Publications by authors named "Felipe Soares"

25 Publications

  • Page 1 of 1

O-JMeSH: creating a bilingual English-Japanese controlled vocabulary of MeSH UIDs through machine translation and mutual information.

Genomics Inform 2021 Sep 30;19(3):e26. Epub 2021 Sep 30.

Graduate School of Integrative Science and Engineering, Tokyo City University, Tokyo 158-8557, Japan.

Previous approaches to create a controlled vocabulary for Japanese have resorted to existing bilingual dictionary and transformation rules to allow such mappings. However, given the possible new terms introduced due to coronavirus disease 2019 (COVID-19) and the emphasis on respiratory and infection-related terms, coverage might not be guaranteed. We propose creating a Japanese bilingual controlled vocabulary based on MeSH terms assigned to COVID-19 related publications in this work. For such, we resorted to manual curation of several bilingual dictionaries and a computational approach based on machine translation of sentences containing such terms and the ranking of possible translations for the individual terms by mutual information. Our results show that we achieved nearly 99% occurrence coverage in LitCovid, while our computational approach presented average accuracy of 63.33% for all terms, and 84.51% for drugs and chemicals.
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http://dx.doi.org/10.5808/gi.21014DOI Listing
September 2021

Constructing Japanese MeSH term dictionaries related to the COVID-19 literature.

Genomics Inform 2021 Sep 30;19(3):e25. Epub 2021 Sep 30.

Computer Science Department, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

The coronavirus disease 2019 (COVID-19) pandemic has led to a flood of research papers and the information has been updated with considerable frequency. For society to derive benefits from this research, it is necessary to promote sharing up-to-date knowledge from these papers. However, because most research papers are written in English, it is difficult for people who are not familiar with English medical terms to obtain knowledge from them. To facilitate sharing knowledge from COVID-19 papers written in English for Japanese speakers, we tried to construct a dictionary with an open license by assigning Japanese terms to MeSH unique identifiers (UIDs) annotated to words in the texts of COVID-19 papers. Using this dictionary, 98.99% of all occurrences of MeSH terms in COVID-19 papers were covered. We also created a curated version of the dictionary and uploaded it to PubDictionary for wider use in the PubAnnotation system.
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http://dx.doi.org/10.5808/gi.21012DOI Listing
September 2021

Dissolved air flotation as potential new mechanism for intestinal parasite diagnosis in feces.

Acta Trop 2021 Sep 22;224:106137. Epub 2021 Sep 22.

School of Medical Sciences, University of Campinas, Campinas, São Paulo 13083-889, Brazil; Laboratory of Image Data Science (LIDS), Institute of Computing (IC), University of Campinas, Campinas, São Paulo, Brazil.

The parasitological examination of feces is recommended for the laboratory diagnosis of intestinal parasites due to its practicality, low-cost, and moderate diagnostic sensitivity. Dissolved Air Flotation (DAF) is an efficient technical principle used in other areas to separate dispersed solids. This study sought the preliminary evaluation of a proof-of-concept prototype as a tool for detecting species of parasites by adjusting DAF. Two DAF prototype units were developed to evaluate microbubbles' generation amidst fecal suspension and parasites' capture. For this evaluation, samples were screened and processed by the TF-Test technique (Control) and simultaneously by DAF device. The dimensional and attachment characteristics in the formation of the microbubbles were evaluated, and the percentage of parasitic recovery in floated and not-floated regions compared by Student's t-test. The second prototype unit proved to be more efficient in forming microbubbles with diameters between 34 and 170µm. The flotation tests showed a recovery of 73.27%, 58.12%, 37.85%, and 91.89% for Ascaris lumbricoides, Hymenolepis diminuta, Giardia duodenalis, and Strongyloides stercoralis, respectively. This study confirmed the selective interaction between microbubbles and parasite eggs and larvae during the flotation process using the DAF principle for the first time through imaging.
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http://dx.doi.org/10.1016/j.actatropica.2021.106137DOI Listing
September 2021

The importance of being external. methodological insights for the external validation of machine learning models in medicine.

Comput Methods Programs Biomed 2021 Sep 22;208:106288. Epub 2021 Jul 22.

Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background and Objective Medical machine learning (ML) models tend to perform better on data from the same cohort than on new data, often due to overfitting, or co-variate shifts. For these reasons, external validation (EV) is a necessary practice in the evaluation of medical ML. However, there is still a gap in the literature on how to interpret EV results and hence assess the robustness of ML models.

Methods: We fill this gap by proposing a meta-validation method, to assess the soundness of EV procedures. In doing so, we complement the usual way to assess EV by considering both dataset cardinality, and the similarity of the EV dataset with respect to the training set. We then investigate how the notions of cardinality and similarity can be used to inform on the reliability of a validation procedure, by integrating them into two summative data visualizations.

Results: We illustrate our methodology by applying it to the validation of a state-of-the-art COVID-19 diagnostic model on 8 EV sets, collected across 3 different continents. The model performance was moderately impacted by data similarity (Pearson ρ = 0.38, p< 0.001). In the EV, the validated model reported good AUC (average: 0.84), acceptable calibration (average: 0.17) and utility (average: 0.50). The validation datasets were adequate in terms of dataset cardinality and similarity, thus suggesting the soundness of the results. We also provide a qualitative guideline to evaluate the reliability of validation procedures, and we discuss the importance of proper external validation in light of the obtained results.

Conclusions: In this paper, we propose a novel, lean methodology to: 1) study how the similarity between training and validation sets impacts the generalizability of a ML model; 2) assess the soundness of EV evaluations along three complementary performance dimensions: discrimination, utility and calibration; 3) draw conclusions on the robustness of the model under validation. We applied this methodology to a state-of-the-art model for the diagnosis of COVID-19 from routine blood tests, and showed how to interpret the results in light of the presented framework.
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http://dx.doi.org/10.1016/j.cmpb.2021.106288DOI Listing
September 2021

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study.

Lancet 2021 07;398(10296):223-237

Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.

Background: COVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to have important short-term and long-term consequences for patients, health-care utilisation, health-care system preparedness, and society amidst the ongoing COVID-19 pandemic. Our aim was to characterise the extent and effect of COVID-19 complications, particularly in those who survive, using the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK.

Methods: We did a prospective, multicentre cohort study in 302 UK health-care facilities. Adult patients aged 19 years or older, with confirmed or highly suspected SARS-CoV-2 infection leading to COVID-19 were included in the study. The primary outcome of this study was the incidence of in-hospital complications, defined as organ-specific diagnoses occurring alone or in addition to any hallmarks of COVID-19 illness. We used multilevel logistic regression and survival models to explore associations between these outcomes and in-hospital complications, age, and pre-existing comorbidities.

Findings: Between Jan 17 and Aug 4, 2020, 80 388 patients were included in the study. Of the patients admitted to hospital for management of COVID-19, 49·7% (36 367 of 73 197) had at least one complication. The mean age of our cohort was 71·1 years (SD 18·7), with 56·0% (41 025 of 73 197) being male and 81·0% (59 289 of 73 197) having at least one comorbidity. Males and those aged older than 60 years were most likely to have a complication (aged ≥60 years: 54·5% [16 579 of 30 416] in males and 48·2% [11 707 of 24 288] in females; aged <60 years: 48·8% [5179 of 10 609] in males and 36·6% [2814 of 7689] in females). Renal (24·3%, 17 752 of 73 197), complex respiratory (18·4%, 13 486 of 73 197), and systemic (16·3%, 11 895 of 73 197) complications were the most frequent. Cardiovascular (12·3%, 8973 of 73 197), neurological (4·3%, 3115 of 73 197), and gastrointestinal or liver (0·8%, 7901 of 73 197) complications were also reported.

Interpretation: Complications and worse functional outcomes in patients admitted to hospital with COVID-19 are high, even in young, previously healthy individuals. Acute complications are associated with reduced ability to self-care at discharge, with neurological complications being associated with the worst functional outcomes. COVID-19 complications are likely to cause a substantial strain on health and social care in the coming years. These data will help in the design and provision of services aimed at the post-hospitalisation care of patients with COVID-19.

Funding: National Institute for Health Research and the UK Medical Research Council.
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http://dx.doi.org/10.1016/S0140-6736(21)00799-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285118PMC
July 2021

Prevalence and characteristics of new-onset pain in COVID-19 survivours, a controlled study.

Eur J Pain 2021 07 8;25(6):1342-1354. Epub 2021 Apr 8.

Pain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.

Background: We assessed whether COVID-19 is associated with de novo pain and de novo chronic pain (CP).

Methods: This controlled cross-sectional study was based on phone interviews of patients discharged from hospital after COVID-19 compared to the control group composed of individuals hospitalized during the same period due to non-COVID-19 causes. Patients were classified as having previous CP based on the ICD-11/IASP criteria, de novo pain (i.e. any new type of pain, irrespective of the pain status before hospital stay), and de novo CP (i.e. persistent or recurring de novo pain, lasting more than 3 months) after COVID-19. We assessed pain prevalence and its characteristics, including headache profile, pain location, intensity, interference, and its relationship with fatigue, and persistent anosmia. Forty-six COVID-19 and 73 control patients were included. Both groups had similar sociodemographic characteristics and past medical history.

Results: Length of in-hospital-stay and ICU admission rates were significantly higher amongst COVID-19 survivours, while mechanical ventilation requirement was similar between groups. Pre-hospitalisation pain was lower in COVID-19 compared to control group (10.9% vs. 42.5%; p = 0.001). However, the COVID-19 group had a significantly higher prevalence of de novo pain (65.2% vs. 11.0%, p = 0.001), as well as more de novo headache (39.1%) compared to controls (2.7%, p = 0.001). New-onset CP was 19.6% in COVID-19 patients and 1.4% (p = 0.002) in controls. These differences remained significant (p = 0.001) even after analysing exclusively (COVID: n = 40; controls: n = 34) patients who did not report previous pain before the hospital stay. No statistically significant differences were found for mean new-onset pain intensity and interference with daily activities between both groups. COVID-19 pain was more frequently located in the head/neck and lower limbs (p < 0.05). New-onset fatigue was more common in COVID-19 survivours necessitating inpatient hospital care (66.8%) compared to controls (2.5%, p = 0.001). COVID-19 patients who reported anosmia had more new-onset pain (83.3%) compared to those who did not (48.0%, p = 0.024).

Conclusion: COVID-19 was associated with a significantly higher prevalence of de novo CP, chronic daily headache, and new-onset pain in general, which was associated with persistent anosmia.

Significance: There exists de novo pain in a substantial number of COVID-19 survivours, and some develop chronic pain. New-onset pain after the infection was more common in patients who reported anosmia after hospital discharge.
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http://dx.doi.org/10.1002/ejp.1755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013219PMC
July 2021

SciBabel: a system for crowd-sourced validation of automatic translations of scientific texts.

Genomics Inform 2020 Jun 15;18(2):e21. Epub 2020 Jun 15.

Computer Science Department, University of Sheffield, Sheffield, UK.

Scientific research is mostly published in English, regardless of the researcher's nationality. However, this growing practice impairs or hinders the comprehension of professionals who depend on the results of these studies to provide adequate care for their patients. We suggest that machine translation (MT) can be used as a way of providing useful translation for biomedical articles, even though the translation itself may not be fluent. To tackle possible mistranslation that can harm a patient, we resort to crowd-sourced validation of translations. We developed a prototype of MT validation and edition, where users can vote for that translation as valid, or suggest modifications (i.e., post-editing the MT). A glossary match system is also included, aiming at terminology consistency.
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http://dx.doi.org/10.5808/GI.2020.18.2.e21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362948PMC
June 2020

A historical review of the techniques of recovery of parasites for their detection in human stools.

Rev Soc Bras Med Trop 2020 1;53:e20190535. Epub 2020 Jun 1.

Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Since the early 20th century, the detection of intestinal parasites has improved with the development of several techniques for parasitic structures recovery and identification, which differ in sensitivity, specificity, practicality, cost, and infrastructure demand. This study aims to review, in chronological order, the stool examination techniques and discuss their advantages, limitations, and perspectives, and to provide professionals and specialists in this field with data that lays a foundation for critical analysis on the use of such procedures. The concentration procedures that constitute the main techniques applied in routine research and in parasitological kits are a) spontaneous sedimentation; b) centrifugation-sedimentation with formalin-ethyl acetate; and c) flotation with zinc sulfate solution. While selecting a technique, one should consider the purpose of its application and the technical-operational, biological, and physicochemical factors inherent in the procedures used in stool processing, which may restrict its use. These intrinsic limitations may have undergone procedural changes driven by scientific and technological development and by development of alternative methods, which now contribute to the improvement of diagnostic accuracy.
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http://dx.doi.org/10.1590/0037-8682-0535-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269538PMC
June 2020

On the crucial role of multilingual biomedical databases in epidemic events (SARS-CoV-2 analysis).

Int J Infect Dis 2020 Jul 11;96:352-354. Epub 2020 May 11.

Universidade Federal do Rio Grande do Sul, Departamento de Engenharia de Produção, Brazil.

The need for multilingual biomedical databases was already pointed out by different authors. They argue about the need for making translations available in other languages and centralized access to regional databases and that one should not disregard citations in other languages. This fact could not be any more real in the current situation regarding the novel coronavirus. When considering treatment, diagnosis and prevention, around 44% of the articles in PubMed were written in Chinese. This prompts the urgent need for quality automatic translation to make such extremely valuable information available to medical personnel in as many languages as possible. We also point out that the community should also make efforts to guarantee editorial quality and to follow the best practices in editing and publishing. This is of critical importance as well, such that the content is properly scrutinized before being published.
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http://dx.doi.org/10.1016/j.ijid.2020.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211736PMC
July 2020

Automated Diagnosis of Canine Gastrointestinal Parasites Using Image Analysis.

Pathogens 2020 Feb 20;9(2). Epub 2020 Feb 20.

School of Veterinary Medicine, São Paulo State University, Araçatuba, São Paulo 16050-680, Brazil.

Because canine intestinal parasites are considered cosmopolitan, they carry significant zoonotic potential to public health. These etiological agents are routinely diagnosed using microscopic examination commonly used because of its low cost, simple execution, and direct evidence. However, there are reports in the literature on the poor performance of this test due to low to moderate sensitivity resulting from frequent errors, procedures and interpretation. Therefore, to improve the diagnostic efficiency of microscopic examination in veterinary medicine, we developed and evaluated a unique new protocol. This system was tested in a study involving four genera of highly prevalent canine intestinal parasites in an endemic region in São Paulo state, Brazil. Fecal samples from 104 animals were collected for this research. The new protocol had a significantly higher ( < 0.0001) number of positive cases on image data, including parasites and impurities, and was elaborate to test them with the TF-GII/Dog technique, with a moderate agreement and Kappa index of 0.7636. We concluded that the new Prototic Coproparasitological Test for Dogs (PC-Test Dog) allowed a better visualization of the parasitic structures and showed a favorable result for the diagnosis of intestinal parasites in dogs.
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http://dx.doi.org/10.3390/pathogens9020139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169455PMC
February 2020

Decision Support for Breast Cancer Detection: Classification Improvement Through Feature Selection.

Cancer Control 2019 Jan-Dec;26(1):1073274819876598

Industrial Engineering Department, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Several statistical-based approaches have been developed to support medical personnel in early breast cancer detection. This article presents a method for feature selection aimed at classifying cases into categories based on patients' breast tissue measures and protein microarray. The effectiveness of this feature selection strategy was evaluated against the commonly used Wisconsin Breast Cancer Database-WBCD (with several patients and fewer features) and a new protein microarray data set (with several features and fewer patients). Features were ranked according to a feature importance index that combines parameters emerging from the unsupervised method of principal component analysis and the supervised method of Bhattacharyya distance. Observations of a training set were iteratively categorized into malignant and benign cases through 3 classification techniques: k-Nearest Neighbor, linear discriminant analysis, and probabilistic neural network. After each classification, the feature with the smallest importance index was removed, and a new categorization was carried out until there was only one feature left. The subset yielding maximum accuracy was used to classify observations in the testing set. Our method yielded average 99.17% accurate classifications in the testing set while retaining average 4.61 out of 9 features in the WBCD, which is comparable to the best results reported by the literature on that data set, with the advantage of relying on simple and widely available multivariate techniques. When applied to the microarray data, the method yielded average accuracy of 98.30% while retaining average 2.17% of the original features. Our results can aid health-care professionals during early diagnosis of breast cancer.
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http://dx.doi.org/10.1177/1073274819876598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755645PMC
May 2020

Use of the aqueous biphasic system as an alternative for concentration of Ascaris lumbricoides eggs, with non-toxic separation of faecal residues and fats.

Trop Med Int Health 2019 11 3;24(11):1320-1329. Epub 2019 Oct 3.

School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Objectives: Human enteroparasites are considered a serious public health problem in underdeveloped countries located in world regions with tropical, subtropical and equatorial climates. These parasites are commonly diagnosed by the Parasitological Examination of Faeces (PEF), performed by conventional techniques and/or commercial kits that result in tests with low-to-moderate sensitivity, due to the use of destructive chemical solvents to parasite structures, and to present excess adipose substance and digestive residues in their microscopic slides. In order to improve the efficacy of these tests/examinations, this study aimed to investigate a new alternative for the PEF, with the use of Aqueous Biphasic System (ABS).

Methods: For this, four ABSs containing poly (ethylene glycol), PEG (PEG-4000 and PEG-6000), dipotassium phosphate and sodium citrate at different concentrations in the biphasic systems were evaluated with faecal samples containing eggs of Ascaris lumbricoides.

Results: The ABS consisting of PEG-4000 and dipotassium phosphate, at concentrations of 55% w/w and 20% w/w, respectively, achieved 100% satisfactory results compared to the conventional TF-Test technique in terms of preservation and concentration of A. lumbricoides eggs, with adequate separation of digestive residues, without using a centrifuge or chemical solvents that may cause harm to the parasites.

Conclusions: This study presents ABS as a new low-cost technical principle for the detection of parasite eggs in PEF. The new technique is simple, fast, non-toxic, not harmful to the parasite and does not require a centrifuge.
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http://dx.doi.org/10.1111/tmi.13308DOI Listing
November 2019

PharmacoNER Tagger: a deep learning-based tool for automatically finding chemicals and drugs in Spanish medical texts.

Genomics Inform 2019 Jun 19;17(2):e15. Epub 2019 Jun 19.

Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.

Automatically detecting mentions of pharmaceutical drugs and chemical substances is key for the subsequent extraction of relations of chemicals with other biomedical entities such as genes, proteins, diseases, adverse reactions or symptoms. The identification of drug mentions is also a prior step for complex event types such as drug dosage recognition, duration of medical treatments or drug repurposing. Formally, this task is known as named entity recognition (NER), meaning automatically identifying mentions of predefined entities of interest in running text. In the domain of medical texts, for chemical entity recognition (CER), techniques based on hand-crafted rules and graph-based models can provide adequate performance. In the recent years, the field of natural language processing has mainly pivoted to deep learning and state-of-the-art results for most tasks involving natural language are usually obtained with artificial neural networks. Competitive resources for drug name recognition in English medical texts are already available and heavily used, while for other languages such as Spanish these tools, although clearly needed were missing. In this work, we adapt an existing neural NER system, NeuroNER, to the particular domain of Spanish clinical case texts, and extend the neural network to be able to take into account additional features apart from the plain text. NeuroNER can be considered a competitive baseline system for Spanish drug and CER promoted by the Spanish national plan for the advancement of language technologies (Plan TL). PharmacoNER Tagger can be accessed at https://github.com/PlanTL-SANIDAD/PharmacoNER.
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http://dx.doi.org/10.5808/GI.2019.17.2.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808625PMC
June 2019

Enhancing counterfeit and illicit medicines grouping via feature selection and X-ray fluorescence spectrometry.

J Pharm Biomed Anal 2019 Sep 30;174:198-205. Epub 2019 May 30.

Programa de Pós-Graduação em Química, Instituto de Química - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Instituto Nacional de Ciência e Tecnologia Forense (INCT Forense), Brazil.

In this paper, we propose a novel framework to select the most relevant X-Ray Fluorescence (XRF) energy values (i.e., features) to enhance the clustering (grouping) of counterfeit and illicit medical tablets. The framework is based on the integration of multidimensional scaling (MDS) and Procrustes analysis (PA) multivariate techniques. MDS provides a projection of the original data into a lower dimension, while PA finds a projection matrix from the original data. Such outputs give rise to a feature importance index that guides an iterative feature selection process; after each feature is inserted in the subset, an optimization procedure based on a greedy search method is carried out to maximize the clustering quality assessed through the Silhouette Index (SI). The inorganic chemical fingerprinting of 41 commercial samples (Viagra®, Cialis®, Lazar®, Libiden®, Maxfil®, Plenovit®, Potent 75®, Rigix®, V-50®, Vimax® and Pramil®) and 56 seized counterfeit samples (Viagra and Cialis) was used to validate the proposed framework. From the original 2048 data points in the full spectra, we identified a subset comprised of 41 energy values that substantially improved clustering quality; the obtained groups were assessed by visual inspection of the PCA plots.
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http://dx.doi.org/10.1016/j.jpba.2019.05.064DOI Listing
September 2019

TF-Test Quantified: a new technique for diagnosis of Schistosoma mansoni eggs.

Trop Med Int Health 2019 05 7;24(5):586-595. Epub 2019 Mar 7.

School of Medical Sciences, University of Campinas, São Paulo, Brazil.

Objectives: Laboratory diagnosis of Schistosoma mansoni eggs is routinely performed by conventional quantitative techniques through the parasitological examination of human faeces. However, the diagnostic sensitivity of this type of exam varies from low to moderate. We aimed to develop a new parasitological technique called TF-Test Quantified (TFT-Quant), for the quantitative detection of S. mansoni eggs in human faeces.

Methods: Four study stages were performed using 43 mice infected by S. mansoni cercariae. These experiments allowed the definition of an operational protocol for TFT-Quant and a comparison of this new technique to the conventional Helm-Teste technique.

Results: The results show a good diagnostic efficacy of TFT-Quant, which reached 100% in sensitivity and specificity, indicating an 'Almost Perfect' Kappa (k) agreement.

Conclusions: This new technique provided a quantitative gain in the detection of S. mansoni eggs, largely free of faecal debris. The next stage of this study is the field validation of the TFT-Quant technique with the use of human faecal samples from an endemic region for mansonic schistosomiasis in Brazil (Microregion Jequitinhonha, State of Minas Gerais). In parallel to this validation, computational algorithms will be developed to allow the automated quantitative diagnosis of S. mansoni eggs.
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http://dx.doi.org/10.1111/tmi.13215DOI Listing
May 2019

Assessment of plasma lactate and core-peripheral temperature gradient in association with stages of naturally occurring myxomatous mitral valve disease in dogs.

J Vet Emerg Crit Care (San Antonio) 2018 Nov 7;28(6):532-540. Epub 2018 Oct 7.

Intensivet Veterinary Consulting, Brasília, Brazil.

Objective: To evaluate plasma lactate concentrations and core-peripheral temperature gradients as perfusion parameters in dogs with heart failure caused by myxomatous mitral valve disease (MMVD) and to determine whether the above perfusion parameters are correlated with disease stages.

Design: Prospective observational study.

Setting: University teaching hospital.

Animals: After excluding 129 dogs because of exclusion criteria, 7 dogs with heart failure classified as stage B2 and 10 dogs classified as stage C according to the American Heart Association (AHA)/American College of Cardiology (ACC) were included in the study. Six dogs without MMVD were evaluated as the control group.

Interventions: None.

Measurements And Main Results: Among the evaluated parameters, the plasma lactate concentrations were increased in stage C (median 3.70 mmol/L [33.3 mg/dL], interquartile range (IQR) 0.72 mmol/L [6.5 mg/dL]) compared with those in the control (median 2.80 mmol/L [25.2 mg/dL], IQR 0.8 mmol/L [7.2 mg/dL]; P = 0.024) and stage B2 groups (median 2.70 mmol/L [24.3 mg/dL], IQR 1.8 mmol/L [16.2 mg/dL]; P = 0.045). Significant differences were not observed in the core-peripheral temperature gradients among the control, stage B2, and stage C dogs.

Conclusions: Dogs with structural heart disease as a result of MMVD may have occult tissue hypoperfusion in stage C that is demonstrated by hyperlactatemia.
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http://dx.doi.org/10.1111/vec.12771DOI Listing
November 2018

A hierarchical classifier based on human blood plasma fluorescence for non-invasive colorectal cancer screening.

Artif Intell Med 2017 Oct 20;82:1-10. Epub 2017 Sep 20.

Department of Industrial Engineering - Universidade Federal do Rio Grande do Sul, Av. Osvaldo Aranha, 99-5° andar, Porto Alegre, RS, Brazil. Electronic address:

Colorectal cancer (CRC) a leading cause of death by cancer, and screening programs for its early identification are at the heart of the increasing survival rates. To motivate population participation, non-invasive, accurate, scalable and cost-effective diagnosis methods are required. Blood fluorescence spectroscopy provides rich information that can be used for cancer identification. The main challenges in analyzing blood fluorescence data for CRC classification are related to its high dimensionality and inherent variability, especially when analyzing a small number of samples. In this paper, we present a hierarchical classification method based on plasma fluorescence to identify not only CRC, but also adenomas and other non-malignant colorectal findings that may require further medical investigation. A feature selection algorithm is proposed to deal with the high dimensionality and select discriminant fluorescence wavelengths. These are used to train a binary support vector machine (SVM) in the first level to identify the CRC samples. The remaining samples are then presented to a one-class SVM trained on healthy subjects to detect deviant samples, and thus non-malignant findings. This hierarchical design, together with the one class-SVM, aims to reduce the effects of small samples and high variability. Using a dataset analyzed in previous studies comprised of 12,341 wavelengths, we achieved much superior results. Sensitivity and specificity are 0.87 and 0.95 for CRC detection, and 0.60 and 0.79 for non-malignant findings, respectively. Compared to related work, the proposed method presented a better accuracy, required fewer features, and provides a unified approach that expands CRC detection to non-malignant findings.
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http://dx.doi.org/10.1016/j.artmed.2017.09.004DOI Listing
October 2017

Outcome of Single- vs Multiple-visit Endodontic Therapy of Nonvital Teeth: A Meta-analysis.

J Contemp Dent Pract 2017 Apr 1;18(4):330-336. Epub 2017 Apr 1.

Department of Community Health, Federal University of Bahia Bahia, Brazil.

Introduction: Endodontic therapy is a specialized procedure more demanded by patients within public oral health care in the country. Then, single-visit endodontic therapy may offer advantages to the health care services, to the professionals, and to the patients by reducing access barriers.

Materials And Methods: A meta-analysis was done and the variables evaluated were periapical repair, microbiological control, and postobturation pain in randomized clinical trials (RCTs) involving endodontic treatment of nonvital teeth at single- or multiple visits.

Results: About 17 RCTs were included. There were no differences found in periapical repair or microbiological control in single- and multiple-visit therapy. Single-visit endodontic therapy resulted in 21% less postobturation pain (relative risks = 0.79; 95%, confidence interval: 0.66-0.94).

Conclusion: There was less postobturation pain in the single-visit endodontic therapy group. In the public dental care, this analysis favors the adoption of this one therapy because it will be possible to increase the patient access and the supply of this therapy.

Clinical Significance: It is possible to get a better cost-effectiveness for the patients and the health care service. This is very important because the reduction of the cost to the patient allows it to become a complete treatment. The health service, in turn, is able to be better used, with a greater supply of this service.
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http://dx.doi.org/10.5005/jp-journals-10024-2041DOI Listing
April 2017

Maternal risk behavior and caries incidence in children with sickle cell disease.

Braz Oral Res 2016 15;30. Epub 2015 Dec 15.

Departamento de Odontologia Social e Pediátrica, Faculdade de Odontologia, Universidade Federal da Bahia, Salvador, BA, Brazil.

The aim of this study was to analyze the incidence of caries, in relation to maternal risk behaviors and clinical conditions representing different levels of sickle cell disease severity. A total of 295 children aged 6 to 60 months participated in this cohort conducted from August 2007 to December 2008. They were diagnosed and monitored by the referral service of the state. Interviews were made with families to identify sociodemographic variables, and an oral exam was performed to determine dental caries. The SRQ (Self Report Questionnaire) scale was used to diagnose the presence of common mental disorders, and the CAGE (Cut down, Annoyed, Guilty and Eye opener) was applied to determine abusive use of alcohol. The absolute and relative frequencies of the variables of interest were analyzed by Chi-square and Mann-Whitney, with a 5% significance level. The incidence variables were analyzed according to the logistic regression model, with a confidence interval of 95%. Caries incidence (1.98; SD = 4.68) was higher in the HbSS genotype. There was a statistically significant association between caries incidence and both abusive use of alcohol (32.43%, RR = 1.99; 1.05-3.78; 95%CI) and common mental disorders (8.77% RR = 0.37; 0.15-0.93; 95%CI). There was also an association between caries incidence and maternal risk behavior, indicating that the care network should be expanded to include patients with sickle cell disease.
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http://dx.doi.org/10.1590/1807-3107BOR-2016.vol30.0007DOI Listing
May 2016

Reproductive and productive performances of Santa Inês ewes submitted to breeding in different periods of the Amazonian humid tropical climate.

Trop Anim Health Prod 2015 Dec 30;47(8):1465-71. Epub 2015 Jul 30.

Institute of Animal Health and Production, Federal Rural University of Amazon, Belém, Pará, Brazil.

The objective of this study was to evaluate the reproductive and productive performance of Santa Inês ewes bred at different times of the year in humid tropical climate. One hundred and forty-eight Santa Inês ewes were grouped according to the time of the year of their breeding season (i.e., mating period) (dry/wet, wet, wet/dry, and dry season). The service type was natural mating and the ewes and rams were kept together every night for 45 days. Reproductive efficiency was assessed by service, pregnancy, lambing, prolificacy, twinning, pregnancy loss, weaning, and lamb mortality rates. Ewes were weighed at the beginning and at the end of the breeding season and before and after parturition, and sequential weighing of the lambs was performed (at birth, 15, 30, 60, and 90 days). Reproductive efficiency index (number of lambs weaned/total of served ewes) and productive efficiency (kg of weaned lamb/kg of served or lambed ewes) were calculated. All ewes expressed estrus early in the breeding season; however, a higher percentage (53.5 and 7.1 % at 30 and 45 days, respectively) of ewes returned to estrus during the wet/dry period. The lower rates (13.9 %) of return to estrus at 30 days were during the wet season (P < 0.05). There were no (P > 0.05) effects of breeding seasons on the remaining reproductive rates. Ewes that lambed during the wet/dry transition period weighted less, before (40.5 ± 2.5 kg) and after (38.6 ± 1.6 kg) parturition, than those of other groups (P < 0.05). Lamb weight at birth did not vary between groups, however, weight at weaning was higher (15.6 ± 2.1 kg) in lambs born during the wet season (P < 0.05). The reproductive efficiency index was lower (0.66) when the breeding season took place during the dry/wet period (P < 0.05). Productive rates were significantly higher (0.29 and 0.33 for kg of weaned lamb/kg of served and lambed ewes, respectively; P < 0.05) in ewes served in the dry season. The reproductive performance of Santa Inês ewes was not significantly influenced by the period of the year in which the breeding seasons took place, allowing for four breeding seasons a year in the Amazon region. Variations between periods in return to estrus rates, weight of ewes close to parturition and lamb weight at weaning indicate that climate changes can also affect reproductive rates.
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http://dx.doi.org/10.1007/s11250-015-0886-4DOI Listing
December 2015

Comparative study of five techniques for the diagnosis of canine gastrointestinal parasites.

Rev Bras Parasitol Vet 2015 Apr-Jun;24(2):223-6

Departamento de Apoio, Produção e Saúde Animal, Faculdade de Medicina Veterinária de Araçatuba, Universidade Estadual Paulista, Araçatuba, SP, Brasil.

Differences in the efficacy of diagnostic techniques employed in the parasitological examination of feces are a limiting factor of this laboratory procedure in the field of Veterinary Parasitology. To verify advances in this type of examination in dogs, we conducted a study using a new technique (TFGII/Dog). Fifty naturally infected dogs were housed in individual stalls, and their feces were evaluated comparatively using this technique and four other conventional techniques. The TFGII/Dog showed high levels of sensitivity and efficiency, surpassing the diagnostic accuracy of the other techniques with a kappa concordance index of 0.739 (Substantial), as opposed to 0.546 (Moderate), 0.485 (Moderate), 0.467 (Moderate), and 0.325 (Fair) of the Spontaneous-Sedimentation, Centrifugal-Flotation in Saturated Zinc Sulfate Solution, Centrifugal-Flotation in Saturated Sugar Solution, and Spontaneous-Flotation in Saturated Sodium Chloride Solution techniques, respectively. The combination of positive results of all techniques comprises eight genera of parasites, with Ancylostoma spp. predominating among helminths, and Cystoisospora spp. among protozoa. The TFGII/Dog technique showed better diagnostic performance, and can therefore be considered an important tool for optimizing the results of laboratory routines and for the control of canine gastrointestinal parasites.
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http://dx.doi.org/10.1590/S1984-29612015032DOI Listing
July 2017

[Local government and public dental health services: an analysis of inequality in use].

Cad Saude Publica 2015 Mar;31(3):586-96

The aim of this study was to identify factors associated with the use of primary and specialized public dental health services and private services. A population-based household survey was conducted in two cities of Bahia State, Brazil. Key informants provided data on socioeconomic variables and use of dental health services. Organization of the local public dental health service was ranked as worse versus better. Univariate and multivariate polytomous logistic regression was performed. Of the total of 1,290 individuals, 38.76% used private services, 33.80% used public primary care, and 17.29% used both primary care and the Center for Dental Specialties. Less use of both primary care and specialized public services was associated with lower education (OR = 1.47; 95%CI: 1.03-2.10) and worse organization of services (OR = 1.74; 95%CI: 1.22-2.48), when compared to the exclusive use of primary care. The study showed inequality in the use of dental services, even when comparing more homogeneous groups, namely users of public services.
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http://dx.doi.org/10.1590/0102-311x00077214DOI Listing
March 2015

[Inequalities in oral health care use in the primary care setting and associated factors in two Brazilian municipalities].

Rev Panam Salud Publica 2013 Dec;34(6):401-6

Departamento de Odontologia Social e Pediátrica, Faculdade de Odontologia, Universidade Federal da Bahia, Salvador, BA, Brasil.

Objective: To investigate the factors associated with inequality in the use of oral health services in the Brazilian Family Health Program (Estratégia Saúde da Família, ESF) as measured by dental extractions.

Methods: A population-based household survey was carried out in two municipalities with full coverage by the ESF in the state of Bahia, Brazil. Ten census tracts were randomly selected. Households were selected by systematic sampling. To assess the use of public services by the population, a prevalence of 50%, sampling error of 4%, and confidence interval of 95% were considered. Trained community health workers conducted key informant interviews on use of oral health services and collected demographic data for all household members aged 15 years or older. Dental extraction was the main outcome. The association between dental extraction and predictive variables was assessed using prevalence ratio, and multivar logistic regression analysis was performed using odds ratio (OR).

Results: Data from 2,539 people was collected. Of these, 682 (26.86%) had used primary oral health care services in the previous 12 months. Dental extraction was performed in 218 (31.96%) out of 682 primary care patients. Being assisted by social programs (OR = 1.43; IC95%: 1.02-2.01), being older than 35 years (OR = 1.59; IC95%: 1.12-2.27), and having lower education levels (OR = 1.81; IC95%: 1.27-2.56) were independently associated with the outcome.

Conclusions: The present results suggest that historical inequalities of access to oral health services persist. Intersectoral actions may play an important role in improving oral health conditions.
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December 2013

Influence of co-dopant in the europium reduction in SrAl2O4 host.

J Synchrotron Radiat 2014 Jan 2;21(Pt 1):143-8. Epub 2013 Nov 2.

Departamento de Física, Universidade Federal de Sergipe, Campus Universitário, São Cristovão, SE 49100-000, Brazil.

Xerogels of strontium chlorate and aluminium chlorate doped with europium (un-co-doped) and co-doped with rare earth ions (Ln = Gd, Dy, Er and Y) were prepared using the proteic sol-gel route. Synchrotron radiation was used to investigate the effect of different co-dopants on the Eu(3+) → Eu(2+) reduction process during the synthesis of the samples. Samples were excited at the Eu LIII-edge and the XANES regions were analyzed. The results suggest that some of the Eu ions can be stabilized in the divalent state and that it is difficult to completely reduce Eu(3+) to Eu(2+) during thermal treatment. The mechanisms of the Eu reduction processes are explained by a proposed model based on the incorporation of charge-compensation defects.
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http://dx.doi.org/10.1107/S1600577513025708DOI Listing
January 2014

[Characteristics of the access and utilization of public dental services in medium-sized cities].

Cien Saude Colet 2012 Nov;17(11):3115-24

Universidade Federal da Bahia, Departamento de Odontologia Social, Faculdade de Odontologia, R. Araújo Pinho 62, Canela, 40110-912 Salvador BA, Brazil.

This cross-sectional study sought to describe the main characteristics of access and utilization of primary and specialized public dental services in two medium-sized cities in Bahia with 100% coverage of the Family Health Program. A survey of 952 households and 2.539 individuals aged over 15 years was conducted. The main variables analyzed were: perceived oral health needs, demand for the service, barriers of organizational access and the type of service and procedure utilized. The use of specialized public dental services was of 11.7% and primary care was 26%. In the city where there was greater use of public dental services, there was less use of private services. The main barrier to access remained in primary care (from 5.0% to 15.2%). There was little interface between secondary care a primary care, as only 16.6% of users returned to this level of care. In conclusion, the main barrier to access in cities with specific organizational and geographic realities appears to be in primary dental care. Individual preventive actions were little reported. It is recommended that barriers to access in primary care be eliminated, and also that a protocol (clinical guides) be established to foster the continuity and longitudinality of primary dental care.
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http://dx.doi.org/10.1590/s1413-81232012001100027DOI Listing
November 2012
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