Faraz Kazmi

Faraz Kazmi

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Faraz Kazmi

Faraz Kazmi

Publications by authors named "Faraz Kazmi"

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17Publications

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Characterization of the In Vitro Inhibitory Potential of the Oligonucleotide Imetelstat on Human Cytochrome P450 Enzymes with Predictions of In Vivo Drug-Drug Interactions.

Drug Metab Dispos 2019 01 2;47(1):9-14. Epub 2018 Nov 2.

Drug Metabolism and Pharmacokinetics, Janssen Research & Development, LLC, Spring House, Pennsylvania (F.K., C.S.) and Drug Metabolism and Pharmacokinetics, Janssen Research & Development, LLC., Raritan, New Jersey (T.G.).

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0841
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http://dx.doi.org/10.1124/dmd.118.084103DOI Listing
January 2019

An Assessment of the In Vitro Inhibition of Cytochrome P450 Enzymes, UDP-Glucuronosyltransferases, and Transporters by Phosphodiester- or Phosphorothioate-Linked Oligonucleotides.

Drug Metab Dispos 2018 Aug 7;46(8):1066-1074. Epub 2018 May 7.

Sekisui XenoTech LLC, Kansas City, Kansas (F.K., P.Y., C.M., D.B.B., B.W.O.); Janssen Research & Development LLC, Spring House, Pennsylvania (F.K.); XPD Consulting, Shawnee, Kansas (A.P.); and Roivant Sciences, Durham, North Carolina (D.B.B.).

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http://dx.doi.org/10.1124/dmd.118.081729DOI Listing
August 2018

A new 4-variable formula to differentiate normal variant ST segment elevation in V2-V4 (early repolarization) from subtle left anterior descending coronary occlusion - Adding QRS amplitude of V2 improves the model.

J Electrocardiol 2017 Sep - Oct;50(5):561-569. Epub 2017 Apr 19.

Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN. Electronic address:

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http://dx.doi.org/10.1016/j.jelectrocard.2017.04.005DOI Listing
June 2018

The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments.

Drug Metab Dispos 2015 Nov 9;43(11):1744-50. Epub 2015 Sep 9.

XenoTech, LLC, Lenexa, Kansas (L.J.H., F.K., B.W.O., D.B.B., B.D.S., S.L.); and XPD Consulting, Shawnee, Kansas (B.P., O.P., A.P.)

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http://dx.doi.org/10.1124/dmd.115.066597DOI Listing
November 2015

Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor.

Drug Metab Dispos 2015 Sep 1;43(9):1294-302. Epub 2015 Jul 1.

XenoTech, LLC, Lenexa, Kansas (F.K., P.Y., J.E.B.) and XPD Consulting, Shawnee, Kansas (A.P)

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http://dx.doi.org/10.1124/dmd.115.065011DOI Listing
September 2015

A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.

Drug Metab Dispos 2015 Apr 16;43(4):523-33. Epub 2015 Jan 16.

XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.).

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http://dx.doi.org/10.1124/dmd.114.062620DOI Listing
April 2015

Anti-CD28 monoclonal antibody-stimulated cytokines released from blood suppress CYP1A2, CYP2B6, and CYP3A4 in human hepatocytes in vitro.

Drug Metab Dispos 2015 Jan 17;43(1):42-52. Epub 2014 Oct 17.

XenoTech, LLC, Lenexa, Kansas (M.C., F.K., D.B.B.); and XPD Consulting, Shawnee, Kansas (A.P.).

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http://dx.doi.org/10.1124/dmd.114.060186DOI Listing
January 2015

Association between tumour volume and recurrence of squamous cell carcinoma of the head and neck.

J Pak Med Assoc 2012 Nov;62(11):1129-33

Aga Khan University Hospital, Karachi, Pakistan.

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November 2012

Familial presence of early onset Fuchs' corneal endothelial dystrophy, a report of two rare cases.

J Pak Med Assoc 2012 Jul;62(7):728-30

Section of Ophthalmology, Department of Surgery, Aga Khan University, Karachi.

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July 2012