Publications by authors named "Farnaz Khatami"

11 Publications

  • Page 1 of 1

Promoting sustainable physical activity among middle-aged Iranian women: a conceptual model-based interventional study.

BMC Womens Health 2021 Jan 2;21(1). Epub 2021 Jan 2.

Community Medicine Department, Tehran University of Medical Sciences, Tehran, Iran.

Background: Physical inactivity enhances the risk of adverse health conditions such as non-communicable diseases, morbidity, and mortality among middle- and older-aged population. This study is aimed to design, implement, and evaluate a conceptual model of physical activity (PA) promotion among middle-aged Iranian women (MAIW).

Methods: An interventional study was conducted with 80 women aged between 30 and 59 years in intervention and control groups during 2018-2019. The subjects referred to health centers were selected by the available convenience sampling method. Data collection tools to assess the MAIW' PA level (metabolic equivalent tasks (MET)-min/week) included face-to-face interviews, body mass index (BMI) measurements, the four-question form of PA vital signs in the framework of Iran's Package of Essential Non-communicable (IraPEN) program, and the questionnaire is based on the Health Belief Model (HBM) constructs.

Results: The intervention led to a three-fold increase in the average PA (from 280.63 to 927.70 MET-min/week) of the intervention group. Although no significant difference in the BMI between both groups was found before the intervention, this educational program decreased the mean BMI from 30.36 to 28.83 kg/m (p = 0.01). After the intervention, the values of HBM-based perceived sensitivity/severity and self-efficacy were increased from 62.09 to 71.03% and from 27.01 to 83.15%, respectively (p < 0.0001). There were no significant differences in the cue to action and perceived benefits and barriers after the intervention.

Conclusion: The developed model by increasing the motivation of MAIW could remarkably improve the PA level with a decrease in their BMI. Trial register Iranian Registry of Clinical Trials (IRCT): IRCT20200717048124N1 at 2020-08-05, retrospectively registered.
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http://dx.doi.org/10.1186/s12905-020-01152-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777291PMC
January 2021

The effect of vitamin D supplementation on the progression of benign prostatic hyperplasia: A randomized controlled trial.

Clin Nutr 2020 Nov 7. Epub 2020 Nov 7.

Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aims: Inflammation and proliferation are the cause of benign prostatic hyperplasia (BPH) and are the key components of its mechanism of action. In this study we sought to determine the role of 25-hydroxyvitamin D in BPH, because of its anti-inflammatory activities, and its effect on prostate volume and BPH symptoms.

Methods: This randomized clinical trial (RCT) was conducted on 108 participants >50 years of age who had either asymptomatic or mild BPH symptoms according to the International Prostate Symptom Score (IPSS) questionnaire. Patients were randomly divided into two groups, intervention and control. The intervention group received 50 000 units of vitamin D3 and the control group received a placebo every two weeks for six months. Prostate ultrasound, routine clinical examinations, toucher rectal (TR), and laboratory tests were performed for all patients. After six months, the patients underwent another ultrasound evaluation, measurement of prostate-specific antigen (PSA) levels and completed the IPSS. Results of the evaluations before and after the intervention were compared between the groups using the chi-square, t-test, and logistic regression analysis. Repeated measure analysis was used to evaluate the effect of vitamin D intervention on the changes in the IPSS score.

Results: The mean age of the participants was 56 ± 9 years. In the control group, the mean prostate volume was higher compared to the intervention group (p < 0.001). The control group had a higher mean PSA level than the intervention group (p < 0.001). Although the IPSS score decreased over time in both groups, analysis of variance showed that the amount of change or decrease in IPSS score in the intervention group was significantly more than the control group (p < 0.001).

Conclusions: The results of our study support the effect of vitamin D in reducing prostate volume and PSA levels, and in improving BPH symptoms. Further studies are needed to confirm these findings to verify the use of vitamin D as a treatment for BPH.
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http://dx.doi.org/10.1016/j.clnu.2020.11.005DOI Listing
November 2020

Patients' preferences in selecting family physician in primary health centers: a qualitative-quantitative approach.

BMC Fam Pract 2020 06 11;21(1):107. Epub 2020 Jun 11.

Department of Family Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: The role of family physicians (FPs) in the metropolitan area is critical in identifying risk factors for disease prevention/control and health promotion in various age groups. Understanding patients' preferences and interests in choosing a FP can be an effective and fundamental step in the success of this program. In this study factors affecting the FP selection by Iranian patients referred to health centers in the most populous areas in the south of Tehran were assessed and ranked.

Methods: A sequential mixed-method (qualitative-quantitative) triangulation approach was designed with three subject groups of patients, physicians, and health officials. The Framework method was used to analyze interviews transcribed verbatim. After implementing an iterative thematic process, a 26-item quantitative questionnaire with high validity and reliability was drafted to evaluate the different factors. A convenient sampling method was used to select 400 subjects on a population-based scale to quantitatively rank the most critical selection factors as a mean score of items.

Results: The selection factors were divided into six centralized codes, including FPs' ethics, individual, professional and performance factors; patients' underlying disease and individual health, and disease-related factors, office's location and management factors, democracy factors, economic factors, and social factors. After filling out the questionnaires, the most important factors in selecting FP were a specialist degree in family medicine (FM) (4.49 ± 0.70), performing accurate examinations with receiving a detailed medical history (4.43 ± 0.68), and spending enough time to visit patients (4.28 ± 0.75), respectively. However, the parameters such as being a fellow-citizen, being the same gender, and physician's appearance were of the least importance.

Conclusion: There is a possibility to screen the most important factors affecting the FP choice through the combination of qualitative and quantitative studies. The first and last patients' priority was physicians' specialty in FM and being a fellow-citizen with them, respectively. The clinical and administrative healthcare systems should schedule the entire implementation process to oversee the doctor's professional commitment and setting the visit times of FP.
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http://dx.doi.org/10.1186/s12875-020-01181-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291526PMC
June 2020

Association of Internet Addiction with Emotional and Behavioral Characteristics of Adolescents.

Iran J Psychiatry 2020 Jan;15(1):55-66

Department of Epidemiology and Biostatistics, School of Public health, Tehran University of Medical Sciences, Tehran, Iran.

This study aimed to measure the prevalence of internet addiction and its impact on the psychological well-being of adolescents in Tehran, considering the sociodemographic characteristics. In this cross sectional study, a total of 945 (mean age of 14.85) students (522 boys and 423 girls) were recruited by 2-stage clustering sampling method in 2017. The Chen Internet Addiction Scale (CIAS) and Youth Self-Report (YSR) were used to measure internet addiction and psychological characteristics, respectively. The data were analyzed using multiple-logistic regression analysis adjusted for internet addiction and sociodemographic variables. Overall, 20% of the adolescents were internet addicts. Gender, consanguineous marriage, and father's education level were significantly associated with internet addiction. Regarding emotional and behavioral characteristics, internet addiction was significantly associated with the scores of internalizing (OR = 5.03; 95% CI: 3.05-8.28) and externalizing problems (OR = 5.84; 95% CI: 3.61-9.43), the total score of empirical scales (OR = 6.51; 95% CI: 3.71-11.6), and all DSM-oriented scales of the YSR (p < 0.001). Except for school performance, other competency scales had no correlations with internet addiction. Regarding the high prevalence of the internet addiction and its correlation with emotional and behavioral characteristics, students and their parents should be advised of the detrimental impacts of internet addiction and try to focus on its constructive application.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193233PMC
January 2020

Association between ABO blood group and severity of coronary artery disease in unstable angina.

ARYA Atheroscler 2017 Jul;13(4):172-175

Assistant Professor, Department of Cardiology, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: ABO blood groups are genetically transmitted through chromosome 9 at locus 9q34. It is supposed that there is a locus on 9p21, which has a role in developing coronary artery disease.

Methods: Our study population consisted of 309 patients with unstable angina admitted to the Ziaeian Hospital, Tehran, Iran, who underwent coronary angiography. The association between types of blood group (O and non-O) with the severity of coronary artery disease was investigated.

Results: Compared to the non-O groups, the O group had more severe coronary artery involvement (P = 0.004).

Conclusion: Our study supports recent suggestions on the association between blood group and coronary artery disease. Further studies are needed to evaluate the effect of blood group on atherosclerosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677320PMC
July 2017

Short stay in general intensive care units: is it always necessary?

Med J Islam Repub Iran 2014 8;28:143. Epub 2014 Dec 8.

2. MD, Resident in Community Medicine, Community Medicine specialist, Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: There are challenges ahead of short-term hospitalization of low-risk patients hospitalized only for monitoring of severe disease who may die soon after admission. The purpose of this study was to suggest strategies forthe management of ICU stay lengths and to ensure optimal use of ICU resources.

Methods: The study was conducted retrospectively on 246 patients admitted to 9 general ICUs in Tehran, from September 2011 to March 2012. Patients staying for≤2 days in the ICU were compared to each other after being categorized into two medical and surgical groups.

Results: Of 129 patients with≤2 days ICU stay (52.4%), 88.4% survived. Of these, 25 (19.4%) were placed in the medical and 104 (80.6%) to surgical groups. Survival rates were significantly greater in surgical group; only 7.7% of them were in need of mechanical ventilation in the first 24 hours of admission (p<0.001). In contrast to medical group, the average Acute Physiology and Chronic Health Evaluation (APACHE) II score in the surgical group was significantly lower (9.8±3.6 and 17.3±5.8) (p<0.001).

Conclusion: The majority of patients with≤2 days LOS in the surgical group hospitalized for monitoring after surgery had low mortality rate and APACHE-II score. Therefore, it would seem that transferring such patients to the intermediate care unit leads to more efficient and optimal use of ICU resources.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322340PMC
February 2015

Socioeconomic position and incidence of gastric cancer: a systematic review and meta-analysis.

J Epidemiol Community Health 2015 Aug 5;69(8):818-9. Epub 2014 Aug 5.

Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

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http://dx.doi.org/10.1136/jech-2013-203784DOI Listing
August 2015

The relationship between body mass index and outcomes in leukemic patients undergoing allogeneic hematopoietic stem cell transplantation.

Clin Transplant 2012 Jan-Feb;26(1):149-55. Epub 2011 Apr 7.

Faculty of Pharmacy, Department of Clinical Pharmacy, Tehran University of Medical Sciences Hematology-Oncology, Tehran, Iran.

Hematopoietic stem cell transplantation (HSCT) is being used increasingly in an attempt to cure many hematological disorders. Obesity has become a world wide phenomenon and is a known risk factor for numerous medical conditions, but its role in transplant outcomes remained controversial. Total of 192 patients with acute leukemia who underwent sibling HLA matched HSCT were analyzed to find the effect of pre-transplant body mass index (BMI) on transplant outcomes such as time to engraftment, infections, graft vs. host disease (GvHD), and overall survival (OS) for the period of three yr (April 2006-March 2009). There was a significant correlation between higher pre-transplant BMI and shorter engraftment time (p = 0.010); but no relation between BMI and GvHD, infection, and OS was found. The results of this study showed that patients with higher BMI may have a shorter engraftment time; but lower, although not significant, survival rate compared to non-obese patients.
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http://dx.doi.org/10.1111/j.1399-0012.2011.01445.xDOI Listing
June 2012

Comparison of peripheral blood stem cell transplant with bone marrow transplant in class 3 thalassemic patients.

Exp Clin Transplant 2010 Mar;8(1):66-73

Tehran University of Medical Sciences, Department of Hematology, Tehran, Iran.

Objectives: This study aimed to compare outcome of bone marrow transplant with peripheral blood stem cell transplant in class 3 thalassemic patients.

Materials And Methods: Respectively, 32 and 20 class 3 thalassemic patients received bone marrow transplant and peripheral blood stem cell transplant from human leukocyte antigen identical sibling donors. Conditioning regimen consisted of busulfan (16 mg/kg) and cyclophosphamide (160 mg/kg) followed by cyclosporine and methotrexate as graft-versus-host disease prophylaxes.

Results: Median time to absolute neutrophil count was significantly shorter in the peripheral blood stem cell transplant group (12 vs 23 days); however, there was no significant difference regarding platelet recovery between the 2 groups (20 vs 28 days). Acute graft-versus-host disease occurred in 47% of patients. Chronic graft-versus-host disease developed in 28% of patients which was significantly higher in the peripheral blood stem cell transplant group (P = .06). During 50 months follow-up, thalassemia recurrence, overall survival, and thalassemia-free survival were 17%, 80%, and 65%, respectively, and there were no significant differences between the 2 groups.

Conclusions: These results showed that stem cell transplant is an effective treatment in class 3 thalassemic patients with the outcome relatively similar to bone marrow transplant. Although engraftment time is shorter in peripheral blood stem cell transplant method, it is associated with higher rate of chronic graft-versus-host disease.
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March 2010

Stem cell transplantation; Iranian experience.

Arch Iran Med 2009 Jan;12(1):69-72

Hematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

From March 1991 through 31st December 2007, 2042 patients underwent stem cell transplantation at the Hematology-Oncology and Stem Cell Transplantation Research Center, affiliated to Tehran University of Medical Sciences. These transplantations included 1405 allogeneic stem cell transplantation, 624 autologous stem cell transplantation, and 13 syngeneic stem cell transplantation. Stem cell transplantation was performed for various diseases including acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphoblastic leukemia, thalassemia major, sickle cell thalassemia, sickle cell disease, multiple myeloma, myelodysplasia, mucopolysaccharidosis, paroxysmal nocturnal hemoglobinuria, non-Hodgkin's lymphoma, Hodgkin's disease, severe aplastic anemia, plasma cell leukemia, Niemann-Pick disease, Fanconi anemia, severe combine immunodeficiency, congenital neutropenia, leukocyte adhesion deficiencies, Chediak-Higashi syndrome, osteopetrosis, histiocytosis X, Hurler syndrome, amyloidosis, systemic sclerosis, breast cancer, Ewing's sarcoma, testicular cancer, germ cell tumors, neuroblastoma, medulloblastoma, renal cell carcinoma, nasopharyngeal carcinoma, ovarian cancer, Wilms' tumor, rhabdomyosarcoma, pancreatoblastoma, and multiple sclerosis. We had 105 cellular therapies for postmyocardial infarction, multiple sclerosis, cirrhosis, head of femur necrosis, and renal cell carcinoma. About 30 patients were retransplanted in this center. About 74.9% of the patients (1530 of 2042) remained alive between one to 168 months after stem cell transplantation. Nearly 25.1% (512 of 2042) of our patients died after stem cell transplantation. The causes of deaths were relapse, infections, hemorrhagic cystitis, graft versus host disease, and others.
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January 2009

Hematopoietic stem cell transplantation in Iran: 1991 to 2008.

Hematol Oncol Stem Cell Ther 2008 Oct-Dec;1(4):231-8

Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, Iran.

Since 1991, 2042 first hematopoietic stem cell transplants (HSCT) have been performed at the Hematology-Oncology and Stem Cell Transplantation Research Center at Tehran University of Medical Sciences. Acute myelogenous leukemia (548 patients), thalassemia major (335 patients) and acute lymphoblastic leukemia (275 patients) have been the most common transplanted disorders. There were 1418 cases that received allogeneic HSCT and 624 cases that have received autologous HSCT. The numbers of allogeneic and autologous HSCT have increased, but the allogeneic to autologous ratio has remained constant. The first peripheral blood hematopoietic stem cell transplantation was performed in 1996; since then, 1671 have been done. The donor types for 1418 allogeneic first HSCT were 1367 (96.4%) human leukocyte antigen (HLA) matched-identical siblings, 29 (2%) HLA-mismatched sibling/other relative, 13 (0.9%) syngeneic twins, 5 (0.4%) HLA-matched other relatives and 4 (0.3%) unrelated. The first cord blood hematopoietic stem cell transplantation was performed in 1998 and since then there have been 14 patients that have obtained cord blood transplantations. Recently, new methods have been used like donor lymphocyte infusion (DLI) and cellular therapy. There were 111 patients with cellular therapy for post-myocardial infarction, cirrhosis, thalassemia major, multiple sclerosis, head of femur necrosis and renal cell carcinoma.
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http://dx.doi.org/10.1016/s1658-3876(08)50010-0DOI Listing
May 2010