Publications by authors named "Fatemeh Ghorbani"

32 Publications

Molecular Phylogeny of the Subgenus Reveals Genetic Signature of Post-Glacial Colonization of (Rodentia: Muridae) in the Zagros Mountains from Different Refugia.

Zoolog Sci 2021 Feb;38(1):72-81

University of Gothenburg, Department of Biology and Environmental Sciences, Systematics and Biodiversity, SE-405 30 Göteborg, Sweden.

Eastern broad-toothed field mouse, , is a rocky habitat dwelling rodent distributed in Asia Minor, the Levant, the Caucasus, and the Zagros Mountains. In this study, we investigated the phylogenetic relationship between different populations of throughout its range, based on the mitochondrial marker. Phylogenetic analyses revealed the existence of five separately evolving lineages within , of which two previously unrecognized lineages were identified in the Zagros Mountains and the Levant. Divergence between two major clades of the subgenus , corresponding to and , is inferred to coincide with the Messinian Salinity Crisis (Late Miocene), whereas the splits between major lineages of are inferred to have occurred during the Pleistocene. Colonization of the Zagros may have occurred from different refugia via eastward migration of the Turkish population and then again by a more recent colonization from the Caucasus, after reopening of the land corridor between the Caucasus and the Zagros Mountains during the Holocene drought.
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http://dx.doi.org/10.2108/zs200065DOI Listing
February 2021

Prevalence and correlates of chronic fatigue syndrome and post-traumatic stress disorder after the outbreak of the COVID-19.

J Neurovirol 2021 02 2;27(1):154-159. Epub 2021 Feb 2.

Brain Mapping Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

As the SARS-COV-2 becomes a global pandemic, many researchers have a concern about the long COVID-19 complications. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a persistent, debilitating, and unexplained fatigue disorder. We investigated psychological morbidities such as CFS and post-traumatic stress disorder (PTSD) among survivors of COVID-19 over 6 months. All COVID-19 survivors from the university-affiliated hospital of Tehran, Iran, were assessed 6 months after infection onset by a previously validated questionnaire based on the Fukuda guidelines for CFS/EM and DSM-5 Checklist for PTSD (The Post-traumatic Stress Disorder Checklist for DSM-5 or PCL-5) to determine the presence of stress disorder and chronic fatigue problems. A total of 120 patients were enrolled. The prevalence rate of fatigue symptoms was 17.5%. Twelve (10%) screened positive for chronic idiopathic fatigue (CIF), 6 (5%) for CFS-like with insufficient fatigue syndrome (CFSWIFS), and 3 (2.5%) for CFS. The mean total scores in PCL-5 were 9.27 ± 10.76 (range:0-44), and the prevalence rate of PTSD was 5.8%. There was no significant association after adjusting between CFS and PTSD, gender, comorbidities, and chloroquine phosphate administration. The obtained data revealed the prevalence of CFS among patients with COVID-19, which is almost similar to CFS prevalence in the general population. Moreover, PTSD in patients with COVID-19 is not associated with the increased risk of CFS. Our study suggested that medical institutions should pay attention to the psychological consequences of the COVID-19 outbreak.
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http://dx.doi.org/10.1007/s13365-021-00949-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852482PMC
February 2021

Effect of rosiglitazone on circulating malondialdehyde (MDA) level in diabetes based on a systematic review and meta-analysis of eight clinical trials.

J Investig Med 2021 Mar 22;69(3):697-703. Epub 2020 Dec 22.

Department of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran (the Islamic Republic of)

Patients with type 2 diabetes have high levels of malondialdehyde (MDA), and clinical data suggest a reducing effect of rosiglitazone (RSG) on the level of MDA in these patients. However, the results of available studies on the level of MDA in RSG-treated patients are not univocal. This meta-analysis aimed to assess the impact of RSG on the level of MDA. We performed a comprehensive search of PubMed, the Institute for Scientific Information Web of Science, Embase, Scopus, and Cochrane Library for related controlled trials until July 2020. Eligible studies were selected based on the inclusion criteria. Extracted data from each study were combined using a random-effects model. Sensitivity and subgroup analyses were conducted to explore potential heterogeneity. Eight trials with 456 subjects met the inclusion criteria. The results significantly showed the reducing effect of RSG on circulating MDA level (-0.47 μmol/mL; 95% CI -0.93 to -0.01; p=0.04; I=82.1%; p heterogeneity=0.00) in individuals with T2D. No publication bias was observed with Begg's rank correlation (p=0.71) and Egger's linear regression (p=0.52) tests. Subgroup analyses showed that an intervention dose of 8 mg/day in serum samples was found to have a reducing effect on the level of MDA (-0.56 μmol/mL; 95% CI -0.98 to -0.14; p=0.008; I=11.4%; p heterogeneity=0.32). Random-effects meta-regression did not show any significant association between the level of MDA and potential confounders including RSG dose, treatment duration, and sex. In conclusion, we found a significant reduction in MDA concentration in subjects with T2D who received a dose of 8 mg of RSG daily.
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http://dx.doi.org/10.1136/jim-2020-001588DOI Listing
March 2021

Multiple species delimitation approaches applied to the avian lark genus Alaudala.

Mol Phylogenet Evol 2021 01 22;154:106994. Epub 2020 Oct 22.

Systematics and Biodiversity, Department of Biology and Environmental Sciences, University of Gothenburg, Box 463, SE-405 30 Göteborg, Sweden; Gothenburg Global Biodiversity Centre, Box 461, SE-405 30 Gothenburg, Sweden.

Species delimitation has advanced from a purely phenotypic exercise to a branch of science that integrates multiple sources of data to identify independently evolving lineages that can be treated as species. We here test species limits in the avian Lesser Short-toed Lark Alaudala rufesens-Sand Lark A. raytal complex, which has an intricate taxonomic history, ranging from a single to three recognised species, with different inclusiveness in different treatments. Our integrative taxonomic approach is based on a combination of DNA sequences, plumage, biometrics, songs, song-flights, geographical distributions, habitat, and bioclimatic data, and using various methods including a species delimitation program (STACEY) based on the multispecies coalescent model. We propose that four species should be recognised: Lesser Short-toed Lark A. rufescens (sensu stricto), Heine's Short-toed Lark A. heinei, Asian Short-toed Lark A. cheleensis and Sand Lark A. raytal. There is also some evidence suggesting lineage separation within A. cheleensis and A. raytal, but additional data are required to evaluate this. The species delimitation based on STACEY agrees well with the non-genetic data. Although computer-based species delimitation programs can be useful in identifying independently evolving lineages, we stress that whenever possible, species hypotheses proposed by these programs should be tested by independent, non-genetic data. Our results highlight the difficulty and subjectivity of delimiting lineages and species, especially at early stages in the speciation process.
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http://dx.doi.org/10.1016/j.ympev.2020.106994DOI Listing
January 2021

Gastrointestinal symptoms in patients with mild and severe COVID-19: a scoping review and meta-analysis.

Gastroenterol Hepatol Bed Bench 2020 ;13(4):321-330

Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: The current research aimed to analyze and summarize observational studies that compared the incidence of gastrointestinal symptoms in mild and severe COVID-19 infection.

Background: Coronavirus disease 2019 (COVID-19) has been identified as a public health threat worldwide. Previous studies, however, have reported contradictory results of COVID-19-related gastrointestinal symptoms in severe and mild forms.

Methods: A search of Medline, ISI Web of Science, EMBASE, and Cochrane Library databases was conducted for articles published up to May 2020. Data from each study was combined using the random-effects model to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Sensitivity was examined by sequentially excluding one study in each turn. Publication bias was evaluated using the Egger's and Begg's tests.

Results: Twenty studies (4,265 patients) were reviewed. It was found that the prevalence of diarrhea [OR (0.40), (95% CI 0.91, -2.16), p = 0.03, I2 = 88.1%, PHeterogenity = 0.00)] and nausea and vomiting [OR (0.27), (95% CI 0.07, 1.01), p = 0.05, I2 = 89.3%, PHeterogenity = 0.00)] increased significantly in the severe form compared to the mild form of COVID-19, while abdominal pain and anorexia had no significant increased prevalence in admitted and hospitalized COVID-19 patients. Moreover, COVID-19-related gastrointestinal symptoms were seen in higher rates in males [OR (1.42), (95% CI 1.23, 1.65), p < 0.05, I2= 18.4%, PHeterogenity = 0.23] than in females. No significant publication bias was observed in the meta-analysis. Sensitivity analyses showed a similar effect size while reducing the heterogeneity.

Conclusion: The data provides valuable information for the discovery of prognosis biomarkers to diagnosis more severe disease in the early stages of COVID-19.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682965PMC
January 2020

Positive association between severity of COVID-19 infection and liver damage: a systematic review and meta-analysis.

Gastroenterol Hepatol Bed Bench 2020 ;13(4):292-304

Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: The current study aimed to report a pooled analysis of the association of the circulating levels of liver enzymes and total bilirubin with severe and non-severe COVID-19.

Background: The ongoing coronavirus outbreak is an important threat to health worldwide. Epidemiological data representing greater risk of liver failure in patients infected with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).

Methods: Electronic databases were comprehensively searched using Medline, ISI Web of Science, EMBASE, and the Cochrane Library up to July 2020. Outcomes from each relevant study were pooled using a random-effects model. Heterogeneity was analyzed by Q test and I statistics. Sensitivity analysis was also evaluated.

Results: A total of 24 studies were included (4,246 patients) in this study. We found a significant association of COVID-19 severity with increased levels of ALT [SMD: 1.40 U/L; 95% CI (0.93, 1.88); < 0.05, I = 96.5%, 0.000 ], AST [SMD: 2.11 U/L; 95% CI (1.40, 2.83); < 0.05, I = 97.9%, 0.000], LDH [SMD: 3.88 U/L; 95% CI (2.70, 5); < 0.05, I = 98.7%, 0.000] and TBil [SMD: 1.08 mol/L; 95% CI (0.44, 1.72); = 0.001, I = 97.7, 0.000], whereas, ALP values [SMD: 0.31; 95% CI (-1.57, 2.20); = 0.74] was not significant between severe and non-severe COVID-19 patients. Moreover, elevated liver enzymes were found more in males [OR: 1.52, (95% CI 1.26, 1.83), < 0.05] with severe COVID-19 infection than in females.

Conclusion: The alterations of liver function indexes caused by SARS-CoV-2 infection suggested a potential prognosis biomarker for screening of severe patients at early stages of the disease.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682972PMC
January 2020

Increased inflammatory markers correlate with liver damage and predict severe COVID-19: a systematic review and meta-analysis.

Gastroenterol Hepatol Bed Bench 2020 ;13(4):282-291

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: This study aimed to determine whether patients with elevated CRP, TNFα, and IL-6 levels may be at increased risk for severe infection and liver damage of COVID-19.

Background: The COVID-19 outbreak is a serious health problem to human beings. The evidence suggests that inflammatory markers related to liver damage increase in severe forms of COVID-19 compared to mild cases.

Methods: The electronic databases ISI Web of Science, EMBASE, and Cochrane Library were comprehensively searched for articles published up to May, 2020. Data from each identified study was combined using the random effects model to estimate standardized mean difference (SMD) and 95% confidence intervals (95% CIs). Sensitivity and publication bias were also calculated.

Results: Totally, 23 studies were included in this meta-analysis comprising 4313 patients with COVID-19. The random effects results demonstrated that patients with severe COVID-19 had significantly higher levels of CRP [SMD = 3.26 mg/L; (95% CI 2.5, 3.9); p<0.05; I2 = 98.02%; PHeterogeneity = 0.00], TNFα [SMD = 1.78 ng/mL; (95% CI 0.39, 3.1); p=0.012; I2 = 98.2%; PHeterogeneity = 0.00], and IL-6 [ SMD = 3.67 ng/mL; (95% CI 2.4, 4.8); p<0.05; I2 = 97.8%; PHeterogeneity = 0.00] compared with those with the mild form of the disease. Significant heterogeneity was present. No significant publication bias was observed in the meta-analysis. Sensitivity analyses showed a similar effect size while reducing the heterogeneity.

Conclusion: The data suggests that enhanced inflammation may be associated with COVID-19-related liver damage, possibly involving inflammatory marker-related mechanisms.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682967PMC
January 2020

Associations of BCL2 CA-Repeat Polymorphism and Breast Cancer Susceptibility in Isfahan Province of Iran.

Biochem Genet 2020 Nov 5. Epub 2020 Nov 5.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

BCL2 apoptosis regulator (BCL2) is a cause of tumorigenesis whose CA-repeat promoter polymorphisms has inconsistent association with various types of cancers. The association of BCL2 polymorphism with breast cancer was investigated in the Isfahan province of Iran. PCRamplification of the CA-repeat was followed by polyacrylamide gel electrophoresis and direct sequencing for 120 breast cancer women and an equal number of corresponding healthy control individuals. Seven different alleles, ranging from 11 to 17 CA-repeats were observed. Short alleles with 11 to 14 repeats were protective (OR 0.363, P = 0.001), but large alleles with 15 to 17 repeats were threatening against breast cancer development (OR 2.780, P = 0.001). Accordingly, genotypes with large alleles showed a higher risk of breast cancer development (OR 3.400, P = 0.004). ERS1\ERBB2 positive breast cancer patients, but not PGRpositive ones, showed protection against breast cancer (OR 0.405, OR 0.346 respectively). In conclusion, women with at least one large allele of BCL2 were 3.4 times at higher risk of breast cancer development in the Isfahan province of Iran.
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http://dx.doi.org/10.1007/s10528-020-10013-yDOI Listing
November 2020

Boric acid modified S and N co-doped graphene quantum dots as simple and inexpensive turn-on fluorescent nanosensor for quantification of glucose.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jan 28;245:118892. Epub 2020 Aug 28.

Faculty of Chemistry, Kharazmi University, Tehran, Iran; Research Institute of Green Chemistry, Kharazmi University, Tehran, Iran.

A new fluorescent nanosensor based on S and N co-doped graphene quantum dots (S,N-GQDs) modified by boric acid was designed for glucose detection. First, the S,N-GQDs was prepared via one pot hydrothermal process utilizing citric acid and thiourea as precursors. Then, S,N-GQDs was modified by boric acid to fabricate (B)/S,N-GQDs. The excitation dependent photoluminescence spectra of (B)/S,N-GQDs confirmed the heteroatom (S,N) dopant effect on GQDs emission. FT-IR and energy dispersive X-ray (EDX) spectroscopies confirmed the modification of S,N-GQDs with boric acid. The optical and electrochemical band gaps of the obtained (B)/S,N-GQDs were found to be 2.7 and 2.5 eV, respectively. The boric acid functionalized S,N-GQDs exhibited fluorescent enhancement at 455 nm upon addition of glucose. Such fluorescence response was used for glucose quantification with a detection limit of 5.5 μM which is comparable with previous boronic acid based fluorescent sensing systems. However, compared with earlier reported expensive boronic acid based glucose sensors, this modified system is simpler, more economical, and efficient. A mechanism was proposed for fluorescence enhancement based on the reaction of cis-diol units of glucose with the boric acid groups of (B)/S,N-GQDs which creates rigid (B)/S,N-GQDs-glucose structures, restricting the non-radiative intramolecular motions and results in the fluorescent enhancement.
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http://dx.doi.org/10.1016/j.saa.2020.118892DOI Listing
January 2021

Distress tolerance and special alcohol metacognitions behave differently in the association of negative affect with alcohol-related patterns in men with problematic alcohol use in the abstinence phase.

Clin Psychol Psychother 2020 Sep 7. Epub 2020 Sep 7.

Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Negative affect may be related to alcohol-related patterns (e.g., craving and problematic alcohol use). Distress intolerance and positive and negative alcohol-related metacognitions may be underlying mechanisms in this link. This study aimed to evaluate the effect of negative affect including depressive, anxious, and stress symptoms on alcohol craving and problematic alcohol use via the paths of distress tolerance and both positive and negative alcohol-related metacognitions. Three hundred men with problematic alcohol use during the abstinence phase completed psychological and clinical measures. Results showed that craving and negative alcohol metacognitions mediated the relationship between negative affect and problematic alcohol use. Negative affect had a direct and positive effect on craving and indirect effect via distress intolerance and positive alcohol metacognitions. In turn, distress intolerance and positive alcohol metacognitions indirectly and positively affected problematic alcohol use via craving. The study indicates that distress tolerance and distinct alcohol metacognitions may be differently related to various patterns of alcohol-related problems, such that alcohol drinkers with high levels of negative affect, distress intolerance, and positive alcohol metacognitions show higher levels of craving, while high negative affect in relation to high negative alcohol metacognitions and alcohol craving is related to the perpetuation of alcohol use or problematic alcohol use.
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http://dx.doi.org/10.1002/cpp.2514DOI Listing
September 2020

Comparison of the Effect of Massage and EMLA Cream on Children's Physiological Indices During Venipuncture: A Factorial Clinical Trial.

J Perianesth Nurs 2020 Dec 8;35(6):619-624. Epub 2020 Aug 8.

School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran; Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Purpose: The aim of this study was to identify the effect of massage, EMLA cream, and the combination of these two methods on changes in physiological indices because of pain caused by intravenous line insertion in preschool children.

Design: A four-group randomized nonblinded clinical trial with factorial design.

Methods: In total, 140 eligible 3- to 6-year-old children entered the study in Tabriz Children's Hospital in 2017 and were randomly allocated to four groups (EMLA cream, massage, combination of the two, and control). Physiological responses were measured before and immediately after interventions in all groups. Data were collected and analyzed using SPSS version 19.

Findings: Comparison of the physiological indices changes caused by pain between groups showed that changes in children's heart rate (HR) and respiratory rate (RR) in the EMLA group and in the combined-method group were statistically significant (P < .05). No significant differences were found in systolic blood pressure and oxygen saturation (SPo) between the four groups.

Conclusions: Results indicated that EMLA cream was more effective than massage and a combination of EMLA and massage in reducing an increase in the HR and RR caused by pain in children. Massage alone was not effective in significantly lowering the children's increased physiological indices such as the HR and RR, and it seems the effectiveness of massage is more noticeable in conjunction with EMLA cream.
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http://dx.doi.org/10.1016/j.jopan.2020.04.005DOI Listing
December 2020

Runx2 silencing promotes adipogenesis via down-regulation of DLK1 in chondrogenic differentiating MSCs.

J Gene Med 2020 11 10;22(11):e3244. Epub 2020 Jul 10.

Department of Medical Biotechnology, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.

Background: For cartilage regeneration, stem cells are a promising cell source; however, even the advances made in the differentiation of stem cells into precursor-differentiated cartilage cells have not been successful with respect to reprograming these cells to achieve complete differentiation and fully functioning cells until now. Previous findings suggest that Runx2 plays a major role in chondrocyte differentiation and maturation. Although targeting Runx2 has enhanced some chondrocyte properties, the adipogenic lineage shift has eventually occurred in these cells. The present study mainly aimed to reveal the mechanism of this adipogenesis.

Methods: To create inducible artificial shRNA-miR expressing vectors, the designed short hairpin RNAs (shRNAs) were inserted into the pri-mir-30 backbone, cloned into lentiviral pLVET-Tet-on, and transducted into mesenchymal stem cells (MSCs). Runx2 gene was silenced in MSCs either for 1 week or 4 weeks and cultured in the chondrogenic medium. At days 7, 14 and 28, cells were harvested, and chondrogenesis, adipogenesis and hypertrophic states were examined using histochemical staining and a real-time polymerase chain reaction assay.

Results: The results showed that the designed shRNA-miR effectively targeted Runx2 in mRNA and protein levels. Chondrogenic markers were up-regulated in constantly silenced Runx2 group; however, adipogenic markers and fat droplets appeared gradually. DLK1 gene was also significantly down-regulated in this group, and overexpression of DLK1 abrogated adipogenesis in the Runx2 targeted group.

Conclusions: Based on these results, it can be concluded that DLK1 is responsible for the lineage shift in Runx2 targeted chondrogenic differentiating MSCs.
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http://dx.doi.org/10.1002/jgm.3244DOI Listing
November 2020

First Report of Biochemical Mechanisms of Insecticide Resistance in the Field Population of (Diptera: Culicidae) from Sari, Mazandaran, North of Iran.

J Arthropod Borne Dis 2019 Dec 31;13(4):378-390. Epub 2019 Dec 31.

Department of Medical Entomology and Vector Control, School of Public Health and Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Background: play an important role in transmission of infectious diseases. Vector control by chemical pesticides, leads inevitably to resistance development. Understanding the underlying resistance mechanisms can help improve the control programmes and insecticide resistance management.

Methods: The total contents of cytochrome p450s and the activities of glutathione S-transferases, alpha- and beta-esterases and inhibition rates of acetylcholine esterase (by propoxur) were measured in the field population of collected from Sari County, North of Iran, in 2016 and the results were compared with those of the laboratory susceptible strain according to the biochemical assay methods of WHO for adult mosquitoes. Independent sample -test was used to compare the mean values of enzyme activities/contents between filed and laboratory susceptible populations.

Results: The enzyme ratio of cytochrome p450s, alpha- and beta-esterases in the field population was 2.07, 3.72 and 1.36 respectively when compared with the results of the laboratory population. Although not statistically significant, the mean GSTs activities in the field population was marginally less than the laboratory population (ER=0.92). Acetylcholinesterase was insensitive to propoxur in 62.82% of the individuals of the tested field population. There was a significant difference (P< 0.05) between all values of the activities/contents of the enzyme in the field population except for GSTs compared with the laboratory susceptible strain. The highest enzyme activity was related to alpha esterase.

Conclusion: The present study showed a range of metabolic mechanisms, comprising p450s and esterases combined with target site insensitivity of AChE, contributing to organophosphate, carbamate and pyrethroid resistance in the field population of .
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188772PMC
December 2019

Novel Biomass Derived from Grape Pomace Waste as an Efficient Nanocatalyst for the Synthesis of Dibenzoxanthene, Tetraketone, bis(indolyl)alkane and Chromene Derivatives and their Antimicrobial Evaluation.

Curr Org Synth 2020 ;17(6):440-456

School of Chemistry, Damghan University, Damghan, 36716-41167, Iran.

Background: Sulfonated carbon-based solid acids (CBSAs) have been reported as an efficient solid acid catalyst for many acid-catalyzed reactions. Furthermore, the use of carbon obtained from biomass waste has been explored and these materials showed a higher catalytic performance and higher stability compared to other solid acids.

Objective: Novel biomass carbon-based solid acids nanoparticles with high catalytic activity in organic transformation, such as Grape pomace waste-SO3H Nanoparticles (GPW-SO3H NPs), were successfully synthesized.

Materials And Methods: Grape pomace waste-SO3H Nanoparticles (GPW-SO3H NPs) were successfully synthesized. The grape pomace waste was dried in an oven at a temperature of 70°C and crushed to powder using an electric spice grinder. A mixture of powdered grape pomace waste (1 g) and concentrated sulfuric acid (>98%, 10 mL) was stirred at room temperature. Then, the resultant mixture was transferred into a 100 mL sealed Teflon-lined autoclave and kept at 180°C for 12 h. After cooling to room temperature, the resulting black solid was dried at 100°C in an oven under vacuum and the sulfonic acid-functionalized magnetic nanoparticles (Fe3O4@C-SO3H) were obtained.

Results And Discussions: The catalytic activity of GPW-SO3H was assessed through an easy and rapid protocol developed for the one-pot synthesis of 14-aryl-14-H-dibenzo [a,j]xanthene, arylmethylene [bis(3- hydroxy-2-cyclohexene-1-one)], bis(indolyl)alkane and 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitrile derivatives in excellent yields. The advantages of this method include use of waste material for catalyst synthesis, high yields, mild reaction conditions, uncomplicated work-up procedures, neutral conditions, and recoverable catalyst.

Conclusion: We have shown that biomass-derived solid acids, prepared from grape pomace waste, serve as a non-toxic, inexpensive and a promising eco-friendly and novel carbon-based solid acid nanocatalyst for organic transformations.
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http://dx.doi.org/10.2174/1570179417666200409144600DOI Listing
January 2020

Comparative Evaluation of the Effects of CO and Er:YAG Lasers on Smear Layer Removal and Blood Cell Attachment to Tooth Root Surfaces.

J Lasers Med Sci 2020 18;11(1):74-80. Epub 2020 Jan 18.

Dental Implant Research Center, Department of Periodontology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

The tooth root surfaces are modified by different agents for better removal of the smear layer, the formation of fibrin clots, and the attachment of blood cells. This in vitro study compared the removal of the smear layer, the formation of fibrin clots and the attachment of blood cells after exposing periodontally compromised root surfaces to ER:YAG and CO laser beams. Eighteen dentin block samples were prepared from freshly extracted periodontally compromised teeth that were deemed hopeless, and they were divided into 3 groups: exposed to Er:YAG laser beams, exposed to CO laser beams, and the control group. The samples were evaluated using scanning electron microscopy and micrographs were taken. Smear layer removal and blood cell attachment were scored. Data were analyzed using Kruskal-Wallis and MannWhitney tests. In the Er:YAG laser group, the smear layer was removed completely. In the specimens exposed to blood, better fibrin clot formation and blood cell attachment were observed in the Er:YAG laser group. In the CO laser group, the smear layer was also removed; however, there were no significant differences between the CO laser and control groups in fibrin clot formation and blood cell attachment. The application of the Er:YAG laser to the root dentin appears to result in the formation of a suitable surface for fibrin clot formation and blood cell attachment. Further clinical studies are necessary to support these results.
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http://dx.doi.org/10.15171/jlms.2020.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008746PMC
January 2020

Genetic Analysis of Gene in Iranian Patients with Rett Syndrome.

Iran J Child Neurol 2019 ;13(3):25-34

Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Objectives: Rett syndrome is an X linked dominant neurodevelopmental disorder which almost exclusively affects females. The syndrome is usually caused by mutations in gene, which is a nuclear protein that selectively binds CpG dinucleotides in the genome.

Materials & Methods: To provide further insights into the distribution of mutations in gene, we investigated 24 females with clinical characters of Rett syndrome referred to Alzahra University Hospital in Isfahan, Iran during 2015-2017. We sequenced the entire coding region and splice sites for detection of point mutations in this gene. Freely available programs including JALVIEW, SIFT, and PolyPhen were used to find out the damaging effects of unknown mutations.

Results: Direct sequencing revealed mutations in 13 of the 24 patients. We identified in 13 patients, 10 different mutations in gene. Three of these mutations have not been reported elsewhere and are most likely pathogenic.

Conclusion: Defects in gene play an important role in pathogenesis of Rett syndrome. Mutations in gene can be found in the majority of Iranian RTT patients. We failed to identify mutations in gene in 46% of our patients. For these patients, further molecular analysis might be necessary.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586453PMC
January 2019

Effects of childhood emotional maltreatment on depressive symptoms through emotion dysregulation in treatment-seeking patients with heroin-dependence.

J Affect Disord 2019 09 22;256:448-457. Epub 2019 Jun 22.

Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Background: Although individuals who experience childhood emotional maltreatment (CEM) are more likely to use maladaptive emotion regulation strategies, resulting in vulnerability to depression, no research has examined whether emotion dysregulation may explain the association between CEM and current depressive symptoms in a clinical sample of heroin-dependent individuals.

Objectives: The current study aimed to assess the direct effect of CEM on current depressive symptoms and its indirect effect via emotion dysregulation in a treatment-seeking sample of males with heroin dependence. In a cross-sectional design, participants (N = 350) completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Difficulties in Emotion Regulation Scale (DERS), the Obsessive-Compulsive Drug Use Scale (OCDUS), and the Beck Depression Inventory-II (BDI-II).

Results: Emotional abuse and neglect severity had significant direct effects on current depressive symptoms and significant indirect effects through emotion dysregulation after controlling for clinical factors related to heroin use.

Limitations: Study limitations include the cross-sectional design and use of self-report scales.

Conclusions: Findings suggest emotion dysregulation may increase depressive symptoms in heroin users who experienced CEM. Training in emotion regulation strategies may decrease depressive symptoms in heroin-dependent individuals with CEM. Additional research with a longitudinal design to confirm these results is warranted.
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http://dx.doi.org/10.1016/j.jad.2019.06.021DOI Listing
September 2019

The role of emotion dysregulation in the relation of childhood trauma to heroin craving in individuals with heroin dependence.

Drug Alcohol Depend 2019 02 4;195:132-139. Epub 2019 Jan 4.

Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: Difficulties in emotion regulation (DER) may be important in heroin craving in individuals with heroin dependence who have experienced childhood trauma (CT). However, no research has been performed on DER in the context of heroin dependence. The aim of this study was to evaluate direct and indirect relations of CT to the subscales of heroin craving (i.e., heroin thoughts and interference, intention to use heroin and control of its consumption, and resistance to thoughts and decisions to use heroin) via DER dimensions in individuals with a DSM diagnosis of heroin dependence.

Methods: In a cross-sectional design, 330 males with heroin dependence completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Difficulties in Emotion Regulation Scale (DERS), the Obsessive-Compulsive Drug Use Scale-Form Heroin (OCDUS-Form Heroin), and the Depression Anxiety Stress Scales (DASS).

Results: The results revealed that CT had no direct relations to the subscales of heroin craving, but it indirectly was related to all three subscales of heroin craving via one of the DER dimensions named limited access to emotion regulation strategies (Strategies) after adjusting for demographic and clinical factors.

Conclusions: The findings suggest that Strategies may be related to heroin craving in individuals with heroin dependence who have CT. This proposes that treatment and prevention attempts focused on training the use of effective emotion regulation strategies may be useful to reduce heroin craving in individuals with heroin dependence who have experienced a history of CT.
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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.008DOI Listing
February 2019

A survey on endoparasites in wild rodents of the Jaz Murian depression and adjacent areas, southeast of Iran.

J Parasit Dis 2018 Dec 13;42(4):589-597. Epub 2018 Oct 13.

Department of Plant Protection, Faculty of Agriculture, Higher Educational Complex of Saravan, Saravan, Iran.

In this survey, rodents and their endoparasites were investigated in the Jaz Murian depression and adjacent areas, southeast Iran. In total, 146 specimens of rodents belong to 13 species were trapped. In general, 10 different genera of endoparasites including 11 species were collected. The endoparasites were identified as follows: (1) Nematodes: , , sp., , , and sp. (2) Cestodes: sp., sp., and . Of 146 captured rodents, was found with high parasitic infestation (with 93% infested) comparing to (66%), (50%), (15%), (14%) and (8%) whereas, seven rodent species, , , and were free from any parasitic infestation. Those six infested rodent species were collected from the center of the Jaz Murian depression, whereas seven non-infested rodents' species except and live in the marginal ranges of the Jaz Murian depression, therefore, these species inhabiting the central parts were supposed to be more important from the health aspect. The species, collected from is the first report of this species in rodents from Iran.
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http://dx.doi.org/10.1007/s12639-018-1040-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261136PMC
December 2018

Comparison between rosuvastatin and atorvastatin for the prevention of contrast-induced nephropathy in patients with STEMI undergoing primary percutaneous coronary intervention.

J Cardiovasc Thorac Res 2018 24;10(3):149-152. Epub 2018 Sep 24.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

There is some controversy over the efficacy of statins for the prevention of contrastinduced nephropathy (CIN). There have also been reports on varying efficacies of different statins. Hence, in this study the efficacy of atorvastatin and rosuvastatin for the prevention of CIN was assessed. This single-blind randomized clinical trial was performed on 495 random patients with myocardial infarction with ST-segment elevation undergoing primary percutaneous coronary intervention (PCI) in a training referral hospital in 2015. Patients were randomly assigned to receive either atorvastatin 80 mg at admission and daily or rosuvastatin 40 mg at admission and daily. CIN was defined based on serum creatinine elevation after 48 hours from the PCI. The incidence of CIN was observed in 63 patients (21.4%) After 48 hours from primary PCI. Of those, 17% (n = 50) were grade 1 CIN, while 4.4% (n = 13) were grade 2 CIN. There was no significant difference between rosuvastatin group compared with atorvastatin group, regarding the CIN grading ( = 0.14). Our results indicate that atorvastatin and rosuvastatin have similar efficacy for the prevention of CIN.
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http://dx.doi.org/10.15171/jcvtr.2018.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203872PMC
September 2018

High Resistance of Vector of West Nile Virus, Linnaeus (Diptera: Culicidae) to Different Insecticides Recommended by WHO in Northern Iran.

J Arthropod Borne Dis 2018 Mar 18;12(1):24-30. Epub 2018 Mar 18.

Department of Medical Entomology and Vector Control, School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran.

Background: is a mosquito species distributed in different parts of Iran. It is known as vector of some diseases as well as a nuisance insect. A successful control campaign needs to study the biology, ecology and susceptibility status of the target pest. The aim of this study was to investigate the susceptibility status of to some insecticides recommended by WHO in north of Iran.

Methods: Larvae were collected from different breeding places in Sari County by standard dipping method. They were reared to adult stage in an under standard condition. World Health Organization (WHO) standard test kits and the diagnostic dose of 12 imagicides were used for adults, while two larvicides were used against larvae.

Results: The least and highest mortality rates after exposure to insecticides were 4.7% (Propoxur 0.1%) and 76.4% (Etofenprox 0.5%), respectively. Larvae showed high resistance to temephos (19.19%) and malathion (54.63%). was found to be resistant to all used insecticides/larvicides at diagnostic dose.

Conclusion: Intensive use of pesticides against agriculture and urban pests increased the resistance level of this species to different insecticides, although currently there is no control program against it. Study on the mechanisms of resistant in this species to different insecticides is recommended.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046112PMC
March 2018

Dark and Bright-Two Sides of Family-Centered Care in the NICU: A Qualitative Study.

Clin Nurs Res 2019 09 19;28(7):869-885. Epub 2018 Feb 19.

2 Tabriz University of Medical Sciences, Iran.

Nurses in the Neonatal Intensive Care Unit (NICU) have an important role in implementing family-centered care (FCC). The aim of the study was to explore the lived experiences of NICU nurses on implementing FCC. An interpretative phenomenological study was conducted and 11 employed nurses were interviewed from April 2015 to February 2016. The data were analyzed through the Diekelmann, Allen, and Tanner approach. Four main themes of "strain to achieve stability," "bewildered by taking multiple roles," "accepting the family," and "reaching bright horizon" were extracted. This study provided deeper understanding about nurses' perceptions of FCC implementation. In Muslim developing countries, FCC implementation is challenging and nurses are under extra pressure because of a shortage in nursing workforce; however, having positive experiences with family participation and valuing theism beliefs allowed them to support family involvement. Support of nurses to take FCC strategies in the NICU is needed by officials overseeing the health care system.
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http://dx.doi.org/10.1177/1054773818758171DOI Listing
September 2019

Fathers: The Lost Ring in the Chain of Family-Centered Care: A Phenomenological Study in Neonatal Intensive Care Units of Iran.

Adv Neonatal Care 2018 Feb;18(1):E3-E11

Pediatric Nursing Department (Dr Valizadeh and Ms Ghorbani), Pediatric and Neonatal Nursing Department (Dr Mirlashari), and Critical Care Nursing Department (Dr Navab), Clinical Research Fellow (Dr Higman). School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran (Dr Valizadeh and Ms Ghorbani); School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran (Dr Mirlashari and Dr Navab); and Coventry University, Coventry, England (Dr Higman).

Background: The basic principles of family-centered care in neonatal intensive care unit (NICU) include the unlimited presence of parents and their participation in infant's care. Nurses play a central role in encouraging parental attachment with their infant.

Purpose: This study was carried out with the aim of understanding NICU nurses' lived experiences of family participation in family-centered care.

Methods: This interpretative phenomenological study was conducted on the basis of Heideggerian philosophy. The data were collected using semistructured interviews and field notes and analyzed through the 7-stage Diekelmann, Allen, and Tanner approach.

Findings: Two overarching themes emerged including "mother's centrality in the care chain" and "fathers; the lost ring in the care chain" each of which consisted of 3 and 4 subthemes, respectively. Interviews indicated that in Iran's NICUs, conditions for the presence of parents were appropriate for the mothers and they were encouraged to engage in family-centered care but the fathers' participation was limited due to traditional attitudes, cultural-religious background, and difficulties relating to the hospitals' organizational rules.

Implications For Practice: Fathers' participation in family-centered care seems to be enhanced through providing facilities, altering the organizational rules, attempting to modify traditional social attitudes, and educating parents and nurses.

Implications For Research: Future research should explore the experience of mothers and fathers of infants in NICU in Iran to achieve a comprehensive understanding of their role in family-centered care.
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http://dx.doi.org/10.1097/ANC.0000000000000449DOI Listing
February 2018

Protective effect of hydroalcoholic extract of Teucrium polium on diabetes-induced testicular damage and serum testosterone concentration.

Int J Reprod Biomed 2017 Apr;15(4):195-202

School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Diabetes has an adverse effect on spermatogenesis by rising oxidative stress.

Objective: The aim of this study was to investigate the effect of Teucrium Polium extract administration on spermatogenesis and testicular structure in diabetic rats induced with Streptozotocin.

Materials And Methods: 32 male Wistar rats were randomly divided into four groups (n=8/each): control group, diabetic group received distilled water, and two experimental groups included diabetic rats treated with 50 and 100 mg/body weigh of Teucrium Polium extract for 6 six weeks. After six weeks, the left testis had been removed and the morphometrical study was performed. Blood samples were collected from the ophthalmic veins of the rats and plasma levels of glucose and testosterone hormone were measured afterward.

Results: The reduction in diameters of the seminiferous tubules and thickening of the wall of the seminiferous tubules (p=0.05) were seen in diabetic rats. Also, the degenerative changes in cells arrangement have been observed. Statistical analysis showed the use of Teucrium Polium significantly improved the above disorders in treatment group (100 mg/BW) in contrast to the non treated diabetic group (p=0.05), but no significant difference was seen between the experimental group treated with 50 mg/BW of Teucrium polium and diabetic group (p=0.08). These data also revealed that treatment of diabetic rats with 100 mg/BW of Teucrium Polium extract significantly improves the change in serum glucose (p=0.001) and testosterone (p=0.03).

Conclusion: The results of the present study indicate that diabetes produces degenerative changes in the testis of rats and administration of Teucrium polium reduces complications resulted from diabetes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555036PMC
April 2017

Comparison of the Effect of Plastic Cover and Blanket on Body Temperature of Preterm Infants Hospitalized in NICU: Randomized Clinical Trial.

J Caring Sci 2017 Jun 1;6(2):163-172. Epub 2017 Jun 1.

Department of Pediatric Nursing, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Preterm infants are unable to regulate their body temperature and there are insufficient research evidences on different kinds of covers for hospitalized preterm infants; therefore, the present study was conducted with the aim of comparing the effects of plastic and blanket covers on the body temperature of preterm infants under radiant warmer. This randomized cross-over clinical trial was carried out upon 80 infants with the gestational age of 28-30 weeks and birth weight of 800- 1250 gr who were in Neonatal Intensive Care Unit on the second day of their hospitalization. The study lasted for two days. In group 1, the plastic cover was used during the first day of the study while the blankets were used during the second day. Infants' heads were kept out of the cover and coated with a hat. In group 2, the plastic cover was used during the first day of the study while the blanket was used during second day. Digital thermometer was used to measure infants' axillary temperature. The data was analyzed using SPSS ver 13 and MiniTab software. Descriptive statistics, (Mean (SE), 95%CI) and inferential statistics (Repeated measurement and ANCOVA tests) were used. The mean body temperature of the infants in the group covered with the plastic was calculated to be higher and the warmer was set on low temperature. Using plastic cover during the first few days of hospitalization in NICU resulted in regulation of preterm infants' body temperature.
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http://dx.doi.org/10.15171/jcs.2017.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488671PMC
June 2017

Comparison of the Effect of Plastic Cover and Blanket on Body Temperature of Preterm Infants Hospitalized in NICU: Randomized Clinical Trial.

J Caring Sci 2017 Jun 1;6(2):163-172. Epub 2017 Jun 1.

Department of Pediatric Nursing, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Preterm infants are unable to regulate their body temperature and there are insufficient research evidences on different kinds of covers for hospitalized preterm infants; therefore, the present study was conducted with the aim of comparing the effects of plastic and blanket covers on the body temperature of preterm infants under radiant warmer. This randomized cross-over clinical trial was carried out upon 80 infants with the gestational age of 28-30 weeks and birth weight of 800- 1250 gr who were in Neonatal Intensive Care Unit on the second day of their hospitalization. The study lasted for two days. In group 1, the plastic cover was used during the first day of the study while the blankets were used during the second day. Infants' heads were kept out of the cover and coated with a hat. In group 2, the plastic cover was used during the first day of the study while the blanket was used during second day. Digital thermometer was used to measure infants' axillary temperature. The data was analyzed using SPSS ver 13 and MiniTab software. Descriptive statistics, (Mean (SE), 95%CI) and inferential statistics (Repeated measurement and ANCOVA tests) were used. The mean body temperature of the infants in the group covered with the plastic was calculated to be higher and the warmer was set on low temperature. Using plastic cover during the first few days of hospitalization in NICU resulted in regulation of preterm infants' body temperature.
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http://dx.doi.org/10.15171/jcs.2017.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488671PMC
June 2017

Comparison of the Effect of Plastic Cover and Blanket on Body Temperature of Preterm Infants Hospitalized in NICU: Randomized Clinical Trial.

J Caring Sci 2017 Jun 1;6(2):163-172. Epub 2017 Jun 1.

Department of Pediatric Nursing, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Preterm infants are unable to regulate their body temperature and there are insufficient research evidences on different kinds of covers for hospitalized preterm infants; therefore, the present study was conducted with the aim of comparing the effects of plastic and blanket covers on the body temperature of preterm infants under radiant warmer. This randomized cross-over clinical trial was carried out upon 80 infants with the gestational age of 28-30 weeks and birth weight of 800- 1250 gr who were in Neonatal Intensive Care Unit on the second day of their hospitalization. The study lasted for two days. In group 1, the plastic cover was used during the first day of the study while the blankets were used during the second day. Infants' heads were kept out of the cover and coated with a hat. In group 2, the plastic cover was used during the first day of the study while the blanket was used during second day. Digital thermometer was used to measure infants' axillary temperature. The data was analyzed using SPSS ver 13 and MiniTab software. Descriptive statistics, (Mean (SE), 95%CI) and inferential statistics (Repeated measurement and ANCOVA tests) were used. The mean body temperature of the infants in the group covered with the plastic was calculated to be higher and the warmer was set on low temperature. Using plastic cover during the first few days of hospitalization in NICU resulted in regulation of preterm infants' body temperature.
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http://dx.doi.org/10.15171/jcs.2017.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488671PMC
June 2017

Difficulties in emotion regulation mediate negative and positive affects and craving in alcoholic patients.

Addict Behav 2017 08 2;71:75-81. Epub 2017 Mar 2.

University Technology Malaysia (UTM), Johor Bahru, Malaysia. Electronic address:

The aim of this study was to assess the mediating effects of difficulties in emotion regulation (DER) on the relations of negative and positive affects to craving in alcoholic patients. 205 treatment-seeking alcoholic outpatients were included. DER, positive and negative affects as well as craving were evaluated by the Difficulties in Emotion Regulation Scale (DERS), the Positive/Negative Affect Scales, and the Obsessive Compulsive Drinking Scale (OCDS) respectively. Clinical factors including depression and severity of alcohol dependence were investigated by the Alcohol Use Disorders Identification Test (AUDIT) and the Beck Depression Inventory-II (BDI-II) respectively. Results revealed that both increased negative affect and decreased positive affect indirectly influenced craving through limited access to emotion regulation strategies. It was concluded that limited access to emotion regulation strategies may be important in predicting craving for alcoholics who experience both increased negative affect and decreased positive affect. This suggests that treatment and prevention efforts focused on increasing positive affect, decreasing negative affect and teaching effective regulation strategies may be critical in reducing craving in alcoholic patients.
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http://dx.doi.org/10.1016/j.addbeh.2017.02.029DOI Listing
August 2017

The mediating effects of cognitive emotion regulation strategies on the relationship between alexithymia and physical symptoms: Evidence from Iranian asthmatic patients.

Psychiatry Res 2017 Jan 12;247:144-151. Epub 2016 Nov 12.

Allergist & Asthma Specialist at Private Allergic Office, Shiraz, Iran. Electronic address:

Asthma is a chronic and episodic psychosomatic disease whose symptoms include coughing, wheezing, chest tightness, and shortness of breath. The present study aimed to investigate the effects of cognitive emotion regulation strategies (CERS) as mediators on the relationships between alexithymia subscales and physical symptoms (PS). 300 asthmatic patients (males=42.7%, females=57.3%, age =16-65, mean =29.40) and 100 normal controls participated in the study and completed the demographic questionnaire, the Cognitive Emotion Regulation Questionnaire (CERQ), the Persian version of the Toronto Alexithymia Scale (FTAS-20), and the Powell & Enright Physical Symptoms Inventory (PSI). Asthmatic patients showed higher scores on all three alexithymia subscales including difficulty in identifying feelings (DIF), difficulty in describing feelings (DDF), and externally oriented thinking (EOT) as well as non-adaptive CERS than normal controls. On the other hand, normal controls earned higher means in adaptive CERS. Results revealed that each of the three alexithymia subscales had indirect effects on PS through the non-adaptive cognitive emotion regulation strategy of catastrophizing. It is concluded that alexithymia can intensify PS through catastrophizing in asthmatic patients.
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http://dx.doi.org/10.1016/j.psychres.2016.11.015DOI Listing
January 2017

Homozygous MAPT R406W mutation causing FTDP phenotype: A unique instance of a unique mutation.

Gene 2015 Oct 15;570(1):150-2. Epub 2015 Jun 15.

Neurology Department, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Frontotemporal dementia is a neurodegenerative disorder among adults. An autosomal-dominantly form of frontotemporal dementia and parkinsonism linked to chromosome 17q21.2 (FTDP-17) was defined in 1996. The MAPT gene is responsible for the major cases of FTDP-17, and tau also has a role in Alzheimer's disease. So far, different FTDP-17 causing mutations have been identified in the MAPT gene. Among different MAPT mutations, the R406W mutation has been reported with a phenotype resembling Alzheimer's disease. Nonetheless, in this study we have identified the first homozygous case of R406W mutation in an Iranian family which shows characteristics of FTDP, just like the other heterozygous mutations of MAPT. This study clearly indicates that homozygous R406W mutation could result in FTDP phenotype. Our family confirms heterogeneity in the clinical phenotype of MAPT mutations; moreover, in the R406W mutation, a dosage effect is likely to contribute to this clinical heterogeneity.
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http://dx.doi.org/10.1016/j.gene.2015.06.033DOI Listing
October 2015