Publications by authors named "Fausto G Hegardt"

40Publications

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.

Eur J Med Chem 2017 May 12;131:207-221. Epub 2017 Mar 12.

Department of Biochemistry and Physiology, Facultat de Farmàcia i Ciències de l'A limentació and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2017.03.012DOI Listing
May 2017

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

Int J Cancer 2015 May 3;136(9):2078-90. Epub 2014 Nov 3.

Signaling Networks Program, Division of Oncology, Department of Medicine I, Medical University Vienna, Vienna, Austria; Comprehensive Cancer Center, Medical University Vienna, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.29261DOI Listing
May 2015

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.

Diabetes 2014 Oct 21;63(10):3242-52. Epub 2014 May 21.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db14-0388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171656PMC
October 2014

Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile.

PLoS One 2014 12;9(5):e97195. Epub 2014 May 12.

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona and Institut de Biomedicina de la Universitat de Barcelona (IBUB) and CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097195PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018328PMC
June 2015

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

Am J Physiol Endocrinol Metab 2013 Aug 4;305(3):E336-47. Epub 2013 Jun 4.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00168.2013DOI Listing
August 2013

Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity.

Chirality 2013 May;25(5):281-7

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/chir.22139
Publisher Site
http://dx.doi.org/10.1002/chir.22139DOI Listing
May 2013

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

Diabetes 2013 Jul 14;62(7):2329-37. Epub 2013 Mar 14.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db12-1451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712075PMC
July 2013

Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol.

J Lipid Res 2012 Oct 30;53(10):2046-56. Epub 2012 Jul 30.

Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology and Physiology, School of Medicine, University of Zaragoza, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M025700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435538PMC
October 2012

Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.

J Biol Chem 2012 Jun 26;287(25):21224-32. Epub 2012 Apr 26.

From the Department of Basic Sciences, Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Vallès, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.337493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375544PMC
June 2012

Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.

Mol Biol Rep 2012 Apr 28;39(4):4777-85. Epub 2011 Sep 28.

Unit of Clinical Genetics and Functional Genomics, Departments of Pharmacology-Physiology and Pediatrics, School of Medicine, University of Zaragoza, C/Domingo Miral s/n, 50009, Zaragoza, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11033-011-1270-8DOI Listing
April 2012

Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.

Proc Natl Acad Sci U S A 2011 Jun 18;108(23):9691-6. Epub 2011 May 18.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada T6G 2S2.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1103267108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111271PMC
June 2011

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.

Am J Physiol Regul Integr Comp Physiol 2011 Jul 20;301(1):R209-17. Epub 2011 Apr 20.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00092.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747894PMC
July 2011

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.

Hepatology 2011 Mar 11;53(3):821-32. Epub 2011 Feb 11.

Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.24140DOI Listing
March 2011

Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria.

J Inherit Metab Dis 2010 Aug 8;33(4):405-10. Epub 2010 Jun 8.

Laboratory of Clinical Genetics and Functional Genomics, Department of Pharmacology and Physiology, School of Medicine, University of Zaragoza, C/ Domingo Miral s/n, 50009, Zaragoza, Spain.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s10545-010-9097
Web Search
http://link.springer.com/10.1007/s10545-010-9097-3
Publisher Site
http://dx.doi.org/10.1007/s10545-010-9097-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903694PMC
August 2010

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.

J Biol Chem 2009 Aug 24;284(34):22840-52. Epub 2009 Jun 24.

Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina 27710, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.032888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755692PMC
August 2009

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells.

J Lipid Res 2009 Sep 9;50(9):1789-99. Epub 2009 May 9.

Departments of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M800535-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724792PMC
September 2009

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.

J Biol Chem 2008 Mar 11;283(11):6878-85. Epub 2008 Jan 11.

Molecular and Cellular Unit, School of Health Sciences, Universitat Internacional de Catalunya, Josep Trueta s/n, Sant Cugat del Vallés, Barcelona 08195, Spain.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M707965200
Publisher Site
http://dx.doi.org/10.1074/jbc.M707965200DOI Listing
March 2008

A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells.

Anal Chim Acta 2007 Sep 3;599(1):1-6. Epub 2007 Aug 3.

Scientific & Technical Services, University of Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aca.2007.07.066DOI Listing
September 2007

Molecular genetics of HMG-CoA lyase deficiency.

Mol Genet Metab 2007 Nov 9;92(3):198-209. Epub 2007 Aug 9.

Laboratory of Clinical Genetics and Functional Genomics, University of Zaragoza Medical School, E-50009 Zaragoza, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2007.06.020DOI Listing
November 2007

C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.

Mol Genet Metab 2007 Jun 24;91(2):120-7. Epub 2007 Apr 24.

Department of Biochemistry and Molecular Biology, School of Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2007.03.007DOI Listing
June 2007

Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.

J Biol Chem 2007 Jun 23;282(25):18212-24. Epub 2007 Apr 23.

Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Cantoblanco, E-28049 Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M700885200DOI Listing
June 2007

Modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae.

FEMS Microbiol Lett 2007 Feb 29;267(2):159-66. Epub 2006 Nov 29.

The Australian Wine Research Institute, Glen Osmond, Adelaide, SA, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1574-6968.2006.00548.xDOI Listing
February 2007

Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.

Am J Physiol Endocrinol Metab 2007 Apr 5;292(4):E1041-51. Epub 2006 Dec 5.

Evans Department of Medicine, Obesity Research Center, Boston University Medical Center, 88 E. Newton St., Boston, MA 02118, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00557.2006DOI Listing
April 2007

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.

Am J Physiol Endocrinol Metab 2007 Mar 24;292(3):E677-86. Epub 2006 Oct 24.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00360.2006DOI Listing
March 2007

Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.

Biochemistry 2006 May;45(19):6133-41

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0602664DOI Listing
May 2006

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.

Biochemistry 2006 Apr;45(14):4339-50

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi052186qDOI Listing
April 2006

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Diabetes 2005 Feb;54(2):462-71

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.54.2.462DOI Listing
February 2005

Redesign of carnitine acetyltransferase specificity by protein engineering.

J Biol Chem 2004 Aug 21;279(32):33899-908. Epub 2004 May 21.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M402685200DOI Listing
August 2004

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.

Biochem J 2004 May;379(Pt 3):777-84

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20031373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224103PMC
May 2004

The diagnosis of mitochondrial HMG-CoA synthase deficiency.

J Pediatr 2002 Jun;140(6):778-80

Division of Metabolic and Endocrine Diseases, University Children's Hospital, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1067/mpd.2002.123854DOI Listing
June 2002

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.

J Biol Chem 2002 Mar 14;277(13):11473-80. Epub 2002 Jan 14.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111628200DOI Listing
March 2002