Publications by authors named "Federica Piccioni"

47Publications

A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer.

Mol Cancer Ther 2020 07 5;19(7):1423-1435. Epub 2020 May 5.

Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-1131DOI Listing
July 2020

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering.

Cell 2019 11;179(5):1222-1238.e17

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053407PMC
November 2019

Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization.

Cell Syst 2020 01 23;10(1):52-65.e7. Epub 2019 Oct 23.

Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; New York Genome Center, New York, NY 10013, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981068PMC
January 2020

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Rep 2019 10;29(1):118-134.e8

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918830PMC
October 2019

Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer.

Cell Rep 2018 09;24(12):3237-3250

Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183133
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http://dx.doi.org/10.1016/j.celrep.2018.08.053DOI Listing
September 2018

Pooled Lentiviral-Delivery Genetic Screens.

Curr Protoc Mol Biol 2018 01 16;121:32.1.1-32.1.21. Epub 2018 Jan 16.

Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/cpmb.52DOI Listing
January 2018

ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.

Cell Rep 2017 02;18(6):1543-1557

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313047PMC
February 2017

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

Cell Syst 2016 09;3(3):302-316.e4

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455996PMC
September 2016

Genetic modifiers of EGFR dependence in non-small cell lung cancer.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):18661-6. Epub 2014 Dec 15.

Broad Institute of Harvard and MIT, Cambridge, MA 02142; Departments of Pathology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; and

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http://dx.doi.org/10.1073/pnas.1412228112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284598PMC
December 2014

KRAS and YAP1 converge to regulate EMT and tumor survival.

Cell 2014 Jul 19;158(1):171-84. Epub 2014 Jun 19.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110062PMC
July 2014

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Nat Genet 2014 Apr 2;46(4):364-70. Epub 2014 Mar 2.

1] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

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http://www.nature.com/articles/ng.2913
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http://dx.doi.org/10.1038/ng.2913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086945PMC
April 2014

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.

Nature 2013 Dec 3;504(7478):138-42. Epub 2013 Nov 3.

1] The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA [3] Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature12688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098832PMC
December 2013

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.

Autophagy 2012 Dec 4;8(12):1724-40. Epub 2012 Sep 4.

Istituto Toscano Tumori-Core Research Laboratory, Signal Transduction Unit, AOU Senese, Siena, Italy.

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http://dx.doi.org/10.4161/auto.21857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541284PMC
December 2012

Diminution of eIF4E activity suppresses parkin mutant phenotypes.

Gene 2011 Jan 29;470(1-2):12-9. Epub 2010 Sep 29.

CEINGE-Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy.

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http://dx.doi.org/10.1016/j.gene.2010.09.003DOI Listing
January 2011

A cup full of functions.

RNA Biol 2005 Oct-Dec;2(4):125-8. Epub 2005 Dec 14.

CEINGE-Biotecnologie Avanzate, Napoli, Italy.

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http://dx.doi.org/10.4161/rna.2.4.2416DOI Listing
July 2009

Translational regulation during oogenesis and early development: the cap-poly(A) tail relationship.

C R Biol 2005 Oct-Nov;328(10-11):863-81. Epub 2005 Jun 8.

CEINGE-Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy.

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http://dx.doi.org/10.1016/j.crvi.2005.05.006DOI Listing
December 2005

Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development.

Proc Natl Acad Sci U S A 2004 Oct 1;101(41):14800-5. Epub 2004 Oct 1.

Dipartimento di Biologia Animale, Università di Modena e Reggio Emilia, Via G. Campi 213d, 41100 Modena, Italy.

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http://dx.doi.org/10.1073/pnas.0406451101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522052PMC
October 2004

A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.

Hum Mol Genet 2004 Feb 6;13(4):437-46. Epub 2004 Jan 6.

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MS 20892-1250, USA.

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http://dx.doi.org/10.1093/hmg/ddh045DOI Listing
February 2004

Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes.

FASEB J 2002 Sep 18;16(11):1418-20. Epub 2002 Jul 18.

Institute of Endocrinology, Centre of Excellence for the Study and Treatment of Neurodegenerative Diseases, University of Milan, Milano, Italy.

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http://dx.doi.org/10.1096/fj.01-1035fjeDOI Listing
September 2002

Short-term treatment with low doses of recombinant human GH stimulates lipolysis in visceral obese men.

J Clin Endocrinol Metab 2002 Jul;87(7):3105-9

Department of Internal Medicine, Section of Internal Medicine, Endocrine and Metabolic Sciences, University of Perugia, Via Dal Pozzo, Perugia 06126, Italy.

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http://dx.doi.org/10.1210/jcem.87.7.8590DOI Listing
July 2002