Publications by authors named "Fatemeh Ashouri"

3 Publications

  • Page 1 of 1

A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo studies.

Carbohydr Polym 2021 Feb 23;254:117262. Epub 2020 Oct 23.

Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176, Iran. Electronic address:

A novel theranostic nanoplatform was prepared based on FeO nanoparticles (NPs) coated with gadolinium ions decorated-polycyclodextrin (PCD) layer ([email protected]) and employed for Curcumin (CUR) loading. The dissolution profile of CUR indicated a pH sensitive release manner. [email protected] NPs exhibited no significant toxicity against both normal and cancerous cell lines (MCF 10A and 4T1, respectively); while the CUR-free NPs showed more toxicity against 4T1 than MCF 10A cells. In vivo anticancer study revealed appropriate capability of the system in tumor shrinking with no tissue toxicity and adverse effect on body weight. In vivo MR imaging of BALB/c mouse showed both T and T contrast enhancement on the tumor cells. [email protected]/CUR NPs showed significant features as a promising multifunctional system having appropriate T-T dual contrast enhancement and therapeutic efficacy in cancer theranostics.
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http://dx.doi.org/10.1016/j.carbpol.2020.117262DOI Listing
February 2021

Macrophage polarization in wound healing: role of aloe vera/chitosan nanohydrogel.

Drug Deliv Transl Res 2019 12;9(6):1027-1042

Department of Immunology, School of Medicine, Lorestan University of Medical Sciences, P.O. Box: 381351698, Khorramabad, Iran.

The balance between M1 and M2 macrophages plays an important role in wound healing. Interestingly, this immune response can be modulated by natural biomaterials such as chitosan nanohydrogel (Ch) and aloe vera (AV). Therefore, we aimed to improve wound recovery response by exploiting the potential healing properties of Ch and AV. Wounds were created in rats and were treated daily with either saline (control), AV, Ch, or different ratios of AV (volume):Ch (weight) (1:1), (2:1), and (3:1). M1 (iNOS, TNF-α) and M2 (CD163, TGF-β) responses were analyzed at days 3, 7, 14, 21, and 28. Wound healing increased within the third and seventh days in AV-Ch (3:1) (P < 0.001 and P < 0.002, respectively). In the treated groups, immunohistochemistry of iNOS expression decreased on the third day (P < 0.0001) while CD163 increased (P < 0.0001) on the 3rd, 7th, and 14th days. The gene expression of TGF-β decreased on the third day in AV group (P < 0.03) and on the 21st and 28th days in Ch-treated group (P < 0.00). TNF-α expression decreased in AV, Ch, and AV-Ch (3:1 v/w) on the 14th and 28th days (P < 0.00). TGF-β and TNF-α proteins decreased on the 28th day compared to the control and AV-Ch (3:1 v/w), respectively. AV-Ch (1 and 3:1 v/w) and Ch resulted in optimum wound repair by decreasing M1 after 3 days and increasing M2 after 14. Thus, Ch nanohydrogel, especially in combination with 1:1 and 1:3 ratio to AV, could be a proper candidate for modulating macrophages in response to wound healing.
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http://dx.doi.org/10.1007/s13346-019-00643-0DOI Listing
December 2019

Synthesis and characterization of cobalt-supported catalysts on modified magnetic nanoparticle: Green and highly efficient heterogeneous nanocatalyst for selective oxidation of ethylbenzene, cyclohexene and oximes with molecular oxygen.

J Colloid Interface Sci 2017 Nov 30;506:10-26. Epub 2017 Jun 30.

Department of Applied Chemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.

In this study, a new supported cobalt nanocatalyst has been described. The FeO magnetic nanoparticles (FeO MNPs) modified by SiO/aminopropyl trimethoxy silane/cyanuric chloride ([email protected]/CC) utilized for anchoring metformin-cobalt complex (FeO [email protected]/CC/[email protected](II)). The structure of novel complex well defined by elemental analysis, ICP, AAS, BET, FT-IR, EDX, SEM, TEM, DLS, XRD, TG-DTG, VSM and XPS. The catalytic efficiency of the synthesized cobalt nanocatalyst was studied in the oxidation of ethylbenzene (EB), cyclohexene (CYHE) and various oximes using molecular oxygen as ecofriendly oxidant and high catalytic activity and selectivity toward oxidation is observed. Selective aerobic oxidation of EB and CYHE and various oximes catalyzed by the cobalt nanocatalyst without any reducing agent by using N-hydroxyphthalimide (NHPI), gave acetophenone (AcPO), 2-cyclohexene-1-one and corresponding carbonyl compounds respectively, as major products. To achieve high level of efficiency of heterogeneous nanocatalyst, various parameters such as the ratio and amount of nanocatalyst/NHPI, reaction time, temperature and solvents were evaluated. The easily preparation from inexpensive and commercially available reagent, thermal stability, suitable performance in reusability, high efficiency and selectivity in oxidation reactions, short reaction time, easy recovery and separation from reaction mixture, are advantages of this novel catalyst.
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http://dx.doi.org/10.1016/j.jcis.2017.06.100DOI Listing
November 2017
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