Khazaee-Pool Salman Khazaei Abdullah T Khoja Mohammad Hossein Khosravi Jagdish Khubchandani Neda Kianipour Daniel Kim Yun Jin Kim Adnan Kisa Sezer Kisa Katarzyna Kissimova-Skarbek Hamidreza Komaki Ai Koyanagi Kristopher J Krohn Burcu Kucuk Bicer Nuworza Kugbey Vivek Kumar Desmond Kuupiel Carlo La Vecchia Deepesh P Lad Eyasu Alem Lake Ayenew Molla Lakew Dharmesh Kumar Lal Faris Hasan Lami Qing Lan Savita Lasrado Paolo Lauriola Jeffrey V Lazarus James Leigh Cheru Tesema Leshargie Yu Liao Miteku Andualem Limenih Stefan Listl Alan D Lopez Platon D Lopukhov Raimundas Lunevicius Mohammed Madadin Sameh Magdeldin Hassan Magdy Abd El Razek Azeem Majeed Afshin Maleki Reza Malekzadeh Ali Manafi Navid Manafi Wondimu Ayele Manamo Morteza Mansourian Mohammad Ali Mansournia Lorenzo Giovanni Mantovani Saman Maroufizadeh Santi Martini S Martini Tivani Phosa Mashamba-Thompson Benjamin Ballard Massenburg Motswadi Titus Maswabi Manu Raj Mathur Colm McAlinden Martin McKee Hailemariam Abiy Alemu Meheretu Ravi Mehrotra Varshil Mehta Toni Meier Yohannes A Melaku Gebrekiros Gebremichael Meles Hagazi Gebre Meles Addisu Melese Mulugeta Melku Peter T N Memiah Walter Mendoza Ritesh G Menezes Shahin Merat Tuomo J Meretoja Tomislav Mestrovic Bartosz Miazgowski Tomasz Miazgowski Kebadnew Mulatu M Mihretie Ted R Miller Edward J Mills Seyed Mostafa Mir Hamed Mirzaei Hamid Reza Mirzaei Rashmi Mishra Babak Moazen Dara K Mohammad Karzan Abdulmuhsin Mohammad Yousef Mohammad Aso Mohammad Darwesh Abolfazl Mohammadbeigi Hiwa Mohammadi Moslem Mohammadi Mahdi Mohammadian Abdollah Mohammadian-Hafshejani Milad Mohammadoo-Khorasani Reza Mohammadpourhodki Ammas Siraj Mohammed Jemal Abdu Mohammed Shafiu Mohammed Farnam Mohebi Ali H Mokdad Lorenzo Monasta Yoshan Moodley Mahmood Moosazadeh Maryam Moossavi Ghobad Moradi Mohammad Moradi-Joo Maziar Moradi-Lakeh Farhad Moradpour Lidia Morawska Joana Morgado-da-Costa Naho Morisaki Shane Douglas Morrison Abbas Mosapour Seyyed Meysam Mousavi Achenef Asmamaw Muche Oumer Sada S Muhammed Jonah Musa Ashraf R Nabhan Mehdi Naderi Ahamarshan Jayaraman Nagarajan Gabriele Nagel Azin Nahvijou Gurudatta Naik Farid Najafi Luigi Naldi Hae Sung Nam Naser Nasiri Javad Nazari Ionut Negoi Subas Neupane Polly A Newcomb Haruna Asura Nggada Josephine W Ngunjiri Cuong Tat Nguyen Leila Nikniaz Dina Nur Anggraini Ningrum Yirga Legesse Nirayo Molly R Nixon Chukwudi A Nnaji Marzieh Nojomi Shirin Nosratnejad Malihe Nourollahpour Shiadeh Mohammed Suleiman Obsa Richard Ofori-Asenso Felix Akpojene Ogbo In-Hwan Oh Andrew T Olagunju Tinuke O Olagunju Mojisola Morenike Oluwasanu Abidemi E Omonisi Obinna E Onwujekwe Anu Mary Oommen Eyal Oren Doris D V Ortega-Altamirano Erika Ota Stanislav S Otstavnov Mayowa Ojo Owolabi Mahesh P A Jagadish Rao Padubidri Smita Pakhale Amir H Pakpour Adrian Pana Eun-Kee Park Hadi Parsian Tahereh Pashaei Shanti Patel Snehal T Patil Alyssa Pennini David M Pereira Cristiano Piccinelli Julian David Pillay Majid Pirestani Farhad Pishgar Maarten J Postma Hadi Pourjafar Farshad Pourmalek Akram Pourshams Swayam Prakash Narayan Prasad Mostafa Qorbani Mohammad Rabiee Navid Rabiee Amir Radfar Alireza Rafiei Fakher Rahim Mahdi Rahimi Muhammad Aziz Rahman Fatemeh Rajati Saleem M Rana Samira Raoofi Goura Kishor Rath David Laith Rawaf Salman Rawaf Robert C Reiner Andre M N Renzaho Nima Rezaei Aziz Rezapour Ana Isabel Ribeiro Daniela Ribeiro Luca Ronfani Elias Merdassa Roro Gholamreza Roshandel Ali Rostami Ragy Safwat Saad Parisa Sabbagh Siamak Sabour Basema Saddik Saeid Safiri Amirhossein Sahebkar Mohammad Reza Salahshoor Farkhonde Salehi Hosni Salem Marwa Rashad Salem Hamideh Salimzadeh Joshua A Salomon Abdallah M Samy Juan Sanabria Milena M Santric Milicevic Benn Sartorius Arash Sarveazad Brijesh Sathian Maheswar Satpathy Miloje Savic Monika Sawhney Mehdi Sayyah Ione J C Schneider Ben Schöttker Mario Sekerija Sadaf G Sepanlou Masood Sepehrimanesh Seyedmojtaba Seyedmousavi Faramarz Shaahmadi Hosein Shabaninejad Mohammad Shahbaz Masood Ali Shaikh Amir Shamshirian Morteza Shamsizadeh Heidar Sharafi Zeinab Sharafi Mehdi Sharif Ali Sharifi Hamid Sharifi Rajesh Sharma Aziz Sheikh Reza Shirkoohi Sharvari Rahul Shukla Si Si Soraya Siabani Diego Augusto Santos Silva Dayane Gabriele Alves Silveira Ambrish Singh Jasvinder A Singh Solomon Sisay Freddy Sitas Eugène Sobngwi Moslem Soofi Joan B Soriano Vasiliki Stathopoulou Mu'awiyyah Babale Sufiyan Rafael Tabarés-Seisdedos Takahiro Tabuchi Ken Takahashi Omid Reza Tamtaji Mohammed Rasoul Tarawneh Segen Gebremeskel Tassew Parvaneh Taymoori Arash Tehrani-Banihashemi Mohamad-Hani Temsah Omar Temsah Berhe Etsay Tesfay Fisaha Haile Tesfay Manaye Yihune Teshale Gizachew Assefa Tessema Subash Thapa Kenean Getaneh Tlaye Roman Topor-Madry Marcos Roberto Tovani-Palone Eugenio Traini Bach Xuan Tran Khanh Bao Tran Afewerki Gebremeskel Tsadik Irfan Ullah Olalekan A Uthman Marco Vacante Maryam Vaezi Patricia Varona Pérez Yousef Veisani Simone Vidale Francesco S Violante Vasily Vlassov Stein Emil Vollset Theo Vos Kia Vosoughi Giang Thu Vu Isidora S Vujcic Henry Wabinga Tesfahun Mulatu Wachamo Fasil Shiferaw Wagnew Yasir Waheed Fitsum Weldegebreal Girmay Teklay Weldesamuel Tissa Wijeratne Dawit Zewdu Wondafrash Tewodros Eshete Wonde Adam Belay Wondmieneh Hailemariam Mekonnen Workie Rajaram Yadav Abbas Yadegar Ali Yadollahpour Mehdi Yaseri Vahid Yazdi-Feyzabadi Alex Yeshaneh Mohammed Ahmed Yimam Ebrahim M Yimer Engida Yisma Naohiro Yonemoto Mustafa Z Younis Bahman Yousefi Mahmoud Yousefifard Chuanhua Yu Erfan Zabeh Vesna Zadnik Telma Zahirian Moghadam Zoubida Zaidi Mohammad Zamani Hamed Zandian Alireza Zangeneh Leila Zaki Kazem Zendehdel Zerihun Menlkalew Zenebe Taye Abuhay Zewale Arash Ziapour Sanjay Zodpey Christopher J L Murray

JAMA Oncol 2019 Sep 27. Epub 2019 Sep 27.

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2019.2996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777271PMC
September 2019

Methods for the analysis of transcriptome dynamics.

Toxicol Res (Camb) 2019 Sep 26;8(5):597-612. Epub 2019 Jul 26.

UCIBIO , REQUIMTE , Laboratory of Toxicology , Faculty of Pharmacy , University of Porto , Rua Jorge Viterbo Ferreira , 228 , 4050-313 , Porto , Portugal . Email: ; Email:

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http://dx.doi.org/10.1039/c9tx00088gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764467PMC
September 2019

Benzo fury: A new trend in the drug misuse scene.

J Appl Toxicol 2019 Aug 5;39(8):1083-1095. Epub 2019 Feb 5.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal.

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http://dx.doi.org/10.1002/jat.3774DOI Listing
August 2019

Synthetic cannabinoids and their impact on neurodevelopmental processes.

Addict Biol 2019 Aug 23:e12824. Epub 2019 Aug 23.

UCIBIO REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Portugal.

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http://dx.doi.org/10.1111/adb.12824DOI Listing
August 2019

The metabolism of imidacloprid by aldehyde oxidase contributes to its clastogenic effect in New Zealand rabbits.

Mutat Res Genet Toxicol Environ Mutagen 2018 May - Jun;829-830:26-32. Epub 2018 Mar 19.

Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.mrgentox.2018.03.002DOI Listing
June 2019

Synthetic Cannabinoids JWH-122 and THJ-2201 Disrupt Endocannabinoid-Regulated Mitochondrial Function and Activate Apoptotic Pathways as a Primary Mechanism of In Vitro Nephrotoxicity at In Vivo Relevant Concentrations.

Toxicol Sci 2019 06;169(2):422-435

UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal.

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http://dx.doi.org/10.1093/toxsci/kfz050DOI Listing
June 2019

An effective antidotal combination of polymyxin B and methylprednisolone for α-amanitin intoxication.

Arch Toxicol 2019 May 19;93(5):1449-1463. Epub 2019 Mar 19.

Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, UCIBIO, REQUIMTE, University of Porto, Rua José Viterbo Ferreira no 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-019-02426-5DOI Listing
May 2019

MDMA modulates 5-HT-mediated contractile response of the human internal thoracic artery in vitro.

Toxicol In Vitro 2019 Mar 15;55:15-17. Epub 2018 Nov 15.

Laboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC.iCBR, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.tiv.2018.11.006DOI Listing
March 2019

The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells.

Biomolecules 2019 03 11;9(3). Epub 2019 Mar 11.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.3390/biom9030098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468772PMC
March 2019

Synthetic cannabinoids and endometrial stromal cell fate: Dissimilar effects of JWH-122, UR-144 and WIN55,212-2.

Toxicology 2019 02 28;413:40-47. Epub 2018 Nov 28.

UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n.º 228, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2018.11.006DOI Listing
February 2019

The novel psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone): A review.

Forensic Sci Int 2019 Feb 3;295:54-63. Epub 2018 Dec 3.

UCIBIO/REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal.

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http://dx.doi.org/10.1016/j.forsciint.2018.11.024DOI Listing
February 2019

Opioids in the Frame of New Psychoactive Substances Network: A Complex Pharmacological and Toxicological Issue.

Curr Mol Pharmacol 2018 ;11(2):97-108

Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.2174/1874467210666170704110146DOI Listing
January 2019

Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells.

Biomolecules 2019 01 10;9(1). Epub 2019 Jan 10.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://www.mdpi.com/2218-273X/9/1/21
Publisher Site
http://dx.doi.org/10.3390/biom9010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358964PMC
January 2019

GC-MS metabolomics reveals disturbed metabolic pathways in primary mouse hepatocytes exposed to subtoxic levels of 3,4-methylenedioxymethamphetamine (MDMA).

Arch Toxicol 2018 11 25;92(11):3307-3323. Epub 2018 Sep 25.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-018-2314-9DOI Listing
November 2018

Calcium Pathways in Human Neutrophils-The Extended Effects of Thapsigargin and ML-9.

Cells 2018 Nov 9;7(11). Epub 2018 Nov 9.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

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http://www.mdpi.com/2073-4409/7/11/204
Publisher Site
http://dx.doi.org/10.3390/cells7110204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262620PMC
November 2018

Analysis of extracellular metabolome by HS-SPME/GC-MS: Optimization and application in a pilot study to evaluate galactosamine-induced hepatotoxicity.

Toxicol Lett 2018 Oct 28;295:22-31. Epub 2018 May 28.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.05.028DOI Listing
October 2018

Antioxidant and pro-oxidant activities of carotenoids and their oxidation products.

Food Chem Toxicol 2018 Oct 2;120:681-699. Epub 2018 Aug 2.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2018.07.060DOI Listing
October 2018

The Analytical Challenge in the Determination of Cathinones, Key-Players in the Worldwide Phenomenon of Novel Psychoactive Substances.

Crit Rev Anal Chem 2018 Sep 21;48(5):372-390. Epub 2018 Mar 21.

a LAQV/REQUIMTE, Department of Chemical Sciences , Faculty of Pharmacy, University of Porto , Porto , Portugal.

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http://dx.doi.org/10.1080/10408347.2018.1439724DOI Listing
September 2018

Immunomodulatory Effects of Flavonoids in the Prophylaxis and Treatment of Inflammatory Bowel Diseases: A Comprehensive Review.

Curr Med Chem 2018 ;25(28):3374-3412

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.2174/0929867325666180214121734DOI Listing
September 2018

Global Mortality From Firearms, 1990-2016.

Authors:
Mohsen Naghavi Laurie B Marczak Michael Kutz Katya Anne Shackelford Megha Arora Molly Miller-Petrie Miloud Taki Eddine Aichour Nadia Akseer Rajaa M Al-Raddadi Khurshid Alam Suliman A Alghnam Carl Abelardo T Antonio Olatunde Aremu Amit Arora Mohsen Asadi-Lari Reza Assadi Tesfay Mehari Atey Leticia Avila-Burgos Ashish Awasthi Beatriz Paulina Ayala Quintanilla Suzanne Lyn Barker-Collo Till Winfried Bärnighausen Shahrzad Bazargan-Hejazi Masoud Behzadifar Meysam Behzadifar James R Bennett Ashish Bhalla Zulfiqar A Bhutta Arebu Issa Bilal Guilherme Borges Rohan Borschmann Alexandra Brazinova Julio Cesar Campuzano Rincon Félix Carvalho Carlos A Castañeda-Orjuela Lalit Dandona Rakhi Dandona Paul I Dargan Diego De Leo Samath Dhamminda Dharmaratne Eric L Ding Huyen Phuc Do David Teye Doku Kerrie E Doyle Tim Robert Driscoll Dumessa Edessa Ziad El-Khatib Aman Yesuf Endries Alireza Esteghamati Andre Faro Farshad Farzadfar Valery L Feigin Florian Fischer Kyle J Foreman Richard Charles Franklin Nancy Fullman Neal D Futran Tsegaye Tewelde Gebrehiwot Reyna Alma Gutiérrez Nima Hafezi-Nejad Hassan Haghparast Bidgoli Gessessew Bugssa Hailu Josep Maria Haro Hamid Yimam Hassen Caitlin Hawley Delia Hendrie Martha Híjar Guoqing Hu Olayinka Stephen Ilesanmi Mihajlo Jakovljevic Spencer L James Sudha Jayaraman Jost B Jonas Amaha Kahsay Amir Kasaeian Peter Njenga Keiyoro Yousef Khader Ibrahim A Khalil Young-Ho Khang Jagdish Khubchandani Aliasghar Ahmad Kiadaliri Christian Kieling Yun Jin Kim Soewarta Kosen Kristopher J Krohn G Anil Kumar Faris Hasan Lami Van C Lansingh Heidi Jane Larson Shai Linn Raimundas Lunevicius Hassan Magdy Abd El Razek Muhammed Magdy Abd El Razek Reza Malekzadeh Deborah Carvalho Malta Amanda J Mason-Jones Richard Matzopoulos Peter T N Memiah Walter Mendoza Tuomo J Meretoja Haftay Berhane Mezgebe Ted R Miller Shafiu Mohammed Maziar Moradi-Lakeh Rintaro Mori Devina Nand Cuong Tat Nguyen Quyen Le Nguyen Dina Nur Anggraini Ningrum Felix Akpojene Ogbo Andrew T Olagunju George C Patton Michael R Phillips Suzanne Polinder Farshad Pourmalek Mostafa Qorbani Afarin Rahimi-Movaghar Vafa Rahimi-Movaghar Mahfuzar Rahman Rajesh Kumar Rai Chhabi Lal Ranabhat David Laith Rawaf Salman Rawaf Ali Rowhani-Rahbar Mahdi Safdarian Saeid Safiri Rajesh Sagar Joseph S Salama Juan Sanabria Milena M Santric Milicevic Rodrigo Sarmiento-Suárez Benn Sartorius Maheswar Satpathy David C Schwebel Soraya Seedat Sadaf G Sepanlou Masood Ali Shaikh Nigussie Tadesse Sharew Ivy Shiue Jasvinder A Singh Mekonnen Sisay Vegard Skirbekk Adauto Martins Soares Filho Dan J Stein Mark Andrew Stokes Mu'awiyyah Babale Sufiyan Mamta Swaroop Bryan L Sykes Rafael Tabarés-Seisdedos Fentaw Tadese Bach Xuan Tran Tung Thanh Tran Kingsley Nnanna Ukwaja Tommi Juhani Vasankari Vasily Vlassov Andrea Werdecker Pengpeng Ye Paul Yip Naohiro Yonemoto Mustafa Z Younis Zoubida Zaidi Maysaa El Sayed Zaki Simon I Hay Stephen S Lim Alan D Lopez Ali H Mokdad Theo Vos Christopher J L Murray

JAMA 2018 08;320(8):792-814

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143020PMC
August 2018

Ethanol addictively enhances the in vitro cardiotoxicity of cocaine through oxidative damage, energetic deregulation, and apoptosis.

Arch Toxicol 2018 07 30;92(7):2311-2325. Epub 2018 May 30.

UCIBIO/REQUIMTE, Laboratory of Toxicology, Biological Sciences Department, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal.

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http://dx.doi.org/10.1007/s00204-018-2227-7DOI Listing
July 2018

Fatal Intoxications in the North of Portugal: 12 Years of Retrospective Analysis.

Curr Drug Saf 2017 ;12(1):39-45

Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto,. Portugal.

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http://dx.doi.org/10.2174/1574886311666160724212407DOI Listing
May 2018

The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis.

Toxicol Lett 2018 May 3;287:59-69. Epub 2018 Feb 3.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.01.023DOI Listing
May 2018

Mitoxantrone is More Toxic than Doxorubicin in SH-SY5Y Human Cells: A 'Chemobrain' In Vitro Study.

Pharmaceuticals (Basel) 2018 May 5;11(2). Epub 2018 May 5.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.3390/ph11020041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027466PMC
May 2018

Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells.

Interdiscip Toxicol 2018 May 6;11(1):13-21. Epub 2018 Aug 6.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.2478/intox-2018-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117818PMC
May 2018

Methylphenidate clinically oral doses improved brain and heart glutathione redox status and evoked renal and cardiac tissue injury in rats.

Biomed Pharmacother 2018 Apr 23;100:551-563. Epub 2018 Feb 23.

UCIBIO, REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal; FP-ENAS (Unidade de Investigação UFP em Energia, Ambiente e Saúde), CEBIMED (Centro de Estudos em Biomedicina), Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.02.017DOI Listing
April 2018

Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758).

Aquat Toxicol 2018 Feb 20;195:49-57. Epub 2017 Dec 20.

ICBAS - Institute of Biomedical Sciences of Abel Salazar, University of Porto, Department of Populations Study, Laboratory of Ecotoxicology & CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Research Group of Ecotoxicology, Stress Ecology and Environmental Health (ECOTOX). ICBAS - Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.aquatox.2017.12.008DOI Listing
February 2018

Combining CXCR4-targeted and nontargeted nanoparticles for effective unassisted in vitro magnetic hyperthermia.

Biointerphases 2018 02 5;13(1):011005. Epub 2018 Feb 5.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Biological Sciences Department, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.1116/1.5009989DOI Listing
February 2018

Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study.

Food Chem Toxicol 2018 Jan 22;111:474-481. Epub 2017 Nov 22.

UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2017.11.039DOI Listing
January 2018

Metabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI).

Crit Rev Toxicol 2017 Sep 24;47(8):633-649. Epub 2017 Apr 24.

a UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy , University of Porto , Porto , Portugal.

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https://www.tandfonline.com/doi/full/10.1080/10408444.2017.1
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http://dx.doi.org/10.1080/10408444.2017.1309638DOI Listing
September 2017

Methylphenidate effects in the young brain: friend or foe?

Int J Dev Neurosci 2017 Aug 13;60:34-47. Epub 2017 Apr 13.

UCIBIO/REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; FP-ENAS (Unidade de Investigação UFP em Energia, Ambiente e Saúde), CEBIMED (Centro de Estudos em Biomedicina), Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, 4020-150 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijdevneu.2017.04.002DOI Listing
August 2017

Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato- and nephrotoxic effects in Wistar rats.

Toxicology 2017 08 6;389:118-129. Epub 2017 Jul 6.

IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, Gandra, Portugal; UCIBIO, REQUIMTE - Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.07.001DOI Listing
August 2017

Street-Like Synthesis of Krokodil Results in the Formation of an Enlarged Cluster of Known and New Morphinans.

Chem Res Toxicol 2017 08 4;30(8):1609-1621. Epub 2017 Aug 4.

Department of Chemical Sciences, Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Porto , José Viterbo Ferreira Stree No. 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00126DOI Listing
August 2017

The effects of physical exercise on nonmotor symptoms and on neuroimmune RAGE network in experimental parkinsonism.

J Appl Physiol (1985) 2017 Jul 6;123(1):161-171. Epub 2017 Apr 6.

Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal;

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http://dx.doi.org/10.1152/japplphysiol.01120.2016DOI Listing
July 2017

Effective analgesic doses of tramadol or tapentadol induce brain, lung and heart toxicity in Wistar rats.

Toxicology 2017 06 9;385:38-47. Epub 2017 May 9.

IINFACTS, Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, Gandra, Portugal; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.05.003DOI Listing
June 2017

Neurotoxicity of β-Keto Amphetamines: Deathly Mechanisms Elicited by Methylone and MDPV in Human Dopaminergic SH-SY5Y Cells.

ACS Chem Neurosci 2017 04 26;8(4):850-859. Epub 2017 Jan 26.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto , 4050-313 Porto, Portugal.

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http://pubs.acs.org/doi/10.1021/acschemneuro.6b00421
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April 2017

Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP.

Molecules 2017 Apr 8;22(4). Epub 2017 Apr 8.

UCIBIO/REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.3390/molecules22040600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153761PMC
April 2017

In vitro hepatotoxicity of 'Legal X': the combination of 1-benzylpiperazine (BZP) and 1-(m-trifluoromethylphenyl)piperazine (TFMPP) triggers oxidative stress, mitochondrial impairment and apoptosis.

Arch Toxicol 2017 Mar 29;91(3):1413-1430. Epub 2016 Jun 29.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Departament of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-016-1777-9DOI Listing
March 2017

Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles.

Nanotoxicology 2017 03 23;11(2):256-266. Epub 2017 Feb 23.

e UCIBIO, REQUIMTE , Laboratory of Histology and Embryology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto , Porto , Portugal.

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http://dx.doi.org/10.1080/17435390.2017.1291865DOI Listing
March 2017

Comparative metabolism of tramadol and tapentadol: a toxicological perspective.

Drug Metab Rev 2016 11 15;48(4):577-592. Epub 2016 Sep 15.

a IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences , University Institute of Health Sciences (IUCS), CESPU, CRL , Gandra , Portugal.

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http://dx.doi.org/10.1080/03602532.2016.1229788DOI Listing
November 2016

Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity.

J Appl Toxicol 2016 10 22;36(10):1321-31. Epub 2016 Apr 22.

UCIBIO-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1002/jat.3323DOI Listing
October 2016

Human and experimental toxicology of orellanine.

Hum Exp Toxicol 2016 Sep 9;35(9):1016-29. Epub 2015 Nov 9.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1177/0960327115613845DOI Listing
September 2016

Editor's Highlight: Characterization of Hepatotoxicity Mechanisms Triggered by Designer Cathinone Drugs (β-Keto Amphetamines).

Toxicol Sci 2016 09 2;153(1):89-102. Epub 2016 Jun 2.

*UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal; FP-ENAS, CEBIMED, Fundação Ensino e Cultura Fernando Pessoa, Porto, Portugal

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http://dx.doi.org/10.1093/toxsci/kfw105DOI Listing
September 2016

3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions.

Arch Toxicol 2016 Aug 16;90(8):1959-73. Epub 2015 Dec 16.

Laboratory of Toxicology, Faculty of Pharmacy, UCIBIO@REQUIMTE, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-015-1653-zDOI Listing
August 2016

Contractile effects of 3,4-methylenedioxymethamphetamine on the human internal mammary artery.

Toxicol In Vitro 2016 Aug 11;34:187-193. Epub 2016 Apr 11.

Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.tiv.2016.04.002DOI Listing
August 2016

Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease.

J Neurochem 2016 08 13;138(4):598-609. Epub 2016 Jun 13.

Laboratory of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1111/jnc.13682DOI Listing
August 2016

Signs and Related Mechanisms of Ethanol Hepatotoxicity.

Curr Drug Abuse Rev 2015 ;8(2):86-103

Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.

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http://dx.doi.org/10.2174/1874473708666150916113352DOI Listing
July 2016

Comparative study of the neurotoxicological effects of tramadol and tapentadol in SH-SY5Y cells.

Toxicology 2016 06 15;359-360:1-10. Epub 2016 Jun 15.

IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, Gandra, Portugal; UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2016.06.010DOI Listing
June 2016

"Ecstasy" toxicity to adolescent rats following an acute low binge dose.

BMC Pharmacol Toxicol 2016 06 28;17(1):28. Epub 2016 Jun 28.

UCIBIO-REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1186/s40360-016-0070-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924304PMC
June 2016

Temperature in the spotlight of drug abuse research.

Temperature (Austin) 2015 Jan-Mar;2(1):27-8. Epub 2015 Feb 27.

Systemic Inflammation Laboratory (FeverLab); Trauma Research; St. Joseph's Hospital and Medical Center ; Phoenix, AZ USA.

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http://dx.doi.org/10.1080/23328940.2015.1008872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843858PMC
May 2016

Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels.

CNS Neurosci Ther 2016 May 4;22(5):396-403. Epub 2016 Feb 4.

Laboratory of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1111/cns.12508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492820PMC
May 2016

Response to the comment on "Promising blood-derived biomarkers for estimation of the interval".

Toxicol Res (Camb) 2016 Mar 20;5(2):716-718. Epub 2016 Jan 20.

IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies , Department of Sciences , University Institute of Health Sciences (IUCS-CESPU) , Gandra , Portugal.

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http://dx.doi.org/10.1039/c5tx00461fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060668PMC
March 2016

Data analysis of "krokodil" samples obtained by street-like synthesis.

Data Brief 2016 Mar 28;6:83-8. Epub 2015 Nov 28.

Department of Chemical Sciences, Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Porto, Porto, Portugal; Interdisciplinary Center of Marine and Environmental Investigation (CIIMAR/CIMAR), Porto, Portugal.

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http://dx.doi.org/10.1016/j.dib.2015.11.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773373PMC
March 2016

Effects of multi-stressors on juveniles of the marine fish Pomatoschistus microps: Gold nanoparticles, microplastics and temperature.

Aquat Toxicol 2016 Jan 28;170:89-103. Epub 2015 Nov 28.

ICBAS-Institute of Biomedical Sciences Abel Salazar, University of Porto, Department of Population Studies, Laboratory of Ecotoxicology, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; CIIMAR/CIMAR-LA-Interdisciplinary Centre of Marine and Environmental Research, Research Group of Ecotoxicology, Stress Ecology and Environmental Health, University of Porto, Rua dos Bragas, 289, 4050-123 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.aquatox.2015.11.011DOI Listing
January 2016

Downgrading the systemic condition of rabbits after long term exposure to cypermethrin and piperonyl butoxide.

Life Sci 2016 Jan 12;145:114-20. Epub 2015 Dec 12.

Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2015.12.026DOI Listing
January 2016

The harmful chemistry behind "krokodil": Street-like synthesis and product analysis.

Forensic Sci Int 2015 Dec 3;257:76-82. Epub 2015 Aug 3.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, Gandra, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03790738150032
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http://dx.doi.org/10.1016/j.forsciint.2015.07.042DOI Listing
December 2015

Amanita phalloides poisoning: Mechanisms of toxicity and treatment.

Food Chem Toxicol 2015 Dec 12;86:41-55. Epub 2015 Sep 12.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua José Viterbo Ferreira n° 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2015.09.008DOI Listing
December 2015

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B.

Arch Toxicol 2015 Dec 18;89(12):2305-23. Epub 2015 Sep 18.

UCIBIO/REQUIMTE-Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua José Viterbo Ferreira no 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-015-1582-xDOI Listing
December 2015

Mitochondria: key players in the neurotoxic effects of amphetamines.

Arch Toxicol 2015 Oct 6;89(10):1695-725. Epub 2015 Mar 6.

UCIBIO/REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.

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http://link.springer.com/10.1007/s00204-015-1478-9
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October 2015

Dual effect of red wine on liver redox status: a concise and mechanistic review.

Arch Toxicol 2015 Oct 31;89(10):1681-93. Epub 2015 May 31.

UCIBIO-REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-015-1538-1DOI Listing
October 2015

Amanita phalloides poisoning: Mechanisms of toxicity and treatment.

Food Chem Toxicol 2015 Dec 12;86:41-55. Epub 2015 Sep 12.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua José Viterbo Ferreira n° 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2015.09.008DOI Listing
December 2015

Preface.

Toxicol Lett 2015 Oct;238(2 Suppl):S1

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http://dx.doi.org/10.1016/j.toxlet.2015.07.015DOI Listing
October 2015

Determination of amatoxins and phallotoxins in Amanita phalloides mushrooms from northeastern Portugal by HPLC-DAD-MS.

Mycologia 2015 Jul-Aug;107(4):679-87. Epub 2015 Apr 24.

UCBIO-REQUIMTE/Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal

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http://dx.doi.org/10.3852/14-253DOI Listing
September 2015

Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report.

Toxicon 2015 Sep 16;103:55-9. Epub 2015 Jun 16.

UCIBIO-REQUIMTE/Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua José Viterbo Ferreira nº 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.06.012DOI Listing
September 2015

The hallucinogenic world of tryptamines: an updated review.

Arch Toxicol 2015 Aug 16;89(8):1151-73. Epub 2015 Apr 16.

UCIBIO-REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal,

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August 2015

Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection.

J Chromatogr B Analyt Technol Biomed Life Sci 2015 Aug 10;997:85-95. Epub 2015 Jun 10.

REQUIMTE/Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua José Viterbo Ferreira n° 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2015.06.001DOI Listing
August 2015

Clinical and forensic signs related to chemical burns: a mechanistic approach.

Burns 2015 Jun 1;41(4):658-79. Epub 2014 Oct 1.

Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; Center of Forensic Sciences (CENCIFOR), Portugal; National Institute of Legal Medicine and Forensic Sciences, North Branch, I.P., Portugal.

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http://dx.doi.org/10.1016/j.burns.2014.09.002DOI Listing
June 2015

Raising awareness of new psychoactive substances: chemical analysis and in vitro toxicity screening of 'legal high' packages containing synthetic cathinones.

Arch Toxicol 2015 May 6;89(5):757-71. Epub 2014 Jun 6.

REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal,

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http://link.springer.com/10.1007/s00204-014-1278-7
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May 2015

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.

Pharmacol Ther 2015 May 27;149:1-123. Epub 2014 Nov 27.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Biological Sciences Department, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2014.11.013DOI Listing
May 2015

Iron Oxide Nanoparticles: An Insight into their Biomedical Applications

Curr Med Chem 2015 05;22(15):1808 - 28

UCIBIO-REQUIMTE, Laboratory of Applied Chemistry Department of Chemical Sciences Faculty of Pharmacy, University of Porto, Porto, Portugal Rua de Jorge Viterbo Ferreira n. º 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.2174/0929867322666150311151403DOI Listing
May 2015

The neurotoxicity of amphetamines during the adolescent period.

Int J Dev Neurosci 2015 Apr 4;41:44-62. Epub 2014 Dec 4.

REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, 4200-150 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijdevneu.2014.12.001DOI Listing
April 2015

Polyacrylic acid coated and non-coated iron oxide nanoparticles are not genotoxic to human T lymphocytes.

Toxicol Lett 2015 Apr 12;234(2):67-73. Epub 2015 Feb 12.

UCIBIO/REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2015.02.010DOI Listing
April 2015

The harmful chemistry behind krokodil (desomorphine) synthesis and mechanisms of toxicity.

Forensic Sci Int 2015 Apr 7;249:207-13. Epub 2015 Feb 7.

Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, Advanced Institute of Health Sciences-North (ISCS-N), CESPU, CRL, Gandra, Portugal. Electronic address:

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April 2015

The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury.

Toxicology 2015 Mar 9;329:106-19. Epub 2015 Jan 9.

UCBIO-REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2015.01.006DOI Listing
March 2015

Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach.

Toxicol Lett 2014 Oct 3;230(2):85-103. Epub 2014 Feb 3.

REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2014.01.039DOI Listing
October 2014

Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line.

Toxicol Lett 2014 Oct 27;230(2):122-31. Epub 2014 Mar 27.

U.S. Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC, United States.

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October 2014

Interleukin-1β genotype and circulating levels in cancer patients: metastatic status and pain perception.

Clin Biochem 2014 Sep 18;47(13-14):1209-13. Epub 2014 Apr 18.

Molecular Oncology GRP and Virology LB, Portuguese Institute of Oncology-Porto, Porto, Portugal; ICBAS, Abel Salazar Institute for the Biomedical Sciences, Porto, Portugal; Faculty of Health Sciences of Fernando Pessoa University, Porto, Portugal; LPCC, Portuguese League Against Cancer, Regional Center of the North, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2014.04.009DOI Listing
September 2014

Analytical investigation of legal high products containing Salvia divinorum traded in smartshops and internet.

Forensic Sci Int 2014 Sep 19;242:255-260. Epub 2014 Jul 19.

REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.forsciint.2014.07.009DOI Listing
September 2014

MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner.

Arch Toxicol 2014 Aug 13;88(8):1561-72. Epub 2014 Feb 13.

REQUIMTE (Rede de Química e Tecnologia), Toxicology Laboratory, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00204-014-1209-7DOI Listing
August 2014

Colchicine effect on P-glycoprotein expression and activity: in silico and in vitro studies.

Chem Biol Interact 2014 Jul 20;218:50-62. Epub 2014 Apr 20.

REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.04.009DOI Listing
July 2014

Morphine glucuronidation increases its analgesic effect in guinea pigs.

Life Sci 2014 Jul 24;109(2):104-10. Epub 2014 Jun 24.

REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2014.06.010DOI Listing
July 2014

The mixture of "ecstasy" and its metabolites impairs mitochondrial fusion/fission equilibrium and trafficking in hippocampal neurons, at in vivo relevant concentrations.

Toxicol Sci 2014 Jun 4;139(2):407-20. Epub 2014 Mar 4.

REQUIMTE (Rede de Química e Tecnologia), Toxicology Laboratory, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

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June 2014

Impaired resolution of inflammation in human chronic heart failure.

Eur J Clin Invest 2014 Jun 22;44(6):527-38. Epub 2014 Apr 22.

Departamento de Farmacologia e Terapêutica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; MedInUP - Centro de Investigação Farmacológica e Inovação Medicamentosa, Universidade do Porto, Porto, Portugal; Departamento de Medicina Interna, Centro Hospitalar São João, Porto, Portugal.

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http://dx.doi.org/10.1111/eci.12265DOI Listing
June 2014

New in silico insights into the inhibition of RNAP II by α-amanitin and the protective effect mediated by effective antidotes.

J Mol Graph Model 2014 Jun 14;51:120-7. Epub 2014 May 14.

REQUIMTE Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua José Viterbo Ferreira n° 228, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2014.05.002DOI Listing
June 2014

Genetic profile and cancer-related pain: a tale from two outlier cases with bone metastatic disease.

Pain Med 2014 Apr 11;15(4):710-2. Epub 2013 Dec 11.

Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; Molecular Oncology GRP and VirologyLB, Portuguese Institute of Oncology-Porto, Porto, Portugal; Department of Sciences, Advanced Institute of Health Sciences-North, CESPU, CRL, Gandra, Portugal.

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April 2014