Federica Perrone

Federica Perrone

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Federica Perrone

Publications by authors named "Federica Perrone"

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Prognostic factors in recurrent or metastatic squamous cell carcinoma of the head and neck.

Head Neck 2019 Jun 16;41(6):1895-1902. Epub 2019 Jan 16.

Head & Neck Cancer Medical Oncology Department, Fondazione IRCCS "Istituto Nazionale dei Tumori" and University of Milan, Milan, Italy.

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http://doi.wiley.com/10.1002/hed.25636
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http://dx.doi.org/10.1002/hed.25636DOI Listing
June 2019

Identification of potentially druggable molecular alterations in skin adnexal malignancies.

J Dermatol 2019 Jun 30;46(6):507-514. Epub 2019 Apr 30.

Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.14
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http://dx.doi.org/10.1111/1346-8138.14889DOI Listing
June 2019

Genomics in non-adenoid cystic group of salivary gland cancers: one or more druggable entities?

Expert Opin Investig Drugs 2019 05 4;28(5):435-443. Epub 2019 Apr 4.

a Head and Neck Cancer Medical Oncology 3 Unit . Fondazione IRCCS Istituto Nazionale dei Tumori di Milano , Milan , Italy.

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https://www.tandfonline.com/doi/full/10.1080/13543784.2019.1
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http://dx.doi.org/10.1080/13543784.2019.1598376DOI Listing
May 2019

Genetic screening in early-onset dementia patients with unclear phenotype: relevance for clinical diagnosis.

Neurobiol Aging 2018 09 9;69:292.e7-292.e14. Epub 2018 May 9.

Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.04.015DOI Listing
September 2018

Prognostic role of PIK3CA and TP53 in human papillomavirus-negative oropharyngeal cancers.

Tumori 2018 Jun 18;104(3):213-220. Epub 2018 Apr 18.

1 Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1177/0300891618765558DOI Listing
June 2018

Correction: miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

Oncotarget 2018 02 23;9(15):12534. Epub 2018 Feb 23.

Department of Experimental Oncology and Molecular Medicine, Molecular Mechanisms Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.18632/oncotarget.24557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844767PMC
February 2018

Uncommon somatic mutations in metastatic NUT midline carcinoma.

Tumori 2017 Nov 15;103(Suppl. 1):e5-e8. Epub 2017 Nov 15.

Medical Oncology Department, IRCCS Fondazione Istituto Nazionale dei Tumori, Milan - Italy.

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http://dx.doi.org/10.5301/tj.5000685DOI Listing
November 2017

Rationale and protocol of MetNET-2 trial: Lanreotide Autogel plus metformin in advanced gastrointestinal or lung neuroendocrine tumors.

Future Oncol 2017 Aug 5;13(19):1677-1683. Epub 2017 Jun 5.

Department of Medical Oncology, Unit 1, ENET Center of Excellence, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milan, Italy.

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https://www.futuremedicine.com/doi/10.2217/fon-2017-0132
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http://dx.doi.org/10.2217/fon-2017-0132DOI Listing
August 2017

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Hum Mutat 2017 03 19;38(3):297-309. Epub 2017 Jan 19.

Center for Molecular Neurology, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1002/humu.23161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324646PMC
March 2017

Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients.

Neurobiol Aging 2017 03 21;51:177.e9-177.e16. Epub 2016 Dec 21.

Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.008DOI Listing
March 2017

Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma.

Oncotarget 2016 Nov;7(45):74362-74379

Laboratory of Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.18632/oncotarget.11413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342059PMC
November 2016

Mutated CTSF in adult-onset neuronal ceroid lipofuscinosis and FTD.

Neurol Genet 2016 Oct 16;2(5):e102. Epub 2016 Sep 16.

Neurodegenerative Brain Diseases Group (J.v.d.Z., S.V.M., L.D., F.P., A.S., C.V.B.), Department of Molecular Genetics, VIB, Antwerp; Institute Born-Bunge (J.v.d.Z., S.V.M., L.D., F.P., S.E., C.C.-D.G., A.S., P.C., J.-J.M., C.V.B.), CLIPS, Computational Linguistics and Psycholinguistics (J. Verhoeven), University of Antwerp; Department of Neurology and Memory Clinic (P.M., R.C., S.V.M., S.E.), ZNA Middelheim and Hoge Beuken, Antwerp; Clinical and Experimental Neurolinguistics (P.M., T.D.), Vrije Universiteit Brussel, Belgium; Department of Language and Communication Science (J. Verhoeven), City University, London, UK; Department of Neurology (A.S.), University Hospital Ghent and University of Ghent; Department of Neurology (S.V.M., P.C.), Antwerp University Hospital; and Department of Neurology (J. Versijpt), University Hospital Brussels, Belgium.

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http://dx.doi.org/10.1212/NXG.0000000000000102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027801PMC
October 2016

Functional Genomics Uncover the Biology behind the Responsiveness of Head and Neck Squamous Cell Cancer Patients to Cetuximab.

Clin Cancer Res 2016 08 26;22(15):3961-70. Epub 2016 Feb 26.

Functional Genomics and Bioinformatics, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2547DOI Listing
August 2016

Panitumumab Treatment for Advanced Penile Squamous Cell Carcinoma When Surgery and Chemotherapy Have Failed.

Clin Genitourin Cancer 2016 Jun 11;14(3):231-6. Epub 2015 Aug 11.

Department of Surgery, Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.clgc.2015.08.001DOI Listing
June 2016

AKT1 and BRAF mutations in pediatric aggressive fibromatosis.

Cancer Med 2016 06 8;5(6):1204-13. Epub 2016 Apr 8.

Laboratory of Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/cam4.669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924379PMC
June 2016

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

Oncotarget 2016 Mar;7(11):12731-47

Department of Experimental Oncology and Molecular Medicine, Molecular Mechanisms Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.18632/oncotarget.7262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914318PMC
March 2016

Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge.

J Thorac Oncol 2015 Nov;10(11):1560-9

*Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; †Department of Biomedical and Clinical Sciences "Luigi Sacco," Università degli Studi, Milan, Italy; ‡Department of Oncology, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy; §Pathologic Anatomy, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy; ‖Department of Oncology and Advanced Technology, Operative Unit of Pathologic Anatomy, IRCCS Azienda Arcispedale S. Maria Nuova, Reggio Emilia, Italy; ¶Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy; #Department of Medical Oncology, and **Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153506
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http://dx.doi.org/10.1097/JTO.0000000000000658DOI Listing
November 2015

Receptor tyrosine kinase profiles and human papillomavirus status in oropharyngeal squamous cell carcinoma.

J Oral Pathol Med 2015 Oct 14;44(9):734-45. Epub 2014 Dec 14.

Laboratory of Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1111/jop.12301DOI Listing
October 2015

Challenging Lung Carcinoma with Coexistent ΔNp63/p40 and Thyroid Transcription Factor-1 Labeling Within the Same Individual Tumor Cells.

J Thorac Oncol 2015 Oct;10(10):1500-2

*Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; †Department of Biomedical and Clinical Sciences Luigi Sacco, Università degli Studi di Milano, Milan, Italy; ‡Division of Pathology, San Paolo Hospital, Università degli Studi di Milano, Milan, Italy; §Department of Medical Oncology, and ‖Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1097/JTO.0000000000000553DOI Listing
October 2015

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma.

Mol Oncol 2015 Feb 26;9(2):389-97. Epub 2014 Sep 26.

Laboratory of Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528667PMC
February 2015

Different clinical effects upon separate inhibition of coexisting EGFR and PI3KCA mutations in a lung adenocarcinoma patient.

Lung Cancer 2015 Feb 19;87(2):204-6. Epub 2014 Dec 19.

Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco", Università degli Studi, Milan, Italy.

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http://dx.doi.org/10.1016/j.lungcan.2014.12.008DOI Listing
February 2015

TP53 mutations in advanced colorectal cancer: the dark side of the moon.

Oncology 2014 7;86(5-6):289-94. Epub 2014 Jun 7.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori (National Cancer Institute), Milan, Italy.

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http://dx.doi.org/10.1159/000360088DOI Listing
September 2014

FOLFOX-4 chemotherapy for patients with unresectable or relapsed peritoneal pseudomyxoma.

Oncologist 2014 Aug 20;19(8):845-50. Epub 2014 Jun 20.

Medical Oncology Department, Surgery Department, Pathology and Molecular Biology Department, Scientific Directorate, and Clinical Nutrition Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1634/theoncologist.2014-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122474PMC
August 2014

Activity of abiraterone in rechallenging two AR-expressing salivary gland adenocarcinomas, resistant to androgen-deprivation therapy.

Cancer Biol Ther 2014 Jun 11;15(6):678-82. Epub 2014 Mar 11.

Laboratory of Experimental Molecular Pathology; Pathology Department; Fondazione IRCCS Istituto Nazionale dei Tumori; Milan, Italy.

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http://dx.doi.org/10.4161/cbt.28410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049783PMC
June 2014

Frequent mutation and nuclear localization of β-catenin in sertoli cell tumors of the testis.

Am J Surg Pathol 2014 Jan;38(1):66-71

Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0b013e31829cdbc6DOI Listing
January 2014

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas.

Lab Invest 2013 Nov 9;93(11):1232-40. Epub 2013 Sep 9.

Laboratory of Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1038/labinvest.2013.107DOI Listing
November 2013

CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study.

Cancer 2013 Oct 31;119(20):3696-702. Epub 2013 Jul 31.

Sarcoma Service, Department of Surgery, Scientific Institute for Research, Hospitalization, and Health Care (IRCCS) Foundation, National Cancer Institute, Milan, Italy.

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http://dx.doi.org/10.1002/cncr.28271DOI Listing
October 2013

Tp53 status as guide for the management of ethmoid sinus intestinal-type adenocarcinoma.

Oral Oncol 2013 May 29;49(5):413-9. Epub 2013 Jan 29.

Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.oraloncology.2012.12.011DOI Listing
May 2013

DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.

Endocr Relat Cancer 2013 Feb 21;20(1):23-37. Epub 2013 Jan 21.

Molecular Mechanisms Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1530/ERC-12-0078DOI Listing
February 2013

Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage.

Autophagy 2012 Aug 25;8(8):1185-96. Epub 2012 May 25.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.4161/auto.20519DOI Listing
August 2012

miRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation.

Mol Cancer Res 2012 Apr 16;10(4):504-15. Epub 2012 Feb 16.

Departments of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0342DOI Listing
April 2012

Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.

Eur J Cancer 2010 Oct 6;46(15):2837-48. Epub 2010 Aug 6.

Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.ejca.2010.06.130DOI Listing
October 2010

Targeted therapies: the rare cancer paradigm.

Mol Oncol 2010 Feb 28;4(1):19-37. Epub 2009 Oct 28.

Scientific Directorate, Fondazione IRCCS - Istituto Nazionale dei Tumori Milano, Via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.molonc.2009.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527958PMC
February 2010

TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma.

J Clin Oncol 2010 Feb 4;28(5):761-6. Epub 2010 Jan 4.

Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy.

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http://dx.doi.org/10.1200/JCO.2009.22.4170DOI Listing
February 2010

Experience with peritoneal mesothelioma at the Milan National Cancer Institute.

World J Gastrointest Oncol 2010 Feb;2(2):76-84

Marcello Deraco, Dario Baratti, Maria Rosaria Balestra, Shigeki Kusamura, Barbara Laterza, Department of Surgery, National Cancer Institute, 20133 Milan, Italy.

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http://dx.doi.org/10.4251/wjgo.v2.i2.76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999160PMC
February 2010

PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor.

Neuro Oncol 2009 Dec;11(6):725-36

Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

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http://dx.doi.org/10.1215/15228517-2009-003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802393PMC
December 2009

Oropharyngeal squamous cell carcinoma treated with radiotherapy or radiochemotherapy: prognostic role of TP53 and HPV status.

Int J Radiat Oncol Biol Phys 2009 Nov 4;75(4):1053-9. Epub 2009 Jul 4.

Radiation Oncology Department, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.ijrobp.2008.12.088DOI Listing
November 2009

Integrative approach for prioritizing cancer genes in sporadic colon cancer.

Genes Chromosomes Cancer 2009 Nov;48(11):953-62

Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Italy.

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http://doi.wiley.com/10.1002/gcc.20697
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http://dx.doi.org/10.1002/gcc.20697DOI Listing
November 2009

Polymorphisms of Metabolizing Enzymes and Susceptibility to Ethmoid Intestinal-type Adenocarcinoma in Professionally Exposed Patients.

Transl Oncol 2009 May;2(2):84-8

Experimental Molecular Pathology, Department of Pathology, Fondazione IRCSS Istituto Nazionale dei Tumori di Milano, Via G. Venezian 1, 20133 Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670575PMC
http://dx.doi.org/10.1593/tlo.08226DOI Listing
May 2009

Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: case report with molecular analysis.

World J Gastroenterol 2008 Nov;14(42):6575-7

Anathomic Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, Milano 20133, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773350PMC
http://dx.doi.org/10.3748/wjg.14.6575DOI Listing
November 2008

PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells.

Cell Signal 2008 May 12;20(5):872-83. Epub 2008 Jan 12.

Unit of Immunotherapy of Human Tumors, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2007.12.024DOI Listing
May 2008

TP53 mutations in head and neck cancer.

N Engl J Med 2008 Mar;358(11):1194-5; author reply 1195

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March 2008

Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report.

Acta Cytol 2007 Jul-Aug;51(4):589-93

Department of Pathology and Experimental Molecular Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

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https://www.karger.com/Article/FullText/325803
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http://dx.doi.org/10.1159/000325803DOI Listing
September 2007

p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx.

Cancer 2007 Jun;109(12):2461-5

Unit of Experimental Molecular Pathology, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/cncr.22702DOI Listing
June 2007

High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma.

J Clin Oncol 2006 Dec;24(36):5630-6

Head and Neck Cancer Medical Oncology Unit, Medical Statistics and Biometry, Department of Head and Neck Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1200/JCO.2005.04.6136DOI Listing
December 2006

Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.

Head Neck 2006 Oct;28(10):909-15

Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1002/hed.20433DOI Listing
October 2006