Dr. Federica Aiello, PhD - Università degli Studi di Pisa

Dr. Federica Aiello

PhD

Università degli Studi di Pisa

Main Specialties: Other

Additional Specialties: NMR spectroscopy

ORCID logohttps://orcid.org/0000-0003-0726-5135


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Dr. Federica Aiello, PhD - Università degli Studi di Pisa

Dr. Federica Aiello

PhD

Introduction

Born in 1987. Graduated in 2012 (110/110 cum laude) at the University of Pisa, discussing the thesis "N-peptidoresorc[4]areni come inibitori dell’attività idrolitica dell’a-Chimotripsina: uno studio meccanicistico tramite spettroscopia di Risonanza Magnetica Nucleare", supervisor Prof. G. Uccello Barretta. PhD in Chemical and Material Sciences in 2015 at the University of Pisa discussing the thesis “Application of Nuclear Magnetic Resonance (NMR) spectroscopy in the study of molecular recognition processes”, supervisor Prof. G. Uccello Barretta.

Primary Affiliation: Università degli Studi di Pisa

Specialties:

Additional Specialties:

Research Interests:


View Dr. Federica Aiello’s Resume / CV

Education

Nov 2015
University of Pisa
PhD

Experience

Sep 2017
Marie Curie fellowship
Researcher
Project ChiPyrNMR (749083)

Publications

13Publications

195Reads

539Profile Views

37PubMed Central Citations

Role of nanostructured aggregation of chitosan derivatives on [5-methionine]enkephalin affinity.

Carbohydr Polym 2017 Feb 29;157:321-324. Epub 2016 Sep 29.

Università di Pisa, Dipartimento di Chimica e Chimica Industriale, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2016.09.089DOI Listing
February 2017
13 Reads
4.074 Impact Factor

Covalently assembled resorcin[4]arenes and molecular tweezers: a chiral recognition rationale by NMR

Supramolecular Chemistry

Chiral diamides and tetramidic resorcin[4]arenes deriving from (R,R)-1,2-diaminocyclohexane and (S,S)-1,2-diphenylethylendiamine, and a valine containing resorcin[4]arene have been compared by NMR in the enantiodiscrimination of mandelic acid. The relevance of cooperation between side arms and external surface of resorcin[4]arene core has been ascertained.

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April 2016
14 Reads

Multiscale morphology design of hybrid halide perovskites through a polymeric template.

Nanoscale 2015 Dec 29;7(45):18956-63. Epub 2015 Oct 29.

Dipartimento di Matematica e Fisica "E. De Giorgi", Universita' del Salento, Via per Arnesano, 73100 Lecce, Italy.

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http://dx.doi.org/10.1039/c5nr04715cDOI Listing
December 2015
13 Reads
2 Citations
7.394 Impact Factor

Monomeric and dimeric 9-O anthraquinone and phenanthryl derivatives of cinchona alkaloids as chiral solvating agents for the NMR enantiodiscrimination of chiral hemiesters.

Chirality 2015 Oct 11;27(10):693-9. Epub 2015 Aug 11.

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Pisa, Italy.

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http://dx.doi.org/10.1002/chir.22488DOI Listing
October 2015
11 Reads
1.890 Impact Factor

Stability of hydrophilic vitamins mixtures in the presence of electrolytes and trace elements for parenteral nutrition: a nuclear magnetic resonance spectroscopy investigation.

J Pharm Biomed Anal 2015 Mar 17;107:7-10. Epub 2014 Dec 17.

U.O. Farmaceutica - Gestione del farmaco, Azienda Ospedaliero Universitaria Pisana, via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.jpba.2014.12.008DOI Listing
March 2015
21 Reads
2.980 Impact Factor

Synergistic effects of trace amounts of water in the enantiodiscrimination processes by lipodex E: a spectroscopic and computational investigation.

Chirality 2015 Feb 20;27(2):95-103. Epub 2014 Oct 20.

Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1002/chir.22394DOI Listing
February 2015
19 Reads
1.890 Impact Factor

From chiral drugs to chiral metabolites: the NMR approach

Applications of NMR Spectroscopy, Vol. 1

Quantification and identification of chiral drugs and their metabolites constitutes a significant issue for both the pharmaceutical industry and the regulatory authorities, which led to a continuous growth of research areas devoted to the development of direct methods of discrimination of enantiomers. Stereoisomers frequently differ in terms of their biological activity and pharmacokinetic profiles as well as their metabolites can be toxic or pharmacologically active, just like drug candidates. NMR spectroscopy provides several tools in the field of the identification and quantification of chiral compounds, based on the use of suitable chiral auxiliaries which have the role of converting enantiomeric mixtures into their diastereoisomeric derivatives or solvates, the NMR resonances of which are distinguishable in principle. The survey will be addressed on the NMR determinations of the enantiomeric purity of chiral compounds, with an outline of the three classes of chiral auxiliaries for NMR, without any intent of giving an exhaustive analysis of literature data. Particular attention will be focused on the literature regarding the use of NMR spectroscopy for the identification and quantification of chiral drugs and metabolites.

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February 2015
13 Reads

Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach.

Org Biomol Chem 2015 Jan;13(3):916-24

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via G. Moruzzi 3, 56124 Pisa, Italy.

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http://dx.doi.org/10.1039/c4ob01936aDOI Listing
January 2015
22 Reads
3.562 Impact Factor

NMR spectroscopy for the determination of mucoadhesive properties of polysaccharides

Polysaccharides

Applications of nuclear magnetic resonance (NMR) spectroscopy to the structural characterization of polysaccharides with mucoadhesive characteristics are described together with some limited cases of uses in the detection of affinity to mucin. Structural characterization spans from quantification of monomeric units of polysaccharides following degradation procedures till to the development of reliable analytical protocols directly on the intact polymeric materials. In these last cases several problems can be solved such as the identification of derivatization sites on monosaccharides units and determination of average length of derivatizing pendants. For non-covalent modifications, the more difficult aspect is the detection of conformational changes. Mucoadhesivity can be determined by exploiting the possibility to detect changes of affinity to mucin of small probe molecules due to the polysaccharide-mucin interaction.

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December 2014
9 Reads

Mucoadhesivity and release properties of quaternary ammonium-chitosan conjugates and their nanoparticulate supramolecular aggregates: an NMR investigation.

Int J Pharm 2014 Jan 22;461(1-2):489-94. Epub 2013 Dec 22.

Dipartimento di Farmacia, Università degli Studi di Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.ijpharm.2013.12.018DOI Listing
January 2014
50 Reads
3.650 Impact Factor

Stereochemical preference of 2'-deoxycytidine for chiral bis(diamido)-bridged basket resorcin[4]arenes.

Chirality 2013 Dec 28;25(12):840-51. Epub 2013 Aug 28.

Dipartimento di Chimica e Tecnologie del Farmaco, Università di Roma "La Sapienza", Roma, Italy.

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http://dx.doi.org/10.1002/chir.22224DOI Listing
December 2013
10 Reads
1 Citation
1.890 Impact Factor

Water soluble heptakis(6-deoxy-6-thio)cyclomaltoheptaose capped gold nanoparticles via metal vapour synthesis: NMR structural characterization and complexation properties.

Carbohydr Res 2011 May 28;346(6):753-8. Epub 2011 Feb 28.

Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, via Risorgimento 35, I-56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.carres.2011.02.001DOI Listing
May 2011
12 Reads
1 Citation
1.930 Impact Factor