Publications by authors named "Fazilath Uzma"

2 Publications

  • Page 1 of 1

Ameliorated Antibacterial and Antioxidant Properties by Mediated Green Synthesis of Silver Nanoparticles.

Biomolecules 2021 04 4;11(4). Epub 2021 Apr 4.

Laboratory of Plant Healthcare and Diagnostics, PG Department of Biotechnology and Microbiology, Karnatak University, Dharwad 580 003, Karnataka, India.

Biosynthesis of silver nanoparticles using beneficial is a simple, eco-friendly and cost-effective route. Secondary metabolites secreted by act as capping and reducing agents that can offer constancy and can contribute to biological activity. The present study aimed to synthesize silver nanoparticles using cell filtrate and investigate different bioactive metabolites based on LC-MS/MS analysis. The synthesized silver nanoparticles (AgNPs) from were characterized by ultraviolet-visible spectrophotometry, Fourier transform infrared spectrometry (FT-IR), energy-dispersive spectroscopy (EDS), dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The surface plasmon resonance of synthesized particles formed a peak centered near 438 nm. The DLS study determined the average size of AgNPs to be 21.49 nm. The average size of AgNPs was measured to be 72 nm by SEM. The cubic crystal structure from XRD analysis confirmed the synthesized particles as silver nanoparticles. The AgNPs exhibited remarkable antioxidant properties, as determined by DPPH and ferric reducing antioxidant power (FRAP) assay. The AgNPs also exhibited broad-spectrum antibacterial activity against two Gram-positive bacteria ( and ) and two Gram-negative bacteria ( and ). The minimum inhibitory concentration (MIC) of AgNPs towards bacterial growth was evaluated. The antibacterial activity of AgNPs was further confirmed by fluorescence microscopy and SEM analysis.
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http://dx.doi.org/10.3390/biom11040535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066458PMC
April 2021

Endophytic Fungi-Alternative Sources of Cytotoxic Compounds: A Review.

Front Pharmacol 2018 26;9:309. Epub 2018 Apr 26.

Plant Production Department, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.

Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines.
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http://dx.doi.org/10.3389/fphar.2018.00309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932204PMC
April 2018
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