Nanomedicine / Urmia University of Medical Science
Solid Tumor Research Center,
urmia | Iran (Islamic Republic of)
Main Specialties: Dentistry, Infectious Disease, Medical Microbiology, Pediatric Infectious Diseases
Farzin Asghari Sana was born on the 20th of October, 1979 in Urmia, Iran. He received PhD degree in nanomedicine from nanotechnology and nanomedicine Institute of Hacettepe University, Turkey. Dr. Sana is a member of Iranian Society of Nanomedicine. Dr. Sana's long term research interests involve the development of a novel antimicrobial nanocomposite against a wide spectrum of bacteria including multi-drug resistance (MDR). His academic training and research experiences have provided an excellent background in multiple biological disciplines including nanomedicine, microbiology, pediatric infections control, and regenerative medicine. In his PhD thesis, he was able to conduct research with Dr. Arlin kiremitçi on the nanomedicine, and regenerative medicine. Sana's work has garnered awards from the 10th Nanoscience and Nanotechnology Conference (NanoTR-10), Istanbul, Turkey. As a postdoctoral fellowship with Dr. Menemse Gümüsderelioglu, his research focused on a protocol for development of antimicrobial nanocomposite against MDR bacteria. In this research, he showed that, nanocomposite with antibacterial and beta-lactamase inhibitory characteristics provides an interesting approach to inhibit adherence and growth of bacteria. Moreower, synergistic effect of nanocomposit/beta-lactam antibiotic combinations extends its spectrum against MDR pathogenic bacteria with safe biocompatibility and appropriate tissue interactions as well as their nontoxicity (PATENT: WO2018070953A1). He started the second postdoctoral fellowship with Dr. Anahita Fathi Azarbayjani in Solid Tumor Research Center, Urmia University of Medical Science Iran, about the development of antimicrobial nanofibers against cancer cells and MDR bacteria.
Primary Affiliation: Nanomedicine / Urmia University of Medical Science - urmia , Iran (Islamic Republic of)
3PubMed Central Citations
Annals of Microbiology
Purpose The purpose of this study was to isolate the surface-associated microorganisms from the dairy plant surfaces with a high
probability of biofilm formation and determine the most adhesive strains in terms of surface properties and exopolysaccharide
Methods Four hundred and ninety-five surface-associated microorganisms were isolated from potential biofilm-forming surfaces
of a dairy plant. One hundred and seventy of these were isolated after cleaning/disinfection of the pasteurized milk, white cheese
and butter tank, yogurt and ice cream filling unit, ice cream air pressing, and condensed milk pipe. It is noteworthy that some
isolates might cause post-production contamination, food infection, and intoxication. Selected 42 isolates were identified by
Gram staining, physiological and biochemical tests, and 16S rRNA gene sequencing. Then, surface properties and
exopolysaccharide production of 10 selected isolates were determined. To evaluate the surface properties, microbial adhesion
to hydrocarbons, static water contact angle, salt aggregation, and surface zeta potential tests were performed.
Result The microbial adhesion to hydrocarbons (MATH) test exhibited the lowest standard deviations, and the most consistent
results between the replicates. The highest hydrophilic characteristics and exopolysaccharide production were exhibited by
Gram-negative Pseudomonas aeruginosa, followed by Gram-positive Bacillus toyonensis. Also, a significant diversity of neutral
sugar was determined in their alditol acetate forms by using gas chromatography–mass spectrometry. In this context, it is believed
that the determination of the EPS content of the isolates would contribute to establishing an effective cleaning/disinfection
procedure for dairy plants.
Conclusion This study indicated that microbial adhesion is still a common problemin the dairy industry. Because of this situation,
dairy plants should be organized and constructed to be suitable for hygiene and sanitary applications.
Keywords Dairy plant . Adhesion . Identification . Surface property . Exopolysaccharide production . Neutral sugar content
Iranian Journal of Pediatrics
Objective: A prospective study to determine the prevalent bacterial agents of neonatal sepsis and their antimicrobial susceptibility in Imam Khomeini teaching hospital, Urmia, from Oct 2002 to Nov 2006. Methods: Newborns with clinical signs of septicemia and positive blood culture during fifty months were prospectively studied. Samples for blood cultures, complete blood count, erythrocyte sedimentation rate, C-reactive protein, sugar, electrolytes, cerebrospinal fluid and urine analysis/culture were obtained; ampicillin and gentamycin were started empirically. Results were analyzed by SPSS13 package and cross tabulation was done. Findings: Two thousand three hundred twenty five newborns from 4827 neonatal admissions were screened for septicemia. Two hundred twenty seven episodes of sepsis occurred in 209 newborns. The boys/girls ratio was 1.67:1 and 63.9% of patients were premature. There were 164 (72.2%) cases of EONS and 63 (27.7%) cases of LONS. Coagulase negative staphylococcus (CONS) was the most common (54%) cause of both early and late onset neonatal sepsis and showed high degree of resistance to commonly used antibiotics; ampicillin (100%), ceftriaxon (65%), cefotaxim (67%) and gentamicin (51%), but comparatively low resistance to vancomycine (10%), imipenem (19%), and ciprofloxacine (23%). Conclusion: Neonatal sepsis in our ward is mainly caused by gram-positive organisms, which are developing resistance to commonly used antibiotics. The initial empirical choice of ampicillin and gentamycin appears to be unreasonable for our environment. KEYWORDS Septicemia, Neonatal sepsis, Antibiotic sensitivity, Coagulase negative staphylococcus,
Journal of Applied Polymer Science
The aim of this study was to investigate the effect of silver nanoparticles (AgNPs) incorporation on the flexural strength (FS) of poly(methyl methacrylate) (PMMA). PMMA specimens (65 mm × 10 mm × 3.3 mm for flexural test, 50 mm × 6 mm × 4 mm for impact test) containing different sizes (40, 50, 60 nm) and concentrations (0.05%, 0.2%) of AgNPs were prepared, along with a control group with no AgNP. Impact strength (IS) and FS of all specimens were measured, and one-way ANOVA and Tukey–Kramer post hoc multiple comparisons tests were used to identify any statistical differences between groups. The addition of AgNPs has no effect on IS of PMMA. The incorporation of AgNPs affected the FS of PMMA depending on the concentration of nanoparticles. The addition of large-sized nanoparticles to PMMA increases its FS. Accordingly, adding AgNP with proper concentrations to PMMA may enhance the mechanical properties of denture bases used in clinical practice. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 135, 45807.
Nigerian Journal of Clinical Practice
Purpose: The aim of this study was to investigate the effect of gold nanoparticle on the flexural strength of polymethyl methacrylate (PMMA). Materials and Methods: PMMA specimens (65 mm × 10 mm × 3.3 mm) containing different sizes (45 nm, 55 nm, and 65 nm) and concentrations (0.05% and 0.2%) of gold nanoparticles were prepared, along with a control group containing no added nanoparticles. Flexural strength of all specimens was measured, and one-way ANOVA and Tukey–Kramer post hoc multiple comparisons tests were performed to identify statistical differences between groups. Results: The addition of gold nanoparticles increased the flexural strength of acrylic resin. Significantly greater increases were obtained with lower concentrations (0.05%) when compared to higher concentrations (0.20%). Conclusion: Differences in concentrations of gold nanoparticles added to PMMA have significantly different effects on PMMA flexural strength, whereas differences in sizes of gold nanoparticles added to PMMA do not significantly affect its flexural strength. Accordingly, adding gold nanoparticles to PMMA may enhance the mechanical properties of denture bases used in clinical practice.
Cytotechnology 2017 Aug 26;69(4):617-630. Epub 2017 Jun 26.
Department of Nanotechnology and Nanomedicine, Hacettepe University, Ankara, Turkey.
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Journal of Pharmacy and Clinical
Idiopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenic purpura and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and the absence of other causes of thrombocytopenia. ITP is a bleeding condition in which the blood doesn't clot as it should. This is due to a low number of blood cell fragments called platelets. It is important to maintain an adequate platelet count in patients with ITP in order to avoid hemorrhagic during surgery. The association between helicobacter pylori infection and the effect of it were observed in an ITP patient over 6 months. Presence of Helicobacter pylori indicated to the increased platelet count and provides a new insight for a nonimmunosuppressive treatment in selective ITP patients. Key words: Helicobacter pylori, Platelet, Idiopathic thrombocytopenic purpura, primary immune hrombocytopenic purpura.
New Cellular and Molecular Biotechnology Journal 1, no. 3 (2011): 17-21.
Aim and Background. The aim of this study was to assess the most common bacterial etiology in neonatal sepsis which has been carried out during the years 2005-2006 at Urumiah Shahid Arefian Hospital. Materials and Methods. In this cross-sectional study, after collecting blood samples from 402 newborns who were suspicious to sepsis and performing microbial culture and bacterial isolation, disk diffusion antibiotic susceptibility test was done according to the CLSI guidelines. Results. Overall, 36 positive cultures were acquired. The prevalence of sepsis were higher in the male infants (61/1%) than female (38/9%) (P=0) Among these, 63/9% were born with normal vaginal delivery and 36/1% were c-section delivered babies (P=0/093). The mean weight of 36 neonates was 2117±837 gr and there was a significant relationship between low birth weight and prevalence of sepsis (p=0). The most common microorganisms of neonatal sepsis were coagulase negative staphylococci (50%) and klebsiella pneumoniea (19/4%). The gram-positive isolates showed the highest sensitivity and resistance rates to vancomycin and to Ampicillin, respectively. The highest sensitivity and resistance rates for the gram negatives were towards ciprofloxacin and cefotaxime, respectively. Low birth weight and prematurity were the major risk factors of sepsis. Conclusion. With respect to increasing prevalence of neonatal sepsis with coagulase negative staphylococci, in this study and similar studies, with appropriate antibiotical therapy according to antibiogram results, with considering hygienic principles in hospitals and prenatal care, we may able to decrease mortality and morbidity of neonatal sepsis.