Publications by authors named "Fei Gao"

2,059 Publications

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High zeolite loading mixed matrix membrane for effective removal of ammonia from surface water.

Water Res 2022 Aug 11;221:118849. Epub 2022 Jul 11.

State Key Laboratory of Pollution Control and Resource Reuse, Shanghai Institute of Pollution Control and Ecological Security, School of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Tongji Advanced Membrane Technology Center, Shanghai 200092, China. Electronic address:

While zeolite-based mixed matrix membrane (MMM) has been proven effective to remove the ammonia in the wastewater by adsorption, its adsorption capacity is limited by the low zeolite loading due to the need of a high concentration of polymer matrix to maintain the mechanical strength. To break the bottleneck, in this study we proposed a facile solvent evaporation method instead of conventional phase inversion method to prepare the zeolite-based MMMs. With this new preparation method, the loading of zeolite could reach up to ∼90wt.% while the MMM still maintained a good mechanical property. The zeolite-based MMM could treat 910 L·m of feedwater before reaching the ammonia breakthrough point (0.5 mg-N·L) when treating the synthetic wastewater water. In addition, it showed a high rejection of turbidity and natural organic material (NOM) (∼90%), mainly due to its high negative surface charge density. When applied to treat real surface water, the membrane demonstrated a high normalized treatable capacity (∼900 L·m) with a high rejection to NOM (87.4%). Moreover, the MMM even showed a higher fouling resistance than the PVDF microfiltration membrane. Regeneration and cleaning with NaClO could efficiently recover the adsorption capacity and water flux of the MMM. After four cycles of operation, the MMM still maintained a high treatable capacity (850 L·m) with a high NOM rejection. This study provides a new strategy for the preparation of high-loading zeolite-based MMM for the effective removal of ammonia from surface water.
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http://dx.doi.org/10.1016/j.watres.2022.118849DOI Listing
August 2022

The value of CT radiomics features to predict visceral pleural invasion in ≤3 cm peripheral type early non-small cell lung cancer.

J Xray Sci Technol 2022 Aug 4. Epub 2022 Aug 4.

Department of Radiotherapy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC West District, Hefei, China.

Objective: To investigate predictive value of CT-based radiomics features on visceral pleural invasion (VPI) in ≤3.0 cm peripheral type early non-small cell lung cancer (NSCLC).

Methods: A total of 221 NSCLC cases were collected. Among them, 115 are VPI-positive and 106 are VPI-negative. Using a stratified random sampling method, 70% cases were assigned to training dataset (n = 155) and 30% cases (n = 66) were assigned to validation dataset. First, CT findings, imaging features, clinical data and pathological findings were retrospectively analyzed, the size, location and density characteristics of nodules and lymph node status, the relationship between lesions and pleura (RAP) were assessed, and their mean CT value and the shortest distance between lesions and pleura (DLP) were measured. Next, the minimum redundancy-maximum relevance (mRMR) and least absolute shrinkage and selection operator (LASSO) features were extracted from the imaging features. Then, CT imaging prediction model, texture feature prediction model and joint prediction model were built using multifactorial logistic regression analysis method, and the area under the ROC curve (AUC) was applied to evaluate model performance in predicting VPI.

Results: Mean diameter, density, fractal relationship with pleura, and presence of lymph node metastasis were all independent predictors of VPI. When applying to the validation dataset, the CT imaging model, texture feature model, and joint prediction model yielded AUC = 0.882, 0.824 and 0.894, respectively, indicating that AUC of the joint prediction model was the highest (p <  0.05).

Conclusion: The study demonstrates that the joint prediction model containing CT morphological features and texture features enables to predict the presence of VPI in early NSCLC preoperatively at the highest level.
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http://dx.doi.org/10.3233/XST-221220DOI Listing
August 2022

Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.

Front Aging Neurosci 2022 22;14:868484. Epub 2022 Jul 22.

Department of Neurology, Hebei Medical University, Shijiazhuang, China.

Inflammatory responses induced by chronic cerebral hypoperfusion (CCH) play a critical role in the progression of vascular dementia. Stimulator of interferon genes (STING) signaling function as a key mediator of inflammation and immunological responses in the central nervous system (CNS), and resveratrol (RES) exerts potent anti-inflammatory effects. However, the role of STING signaling and the relationship between RES and STING signaling in persistent hypoperfusion-induced cerebral inflammation remain unclear. In this study, Sprague-Dawley rats were subjected to either Sham or bilateral common carotid artery occlusion (2VO) surgery and received RES or vehicle daily by intraperitoneal injection for 4 or 8 weeks. Morris's water maze was used for the analysis of cognitive function. The neuroinflammatory responses in white matter and hippocampus of the rat brain were assessed by Western blot, Immunofluorescence staining, and qRT-PCR analyses. Myelin integrity, neutrophil infiltration, and microglia proliferation were assessed by Immunohistochemistry and histologic analysis. We demonstrated that after CCH, neurons, microglia, and astrocyte under endoplasmic reticulum (ER) stress upregulated the expression of STING, TANK-binding kinase 1 (TBK1), and the transcription factor interferon regulatory factor 3 (IRF3), as well as translocation of IRF3 into the nucleus. These were accompanied by infiltration of neutrophils, activation of microglia, and overproduction of proinflammatory mediators. Improvements in cognitive deficits were related to reduced hippocampal neuronal cell death and increased myelin integrity in RES-treated rats. The neuroprotective effects of RES were associated with suppression of the expression of tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecule 1 (ICAM-1), VCAM-1, interferon-β (IFN-β), and IL-1β, likely through mitigation of the STING/TBK1/IRF3 pathway. These inhibitory effects exerted by RES also inhibited the levels of myeloperoxidase, reduced excess expression of reactive astrocytes, and activated microglia. In conclusion, the STING/TBK1/IRF3 axis may be critical for proinflammatory responses in cerebral tissue with persistent hypoperfusion, and RES exerts its anti-inflammatory effects by suppressing STING/TBK1/IRF3 signaling.
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http://dx.doi.org/10.3389/fnagi.2022.868484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354401PMC
July 2022

A deep learning model based on dynamic contrast-enhanced magnetic resonance imaging enables accurate prediction of benign and malignant breast lessons.

Front Oncol 2022 22;12:943415. Epub 2022 Jul 22.

Department of Radiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: The study aims to investigate the value of a convolutional neural network (CNN) based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting malignancy of breast lesions.

Methods: We developed a CNN model based on DCE-MRI to characterize breast lesions. Between November 2018 and October 2019, 6,165 slices of 364 lesions (234 malignant, 130 benign) in 364 patients were pooled in the training/validation set. Lesions were semi-automatically segmented by two breast radiologists using ITK-SNAP software. The standard of reference was histologic consequences. Algorithm performance was evaluated in an independent testing set of 1,560 slices of 127 lesions in 127 patients using weighted sums of the area under the curve (AUC) scores.

Results: The area under the receiver operating characteristic (ROC) curve was 0.955 for breast cancer prediction while the accuracy, sensitivity, and specificity were 90.3, 96.2, and 79.0%, respectively, in the slice-based method. In the case-based method, the efficiency of the model changed by adjusting the standard for the number of positive slices. When a lesion with three or more positive slices was determined as malignant, the sensitivity was above 90%, with a specificity of nearly 60% and an accuracy higher than 80%.

Conclusion: The CNN model based on DCE-MRI demonstrated high accuracy for predicting malignancy among the breast lesions. This method should be validated in a larger and independent cohort.
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http://dx.doi.org/10.3389/fonc.2022.943415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353744PMC
July 2022

RUNX3-Regulated GALNT6 Promotes the Migration and Invasion of Hepatocellular Carcinoma Cells by Mediating O-Glycosylation of MUC1.

Authors:
Fei Gao Gang Zheng

Dis Markers 2022 21;2022:2959846. Epub 2022 Jul 21.

Department of Biliary-Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, China.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Dysregulation of messenger RNAs (mRNA) has been recognized to be associated with HCC carcinogenesis and development. Polypeptide GalNAc Transferase 6 (GALNT6), an O-type glycosyltransferase, has been confirmed as tumor promoter in different cancers. However, the function of GALNT6 in HCC remains to be studied.

Methods: RT-qPCR and western blot experiments were, respectively, performed for evaluating RNA expressions and protein levels. Supported by bioinformatics analysis, mechanism assays were conducted for validating the potential relation between different genes. Functional assays were implemented to analyze HCC cell migration and invasion after different transfections.

Results: GALNT6 was aberrantly upregulated in HCC cells. Knockdown of GALNT6 could repress HCC cell migration and invasion. RUNX3 was verified to bind to GALNT6 promoter and activate GALNT6 transcription. GALNT6 depletion led to inhibited O-glycosylation and aggravated degradation of MUC1. MUC1 overexpression could rescue the impeded HCC cell migration and invasion induced by GALNT6 knockdown.

Conclusion: To sum up, GALNT6 transcriptionally activated by RUNX3 mediated the O-glycosylation of MUC1, thus exerting promoting influence on HCC cell migration and invasion.
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http://dx.doi.org/10.1155/2022/2959846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334053PMC
August 2022

Classification of Alzheimer's Disease Based on Deep Learning of Brain Structural and Metabolic Data.

Front Aging Neurosci 2022 12;14:927217. Epub 2022 Jul 12.

Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

To improve the diagnosis and classification of Alzheimer's disease (AD), a modeling method is proposed based on the combining magnetic resonance images (MRI) brain structural data with metabolite levels of the frontal and parietal regions. First, multi-atlas brain segmentation technology based on T1-weighted images and edited magnetic resonance spectroscopy (MRS) were used to extract data of 279 brain regions and levels of 12 metabolites from regions of interest (ROIs) in the frontal and parietal regions. The -test combined with false discovery rate (FDR) correction was used to reduce the dimensionality in the data, and MRI structural data of 54 brain regions and levels of 4 metabolites that obviously correlated with AD were screened out. Lastly, the stacked auto-encoder neural network (SAE) was used to classify AD and healthy controls (HCs), which judged the effect of classification method by fivefold cross validation. The results indicated that the mean accuracy of the five experimental model increased from 96 to 100%, the AUC value increased from 0.97 to 1, specificity increased from 90 to 100%, and F1 value increased from 0.97 to 1. Comparing the effect of each metabolite on model performance revealed that the gamma-aminobutyric acid (GABA) + levels in the parietal region resulted in the most significant improvement in model performance, with the accuracy rate increasing from 96 to 98%, the AUC value increased from 0.97 to 0.99 and the specificity increasing from 90 to 95%. Moreover, the GABA + levels in the parietal region was significantly correlated with Mini Mental State Examination (MMSE) scores of patients with AD ( = 0.627), and the F statistics were largest ( = 25.538), which supports the hypothesis that dysfunctional GABAergic system play an important role in the pathogenesis of AD. Overall, our findings support that a comprehensive method that combines MRI structural and metabolic data of brain regions can improve model classification efficiency of AD.
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http://dx.doi.org/10.3389/fnagi.2022.927217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315355PMC
July 2022

A Novel High-Throughput Phenotyping Hydroponic System for Nitrogen Deficiency Studies in Arabidopsis thaliana.

Methods Mol Biol 2022 ;2539:19-24

Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR, USA.

High-throughput phenotyping enables the temporal detection of subtle changes in plant plasticity and adaptation to different conditions, such as nitrogen deficiency, in an accurate, nondestructive, and unbiased way. Here, we describe a protocol to assess the contribution of nitrogen addition or deprival using an image-based system to analyze plant phenotype. Thousands of images can be captured throughout the life cycle of Arabidopsis, and those images can be used to quantify parameters such as plant growth (area, caliper length, diameter, etc.), in planta chlorophyll fluorescence, and in planta relative water content.
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http://dx.doi.org/10.1007/978-1-0716-2537-8_3DOI Listing
July 2022

A Genome-Wide CRISPR Screen Identifies Factors Regulating Pluripotency Exit in Mouse Embryonic Stem Cells.

Cells 2022 Jul 25;11(15). Epub 2022 Jul 25.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Pluripotency maintenance and exit in embryonic stem cells is a focal topic in stem cell biology. However, the effects of screening under very stringent culture conditions (e.g., differentiation medium, no leukemia inhibitory factor, no chemical inhibitors such as PD0325901 and CHIR99021, and no feeder cells) and of prolonging culture for key factors that regulate pluripotency exit, have not yet been reported. Here, we used a genome-wide CRISPR library to perform such a screen in mouse embryonic stem cells. Naïve NANOG-GFP mESCs were first transfected with a mouse genome-wide CRISPR knockout library to obtain a mutant mESCs library, followed by screening for two months in a strict N2B27 differentiation medium. The clones that survived our stringent screening were analyzed to identify the inserted sgRNAs. In addition to identifying the enriched genes that were reported in previous studies (, , , , , , and ), we found 17 unreported genes, among which and appeared to be involved in pluripotency exit. Furthermore, knockout ESCs showed a differentiation delay in embryonic chimera experiments, indicating played an important role in pluripotency exit. Our results show that stringent screening with the CRISPR library can reveal key regulators of pluripotency exit.
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http://dx.doi.org/10.3390/cells11152289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331787PMC
July 2022

Microbe-Based Sensor for Long-Term Detection of Urine Glucose.

Sensors (Basel) 2022 Jul 17;22(14). Epub 2022 Jul 17.

Department of Civil, Structural and Environmental Engineering, Trinity College Dublin, D02 PN40 Dublin, Ireland.

The development of a reusable and low-cost urine glucose sensor can benefit the screening and control of diabetes mellitus. This study focused on the feasibility of employing microbial fuel cells (MFC) as a selective glucose sensor for continuous monitoring of glucose levels in human urine. Using MFC technology, a novel cylinder sensor (CS) was developed. It had a quick response time (100 s), a large detection range (0.3-5 mM), and excellent accuracy. More importantly, the CS could last for up to 5 months. The selectivity of the CS was validated by both synthetic and actual diabetes-negative urine samples. It was found that the CS's selectivity could be significantly enhanced by adjusting the concentration of the culture's organic matter. The CS results were comparable to those of a commercial glucose meter (recovery ranged from 93.6% to 127.9%) when the diabetes-positive urine samples were tested. Due to the multiple advantages of high stability, low cost, and high sensitivity over urine test strips, the CS provides a novel and reliable approach for continuous monitoring of urine glucose, which will benefit diabetes assessment and control.
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http://dx.doi.org/10.3390/s22145340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320042PMC
July 2022

Multifunctional hydrogel loaded with 4-octyl itaconate exerts antibacterial, antioxidant and angiogenic properties for diabetic wound repair.

Biomater Adv 2022 Aug 8;139:212979. Epub 2022 Jun 8.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Cutaneous wound healing, especially diabetic wound healing, is a common clinical problem. Reactive oxygen species (ROS) and bacterial infection are two major factors in the induction of oxidative stress and inflammation, leading to impeded angiogenesis and wound healing. However, it is still very difficult to reverse the harsh microenvironment of chronic inflammation and excessive oxidative stress on diabetic wound. Itaconate, an endogenous metabolite, has recently attracted extensive attention as a critical immune-regulator. In this study, we used 4-octyl itaconate (4OI), a cell-permeable itaconate derivative, to have antioxidative and anti-inflammatory functions for diabetic wound regeneration. Simultaneously, an injectable, self-healing, and antibacterial dynamic coordinative hydrogel was manufactured by binding the 4-arm polyethylene glycol (PEG) with silver nitrate to deliver the bioactive molecule. In vitro experiments confirmed that [email protected] hydrogel could inhibit bacterial growth, protect human umbilical vein endothelial cells from ROS damage and enhance neovascularization. In addition, the hydrogel increased mitochondrial polarization and reduced mitochondrial fragmentation by activating the Keap1-Nrf2 antioxidant defense system. In vivo experiments proved that this multifunctional hydrogel facilitated diabetic wound healing by inhibiting local inflammation and promoting angiogenesis. Collectively, 4OI-loaded multifunctional materials could reverse various unfavorable microenvironments, such as excessive oxidative stress, inflammation, and infection, and can promote neovascularization; thus, such materials show great promise for the treatment of diabetic ulcers.
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http://dx.doi.org/10.1016/j.bioadv.2022.212979DOI Listing
August 2022

Sample size calculation for active-arm trial with counterfactual incidence based on recency assay.

Stat Commun Infect Dis 2021 Jan 10;13(1):20200009. Epub 2021 Nov 10.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Objectives: The past decade has seen tremendous progress in the development of biomedical agents that are effective as pre-exposure prophylaxis (PrEP) for HIV prevention. To expand the choice of products and delivery methods, new medications and delivery methods are under development. Future trials of non-inferiority, given the high efficacy of ARV-based PrEP products as they become current or future standard of care, would require a large number of participants and long follow-up time that may not be feasible. This motivates the construction of a counterfactual estimate that approximates incidence for a randomized concurrent control group receiving no PrEP.

Methods: We propose an approach that is to enroll a cohort of prospective PrEP users and aug-ment screening for HIV with laboratory markers of duration of HIV infection to indicate recent infections. We discuss the assumptions under which these data would yield an estimate of the counterfactual HIV incidence and develop sample size and power calculations for comparisons to incidence observed on an investigational PrEP agent.

Results: We consider two hypothetical trials for men who have sex with men (MSM) and transgender women (TGW) from different regions and young women in sub-Saharan Africa. The calculated sample sizes are reasonable and yield desirable power in simulation studies.

Conclusions: Future one-arm trials with counterfactual placebo incidence based on a recency assay can be conducted with reasonable total screening sample sizes and adequate power to determine treatment efficacy.
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http://dx.doi.org/10.1515/scid-2020-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865397PMC
January 2021

Deoxynivalenol Biosynthesis in Significantly Repressed by a Megabirnavirus.

Toxins (Basel) 2022 Jul 19;14(7). Epub 2022 Jul 19.

Department of Plant Protection, Henan Agricultural University, Zhengzhou 450002, China.

Deoxynivalenol (DON) is a mycotoxin widely detected in cereal products contaminated by Fusarium pseudograminearum megabirnavirus 1 (FpgMBV1) is a double-stranded RNA virus infecting . In this study, it was revealed that the amount of DON in was significantly suppressed by FpgMBV1 through a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay. A total of 2564 differentially expressed genes were identified by comparative transcriptomic analysis between the FpgMBV1-containing strain FC136-2A and the virus-free strain FC136-2A-V. Among them, 1585 genes were up-regulated and 979 genes were down-regulated. Particularly, the expression of 12 genes (, , , , , , , , , , and ) in the trichothecene biosynthetic () gene cluster was significantly down-regulated. Specific metabolic and transport processes and pathways including amino acid and lipid metabolism, ergosterol metabolic and biosynthetic processes, carbohydrate metabolism, and biosynthesis were regulated. These results suggest an unrevealing mechanism underlying the repression of DON and gene expression by the mycovirus FpgMBV1, which would provide new methods in the detoxification of DON and reducing the yield loss in wheat.
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http://dx.doi.org/10.3390/toxins14070503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324440PMC
July 2022

Multilevel Feature Learning Method for Accurate Interictal Epileptiform Spike Detection.

IEEE Trans Neural Syst Rehabil Eng 2022 Jul 25;PP. Epub 2022 Jul 25.

Interictal epileptiform spike (referred to as spike) detected from electroencephalograms lasting only 20- to 200-ms can provide a reliable evidence-based indicator for clinical seizure type diagnosis. Recent feature representation approaches focus either on the concrete-level or on abstract-level information mining of the spike, thus demonstrating suboptimal detection performance. Additionally, existing abstract-level information mining methods of the spike based deep learning networks have not realized the effective feature representation of long-term dependent distinguished information within similar waveform cycles caused by morphological heterogeneity, which affects detection performance. Thus, a multilevel feature learning method for accurate spike detection was proposed in this study. Specifically, the spatio-temporal-frequency multidomain information in concrete-level first are inferred the common mimetic properties of the spike using the multidomain feature extractors. Then, the effective feature representation of long-term dependent distinguished information within similar waveform cycles caused by morphological heterogeneity is suitably captured using the temporal convolutional network. Finally, the spatio-temporal-frequency multidomain long-term dependent feature representation of spike is calculated using the element-wise manner to fuse the feature representation in concrete- and abstract-levels. The experimental results indicate that the proposed method can achieve an accuracy of 90.62±1.38%, sensitivity of 90.38±1.52%, specificity of 91.00±1.60%, precision of 90.33±4.71%, and the false detection rate per minute is 0.148±0.020m, which are higher than when using the feature representation in the concrete- or abstract-level alone. Additionally, the detection results indicate that the proposed method avoids the subjectivity and inefficiency of visual inspection, and it enables a highly accurate detection of the spike.
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http://dx.doi.org/10.1109/TNSRE.2022.3193666DOI Listing
July 2022

A Review on Electrode Materials of Fast-Charging Lithium-Ion batteries.

Chem Rec 2022 Jul 25:e202200127. Epub 2022 Jul 25.

School of Energy Sciences and Engineering, Nanjing Tech University, 211816, Nanjing, Jiangsu Province, China.

In recent years, the driving range of electric vehicles (EVs) has been dramatically improved. But the large-scale adoption of EVs still is hindered by long charging time. The high-energy LIBs are unable to be safely fast-charged due to their electrode materials with unsatisfactory rate performance. Thus it is necessary to summarize the properties of cathode and anode materials of fast-charging LIBs. In this review, we summarize the background, the fundamentals, electrode materials and future development of fast-charging LIBs. First, we introduce the research background and the physicochemical basics for fast-charging LIBs. Second, typical cathode materials of LIBs and the method to enhancing their fast-charging properties are discussed. Third, the anode materials of LIBs and the strategies for improving their fast-charging performance are analyzed. Finally, the future development of the cathode materials in fast-charging LIBs is prospected.
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http://dx.doi.org/10.1002/tcr.202200127DOI Listing
July 2022

Main Pathological Changes of Benign Ureteral Strictures.

Front Med (Lausanne) 2022 7;9:916145. Epub 2022 Jul 7.

Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To identify the pathological classification of benign ureteral strictures according to the histological features and explore the relationship between various pathological types and inflammatory cells, fibroblasts, and collagen.

Patients And Methods: Thirty one specimens from patients diagnosed with ureteral strictures between 2013 and 2021 were included and classified according to the histopathological characteristics. The number of fibroblasts and inflammatory cells was counted, and the proportion of type I and type III collagen in ureteral stricture tissues was detected by picrosirius red staining.

Results: We identified three types of benign ureteral strictures in 31 specimens: inflammatory cell infiltration ( = 10, 32%), fibroplasia ( = 14, 45%), and hyalinization ( = 7, 23%), with significant differences in obstruction history and hydronephrosis grades among the three types. The number of inflammatory cells (lymphocytes, neutrophils and eosinophils) was significantly lower in hyalinization ureteral strictures than in the other two types ( < 0.05). The number of foreign-body giant cells associated with foreign-body reactions increased significantly in suture-induced ureteral strictures ( < 0.05). Fibroplasia type had the largest number of fibroblasts, whereas the other two types had smaller numbers. The results of type I and III collagen analysis showed that type I and III collagen were the most abundant in hyalinization among all ureteral stricture types ( < 0.05). Compared to ureteral strictures, the content of type I and III collagen in atresia increased significantly ( < 0.05).

Conclusion: Common pathological types of benign ureteral strictures include inflammatory cell infiltration, fibroplasia, and hyalinization. Changes in type I and III collagen, inflammatory cells, and fibroblasts in different pathological types may be related to the progression of ureteral strictures.
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http://dx.doi.org/10.3389/fmed.2022.916145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300898PMC
July 2022

HSPA5 Inhibitor Meliorate DSS-Induced Colitis through HSPA1A/CHIP.

Dis Markers 2022 13;2022:7115181. Epub 2022 Jul 13.

Department of Integrated Chinese and Western Medicine, Union Hospital Affiliate to Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, Hubei 430022, China.

Objective: Ulcerative colitis (UC) is closely related to immune response, in which Treg cells (Tregs) suppress the autoimmune response of effector T cells to maintain homeostasis. As a marker of endoplasmic reticulum stress (ERS), HSPA5 was highly expressed in the colon tissue of UC patients. This study is aimed at evaluating the therapeutic effect of HSPA5 inhibitor (HA15) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in mice and explored the effect and related mechanism of HSPA5 inhibitor on the differentiation and function of Tregs.

Methods: Thirty-two C57BL/6 mice were randomly divided into four groups (8 mice per group): normal control group, DSS model group, HSPA5 inhibitor (HA15) group (intraperitoneal injection), and dexamethasone (DXM) group (intraperitoneal injection). Except for the blank control group, the other groups were induced with 3% DSS for 7 days and then given corresponding intervention therapy for 7 days.

Results: The disease activity index (DAI) score, colon length, histopathological changes, and scores of DSS-induced mice show that HA15 could significantly improve the degree of inflammation in ulcerative colitis. Moreover, HA15 can better inhibit the expression of HSPA5, HSPA1A, and CHIP in the colon and increase the level of FOXP3 mRNA. Finally, the content of Treg cells and the levels of IL-10 and TGF-1 were significantly increased, and the levels of IL-6 were significantly reduced.

Conclusions: HA15 can improve the differentiation and function of Treg cells by inhibiting the HSPA1A/CHIP pathway, thereby improving ulcerative colitis. Therefore, inhibiting the expression of HSPA5 may serve as a new approach to treat ulcerative colitis.
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http://dx.doi.org/10.1155/2022/7115181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300310PMC
July 2022

Proposal for All-Electrical Spin Manipulation and Detection for a Single Molecule on Boron-Substituted Graphene.

Phys Rev Lett 2022 Jul;129(2):027201

Department of Physics, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

All-electrical writing and reading of spin states attract considerable attention for their promising applications in energy-efficient spintronics devices. Here we show, based on rigorous first-principles calculations, that the spin properties can be manipulated and detected in molecular spinterfaces, where an iron tetraphenyl porphyrin (FeTPP) molecule is deposited on boron-substituted graphene (BG). Notably, a reversible spin switching between the S=1 and S=3/2 states is achieved by a gate electrode. We can trace the origin to a strong hybridization between the Fe-d_{z^{2}} and B-p_{z} orbitals. Combining density functional theory with nonequilibrium Green's function formalism, we propose an experimentally feasible three-terminal setup to probe the spin state. Furthermore, we show how the in-plane quantum transport for the BG, which is non-spin polarized, can be modified by FeTPP, yielding a significant transport spin polarization near the Fermi energy (>10% for typical coverage). Our work paves the way to realize all-electrical spintronics devices using molecular spinterfaces.
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http://dx.doi.org/10.1103/PhysRevLett.129.027201DOI Listing
July 2022

A resource for assessing dynamic binary choices in the adult brain using EEG and mouse-tracking.

Sci Data 2022 07 16;9(1):416. Epub 2022 Jul 16.

Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR, China.

We present a dataset combining high-density Electroencephalography (HD-EEG, 128-channels) and mouse-tracking intended as a resource for examining the dynamic decision process of semantics and preference choices in the human brain. The dataset includes resting-state and task-related (food preference choices and semantic judgments) EEG acquired from 31 individuals (ages: 18-33). Along with the dataset, we also provided the preliminary microstate analysis of resting-state EEG and the ERPs, topomap, and time-frequency maps of the task-related EEG. We believe that the simultaneous mouse-tracking and EEG recording would crack the core components of binary choices and further index the temporal dynamics of decision making and response hesitation. This publicly available dataset could support the development of neural signal processing methods in motor EEG, thus advancing research in both the decision neuroscience and brain-computer interface (BCI) applications.
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http://dx.doi.org/10.1038/s41597-022-01538-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288455PMC
July 2022

Burden of pancreatitis and associated risk factors in China, 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.

Chin Med J (Engl) 2022 Jul 14. Epub 2022 Jul 14.

Graduate School, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing 100853, China.

Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to 2019.

Methods: This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and sex.

Results: From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in 2019.

Conclusions: The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancreatitis in recent years.
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http://dx.doi.org/10.1097/CM9.0000000000002164DOI Listing
July 2022

Lectin Drug Conjugates Targeting High Mannose N-Glycans.

Chembiochem 2022 Jul 11:e202200266. Epub 2022 Jul 11.

Department of Medicinal Chemistry, The University of Kansas, 2034 Becker Drive, Lawrence, KS 66047, USA.

Cancer-associated alterations to glycosylation have been shown to aid cancer development and progression. An increased abundance of high mannose N-glycans has been observed in several cancers. Here, we describe the preparation of lectin drug conjugates (LDCs) that permit toxin delivery to cancer cells presenting high mannose N-glycans. Additionally, we demonstrate that cancer cells presenting low levels of high mannose N-glycans can be rendered sensitive to the LDCs by co-treatment with a type I mannosidase inhibitor. Our findings establish that an increased abundance of high mannose N-glycans in the glycocalyx of cancer cells can be leveraged to enable toxin delivery.
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http://dx.doi.org/10.1002/cbic.202200266DOI Listing
July 2022

Novel Integrated Tiered Cumulative Risk Assessment of Heavy Metals in Food Homologous Traditional Chinese Medicine Based on a Real-Life-Exposure Scenario.

Front Pharmacol 2022 24;13:908986. Epub 2022 Jun 24.

National Institutes for Food and Drug Control, Beijing, China.

In order to serve population health better, the first integrated tiered decision tree for cumulative risk assessment of co-exposure of Pb-, Cd-, and As-associated health risks in food homologous traditional Chinese medicine (TCM) was designed, after measuring their concentrations by inductively coupled plasma-mass spectroscopy (ICP-MS). Basically, our three-step decision tree involving hazard quotient (HQ), hazard index (HI), and target-organ toxicity dose (TTD) modification of the HI method was developed to evaluate the potential risks of 949 batches of 15 types of food homologous TCM. To acquire a real-life exposure scenario, the cumulative risk assessment model was established by optimizing key parameters, such as ingestion rates, frequency, and duration of exposure to food homologous TCM based on questionnaire data. As a result, the mean concentrations of Pb, Cd, and As in 949 batches of food homologous TCM were 0.896, 0.133, and 0.192 mg/kg, respectively. The HQ values of As for (Oliv.) Diels and Thunb. were 1.04 and 1.01, respectively, for females. Other HQs of Pb, Cd, or As in food homologous TCM were lower than 1 for both males and females. However, after rapid screening of the co-exposure health risks of heavy metals by the HI method, cumulative risk assessment results acquired by TTD modification of the HI method implied that the potential health risks associated with the co-exposure of Pb, Cd, and As in Thunb. and Thunb. ingested as both TCM and food were of concern in the clinic. Additionally, the cumulative risks of Pb, Cd, and As in L., L., and (Cantor) only used as food exceeded the human tolerance dose. Collectively, our innovation on the tiered strategy of decision tree based on a real-life exposure scenario provides a novel approach engaging in the cumulative risk assessment of heavy metals in food homologous TCM. All in all, such effort attempts to scientifically guide the rational use of TCM in the treatment of the complex diseases and the improvement of population health.
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http://dx.doi.org/10.3389/fphar.2022.908986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268897PMC
June 2022

Gait Synergy Analysis and Modeling on Amputees and Stroke Patients for Lower Limb Assistive Devices.

Sensors (Basel) 2022 Jun 25;22(13). Epub 2022 Jun 25.

Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

The concept of synergy has drawn attention and been applied to lower limb assistive devices such as exoskeletons and prostheses for improving human-machine interaction. A better understanding of the influence of gait kinematics on synergies and a better synergy-modeling method are important for device design and improvement. To this end, gait data from healthy, amputee, and stroke subjects were collected. First, continuous relative phase (CRP) was used to quantify their synergies and explore the influence of kinematics. Second, long short-term memory (LSTM) and principal component analysis (PCA) were adopted to model interlimb synergy and intralimb synergy, respectively. The results indicate that the limited hip and knee range of motions (RoMs) in stroke patients and amputees significantly influence their synergies in different ways. In interlimb synergy modeling, LSTM (RMSE: 0.798° (hip) and 1.963° (knee)) has lower errors than PCA (RMSE: 5.050° (hip) and 10.353° (knee)), which is frequently used in the literature. Further, in intralimb synergy modeling, LSTM (RMSE: 3.894°) enables better synergy modeling than PCA (RMSE: 10.312°). In conclusion, stroke patients and amputees perform different compensatory mechanisms to adapt to new interlimb and intralimb synergies different from healthy people. LSTM has better synergy modeling and shows a promise for generating trajectories in line with the wearer's motion for lower limb assistive devices.
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http://dx.doi.org/10.3390/s22134814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269045PMC
June 2022

Effect of Different Laser Groove Texture Collation Frequency on Tribological Properties of 0Cr17Ni7Al Stainless Steel.

Materials (Basel) 2022 Jun 22;15(13). Epub 2022 Jun 22.

Luoyang Bearing Research Institute Co., Ltd., Luoyang 471039, China.

Laser surface texture is very effective in antifriction systems, but its applications and research in dry friction are not enough. In this study, the groove texture was prepared on the surface of 0Cr17Ni7Al stainless steel, a common material of sliding bearing, by nanosecond and femtosecond laser, respectively. The tribological properties of the two kinds of laser groove textures with different collision frequencies were studied in depth. The results show that the friction coefficients of groove texture prepared by nanosecond and picosecond lasers are lower than that of the untextured surface. The antifriction characteristics of the laser texture are very good. The average friction coefficient of nanosecond texture at the rotation radius of 15 mm is Z = 0.7318. The best friction-reducing effect is achieved. In general, the friction coefficient of nanosecond texture is lower than that of picosecond texture. When the friction radius is 22.5 mm and the number of collisions is 24,000, the lowest picosecond texture wear rate is = 3.342 × 10 mm/N·mm. However, when the radius is 15 mm and the collision frequency is 36,000 times, the wear rate of nanosecond texture reaches the highest = 13.680 × 10 mm/N·mm. The wear rate of the untextured surface has been exceeded. It can be seen that not all rotation radius textures are more wear-resistant than untextured surfaces. In addition, nanosecond groove texture and picosecond groove texture seem to produce different tribological properties. It is found that, under the same friction experimental conditions, different collision frequencies will affect the friction and wear properties of nanosecond and picosecond groove-textured surfaces.
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http://dx.doi.org/10.3390/ma15134419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267361PMC
June 2022

Highly Selective Recovery of Phosphorus from Wastewater via Capacitive Deionization Enabled by Ferrocene-polyaniline-Functionalized Carbon Nanotube Electrodes.

ACS Appl Mater Interfaces 2022 Jul 8;14(28):31962-31972. Epub 2022 Jul 8.

State Key Laboratory of Pollution Control and Resource Reuse, Shanghai Institute of Pollution Control and Ecological Security, School of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

While capacitive deionization (CDI) is a promising technology for the recovery of nutrients from wastewater, a selective recovery of phosphate from the wastewater containing high concentrations of competing ions is still a huge challenge. Herein, we reported a ferrocene-polyaniline-functionalized carbon nanotube (Fc-PANI/CNT) electrode prepared through amidation reaction and chemical oxidation polymerization, aiming for a highly selective recovery of phosphorus from wastewater. The Fc-PANI/CNT electrode with a unique structure and high conductivity could efficiently adsorb phosphate ions from complex synthetic wastewater with a nearly 100% selectivity, mainly because the integration of ferrocene and an amide bond in Fc-PANI resulted in an enhanced charge transfer (Faradaic reactions) and a strong hydrogen bonding interaction with phosphate ions in its oxidized state. Density functional theory calculations showed that the binding energies of the oxidized Fc-PANI with HPO and HPO were much greater than those of the oxidized Fc-PANI with other competing anions. The affinity of Fc-PANI/CNTs with phosphate can be controlled electrochemically based on the synergetic effects of Faradaic reactions and hydrogen bonding, enabling a selective recovery of phosphate through charging/discharging cycles. The phosphate adsorption capacity reached up to 35 mg PO g in a NaCl/NaSO/NaNO/NaHPO complex mixture at 1.2 V, outperforming most of the other reported CDI systems. The Fc-PANI/CNT electrode also exhibited a decent regeneration ability and durability during repeated CDI tests, demonstrating a great potential for the application of selective recovery and enrichment of phosphate from wastewater.
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http://dx.doi.org/10.1021/acsami.2c06248DOI Listing
July 2022

Prognostic Values of COL4As Transcriptional Expressions in Clear Cell Renal Cell Carcinoma Patients.

Comb Chem High Throughput Screen 2022 Jul 7. Epub 2022 Jul 7.

Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Objective: The COL4A family genes (COL4As) are a set of extracellular matrix-related genes that have been proved a tight relationship among various cancers. However, the functional role of different COL4As (COL4A1/2/3/4/5/6) in clear cell renal cell carcinoma (ccRCC) is unclear.

Methods: We obtained the data from online open-access databases including ONCOMINE, UALCAN, GEPIA, Cancer Genome Atlas (TCGA), cBioPortal, METASCAPE, STRING, TIMER, GSCALite, MEXPRESS, and TISIDB to explore the correlation between COL4As expression and genome-wide difference, progression, prognosis, genetic mutation, functional enrichment, tumor immune microenvironment, and methylation in ccRCC patients.

Results: The significantly higher COL4A1/2 expression and lower COL4A3/4/5/6 expression were observed in ccRCC tissues than in normal kidney tissues. Transcriptomic levels of COL4A1/2/3/4 were significantly correlated with tumor grade and stage. The higher expression levels of COL4A1/2/3/4 were accompanied by a longer overall survival time (OS); the higher expression levels of COL4A3/4 with lower expression levels of COL4A5 were associated with a longer disease-free time (DFS). Univariate/multivariate regression model analysis showed that COL4A4 could be a potential independent biomarker for ccRCC prognosis. And a high mutation rate (29%) of COL4As was observed in ccRCC patients. However, there were no relationships between mutation rates of COL4As and OS, DFS in ccRCC patients (p>0.05). Besides, we founded that the COL4As expressions were significant associated with the infiltration of the immune cells, tumor-infiltrating lymphocytes, three immunomodulators (immunoinhibitory, immunostimulator, MHC molecule), chemokines, and receptors.

Conclusion: The results suggested that the transcript levels of COL4As could act as potential indicators for early disease progression. The expression of COL4A4 could contribute directly to disease prognosis. Besides, COL4A1/2/3/4 widely participated in tumor immunity. However, further studies are needed to confirm their clinical values in the ccRCC patients.
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http://dx.doi.org/10.2174/1386207325666220707113100DOI Listing
July 2022

deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells.

Autophagy 2022 Jul 27:1-16. Epub 2022 Jul 27.

Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, P.R. China.

Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian defect in humans characterized by the premature depletion of ovarian follicles before the age of 40. However, the mechanisms underlying POI remain largely unknown. Here, we show that knockout of (ectopic P-granules autophagy protein 5 homolog ()) results in subfertility in female mice, which exhibit a POI-like phenotype. Single-cell RNA sequencing analysis revealed that the knockout of affected the differentiation of granulosa cells (GCs). Further investigation demonstrated that knockout of blocks macroautophagic/autophagic flux, resulting in the accumulation of WT1 (WT1 transcription factor), an essential transcription factor for GCs, suggesting WT1 needs to be selectively degraded by the autophagy pathway. We found that the insufficient degradation of WT1 in the antral follicular stage contributes to reduced expression of steroidogenesis-related genes, thereby disrupting GC differentiation. Collectively, our studies show that EPG5 promotes WT1 degradation in GCs, indicating that the dysregulation of in GCs can trigger POI pathogenesis. 3-MA, 3-methyladenine; CHX, cycloheximide; CQ, chloroquine; EPG5, ectopic P-granules autophagy protein 5 homolog (); GC, granulosa cell; MAP1LC3/LC3, microtubule-associated protein 1 light chain 3; MII, metaphase II; POI, primary ovarian insufficiency; PB1, polar body 1; SQSTM1/p62, sequestosome 1; WT1, WT1 transcription factor.
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http://dx.doi.org/10.1080/15548627.2022.2094671DOI Listing
July 2022

How the brain encodes morphological constraints during Chinese word reading: An EEG-fNIRS study.

Cortex 2022 Jun 13;154:184-196. Epub 2022 Jun 13.

Centre for Cognitive and Brain Sciences, University of Macau, Macau SAR, China; Faculty of Health Sciences, University of Macau, Macau SAR, China. Electronic address:

Although the role of morphology in alphabetic language processing has been extensively studied, it is still unclear how morphology is enabled and constrained in morpho-syllabic languages like Chinese. This study aims to inspect the time courses and patterns of brain activation associated with Chinese morphological constraint encoding. Chinese native speakers were recruited to perform visual lexical decisions on real Chinese compound words, pseudowords, and nonwords, whilst behavioral, electroencephalographic, and functional near infrared spectroscopy data were simultaneously recorded. For the first time, both morphological and semantic effects were examined to reveal the corresponding spatio-temporal brain activation patterns based on multimodal data. Brain activation differences between pseudowords and real words indexed morphological sensitivity, whereas differences between real words or pseudowords and nonwords characterized semantic effects. Electrophysiological data showed that semantic processing occurred earlier (N400, 300-450 msec) than morphological processing (450-570 msec), while brain activation patterns revealed a differentiation between morphological parsing (specified in the left inferior frontal gyrus) and semantic analysis (in a broader fronto-temporal network). These findings offer new evidence that morphological constraints are encoded at a late stage of compound word processing in Chinese and suggest that the left prefrontal cortex plays an essential role in this process.
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http://dx.doi.org/10.1016/j.cortex.2022.05.016DOI Listing
June 2022

JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis.

Int Immunopharmacol 2022 Jun 28;110:109000. Epub 2022 Jun 28.

Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China.

Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized by chronic inflammation and ulceration of the colonic mucosa, frequent relapse, and cancerization that is difficult to cure. In recent years, the incidence of UC has increased. However, its etiology and pathogenesis are still not completely clear. In this study, dextran sodium sulfate (DSS) was used to induce the model, and GSK-J1 and dexamethasone were administered to the mice. A variety of molecular biology and immunological techniques, such as immunofluorescence, PCR and chromatin immunoprecipitation (ChIP), were used to examine JMJD3/H3K27me3-mediated regulation of Th17/Treg cell differentiation in UC by targeting histone modification. This study will provide an important theoretical basis for understanding the pathogenesis and potential therapeutic targets of UC.
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http://dx.doi.org/10.1016/j.intimp.2022.109000DOI Listing
June 2022

Economic Burden and Influencing Factors of Acute Gastroenteritis in China: A Population-Based Face to Face Survey in 2018.

Front Public Health 2022 3;10:905458. Epub 2022 Jun 3.

School of Health Management, Harbin Medical University, Harbin, China.

Background: Acute gastroenteritis is an important and highly prevalent public health problem worldwide. The purpose of this study was to assess the economic burden of disease and its influencing factors in patients with acute gastroenteritis in Heilongjiang Province, China.

Methods: A multi-stage stratified random sampling method was used in a face-to-face household survey in 2018. Demographic and socioeconomic characteristics, clinical symptoms, suspicious dietary history, and disease treatment information were collected from 19,647 respondents. One-way analysis of variance and multiple stepwise regression analysis were used to investigate the factors associated with the economic burden of acute gastroenteritis. Quantitative risk analysis and sensitivity analysis were performed to estimate the uncertainty and risk factors of the economic burden of acute gastroenteritis.

Results: The total economic burden of patients with acute gastroenteritis was 63,969.22 CNY (Chinese Yuan), of which the direct economic burden accounted for 63.82%; the per capita economic burden was 131.35 CNY per month. Age, region, disease duration, and disease treatment were the main factors significantly associated with the economic burden of acute gastroenteritis ( < 0.05). The average economic burden of patients with acute gastroenteritis was approximately 571.84 CNY/person (95% CI: 227-1,459). Sensitivity analysis showed that the greatest impact was from the indirect economic burden.

Conclusions: Acute gastroenteritis brings a substantial health burden to patients due to its high incidence. The economic burden of self-purchased drugs and the indirect economic burden of patients cannot be ignored. To better estimate the economic burden of acute gastroenteritis in China, further studies on the pathogen-specific economic burden of acute gastroenteritis are required.
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http://dx.doi.org/10.3389/fpubh.2022.905458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235911PMC
July 2022

Boosting the catalytic performance of single-atom catalysts by tuning surface lattice expanding confinement.

Chem Commun (Camb) 2022 Jul 14;58(57):7984-7987. Epub 2022 Jul 14.

State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Jiangsu Key Laboratory of Vehicle Emissions Control, Center of Modern Analysis, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

A Ti-rich rutile TiO with a surface lattice expansion structure was constructed by H treatment, on which the supported Pt single atoms were stabilized in a highly oxidized state under a CO oxidation reaction atmosphere and had a weaker affinity for CO, thus exhibiting robust catalytic performance.
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http://dx.doi.org/10.1039/d2cc02671fDOI Listing
July 2022
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