Publications by authors named "Faruk Öztürk"

71 Publications

Relationships between corneal biomechanics and the structural and functional parameters of glaucoma damage.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):132-140

Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: To investigate the relationships between (i) thickness of the retinal nerve fiber layer, optic nerve head topography, and visual field parameters and (ii) corneal biomechanical properties in normal controls and patients with ocular hypertension and primary open-angle glaucoma.

Methods: This observational, cross-sectional study included 68 eyes with primary open-angle glaucoma, 99 eyes with ocular hypertension and 133 control eyes. Corneal biomechanical properties, optic nerve head topographic features, retinal nerve fiber layer thickness, and visual fields were assessed in all cases. Corneal biomechanical properties, retinal nerve fiber layer thicknesses, and optic nerve head topographic features were compared among the groups. The associations between structural and functional measures of glaucomatous damage and corneal biomechanical factors were also evaluated.

Results: Significantly lower corneal hysteresis and corneal resistance factor values were observed in the primary open-angle glaucoma and ocular hypertension groups as compared with the control group, but there were no significant differences between the primary open-angle glaucoma and ocular hypertension groups. In the ocular hypertension group, no associations were observed between the corneal hysteresis and corneal resistance factor with values and the structural and functional parameters. In the primary open-angle glaucoma group, positive correlations were observed between the corneal hysteresis values and the global retinal nerve fiber layer thickness (p<0.01, r=0.27), mean retinal nerve fiber layer thickness (p<0.01, r=0.33), and mean deviation (p<0.01, r=0.26), and negative correlations were observed between the corneal resistance factor values, and the cup area (p<0.01, r=-0.39), cup-to-disk ratio (p=0.02, r=-0.28), linear cup-to-disk ratio (p=0.02, r=-0.28), and cup shape (p=0.03, r=-0.26). In the control group, weak correlations were detected between the corneal hysteresis and the cup area (p=0.03, r=0.19), cup-to-disk ratio (p=0.01, r=0.21), and linear cup-to-disk ratio (p=0.01, r=0.22).

Conclusions: Distinct correlations were identified between the corneal hysteresis and corneal resistance factor values and the functional and structural parameters in the primary open-angle glaucoma and control groups. Corneal hysteresis and corneal resistance factor may have different roles in the pathophysiology of glaucoma.
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http://dx.doi.org/10.5935/0004-2749.20200019DOI Listing
May 2020

Comparison of preoperative and postoperative measurements of optical low-coherence reflectometry biometry and assessment of its refractive predictability.

Int Ophthalmol 2019 Jun 21;39(6):1337-1343. Epub 2018 Jun 21.

Hacettepe Medical Faculty, Ankara, Turkey.

Purpose: To compare the preoperative and postoperative measurements of optical low-coherence reflectometry (OLCR) biometry and assessment of its refractive predictability.

Methods: A total of 114 eyes of 102 patients who underwent cataract treatment were prospectively examined. The axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), K (keratometry) 1, K2, K average (KAVE) and K astigmatic (KAST) values were recorded using Lenstar LS 900 (Haag-Streit, Koeniz, Switzerland) OLCR device. The IOL (intraocular lens) power was measured based on the SRK/T formula. The cases were divided into three subgroups according to AL (Group 1: AL < 22 mm, Group 2: 22 mm ≤ AL < 24 mm, Group 3: 24 mm ≤ AL). The mean absolute error (MAE) calculated for each eye.

Results: The right eyes of 45 patients (44.1%), left eyes of 45 patients (44.1%), and both eyes of 12 patients (11.7%) were examined. The average AL in the preoperative period was 23.19 ± 1.01; it was 23.20 ± 0.99 in the postoperative period (p > 0.05). A significant deepening was detected in the postoperative ACD (preop 2.76 ± 0.38 mm, postop 3.81 ± 0.46 mm, p < 0.001). CCT was measured as 521.4 ± 36.3 µm in the preoperative period and as 530.8 ± 42.8 (p > 0.05) µm in the postoperative period. The average mean absolute error (MAE) was measured as 0.48 ± 0.41 D, whereas refractive error was - 0.081 ± 0.67 D. The MAE distribution of cases was found to be ≤ 1.5 D 109 (95.6%) eyes, and ≤ 2.0 D in 114 (100%) eyes. MAE values according to AL of the cases were calculated as 0.71 ± 0.83 D in group 1, 0.49 ± 0.43 D in group 2 and 0.41 ± 0.36 D in group 3 (p > 0.05).

Conclusion: When the measurement and refractive results of the OLCR biometry were evaluated, it was observed that there was a very satisfactory result and a predictable device compatible with the current literature. The SRK/T formula, one of the new generation formulas, has shown high MAE and RE results in eyes with AL ≤ 22 mm, although not statistically significant. Other new generation formulas should be tried in these eyes.
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http://dx.doi.org/10.1007/s10792-018-0952-9DOI Listing
June 2019

Increased levels of circulating CD34+ cells in neovascular age-related macular degeneration: relation with clinical and OCT features.

Eur J Ophthalmol 2018 Jan 19;28(1):80-86. Epub 2018 Feb 19.

6 Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara - Turkey.

Purpose: To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings.

Methods: The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by flow cytometry. Demographic and clinical data were recorded.

Results: The mean ages of patients in the study and control groups were 71 ± 8 and 68 ± 6 years, respectively. There was no statistically significant difference in terms of age, sex, or systemic disease association between study and control groups. However, smoking status was significantly higher in the study group (67.9% vs 37.0%; p = 0.02). Stem cell levels were significantly higher in the study group (1.5 ± 0.9 vs 0.5 ± 0.3; p<0.001), but there was no relation between stem cell levels and clinical and OCT findings.

Conclusions: Increased circulating CD34+ stem cell levels were observed in patients with choroidal neovascular membrane associated with AMD, but no significant relation was found between cell levels and clinical and OCT findings.
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http://dx.doi.org/10.5301/ejo.5001012DOI Listing
January 2018

Physical violence among elderly: analysis of admissions to an emergency department.

Ulus Travma Acil Cerrahi Derg 2017 Jan;23(1):56-60

Department of Family Medicine, Tepecik Training and Research Hospital, İzmir-Turkey.

Background: Physical violence is defined as deliberate use of physical force likely to result in trauma, bodily injury, pain, or impairment. Present study is pioneering effort to evaluate mechanisms and sociodemographic features of physical violence targeting the elderly in Turkey and to investigate preventive measures.

Methods: Database records and forensic reports were analyzed in this retrospective study of 54 elderly patients with trauma as result of physical violence who were admitted to emergency department of Şanlıurfa Training and Research Hospital between January 2012 and July 2013.

Results: Of the 54 patients evaluated, 50 (92.4%) were male. History of experiencing previous violence was described by 55.6% (n=30) of the patients. Instances of repeat violence and firearm injuries most often occurred in the home (p=0.006, p=0.007). Need for surgical treatment was also greater among cases that occurred in the home (p=0.016).

Conclusion: Firearm injury, recurrent violence, and surgical treatment rates were higher among cases that occurred in the home. Urgent preventive measures are especially needed for the elderly who have already been victims of physical violence.
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http://dx.doi.org/10.5505/tjtes.2016.90457DOI Listing
January 2017

Isolated Microspherophakia Presenting with Angle-Closure Glaucoma.

Turk J Ophthalmol 2016 Oct 17;46(5):237-240. Epub 2016 Oct 17.

Yıldırım Bayazıt University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

We report a case of 13-year-old girl presenting to our clinic with blurred vision in both eyes. Ophthalmic examination revealed high myopia and angle-closure glaucoma due to pupillary block caused by small, spherical crystalline lenses. Treatment approaches to glaucoma in patients with microspherophakia are discussed in this case report.
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http://dx.doi.org/10.4274/tjo.47135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200837PMC
October 2016

A Surprise in the Lacrimal Sac.

Middle East Afr J Ophthalmol 2016 Jul-Sep;23(3):268-70

Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

To present a case with recurrent dacryocystitis as an unusual complication of medial orbital wall fracture repair with cartilage tissue graft. A 20-year-old male had facial trauma and underwent surgery to reconstruct right medial orbital wall fracture. During follow-up, he presented with continuous epiphora, mucopurulent discharge from the right eye. A thorough history taking indicated that medial orbital fracture was reconstructed with postauricular cartilage. We planned a standard external dacryocystorhinostomy (DCR). During the creation of lacrimal sac flaps, hard tissue was noted in the lacrimal sac. This tissue was excised and sent for pathological examination. The pathological examination revealed cartilage tissue. There were no further ipsilateral symptoms or complications after DCR. In patients with lacrimal system injury related to orbital wall fracture, iatrogenic foreign bodies in the lacrimal sac should be considered in patients with recurrent dacryocystitis who had reconstructive surgery for facial and orbital trauma.
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http://dx.doi.org/10.4103/0974-9233.180777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968152PMC
March 2017

Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma.

Int J Ophthalmol 2016 18;9(2):249-52. Epub 2016 Feb 18.

Department of Biochemistry, Turgut Ozal University, Ankara 06010, Turkey.

Aim: To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma.

Methods: The prospective study was composed of a study group (n=31) and a control group (n=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non-glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels.

Results: Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG.

Conclusion: High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.
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http://dx.doi.org/10.18240/ijo.2016.02.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761736PMC
March 2016

Comparison of the corneal biomechanical properties, optic nerve head topographic parameters, and retinal nerve fiber layer thickness measurements in diabetic and non-diabetic primary open-angle glaucoma.

Int Ophthalmol 2016 Oct 9;36(5):727-36. Epub 2016 Feb 9.

Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

The purpose of this study is to investigate the corneal biomechanical properties, optic nerve head (ONH) topographic parameters, and retinal nerve fiber layer (RNFL) thickness changes in primary open-angle glaucoma (POAG) patients with and without diabetes, as well as to evaluate the effect of the metabolic control of diabetes on corneal biomechanical properties, ONH topography, and RNFL thickness. A total of 101 eyes of 101 POAG patients (60 with diabetes and 41 without diabetes) were recruited in this prospective study. Corneal hysteresis and corneal resistance factor (CRF) were both measured using the ocular response analyzer. Optic disk parameters were evaluated using the Heidelberg Retina Tomograph-III. RNFL thickness was measured by using Spectralis HRA + OCT. CRF, mean rim area, and rim volume were found to be significantly higher in the diabetic group when compared with non-diabetic group (p = 0.01 for CRF, p = 0.04 for rim area and p = 0.02 for rim volume). ANCOVA analysis showed statistically insignificant effects of age, gender, MD, and PSD values over rim area and rim volume (p > 0.05). CRF was not significantly correlated with HbA1c levels (p > 0.05). Cup area (CA), cup volume (CV), and cup shape measure (CSM) were weakly correlated with HbA1c levels (r = 0.35 and p = 0.006 for CA; r = 0.32 and p = 0.01 for CV; r = 0.32 and p = 0.01 for CSM). The difference in mean RNFL thickness values between the groups was found to be insignificant (p > 0.05). The results of this study raise doubts whether or not diabetes does in fact shield POAG patients from glaucomatous optic nerve damage from various perspectives.
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http://dx.doi.org/10.1007/s10792-016-0191-xDOI Listing
October 2016

Evaluation of corneal biomechanical properties using an ocular response analyser to examine aphakic and pseudophakic patients after congenital cataract surgery.

Acta Ophthalmol 2016 May 2;94(3):e198-203. Epub 2015 Nov 2.

Department of Ophthalmology, Hacettepe University, School of Medicine, Ankara, Turkey.

Purpose: We evaluated corneal biomechanical properties in aphakic and pseudophakic patients after congenital cataract surgery and compared the data with those of age-matched normal subjects.

Methods: We included 43 eyes of 43 aphakic or pseudophakic patients treated via congenital cataract surgery. As controls, 42 healthy age- and sex-matched subjects were enrolled. After a complete ophthalmic examination, central corneal thickness (CCT) and intraocular pressure (IOP) were determined. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated IOP (IOPcc) and Goldmann-correlated IOP (IOPg) were recorded using an ocular response analyser.

Results: In the study group, 18 eyes were aphakic and 25 eyes pseudophakic. We found a significant difference in CCT between the aphakic, pseudophakic and control groups (p < 0.001). No significant among-group differences were detected in CH or CRF (p > 0.05). We found significant differences in IOPcc, IOPg and IOP measured with Goldmann applanation tonometry (IOPGAT ) between the study and control groups (p < 0.001). In contrast, we found no significant differences within the two study groups in terms of these three IOP values (p > 0.05).

Conclusion: Although CCT increased after congenital cataract surgery, corneal biomechanical parameters, including CH and the CRF, were not affected by such surgery. Determination of the IOPcc did not provide any additional information on true IOP, which was independent of CCT in both aphakic and pseudophakic patients after congenital cataract surgery.
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http://dx.doi.org/10.1111/aos.12900DOI Listing
May 2016

Are There Any Changes in Corneal Biomechanics and Central Corneal Thickness in Fuchs' Uveitis?

Ocul Immunol Inflamm 2016 Oct 23;24(5):561-7. Epub 2015 Sep 23.

a Ulucanlar Eye Education and Research Hospital , Ankara , Turkey .

Purpose: To compare corneal biomechanics, intraocular pressure (IOP) and central corneal thickness (CCT) of 38 patients with unilateral Fuchs' uveitis (FU) with 42 healthy controls.

Methods: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated and corneal-compensated IOP (IOPg and IOPcc, respectively) and CCT were measured.

Results: The mean CH, CRF, and IOPg of the involved FU eyes were significantly lower (9.5 ± 1.6, 9.0 ± 1.9 and 13.1 ± 4.3 mmHg) than contralateral eyes (10.1 ± 1.7, 9.9 ± 1.7 and 14.6 ± 3.4 mmHg), and controls (10.5 ± 1.5, 10.3 ± 1.5 and 14.8 ± 2.5 mmHg), respectively. There was no significant difference for mean IOPcc between involved FU or contralateral eyes and controls (14.8 ± 4.1, 15.5 ± 3.4 and 15.0 ± 2.7 mmHg). The CCT values correlated with CH and CRF in the involved and contralateral eyes.

Conclusions: Involved FU eyes had lower CH, CRF, and IOPg than contralateral eyes and controls, with no difference regarding IOPcc.
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http://dx.doi.org/10.3109/09273948.2015.1037459DOI Listing
October 2016

Effect of dorzolamide-timolol fixed combination prophylaxis on intraocular pressure spikes after intravitreal bevacizumab injection.

Int J Ophthalmol 2015 18;8(3):496-500. Epub 2015 Jun 18.

Department of Ophthalmology, Gynecology and Pediactric Diseases Hospital, Samsun 55060, Turkey.

Aim: To evaluate the effect of topical dorzolamide-timolol fixed combination prophylaxis on short term intraocular pressure (IOP) changes in patients who had intravitreal bevacizumab injection.

Methods: One hundred and fifty one eyes of 151 patients which were followed up in retina clinic in Ulucanlar Eye Training and Research Hospital were evaluated in this study. Patients were divided into two groups. Group 1 consists of 75 patients who had topical dorzolamid-timolol medication two hours before injection; while Group 2 consists of 76 patients without prophylaxis. Demographic data, IOP measurements prior to the injection and one, thirty and sixty minutes and twenty-four hours after the injection were recorded. The data were analyzed using SPSS software version 15.0 (SPSS Inc., Chicago, IL, USA).

Results: There were no significant difference between two groups in age, gender distrubition and indications for injections. The mean IOPs in Groups 1 and 2 prior to the injection (T0) were 17.84±0.43 and 18.15±0.43 mm Hg, one minute after the injection (T1) were 29.75±1.6 and 34.44±1.59 mm Hg, 30min after the injection (T30) were 20.06±0.6 and 21.71±0.59 mm Hg respectively. The mean IOPs were 18.26±0.56 mm Hg in Group 1 and 19.78±0.56 mm Hg in Group 2 sixty minutes after the injection (T60). All IOP values after the injection were compared between two groups, there was a significant difference between two groups only on T1; one minute after the injection (P=0.04). There were a statiscially significant difference between the baseline values and other recorded values; except on T60, in Groups 1 and 2 (P<0.05).

Conclusion: After intravitreal bevacizumab injection; we observe a transient IOP elevation which normalizes about one hour after intravitreal injection. In patients who had topical dorzolamid-timolol combination prophylaxis before injections, a significant decrease is seen in IOP spikes due to this injection. The appropiate approach will monitor IOP after intravitreal injection and evaluate the using prophylactic antiglaucomatous drugs before the injection in patients with ganglion nerve cell damage.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2015.03.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458652PMC
June 2015

Evaluation of Optical Low Coherence Reflectometry Parameters in Patients with Exfoliation Syndrome.

J Ophthalmol 2015 28;2015:658091. Epub 2015 Apr 28.

Department of Ophthalmology, Ataturk Research and Training Hospital, Ankara, Turkey.

Purpose. To evaluate optical low coherence reflectometry (OLCR) parameters in patients with exfoliation syndrome (EXS) undergoing cataract surgery. Methods. Forty-seven eyes of 47 patients with EXS (Group 1), and 55 eyes of 55 healthy subjects (Group 2) were included in the study. Anterior chamber depth (ACD), lens thickness (LT), axial length (AL), central corneal thickness (CCT), horizontal corneal length (HCL), and pupil diameter (PD) parameters were measured by OLCR (Lenstar LS 900, Haag-Streit) and compared between groups. Shapiro-Wilk test and Mann Whitney U tests were used for statistical analyses. Results. The mean ACD, HCL, and PD values were significantly lower in EXS group than in healthy subjects (P = 0.01, P = 0.04, and P < 0.001, resp.). The mean LT was significantly higher in EXS group than in healthy subjects (P = 0.007). There was no significant difference between groups in means of AXL and CCT. Conclusions. According to OLCR measures, eyes with EXS have shallower ACD, smaller PD, thicker LT, shorter HCL, and no significantly different CCT levels.
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http://dx.doi.org/10.1155/2015/658091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427831PMC
June 2015

Histopathological Analysis of Internal Limiting Membrane Surgically Peeled From Eyes with Epiretinal Membrane.

Curr Eye Res 2016 7;41(2):258-65. Epub 2015 Apr 7.

d Department of Ophthalmology , Atatürk Research and Training Hospital , Ankara , Turkey.

Purpose: To investigate histopathological changes of internal limiting membrane (ILM) in patients with epiretinal membrane (ERM) Materials and Methods: Forty-two eyes of 42 patients who were diagnosed as ERM and enrolled for vitreoretinal surgery were included in this study. Brilliant Blue G (BBG) was used to stain the ILM in all patients. ILM was peeled in all subjects and analyzed by light microscopy (methylene blue-Azur II × 40). ILM samples were then fixed in 2.5% glutaraldehyde solution and examined in JEOL-JEM 1400 and 2100F electron microscope and photographed by CCD camera (Gatan Inc., Pleasanton, CA).

Results: Remained ERM fragments were observed on 80% of ILM's. Vacuolization of ILM was observed in a patient with diabetic ERM. There were cells and cellular fragments observed mostly at retinal side of ILM which was likely to be a fragment of Muller cells of retina.

Conclusions: Most of the ILM's had residual ERM tissue and contained cells and cellular fragments at retinal side of ILM's. ILM peeling might have a role in decreasing ERM recurrence by removal of residual ERM tissues.
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http://dx.doi.org/10.3109/02713683.2015.1008642DOI Listing
October 2016

Age-related changes in biomechanical parameters of the cornea and intraocular pressure in a healthy Turkish population.

Turk J Med Sci 2014 ;44(4):687-90

Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.

Background/aim: To investigate age-related changes in intraocular pressure (IOP) and biomechanical parameters of the cornea in healthy subjects.

Materials And Methods: There were 404 healthy subjects included prospectively in this study. The subjects were divided into 3 groups (Group 1:93 subjects aged < 18, Group 2:189 subjects aged between 18 and 59, and Group 3:122 subjects aged ≥ 60). Corneal compensated IOP (IOPCC), Goldmann correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured by the Ocular Response Analyzer.

Results: When all the study groups were evaluated, a moderately significant negative correlation was found between age and CH and between age and CRF (Spearman's rho = -0.372 and -0.353, respectively; P < 0.0001 for both correlations). There were significant age-related differences among the 3 groups in terms of IOPg, CH, CRF, and central corneal thickness (P = 0.002, P = 0.000, P = 0.000, P = 0.006). There was no confirmation of any difference of IOPcc among the groups (P = 0.427).

Conclusion: The mean values of IOPg, CH, and CRF were lower than the other parameters in Group 3 but no significant differences were determined in IOPcc values in the age groups.
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January 2015

Epidemiology of uveitis in a referral hospital in Turkey.

Turk J Med Sci 2014 ;44(2):337-42

Aim: To investigate the causes and clinical characteristics of uveitis in patients presenting to a specialized eye hospital in Turkey.

Materials And Methods: The clinical records of 1028 uveitis patients admitted between 1990 and 2010 were retrospectively reviewed. Age at first presentation, sex, laterality, etiology, associated systemic disease, clinical presentation, and course of the disease were noted.

Results: The mean age at presentation was 36.23 ± 14.9 years. Males constituted 58.2% of patients. Anatomically, anterior uveitis (42%) was most common, followed by posterior uveitis (24.9%), panuveitis (24.7%), and intermediate uveitis (8.4%). The course of the disease was mostly chronic (65.7%). The cases were idiopathic at 25.7% and Behçet's disease (BD) was the most common cause of uveitis (32.2%), followed by ocular toxoplasmosis (7.2%) and herpetic uveitis (6.8%).

Conclusion: Uveitis tends to affect patients between 20 and 40 years old. BD is the most common cause, leading to male predominance and a higher frequency of a chronic course.
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http://dx.doi.org/10.3906/sag-1302-132DOI Listing
January 2015

Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings.

Indian J Ophthalmol 2014 Aug;62(8):841-5

Department of Glaucoma, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.

Aims: The aim was to compare the intraocular pressure (IOP), central corneal thickness (CCT), and optic disc topography findings of biochemically controlled acromegalic patients and the control group and to evaluate the effect of the duration of acromegaly and serum growth hormone and insulin-like growth factor-1 (IGF-1) levels on these ocular parameters.

Materials And Methods: IOP measurement with Goldmann applanation tonometry, CCT measurement with ultrasonic pachymetry, and topographic analysis with Heidelberg retinal tomograph III were performed on 35 biochemically controlled acromegalic patients and 36 age- and gender-matched controls.

Results: Mean IOP and CCT were 14.7 ± 2.9 mmHg and 559.5 ± 44.9 μm in the acromegaly patients and 13.0 ± 1.6 mmHg and 547.1 ± 26.7 μm in controls (P = 0.006 and P = 0.15, respectively). A significant moderate correlation was found between the duration of acromegaly and CCT (r = 0.391) and IOP (r = 0.367). Mean retinal nerve fiber layer (RNFL) thickness was significantly lower in the acromegalic patients (0.25 ± 0.05 mm) as compared to controls (0.31 ± 0.09 mm) (P = 0.01). A significant moderate correlation was detected between IGF-1 level and disc area (r = 0.362), cup area (r = 0.389) and cup volume (r = 0.491).

Conclusion: Biochemically controlled acromegalic patients showed significantly higher CCT and IOP levels and lower RNFL thickness compared to healthy controls and the duration of disease was correlated with CCT and IOP levels.
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http://dx.doi.org/10.4103/0301-4738.141035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185160PMC
August 2014

Comparison of Optic Nerve Head Topographic Parameters in Patients With Primary Open-Angle Glaucoma With and Without Diabetes Mellitus.

J Glaucoma 2016 Jan;25(1):49-53

*Department of Ophthalmology, Dişkapi Yildirim Beyazit Training and Research Hospital ‡Department of Ophthalmology, Faculty of Medicine, Yildirim Beyazit University, Ankara †Department of Ophthalmology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

Purpose: To evaluate the optic nerve head (ONH) parameters of primary open-angle glaucoma (POAG) patients with and without diabetes and to investigate the effect of the metabolic control of diabetes on ONH topography.

Materials And Methods: A study group of 60 eyes of 60 POAG patients with type 2 diabetes mellitus and a control group of 41 eyes of 41 POAG patients without diabetes were recruited for the study. Complete ophthalmic examinations of all patients were performed and the quantitative optic disc parameters were evaluated with Heidelberg retina tomography (HRT) III. HbA1c measurements of diabetic patients were assessed on the same day when the ophthalmic assessments were performed.

Results: Mean rim area and rim volume of the study group was statistically higher than the control group (P=0.04 for rim area and P=0.02 for rim volume). The difference in other parameters of the HRT between the groups were insignificant (P>0.05). In the study group, the duration of the diabetes was not significantly correlated to rim area and rim volume (r=0.03, P=0.81 for rim area; r=0.03, P=0.79 for rim volume). Analysis of covariance showed insignificant effects of age, sex, MD, and PSD values over rim area and rim volume (P>0.05). There were weak but statistically significant correlations between HbA1c levels and some HRT parameters including disc area, cup area, cup volume, and cup shape measure (r=0.35 and P=0.006 for disc area; r=0.35 and P=0.006 for cup area; r=0.32 and P=0.01 for cup volume; r=0.32 and P=0.01 for cup shape measure).

Conclusions: The results of this study imply the protective effect of diabetes over glaucomatous optic nerve damage in POAG patients. However, larger and controlled studies are warranted to confirm those findings.
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http://dx.doi.org/10.1097/IJG.0000000000000096DOI Listing
January 2016

Surgical outcomes and incidence of retinal redetachment in cases with complicated retinal detachment after silicone oil removal: univariate and multiple risk factors analysis.

Retina 2014 Oct;34(10):1926-38

*Department of Ophthalmology, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey; †Department of Ophthalmology, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey; ‡Department of Biostatistics and Medical Informatics, Ege University Faculty of Medicine, Izmir, Turkey.

Purpose: To analyze the surgical outcomes and retinal redetachment frequency after silicone oil (SO) removal for complex retinal detachment.

Methods: This institutional-based study included 894 consecutive patients who underwent pars plana vitrectomy with SO endotamponade for complicated retinal detachment. The effects of preoperative best-corrected visual acuity, vitreous base shaving, intraoperative scleral buckling, retinectomy, SO viscosity, duration of SO, and vitreous hemorrhage at the first postoperative week on the risk of redetachment were investigated.

Results: During a mean follow-up of 39.9 months, anatomical success was not achieved in 118 patients (13.2%) after SO removal. On multivariate analysis, risk factors for recurrent retinal detachment included giant retinal tear (adjusted odds ratio [aOR], 12.39; P < 0.001), high myopia (aOR, 2.70; P = 0.011), surgeries without scleral buckling (aOR, 1.97; P = 0.039), inadequate vitreous base shaving (aOR, 117.62; P < 0.001), and vitreous hemorrhage at the first postoperative week (aOR, 12.13; P < 0.001).

Conclusion: Retinal detachment etiology, inadequate vitreous base shaving, lack of intraoperative scleral buckling, and vitreous hemorrhage at the first postoperative week after SO removal were significant risk factors for retinal redetachment after SO removal, but preoperative visual acuity, SO viscosity, and duration of SO had no significant effect on redetachment.
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http://dx.doi.org/10.1097/IAE.0000000000000204DOI Listing
October 2014

Disturbed oxidant/antioxidant balance in aqueous humour of patients with exfoliation syndrome.

Jpn J Ophthalmol 2014 Jul 27;58(4):353-8. Epub 2014 May 27.

Department of Ophthalmology, Gazi Mustafa Kemal State Hospital, Silahtar Street No:2 Gazi Mahallesi, Yenimahalle, Ankara, Turkey,

Purpose: To establish the total oxidant status (TOS), total antioxidant capacity (TAC) and oxidative stress index (OSI) of the aqueous humour in patients presenting exfoliation syndrome (EXS) without glaucoma.

Methods: The TOS, TAC and OSI of the aqueous humour of patients with EXS (group 1, n = 17) and patients without EXS (group 2, n = 25) who underwent cataract surgery were evaluated. Samples were measured spectrophotometrically using a colourimetric method. The Mann-Whitney U, independent-samples t tests, Pearson correlation and analysis of covariance tests were used in the statistical analyses.

Results: The mean TOS in group 1 and 2 patients was 57.6 ± 32.4 and 30.4 ± 22.6 mmol/L, respectively, which is a statistically significant difference (p = 0.001). The mean TAC level in group 1 and 2 patients was 2.3 ± 0.7 and 2.5 ± 0.7 mmol/L, respectively, and although TAC was decreased in group 1 relative to group 2, the difference was not statistically significant (p = 0.55). The mean OSI in group 1 and 2 patients was 27.4 ± 17.1 and 12.5 ± 8.3 mmol/L, respectively, with the mean OSI level statistically higher in group 1 (p = 0.03).

Conclusion: Our findings provide evidence that the aqueous humour of EXS patients is characterised by increased oxidative stress and a disturbed oxidant/antioxidant balance. The increased oxidative stress and decreased levels of antioxidants in ocular fluids of EXS patients may play a significant role in the pathogenesis and complications of EXS.
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http://dx.doi.org/10.1007/s10384-014-0325-5DOI Listing
July 2014

Corneal biomechanical properties measured by the ocular response analyzer in acromegalic patients.

Graefes Arch Clin Exp Ophthalmol 2014 Aug 13;252(8):1283-8. Epub 2014 May 13.

Ulucanlar Eye Education and Research Hospital, Altındag, Ankara, Turkey,

Purpose: To investigate the effect of acromegaly on corneal biomechanical parameters.

Methods: This cross-sectional, comparative clinical study included 34 acromegalic patients and 30 age-matched and sex-matched healthy controls. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated and corneal-compensated intraocular pressure (IOPg and IOPcc, respectively) were measured using the Ocular Response Analyzer. Central corneal thickness (CCT) was determined with the ultrasonic pachymeter.

Results: The mean duration of disease for the acromegalic patients was 5.3 years. There was no significant difference between the groups regarding mean CH, CRF, IOPg and IOPcc values. The respective mean values in patients with acromegaly and controls were 10.3 ± 2.2 and 9.5 ± 1.5 mmHg (p = 0.13) for CH; 10.5 ± 2.4 and 9.7 ± 1.7 mmHg (p = 0.16) for CRF, 16.1 ± 3.6 and 15.5 ± 2.9 mmHg (p = 0.49) for IOPg, 16.8 ± 3.4 and 17.0 ± 2.8 mmHg (p = 0.82) for IOPcc, and 544.8 ± 32.2 and 530.7 ± 22.9 μm (p = 0.05) for CCT. A significant moderate correlation was detected between the duration of acromegaly and IOPg OD (r = 0.430, p = 0.01). There was no significant correlation between other ocular parameters and levels of GH and IGF-1 at the time of diagnosis, the status of control, adenoma type, radiotherapy treatment, and drug usage.

Conclusions: In acromegalic patients, the duration of disease was correlated with IOPg OD level. Corneal biomechanical parameters and CCT values were not significantly different than those in age-matched and sex-matched healthy individuals.
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http://dx.doi.org/10.1007/s00417-014-2653-zDOI Listing
August 2014

Comparison of autofluorescence and optical coherence tomography findings in acute and chronic central serous chorioretinopathy.

Int J Ophthalmol 2014 18;7(2):350-4. Epub 2014 Apr 18.

Ulucanlar Eye Research Hospital, Ankara 06240, Turkey.

Aim: To discuss and compare the fundus autofluorescence (FAF) and optical coherence tomography (OCT) in acute or chronic central serous chorioretinopathy (CSCR).

Methods: Medical records of 100 cases of CSCR were reviewed. Acute and chronic cases were evaluated according to the duration of decreased visual acuity, serous retinal detachment (RD) and focal leakage on fluorescein angiography (FA). Chi-square test was used for statistical analysis.

Results: Forty cases had acute and 60 cases had chronic CSCR. FAF showed focal hypo-autofluorescence in 34 (85%) and iso-autofluorescence in 6 (15%) of acute cases and hypo-autofluorescence in 51 (85%), hyper-autofluorescence in 6 (10%) and iso-autofluorescence in 3 (5%) of chronic cases. OCT showed serous RD with distinct borders correlated with FAF findings (hypo-autofluorescence) in all acute CSCR cases. In chronic CSCR group, OCT showed serous RD with indistinct borders correlated with FAF findings. The differences between the OCT and FAF findings of the two groups were significant (P=0.000).

Conclusion: OCT and FAF findings can support the clinical observations in differential diagnosis of acute and chronic CSCR and help clinicians to evaluate retinal pigment epithelium, outer segments of photoreceptors and the components of serous RD.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2014.02.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003096PMC
May 2014

Corneal properties in children with congenital isolated growth hormone deficiency.

Int J Ophthalmol 2014 18;7(2):317-20. Epub 2014 Apr 18.

Department of Pediatric Endocrinology, Dr Sami Ulus Children's Health and Disease Training and Research Hospital, Ankara 06080, Turkey.

Aim: To compare the corneal parameters of children with congenital isolated growth hormone deficiency and healthy subjects.

Methods: In this cross-sectional, prospective study, 50 cases with growth hormone (GH) deficiency treated with recombinant GH and 71 healthy children underwent a complete ophthalmic examination. The corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were measured with the Ocular Response Analyzer (ORA). Central corneal thickness (CCT) was measured by a ultrasonic pachymeter.

Results: The mean age was 13.0±3.0 years in the GH deficiency group consisting of 21 females and 29 males and 13.4±2.4 years in the healthy children group consisting of 41 females and 30 males. There was no statistically significant difference between the groups for gender or age (Chi-square test, P=0.09; independent t-test, P=0.28, respectively). The mean duration of recombinant GH therapy was 3.8±2.4y in the study group. The mean CH, CRF, IOPg and IOPcc values were 11.0±2.0, 10.9±1.9, 15.1±3.3, and 15.1±3.2 mm Hg respectively in the study group. The same values were 10.7±1.7, 10.5±1.7, 15.2±3.3, and 15.3±3.4 mm Hg respectively in the control group. The mean CCT values were 555.7±40.6, 545.1±32.5 µm in the study and control groups respectively. There was no statistically significant difference between the two groups for CH, CRF, IOPg, IOPcc measurements or CCT values (independent t-test, P=0.315, 0.286, 0.145, 0.747, 0.13 respectively).

Conclusion: Our study suggests that GH deficiency does not have an effect on the corneal parameters and CCT values. This observation could be because of the duration between the beginning of disease and the diagnosis and beginning of GH therapy.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2014.02.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003089PMC
May 2014

Effect of End-Tidal Carbon Dioxide Measurement on Resuscitation Efficiency and Termination of Resuscitation.

Turk J Emerg Med 2014 Mar 26;14(1):25-31. Epub 2016 Feb 26.

Department of Emergency Medicine, Bozyaka Training and Research Hospital, Izmir.

Objectives: In this study, the value of end-tidal carbon dioxide (ETCO2) levels measured by capnometry were evaluated as indicators of resuscitation effectiveness and survival in patients presenting to the emergency department with cardiopulmonary arrest.

Methods: ETCO2 was measured after 2 minutes of compression or 150 compressions. ETCO2 values were measured in patients that were intubated and in those who underwent chest compression. The following parameters were recorded for each patient: demographic data, chronic illness, respiration type, pre-hospital CPR, arrest rhythm, arterial blood gas measurements, ETCO2 values with an interval of 5 minutes between the measurement and the estimated time of arrest, time to return to spontaneous circulation.

Results: Cardiac arrest developed in 97 cases, including 56 who were out of the hospital and 41 who were in the hospital. Fifty of these patients returned to spontaneous circulation, and just one of these had an initial ETCO2 value below 10 mmHg. The mean of the final ETCO2 levels was 36.4±4.46 among Patients who Return to Spontaneous Circulation (RSCPs) and 11.74±7.01 among those that died. In all rhythms; Asystole, pulseless electrical activity (PEA) and VF/VT; Overall, RSCPs had higher ETCO2 levels than the cases who died. Among the PEA patients undergoing in-hospital arrests and those asystolic patients undergoing out of hospital arrest, the ETCO2 values of the RSCPs were significantly higher than those of the cases who died.

Conclusions: ETCO2 levels predicted survival as well as the effectiveness of CPR for patients who received CPR and were monitored by capnometry in the emergency department. As a result, we believe that it would be suitable to use capnometry in all units where the CPR is performed.
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http://dx.doi.org/10.5505/1304.7361.2014.65807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909885PMC
March 2014

Corneal biomechanical characteristics in children with diabetes mellitus.

Int Ophthalmol 2014 Aug 23;34(4):881-6. Epub 2014 Jan 23.

Department of Pediatric Opthalmology, Dr Sami Ulus Children's Health and Disease Training and Research Hospital, Babur Street No: 44, Altindag, Ankara, 06080, Turkey,

To compare the corneal biomechanical properties in children with type 1 diabetes mellitus (DM) and healthy children. In this cross-sectional study, the study and control groups were composed of 68 children with DM and 74 healthy children, respectively. The corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were measured with the ocular response analyzer (ORA). Associations between ocular and diabetic parameters were also evaluated. There were no statistically significant differences between the two groups in age or gender distribution. The mean CH was 10.8 ± 1.5 and 10.7 ± 1.7 mmHg while the mean CRF was 10.9 ± 1.9 and 10.5 ± 1.6 mmHg in the diabetic group and control group, respectively. The mean IOPg was 15.9 ± 3.7 and 15.2 ± 3.4 mmHg, and the mean IOPcc was 15.8 ± 3.0 and 15.3 ± 3.4 mmHg in the diabetic and control group, respectively. There were no statistically significant differences between the two groups for CH, CRF, IOPg, and IOPcc measurements (independent t test, p = 0.624, p = 0.207, p = 0.263, p = 0.395, respectively). This study shows that type 1 DM does not have any effect on the corneal biomechanical parameters in childhood.
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http://dx.doi.org/10.1007/s10792-014-9899-7DOI Listing
August 2014

Vogt-Koyanagi-Harada disease: clinical and demographic characteristics of patients in a specialized eye hospital in Turkey.

Ocul Immunol Inflamm 2014 Aug 11;22(4):277-86. Epub 2013 Dec 11.

Ulucanlar Eye Education and Training Hospital Ophthalmology Clinic , Ankara , Turkey and.

Purpose: To evaluate clinical and demographic features of Vogt-Kayanagi-Harada disease (VKH) disease in Turkish patients and compare them with previously published data.

Methods: Demographic and clinical features of 32 patients diagnosed as VKH in a tertiary referral center were retrospectively reviewed.

Results: The mean age at presentation was 33.6 ± 10.4 years. Seventy-five percent of the patients were female and 62.5% of the patients presented during the last 2 years. The disease was complete in 31.2%, incomplete in 50%, and probable in 18.8% of the patients. The clinical course was acute in 50%, chronic recurrent in 34.4%, and chronic in 15.6%. The most common findings were bilateral serous retinal detachment ± papillitis in acute cases and retinal pigment epithelial changes of the macula in chronic cases.

Conclusions: Although rare in Turkey, VKH disease seems to have increased during the last few years. The disease is incomplete and acute in half of the patients and has a quite good visual prognosis.
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http://dx.doi.org/10.3109/09273948.2013.856448DOI Listing
August 2014

Fundus autofluorescence imaging of patients with idiopathic macular hole.

Int J Ophthalmol 2013 18;6(5):685-9. Epub 2013 Oct 18.

Ulucanlar Eye Research and Training Hospital, Ankara 06450, Turkey.

Aim: To investigate the role of fundus autofluorescence (FAF) both in the diagnosis and the preoperative and postoperative evaluation of patients with idiopathic macular hole (MH).

Methods: Forty eyes of 40 patients diagnosed as idiopathic MH between May 2010 and May 2011 were included in this retrospective study. All patients underwent full ophthalmologic examinations and imagings including fluorescein angiography, fundus autofluorescence (FAF) and optical coherence tomography. Thirty of these patients underwent MH surgery. FAF findings were associated with duration of symptoms, visual acuity at presentation, stage of MH, and postoperative anatomical correction.

Results: The mean duration of patients' symptoms was 3.8±2.0 (1-9) months. The MH was stage 2 in 4 (10%), stage 3 in 24 (60%) and stage 4 in 12 (30%) eyes. The median preoperative best corrected visual acuity was 20/200 (between 20/800 and 20/100). Twenty-eight of cases (70%) showed a stellate appearance with dark radiating striae. Having a visual acuity ≥20/200 was significantly more common in eyes with stellate appearance (P<0.001). The mean duration of symptoms was significantly shorter in eyes with stellate appearance (2.75±0.8 vs 6.33±1.61 months) (P<0.001). The frequency of stage 4 MH was significantly higher in eyes with non-stellate appearance (P<0.001). Anatomical correction of MH was achieved in 91.3% (21/23) of eyes with stellate appearance and 71.4% (5/7) of eyes without this appearance (P=0.225).

Conclusion: Stellate appearance in FAF is associated with earlier stages of macular hole, better visual acuity at presentation, shorter duration of symptoms, thus more favorable prognosis.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2013.05.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808922PMC
November 2013

Corneal biomechanical parameters during pregnancy.

Eur J Ophthalmol 2014 May-Jun;24(3):314-9. Epub 2013 Oct 16.

1 Ulucanlar Eye Research Hospital, Ankara - Turkey.

Purpose: To evaluate the variation in biomechanical properties and central corneal thickness (CCT) for each trimester during pregnancy and to compare the values with those in nonpregnant women.

Methods: We prospectively studied the eyes of 32 pregnant and 34 age-matched non-pregnant women. The parameters included corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOP), and corneal-compensated IOP measured by the Ocular Response Analyzer (ORA). The CCT was also measured with an ultrasonic pachymeter attached to the ORA.

Results: The mean age was 27.0 ± 3.8 years in the study group and 28.0 ± 4.1 years in the control group. The mean CH measurement was 10.6 ± 1.4 mmHg in the study group and 10.1 ± 1.3 mmHg in the control group. The mean CRF value was 9.6 ± 1.7 mmHg in the study group and 10.0 ± 1.4 mmHg in the control group. The mean CCT value was 541.1 ± 22.4 µm in the study group and 536.5 ± 27.1 µm in the control group. No statistically significant differences were found regarding CH, CRF, or CCT values between the 2 groups (independent t test, p = 0.160, p = 0.355, p = 0.450, respectively).

Conclusions: Hormonal changes during pregnancy may not affect corneal biomechanics. This may be due to the balanced effect of the various hormones on the cornea during pregnancy.
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http://dx.doi.org/10.5301/ejo.5000378DOI Listing
October 2014

Thirteen-year vitreoretinal surgical outcomes of 5,097 cases from a tertiary referral center in Turkey.

Ophthalmologica 2013 25;230(4):186-94. Epub 2013 Sep 25.

Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.

A 13-year retrospective chart review of 5,097 consecutive cases that underwent pars plana vitrectomy (PPV) in a tertiary referral center in Turkey was performed. Age at onset, sex, laterality, associated systemic disease, pre- and postoperative visual acuities (VA), indications, type of surgery and outcomes of surgery were analyzed. The most common indications for vitreoretinal surgery (VRS) were rhegmatogenous retinal detachment (n = 1,802, 35.4%) and proliferative diabetic retinopathy (n = 1,505, 29.5%). The most common vitreoretinal technique combinations performed were PPV with encircling endolaser (EL) and phacoemulsification with intraocular lens implantation (33.0%), PPV with encircling EL (30.4%), and only PPV (7.0%). A statistically significant increase in the mean VA was noted at the first- (1.16 ± 0.44 logarithm of the minimum angle of resolution, logMAR) and sixth-month (1.06 ± 0.61 logMAR) visits when compared to the preoperative VA (1.77 ± 0.58 logMAR; p < 0.001). Comparisons in the top surgical indications, techniques and outcomes for vitrectomy between the countries could be important for the development of subspecialization in VRS.
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http://dx.doi.org/10.1159/000354062DOI Listing
July 2014

Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy.

Int J Ophthalmol 2013 18;6(4):531-6. Epub 2013 Aug 18.

Department of Ophthalmology, Gazi Mustafa Kemal State Hospital, Ankara 06900, Turkey.

Aim: To measure changes of total oxidant status (TOS) and total antioxidant capacity (TAC) of aqueous humor (AH) in diabetic retinopathy (DR) patients, and to determine if there were any differences in TOS and TAC of AH in diabetic patients without retinopathy compared with non-diabetic patients.

Methods: One hundred and three eyes of 103 patients who were enrolled for cataract surgery were included in this study. Patients were grouped according to presence of diabetes and stage of DR. Prior to cataract surgery, 0.1mL to 0.2mL of AH was aspirated and analyzed for TAC and TOS level using a colorimetric method.

Results: TOS levels were highest among proliferative diabetic retinopathy (PDR) patients and lowest in patients with only cataracts. Results were statistically significant between all groups (P<0.05). Whereas result between diabetic without retinopathy patients and non-proliferative diabetic retinopathy (NPDR) patients was not statistically significant (P=0.757). TAC levels were highest in patients with only cataract and lowest among PDR patients and results were statistically significant between all groups (P<0.05).

Conclusion: Aqueous humor TAC levels are low in diabetic patients and reduced further in DR patients, TOS levels are increased in diabetic patients and this is exacerbated in DR patients.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2013.04.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755317PMC
August 2013

Intravitreal silicone oil induced changes in corneal biomechanics.

Int Ophthalmol 2014 Jun 16;34(3):457-63. Epub 2013 Jul 16.

Ulucanlar Eye Research Hospital, Ulucanlar Caddesi, No: 59, PK06420, Altindag, Ankara, Turkey.

Our aim was to detect the early effects of pars plana vitrectomy (PPV) combined with intravitreal silicone oil (SO) on corneal biomechanics. 19 eyes underwent PPV with SO tamponade (group 1) and 16 eyes underwent. PPV without tamponade (group 2). Corneal biomechanical parameters were measured preoperatively and at the first postoperative month by ocular response analyzer. The mean preoperative intraocular pressure (IOP) by Goldmann applanation tonometry (GAT) and the mean corneal-compensated intraocular pressure (IOPcc) were significantly lower in group 1 than group 2 (p = 0.005, p = 0.002, respectively). The mean preoperative corneal hysteresis (CH) and corneal resistance factor (CRF) were significantly higher in group 1 than group 2 (p = 0.017, p = 0.002, respectively). However, the difference in Goldmann-correlated intraocular pressure (IOPg) between the groups was not significant (p = 0.360). In group 1, IOPcc, IOPg and IOP-GAT significantly increased postoperatively (p = 0.002, p = 0.004, p = 0.002, respectively) but CH and CRF decreased (p = 0.007, p = 0.153, respectively). In group 2, IOPcc, IOPg and IOP (GAT) increased postoperatively but the differences were not significant (p = 0.851, p = 0.693, p = 0.336, respectively). The mean CRF increased significantly (p = 0.026) postoperatively but the decrease in CH was not significant (p = 0.196). Statistically significant differences were found in the changes of preoperative and postoperative means of IOPcc, IOPg, IOP-GAT and CRF between the groups (p = 0.024, p = 0.037, p = 0.014, p = 0.006, respectively). However, the difference in the decreases in CH between the two groups was not statistically significant (p = 0.206). SO tamponade may affect corneal biomechanical parameters in the early postoperative period, which may be related to the surgery itself, SO tamponade or IOP changes.
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http://dx.doi.org/10.1007/s10792-013-9830-7DOI Listing
June 2014