Publications by authors named "Fardin Moradi"

8 Publications

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Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial.

Trials 2021 Mar 25;22(1):231. Epub 2021 Mar 25.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM).

Materials And Methods: In this double-blind, randomized, placebo-controlled trial, 50 T2DM patients were randomly allocated to intervention and control groups which received two tablets of either melatonin or placebo (250 mg) once a day for 8 weeks. Systolic blood pressure (SBP), mean arterial pressure (MAP), pulse pressure (PP), the atherogenic index of plasma (AIP), weight, body mass index (BMI), waist and hip circumference (WC, HC), a body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), lipid accumulation product (LAP), conicity index, and waist-to-height ratio (WHtR) were evaluated in all the patients pre- and post-intervention.

Results: Melatonin supplementation for 8 weeks significantly decreased the mean levels of SBP, MAP, PP, weight, BMI, WC, HC, BAI, AVI, conicity index, and WHtR post-intervention (p <  0.05). Also, the median changes of SBP, MAP, PP, weight, BMI, WC, HC BAI, AVI, and conicity index were significantly lower in the intervention group compared with the control group (p <  0.05). A significant increase (p <  0.001) was observed in the mean levels of ABSI in the intervention group. The median changes of ABSI were significantly greater in the intervention group compared with the control group (p <  0.001).

Conclusions: Consumption of melatonin supplement may be effective in controlling arterial pressure including SBP, MAP, and PP and anthropometric indices (as predictors of obesity) in T2DM patients.

Trial Registration: Iranian Registry of Clinical Trials IRCT20190303042905N1 . Registered on 17 May 2019.
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http://dx.doi.org/10.1186/s13063-021-05174-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995760PMC
March 2021

A pilot study of the effects of chromium picolinate supplementation on serum fetuin-A, metabolic and inflammatory factors in patients with nonalcoholic fatty liver disease: A double-blind, placebo-controlled trial.

J Trace Elem Med Biol 2021 Jan 30;63:126659. Epub 2020 Sep 30.

Nutrition Research Center, Department of Biochemistry & Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Science, Iran. Electronic address:

Background: Evaluating the impact of chromium picolinate supplementation on glycemic status, lipid profile, inflammatory markers and fetuin-A in patients with non-alcoholic fatty liver disease (NAFLD).

Methods: In present research, participants (N = 46) were randomized to (400 mcg/day, n = 23) chromium picolinate and placebo (n = 23) for 3 months.

Results: Glucose indices, and lipid profiles, inflammatory biomarker and fetuin-A were measured before and after the intervention. Chromium reduced triglyceride (TG), atherogenic index of plasma (AIP), very-low-density lipoprotein (VLDL), insulin, homeostatic model assessment for insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), interleukin (IL) -6, tumor necrosis factor-alpha (TNF-α) and fetuin-A significantly compared to placebo group (p < 0.05). Furthermore, chromium significantly increased the quantitative insulin sensitivity check index (QUICKI). There were no significant differences in total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), fasting blood sugar (FBS), Hemoglobin A1c (HbA1C), interleukin (IL)-17 between the two groups (p < 0.05).

Conclusion: Chromium picolinate significantly decreased TG, insulin, HOMA-IR, fetuin-A, the number of inflammatory factors, and increased QUICKI without changing FBS, HbA1C, TC, LDL, HDL, IL-17 levels and liver steatosis intensity in patients with NAFLD. Further studies by examining the effect of different doses of chromium and mechanisms of cellular action, would help further clarify the subject.
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http://dx.doi.org/10.1016/j.jtemb.2020.126659DOI Listing
January 2021

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial.

Eur J Gastroenterol Hepatol 2020 Aug 14. Epub 2020 Aug 14.

Nutrition Research Center, Department of Biochemistry & Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz.

Objective: Nonalcoholic fatty liver disease (NAFLD) is a complicated disease and is considered as a severe global health problem affecting 30% of adults worldwide. The present study aimed to evaluate changes in oxidative stress, adipokines, liver enzyme, and body composition following treatment with chromium picolinate (CrPic) among patients with NAFLD.

Participants And Methods: The current randomized, double-blind, placebo-controlled study was conducted on 46 NAFLD patients with the age range of 20-65 years. Patients were randomly classified into two groups, receiving either 400 µg CrPic tablets in two divided doses of 200 µg (23 patients) or placebo (23 patients) daily for 12 weeks. The participants' body composition and biochemical parameters were evaluated at the baseline and after 12 weeks.

Results: Serum levels of liver enzymes reduced significantly only in the CrPic group (P < 0.05 for all), but not between the groups after the intervention. Besides, there were significant differences between the study groups regarding body weight and body fat mass, total antioxidant capacity, superoxide dismutase, malondialdehyde, leptin, and adiponectin post-intervention (P = 0.017, P = 0.032, P = 0.003, P = 0.023, P = 0.012, P = 0.003, and P = 0.042, respectively). However, glutathione peroxidase and resistin levels did not differ significantly between groups (P = 0.127 and P = 0.688, respectively).

Discussion And Conclusion: This study showed that consuming 400 µg/day of CrPic for 12 weeks in patients with NAFLD causes a significant change in leptin, adiponectin, oxidative stress (expect glutathione peroxidase), and body weight, compared to baseline. Nevertheless, it does not affect liver enzymes. Therefore, the CrPic supplementation may improve adipokines, some anthropometric indices, and oxidative stress in patients with NAFLD.
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http://dx.doi.org/10.1097/MEG.0000000000001830DOI Listing
August 2020

The predictors of access to health services for people with disabilities: A cross sectional study in Iranian context.

Med J Islam Repub Iran 2019 23;33:125. Epub 2019 Nov 23.

Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

In developing countries, people with disabilities (PWD) are more likely to have unequitable access to health care services than their counterparts without disabilities. Access to health care is a multidimensional concept and PWD experience various barriers to use health care. This quantitative study explored the predictors and determents of access to health care for PWD in an Iranian context. Data were collected from a cross sectional study conducted in Tehran in 2017. A total of 403 adults with physical and/or intellectual disabilities were selected using census method. The data on PWD were collected from 14 rehabilitation centers affiliated to Welfare Organization and Red Crescent Organization. The self-report World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to collect data on disability status. T test, ANOVA, and multiple linear regressions were used to determine factors influencing access to health care for PWD. Significance level was set at 5%. Also, SPSS software version 20.0 was used for data analysis. The mean of access to health care among people with intellectual disabilities (mean: 61.77, 95% confidence interval (CI):59.20, 64.35) was significantly lower than their counterparts with physical disabilities (Mean: 67.97, 95% CI: 65.26, 70.69). The results of multiple linear regression analysis showed that in the affordability dimension, type of disability, marital status, and supplemental health insurance could predict access to health services for PWD. In availability dimension, only location predicted the outcome variable significantly. Also, location and type of disability were considered to be potential predictors of access to health services in acceptability dimension. The results indicate that various factors can limit access to health services for PWD. To achieve universal health coverage, vulnerable groups and their needs should be identified to increase equitable access to health care services. Also, the health care system should pay more attention to demographic differences when planning and providing affordable and acceptable health care for PWD. Finally, the role of the government as the heath stewardship is vital to promote health care access for PWD in Iran.
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http://dx.doi.org/10.34171/mjiri.33.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137830PMC
November 2019

Potential roles of chromium on inflammatory biomarkers in diabetes: A Systematic.

Clin Exp Pharmacol Physiol 2019 11 16;46(11):975-983. Epub 2019 Aug 16.

Nutrition Research Centre, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Diabetes, as a low-grade chronic inflammatory disease, causes disruption in proper function of immune and metabolic system. Chromium is an important element required for normal lipid and glucose metabolism. Chromium deficiency is correlated with elevation in cardiometabolic risk, which results from increased inflammation. This systematic review was conducted to discover the potential roles of chromium on inflammatory biomarkers. Eligible studies were all in vitro, animal and human studies published in English-language journals from inception until October 2018. PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched to fined interventional studies from the effects of chromium on inflammatory biomarkers such as tumour necrosis factor a (TNF-a), C-reactive protein (CRP), interleukins, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and adipocytokines in hyperglycaemia and diabetes. Out of 647 articles found in the search, only 14 articles were eligible for analysis, three in vitro studies, eight animal studies and three human studies. Twelve of the 14 studies included in this review, chromium significantly decreased inflammatory factors. The findings of this review indicate, based on in vitro and in vivo studies, that chromium might have potential anti-inflammatory properties, but some of the studies did not show anti-inflammatory effects for chromium (two studies). There are only three studies in humans with controversial results. Therefore, more consistent randomized double-blind controlled trials are needed to reach relevant clinical recommendations, as well as to determine the precise mechanism, of chromium on inflammation in diabetes.
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http://dx.doi.org/10.1111/1440-1681.13144DOI Listing
November 2019

10-year survival in coronary artery bypass grafting surgery patients in Tehran heart center, coronary outcome measurement study: Predictive power of dietary inflammatory index and dietary antioxidant quality.

Nutrition 2019 Jul - Aug;63-64:22-28. Epub 2019 Jan 25.

Road Traffic Injury Research Center, Department of Epidemiology and Biostatistics, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: There is a higher rate of mortality from cardiovascular disease (CVD) in Iran and the mortality rate increases even after coronary artery bypass grafting (CABG). The aim of this study was to evaluate the association between mortality and survival in patients 10 y after CABG, using the dietary inflammatory index (DII) and dietary antioxidant indices.

Methods: In the current prospective cohort study, 450 patients with CVD who were referred to the Tehran Heart Center and who underwent an isolated CABG during the 6-mo period between April and September 2006 were enrolled. Anthropometric measurements and clinical assessments were performed. Biochemical assay, including hemoglobin A1c, serum lipids, creatinine, blood urea nitrogen, lipoprotein(a), albumin, and C-reactive protein, were also measured. DII, dietary antioxidant quality (DAQ) scores, and dietary Mediterranean quality index (MEDQI) were measured using the data obtained from a semi-quantitative food frequency questionnaire. Survival analysis was performed using the Kaplan-Meir method followed by log-rank test. The association between all-cause mortality and study parameters was performed with Cox proportional hazard model.

Results: According to the present results, older ages, male sex, lower educational attainment, opium use, previous history of diabetes and myocardial infarction, and higher hematocrit and creatinine concentrations were associated with higher mortality rates. Among nutritional indices, a high inflammatory diet was a positive predictor of mortality, whereas a higher DAQ score was a negative predictor (P < 0.05). No association was found between the MEDQI score and mortality rate among patients.

Conclusion: According to the present findings, a diet high in inflammatory foods and low in antioxidant content is a potent predictor of mortality 10 y post-CABG. Therefore, reducing the inflammatory potential of the diet and improving its antioxidant content will be a preventive strategy for reducing mortality after CABG.
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http://dx.doi.org/10.1016/j.nut.2019.01.011DOI Listing
September 2020

Potential roles of carnitine in patients with polycystic ovary syndrome: a systematic review.

Gynecol Endocrinol 2019 Jun 26;35(6):463-469. Epub 2019 Feb 26.

c Nutrition Research Center, Faculty of Nutrition and Food Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.

Polycystic ovary syndrome (PCOS) is recognized as the most prevalent endocrinopathy in reproductive-aged women. This systematic review was performed with focus on the current knowledge on carnitine concerning metabolic variables in PCOS. PubMed, Scopus, Embase, ClinicalTrials.gov and Google Scholar databases were searched from inception until May 2018. All clinical trials and observational studies published in English-language journals were eligible. Studies that provided insufficient outcomes, animal and in vitro studies were excluded. Out of 451 articles identified in our search, only six articles were eligible for analysis. Two observational studies evaluated the association of serum carnitine levels with metabolic variables, and four clinical trials examined the effect of carnitine supplementation in patients with PCOS. Serum carnitine levels had inverse relationship with glycemic status, body mass index (BMI) and waist circumference. Also, carnitine supplementation resulted in improved weight loss, glycemic status, oxidative stress, follicles and size of ovarian cells; no significant effects were reported on sex hormones and lipid profile. According to the current evidence, carnitine might improve weight loss, glycemic status and oxidative stress. However, to explore the exact mechanisms of carnitine role in patients with PCOS, further studies are recommended.
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http://dx.doi.org/10.1080/09513590.2019.1576616DOI Listing
June 2019

Obesity in people with disability: The implications for health care expenditures.

J Res Med Sci 2016 8;21:26. Epub 2016 Apr 8.

Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Social Development & Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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http://dx.doi.org/10.4103/1735-1995.179895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122211PMC
April 2016