Publications by authors named "Federica D"

3 Publications

  • Page 1 of 1

Spinal cord involvement in Kearns-Sayre syndrome: a neuroimaging study.

Neuroradiology 2020 Oct 22;62(10):1315-1321. Epub 2020 Jul 22.

Neuroradiology Unit, Imaging Department, Bambino Gesù Children's Hospital, P.zza Sant'Onofrio 4, 00165, Rome, Italy.

Purpose: Spinal cord involvement in Kearns-Sayre (KSS) syndrome could be more frequent than commonly thought. Our aims were to evaluate the involvement of the spinal cord in patients with KSS by means of MRI and to investigate possible correlations of spinal and brain disease with patient disability.

Methods: Eleven patients with KSS disease and spinal cord MRI were retrospectively recruited. The severity of spinal disease was defined as follows: grade 0 (none), grade 1 (focal), and grade 2 (extensive). We calculated a radiologic score of brain involvement based on typical features. We performed a chi-square test to correlate spinal cord and brain MRI involvement to patient disability. For significant variables, a contingency coefficient, phi factor, and Cramer's V were also computed.

Results: Spinal cord lesions were detected in 6/11 patients, showing four patterns: involvement of gray matter, gray matter and posterior columns, posterior columns, and anterior columns. The severity of spinal disease was grade 1 in two and grade 2 in four patients. All patients showed brain involvement (9-point average for patients with spinal involvement and 10 for the others). A significant correlation was found between disability score and spinal cord involvement (χ = 7.64; p = 0.022) or brain score (χ = 26.85; p = 0.043). Significance for brain score-disability correlation increased with the spinal cord as a cofactor (χ = 24.51; p = 0.017, phi factor = 1.201, Cramer's V = 0.849, contingency effect = 0.767; p = 0.017).

Conclusion: Spinal cord lesions are common in KSS. Patients with spinal disease show higher disability than patients without spinal cord lesions, supporting the inclusion of dedicated acquisitions to routine MRI of the brain in patients with KSS.
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http://dx.doi.org/10.1007/s00234-020-02501-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479017PMC
October 2020

The use of rubber foam pads and "sensory ratios" to reduce variability in static posturography assessment.

Gait Posture 2009 Jan 23;29(1):158-60. Epub 2008 Sep 23.

Audiology Unit, I.R.C.C.S. Policlinico, Mangiagalli e Regina Elena, Department of Otolaryngology, Chair of Audiology and Phoniatrics, University of Milan, via Pace 9, Milano, Italy.

Unlabelled: Despite the numerous works published, static posturography has still a limited clinical use due to its intrinsic inter-individual high variability. For this reason, foam pads have been introduced but their use is still not standardized. Aim of the study was to define the variability of static posturography parameters in standard and foam standing.

Methods: 50 healthy subjects were studied with static posturography in four standing conditions: eyes open (EO) and eyes closed (EC), with and without foam pads. Unstable tests have been performed with two different types of rubber foam pads placed on the force platform. "Sensory ratios" have been calculated by the ratio of sway length among the four different conditions, adapted from dynamic posturography, in order to measure the relative contributions of vestibular, visual and somatosensory inputs.

Results: Static posturography in standard conditions showed unacceptable coefficients of variation (>than 15%) for all the parameters. The use of foam pads reduced the high intrinsic variability, in particular for LFS (12.6-15.4%). The use of "sensory ratios" led to decrease the inter-subject coefficient of variation of this measurement to about 9.47-14.42% using the bilayer foam pads.

Conclusions: Further studies are needed to confirm these data by applying the ratio formulas in clinical practice.
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http://dx.doi.org/10.1016/j.gaitpost.2008.08.006DOI Listing
January 2009

FEF75 in asthma management.

Eur Ann Allergy Clin Immunol 2007 Dec;39(10):333-6

Paediatric Allergist, G.P. ASL Milan, Italy.

Rationale: Diagnosis of asthma is based on the presence of symptoms (clinical diagnosis) supported by lung function measurements, such as forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) variability. Recently, it has been reported that the forced expiratory flow at 25-75 of the pulmonary volume might be considered as a possible marker of early bronchial impairment in patients with allergic rhinitis.

Objectives: The aim of this retrospective study was to identify the most reliable spirometric parameter for the follow up of intermittent allergic asthma.

Methods: Data from 108 outpatients with intermittent allergic asthma was studied. The spirometric parameters before and after 1 week of short aerosol therapy were analyzed. Patients were divided into three groups according to basal FEV1 values: those with all spirometric values normal, those with reduced FEV1 and those with normal FEV1 but reduced FEF75.

Results: There was a good correlation between the spirometric parameters analysed. FEF75 showed a greater significant reduction than FEV1 and PEF. Moreover, 26 of 38 patients with normal FEV1 (68 %) showed a reduction in FEF75. No significant differences were observed between FEV1 and PEF. After short aerosol therapy, FEV1 improved in 93% of patients, but many (61%) still had a reduced FEF75 value, thus the correlation between the two parameters decreased (from r= 0.68 to r = 0.40).

Conclusions: On the basis of these observations, FEF75 should be reconsidered a usefull spirometric parameter for allergic asthma follow up.
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December 2007