Publications by authors named "Fatima Nasim"

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A novel granulation non-solvent addition method containing hydrophilic and lipophilic drugs.

Acta Pol Pharm 2012 Mar-Apr;69(2):285-90

Department of Pharmacy, Faculty of Pharmacy & Alternative Medicine, Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Atenolol and simvastatin were granulated in combination by non-solvent addition coacervation method to treat hypertension orally. Dissolution test was performed in water containing 0.5% sodium dodecyl sulfate at 37 0.05 degrees C. FTIR spectrometry, X-ray diffractometry and thermal analysis confirmed the absence of any chemical interaction between polymer and the entrapped drugs. The granules size was about 280-619 μm. Scanning electron microscopy reported irregular morphology of granules. The entrapment efficiency was approximately 90% for atenolol and 70% for simvastatin. A controlled release behavior of both drugs but a burst release phenomenon of simvastatin from the formulations were observed. In conclusion, granules loaded with a hydrophilic and a lipophilic drug were successfully prepared.
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May 2012