Publications by authors named "Felipe Prosper"

100Publications

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

Cell Metab 2020 Dec 1. Epub 2020 Dec 1.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

View Article and Find Full Text PDF
December 2020

CAR T-Cells in Multiple Myeloma Are Ready for Prime Time.

J Clin Med 2020 Nov 6;9(11). Epub 2020 Nov 6.

Clínica Universidad de Navarra, Centro de investigación médica aplicada (Cima), CIBERONC, IDISNA, 31008 Pamplona, Spain.

View Article and Find Full Text PDF
November 2020

Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironment.

Haematologica 2020 09 1;105(9):e470-473. Epub 2020 Sep 1.

Clinica Universidad de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, Spain; Centro de Investigacion Medica Aplicada (CIMA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.

View Article and Find Full Text PDF
September 2020

Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering.

Front Bioeng Biotechnol 2020 11;8:955. Epub 2020 Aug 11.

Regenerative Medicine Program, Cima Universidad de Navarra, Foundation for Applied Medical Research, Pamplona, Spain.

View Article and Find Full Text PDF
August 2020

Correction: Ordoñez, et al.; DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters? Cancers 2019, 11, 1424.

Cancers (Basel) 2020 Jul 13;12(7). Epub 2020 Jul 13.

Área de Hemato-Oncología, Centro de Investigación Médica Aplicada, IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, Spain.

View Article and Find Full Text PDF
July 2020

Strategy for identification of a potential inherited leukemia predisposition in a 299 patient's cohort with tumor-only sequencing data.

Leuk Res 2020 08 24;95:106386. Epub 2020 May 24.

Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; Hematological Diseases Laboratory, CIMA LAB Diagnostics, University of Navarra, Pamplona, Spain; Scientific Co-Director of CIMA LAB Diagnostics, CIMA LAB Diagnostics, University of Navarra, Pamplona, Spain.

View Article and Find Full Text PDF
August 2020

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.

Cell 2020 05 24;181(4):905-913.e7. Epub 2020 Apr 24.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria; Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

View Article and Find Full Text PDF
May 2020

HDAC Inhibitors in Acute Myeloid Leukemia.

Cancers (Basel) 2019 Nov 14;11(11). Epub 2019 Nov 14.

Área de Hemato-Oncología, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Universidad de Navarra, 31008 Pamplona, Spain.

View Article and Find Full Text PDF
November 2019

Generation of an induced pluripotent stem cell line (CIMAi001-A) from a compound heterozygous Primary Hyperoxaluria Type I (PH1) patient carrying p.G170R and p.R122* mutations in the AGXT gene.

Stem Cell Res 2019 12 18;41:101626. Epub 2019 Oct 18.

Regenerative Medicine Program, CIMA Universidad de Navarra, Pamplona, Spain. Instituto de Investigación Sanitaria de Navarra, IdiSNA, Pamplona, Navarra, Spain. Electronic address:

View Article and Find Full Text PDF
December 2019

A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity.

Cancer Lett 2020 01 5;468:1-13. Epub 2019 Oct 5.

University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain; University of Navarra, Department of Biochemistry and Genetics, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

View Article and Find Full Text PDF
January 2020

DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters?

Cancers (Basel) 2019 Sep 24;11(10). Epub 2019 Sep 24.

Área de Hemato-Oncología, Centro de Investigación Médica Aplicada, IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, Spain.

View Article and Find Full Text PDF
September 2019

Long-Term Engraftment of Human Cardiomyocytes Combined with Biodegradable Microparticles Induces Heart Repair.

J Pharmacol Exp Ther 2019 09 6;370(3):761-771. Epub 2019 Feb 6.

Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (L.S., E.G., M.J.B.-P.); Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (L.S., E.G., M.M., B.P., G.A., F.P., M.J.B.-P.); Hematology and Cell Therapy, Clínica Universidad de Navarra and Foundation for Applied Medical Research, Pamplona, Spain (M.M., B.P., G.A., F.P.); Center of Regenerative Medicine in Barcelona (CRMB), Hospitalet de Llobregat, Barcelona, Spain, Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain (O.I.-G., A.R.) and Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain (A.R.)

View Article and Find Full Text PDF
September 2019

The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma.

Clin Cancer Res 2019 May 28;25(10):3176-3187. Epub 2019 Jan 28.

Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), Instituto de Investigación Sanitaria de Navarra (IDISNA), CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain.

View Article and Find Full Text PDF
May 2019

Allogeneic Mesenchymal Stem Cells and Biomaterials: The Perfect Match for Cardiac Repair?

Int J Mol Sci 2018 Oct 19;19(10). Epub 2018 Oct 19.

Laboratory of Regenerative Medicine, Foundation for Applied Medical Research, 31008 Pamplona, Spain.

View Article and Find Full Text PDF
October 2018

Generation of four Isl1 reporter iPSC lines from cardiac and tail-tip fibroblasts derived from Ai6IslCre mouse.

Stem Cell Res 2018 12 11;33:125-129. Epub 2018 Oct 11.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
December 2018

Effect of bone marrow stromal cells in combination with biomaterials in early phases of distraction osteogenesis: An experimental study in a rabbit femur model.

Injury 2018 Nov 6;49(11):1979-1986. Epub 2018 Sep 6.

Tissue Engineering Group, Bioengineering Area, Instituto Biodonostia, San Sebastian, Spain; Department of Biomedical Engineering and Science, School of Engineering, Tecnun-University of Navarra, San Sebastian, Spain. Electronic address:

View Article and Find Full Text PDF
November 2018

Selective increase of cardiomyocyte derived extracellular vesicles after experimental myocardial infarction and functional effects on the endothelium.

Thromb Res 2018 10 1;170:1-9. Epub 2018 Aug 1.

Laboratory of Atherothrombosis, Program of Cardiovascular Diseases, Center for Applied Medical Research (CIMA)-University of Navarra, Spain; CIBERCV, Madrid, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Spain. Electronic address:

View Article and Find Full Text PDF
October 2018

Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction.

Arterioscler Thromb Vasc Biol 2018 09;38(9):2160-2173

From the Department of Immunology and Oncology, National Center for Biotechnology (CNB-CSIC), Madrid, Spain (D.H., S.C., M.S.-B., S.A., R.M.C., J.M.S., A.B.).

View Article and Find Full Text PDF
September 2018

Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds.

Adv Mater 2018 Jul 30;30(28):e1706754. Epub 2018 May 30.

Department for Functional Materials in Medicine and Dentistry and Bavarian Polymer institute (BPI), University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.

View Article and Find Full Text PDF
July 2018

Deregulation of in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells.

Oncotarget 2018 Feb 5;9(16):12842-12852. Epub 2018 Feb 5.

Laboratory of Myeloproliferative Syndromes, Oncology Area, Foundation for Applied Medical Research, IDISNA, CIBERONC, University of Navarra, Pamplona, Spain.

View Article and Find Full Text PDF
February 2018

COBRA methods and metabolic drug targets in cancer.

Mol Cell Oncol 2018 30;5(1):e1389672. Epub 2017 Nov 30.

CEIT and Tecnun, University of Navarra, Manuel de Lardizábal 13, San Sebastián, Spain.

View Article and Find Full Text PDF
November 2017

Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery.

Mol Ther Nucleic Acids 2017 Dec 12;9:1-11. Epub 2017 Aug 12.

Experimental Ophthalmology Laboratory, University of Navarra, Navarra Institute for Health Research, IdiSNA, 31008 Pamplona, Spain; Ophthalmology Department, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

View Article and Find Full Text PDF
December 2017

Role of substrate biomechanics in controlling (stem) cell fate: Implications in regenerative medicine.

J Tissue Eng Regen Med 2018 04 10;12(4):1012-1019. Epub 2017 Nov 10.

Laboratory of Cell Therapy, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.

View Article and Find Full Text PDF
April 2018

An in-silico approach to predict and exploit synthetic lethality in cancer metabolism.

Nat Commun 2017 09 6;8(1):459. Epub 2017 Sep 6.

CEIT and Tecnun, University of Navarra, Manuel de Lardizábal 13, 20018, San Sebastián, Spain.

View Article and Find Full Text PDF
September 2017

Dual epigenetic modifiers for cancer therapy.

Mol Cell Oncol 2017 20;4(4):e1342748. Epub 2017 Jun 20.

Area de Hemato-Oncología, Centro de Investigación Médica Aplicada (CIMA), IDISNA, ciberonc, Universidad de Navarra, Pamplona, Spain.

View Article and Find Full Text PDF
June 2017

Generation of a Sprague-Dawley-GFP rat iPS cell line.

Stem Cell Res 2017 05 31;21:47-50. Epub 2017 Mar 31.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Health Research Institute of Navarra, Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
May 2017

Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells.

Stem Cell Res 2017 05 29;21:40-43. Epub 2017 Mar 29.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Health Research Institute of Navarra, Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
May 2017

Generation of Macaca fascicularis iPS cell line ATCi-MF1 from adult skin fibroblasts using non-integrative Sendai viruses.

Stem Cell Res 2017 05 16;21:1-4. Epub 2017 Mar 16.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Health Research Institute of Navarra, Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
May 2017

Transplantation of adipose-derived stem cells combined with neuregulin-microparticles promotes efficient cardiac repair in a rat myocardial infarction model.

J Control Release 2017 03 19;249:23-31. Epub 2017 Jan 19.

Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra, IdiSNA, Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
March 2017

Is immunotherapy here to stay in multiple myeloma?

Haematologica 2017 03 12;102(3):423-432. Epub 2017 Jan 12.

Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain

View Article and Find Full Text PDF
March 2017

Hydrogel based approaches for cardiac tissue engineering.

Int J Pharm 2017 May 29;523(2):454-475. Epub 2016 Oct 29.

Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, Universidad de Navarra, Pamplona, C/Irunlarrea 1, E-31080, Spain; Instituto de Investigación Sanitaria de Navarra, IdiSNA, Pamplona, C/Irunlarrea 3, E-31008 Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
May 2017

Are we closer to cardiac regeneration?

Stem Cell Investig 2016 20;3:59. Epub 2016 Oct 20.

Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain;; Cell Therapy Area, Clínica Universidad de Navarra, University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.

View Article and Find Full Text PDF
October 2016

Cytokine-loaded PLGA and PEG-PLGA microparticles showed similar heart regeneration in a rat myocardial infarction model.

Int J Pharm 2017 May 9;523(2):531-533. Epub 2016 Nov 9.

Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, Universidad de Navarra, Pamplona, C/Irunlarrea 1, E-31080, Spain; Instituto de Investigación Sanitaria de Navarra, IdiSNA, Pamplona, C/Irunlarrea 3, E-31008 Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
May 2017

Modulation of Synovial Fluid-Derived Mesenchymal Stem Cells by Intra-Articular and Intraosseous Platelet Rich Plasma Administration.

Stem Cells Int 2016 12;2016:1247950. Epub 2016 Oct 12.

Arthroscopic Surgery Unit Research, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain; Arthroscopic Surgery Unit, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain.

View Article and Find Full Text PDF
October 2016

Generation of iPSC from cardiac and tail-tip fibroblasts derived from a second heart field reporter mouse.

Stem Cell Res 2016 05 19;16(3):617-21. Epub 2016 Mar 19.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.

View Article and Find Full Text PDF
May 2016

Generation and characterization of human iPSC lines derived from a Primary Hyperoxaluria Type I patient with p.I244T mutation.

Stem Cell Res 2016 Jan 28;16(1):116-9. Epub 2015 Dec 28.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Instituto de Investigación Sanitaria de Navarra, IdiSNA, Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
January 2016

Generation and characterization of human iPSC line generated from mesenchymal stem cells derived from adipose tissue.

Stem Cell Res 2016 Jan 2;16(1):20-3. Epub 2015 Dec 2.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
January 2016

Pancreatic differentiation of Pdx1-GFP reporter mouse induced pluripotent stem cells.

Differentiation 2016 12 12;92(5):249-256. Epub 2016 May 12.

Centro de Investigación Médica Aplicada (CIMA), University of Navarra, Avda. Pio XII 55, Pamplona 31008, Spain; Hematology and Cell Therapy Area, Clínica Universidad de Navarra, Avda. Pio XII 36, 31008 Pamplona, Spain. Electronic address:

View Article and Find Full Text PDF
December 2016

Phase 1-2 pilot clinical trial in patients with decompensated liver cirrhosis treated with bone marrow-derived endothelial progenitor cells.

Transl Res 2017 10 24;188:80-91.e2. Epub 2016 Feb 24.

Liver Unit and CIBERehd, Clínica Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.

View Article and Find Full Text PDF
October 2017

A new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma.

Expert Opin Biol Ther 2016 21;16(5):627-43. Epub 2016 Mar 21.

b Department of Regenerative Medicine, Laboratory of Regenerative Medicine, BTI Biotechnology Institute , Vitoria , Spain.

View Article and Find Full Text PDF
October 2016