Publications by authors named "Farshid Reza Forghani"

4 Publications

  • Page 1 of 1

Cytotoxicity of two resin-based sealers and a fluoride varnish on human gingival fibroblasts.

Iran Endod J 2015 18;10(2):89-92. Epub 2015 Mar 18.

Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran;

Introduction: Assessment of cellular cytotoxicity is a regular method for evaluating the biocompatibility of novel materials. In a recent study, 5% fluoride varnish (Duraflur) has shown reasonable sealing ability and coverage of root canal walls when used as a sealer. The aim of the present study was to compare the cytotoxicity of Duraflur varnish with two popular commonly used root canal sealers (AH-Plus and AH-26) on human gingival fibroblasts (HGF).

Methods And Materials: The HGFs were incubated with different concentrations (1/2, 1/4, and 1/8) of AH-plus, AH-26, and Duraflur varnish for 24 h. The percentage of cell viability was assessed with methyl-thiazol-tetrazolium (MTT) assay. The data was analyzed using the one-way ANOVA followed by Student-Newman-Keuls test. The level of significance was set at 0.001.

Results: MTT assay showed that higher concentrations of the tested materials resulted in lower viability of HGFs. AH-Plus showed significantly greater cell viability compared to AH-26 at all dilutions (P<0.001); however, no significant difference was found between Duraflur and AH-Plus in terms of cell viability at 1/8 dilution (P>0.001). Duraflur showed significantly higher cell viability compared to AH-26 except at 1/2 dilution (P<0.001).

Conclusion: Although Duraflur varnish had better biocompatibility compared to AH-26, it should still be evaluated with further biocompatibility tests such as intraosseous and subcutaneous implantation.
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April 2015

Fluoride varnish as root canal sealer: a scanning electron microscopy and bacterial penetration study.

Iran Endod J 2015 24;10(1):64-8. Epub 2014 Dec 24.

Department of Endodontic, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: This study was carried out to evaluate the bacterial leakage of root canal fillings when cavity varnish containing 5% fluoride (Duraflur) was used as root canal sealer.

Methods And Materials: Root canals of 88 straight single-rooted teeth were prepared. Eighty teeth were randomly divided into 3 experimental groups (n=20) and two positive and negative control groups of ten each. The roots in group I and II were obturated with gutta-percha and AH-26 sealer using lateral condensation technique. The root canal walls in group II were coated with a layer of varnish before obturation. In group III the canals were obturated with gutta-percha and fluoride varnish as the sealer. Enterococcus faecalis (E. faecalis) was used to determine the bacterial leakage during 90 days. The Kaplan Meier survival analysis was used for assessing the leakage and log rank test was used for pairwise comparison. The rest of eight single rooted teeth were selected for scanning electron microscopy (SEM) evaluation with 5000× magnification.

Results: Leakage occurred between 20 to 89 days. Group III showed significantly less bacterial penetration than groups I and II (P=0.001 and P=0.011, respectively). However, there was no significant difference between group I and II (P>0.05). SEM evaluation showed that the varnish had covered all dentinal tubules.

Conclusion: The present study showed promising results for the use of fluoride varnish as root canal sealer but further in vitro and in vivo studies are needed.
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January 2015

Long-term effect of an educational intervention regarding dental trauma first aid: a phase II study.

Dent Traumatol 2014 Aug 26;30(4):296-301. Epub 2014 Jan 26.

Oral and Dental Diseases Research Center/Department of Endodontics, Kerman University of Medical Sciences, Kerman, Iran.

Aim: Interventions that improve knowledge about emergency management of traumatic dental injuries may be a good way to achieve a more favorable prognosis in such situations. We set out to evaluate the short- and long-term effects of combined educational interventions on health teachers, including lecture presentation, question-and-answer sessions, and informational posters to promote awareness regarding emergency measures for traumatized teeth. Assessment was performed using a three-part questionnaire, including demographic data, knowledge, and self-assessment. Using a census sampling method, 52 health teachers of 68 potential candidates participated in the study. The questionnaires of 38 teachers who participated at all three intervals, including before (T0), immediately after (T1), and 36 months after (T2) the intervention, were analyzed. Statistical analysis involved Cochrane and McNemar's tests. Totally, results revealed an increase in knowledge from T0 to T1 and T2 intervals (P < 0.017). This study shows the positive effect of educational campaigns and, therefore, serves to encourage professionals to embark on innovative educational programs in this field.
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August 2014

Effect of bupivacaine on postoperative pain for inferior alveolar nerve block anesthesia after single-visit root canal treatment in teeth with irreversible pulpitis.

J Endod 2012 Aug 30;38(8):1035-9. Epub 2012 May 30.

Oral and Dental Diseases Research Center, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: Pain control after root canal treatment is of great importance in endodontic practice. The aim of the present study was to investigate the effect of a long-acting anesthetic (bupivacaine) on postoperative pain and the use of analgesics after root canal treatment.

Methods: In a randomized double-blinded clinical trial, 60 patients (30 per group) having first or second mandibular molars with irreversible pulpitis randomly received either 0.5% bupivacaine with 1:200,000 epinephrine or 2% lidocaine with 1:80,000 epinephrine as the anesthetic solutions for inferior alveolar nerve blocks. After single-visit root canal treatment, each patient recorded their pain score on a visual analogue scale at 6, 12, 24, 36, 48, and 72 hours after treatment. Data were analyzed by Mann-Whitney, χ(2), Cochrane Q, and t tests as well as Pearson correlation analysis.

Results: The results indicate that patients who received bupivacaine had significantly lower pain scores at 6 and 12 hours after root canal treatment compared with the patients who received lidocaine (P < .05). The use of analgesics in the bupivacaine patients was significantly lower than in the lidocaine group (P < .05).

Conclusions: Patients who received bupivacaine as the anesthetic agent for single-visit endodontic treatment of irreversible pulpitis in mandibular molars had significantly less early postoperative pain and used fewer analgesics than those who had lidocaine as the anesthetic.
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August 2012