Publications by authors named "Fang Jiang"

199 Publications

Research on remote sensing ecological environmental assessment method optimized by regional scale.

Environ Sci Pollut Res Int 2021 Jul 15. Epub 2021 Jul 15.

Qinghai Bureau of Coal Geology, Qinghai, 810000, China.

As the global ecosystem has been severely disturbed by an increasing number of human activities at different scales, remote sensing technology, as an effective quantitative measure of environmental quality, has been widely used. The remote sensing ecological index (RSEI) is one of the most popular and comprehensive ecological quality assessment indices based on the remote sensing data. However, the RSEI model exhibits that the ecological environment under natural conditions is not limited by the spatial scales. In addition, the model has major shortcomings in index selection and eigenvector, which greatly limit the application of RSEI. In this paper, the RSEI model is improved and a remote sensing ecological index optimized by the regional scale (RO-RSEI) is proposed. The result of the study, conducted in Shuangyang District, Changchun City, Jilin Province, shows that the RO-RSEI model has regional ecological significance after the introduction of the scale theory of landscape ecology; the index is preferred to solve problems like the RSEI model applied mechanization and baseless index selection. Meanwhile, due to the optimization of the eigenvector contribution of the optimal index, it solves the problems like non-unique model calculation result caused by principal component analysis or even antipodal calculation result. Compared with the RSEI model, the monitoring result of RO-RSEI model can better reflect the regional ecological changes. The improved model offers the possibility of monitoring ecological environment quality with remote sensing big data and provides a scientific basis for future scholars' batch computing.
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http://dx.doi.org/10.1007/s11356-021-15262-xDOI Listing
July 2021

Changes of tuning but not dynamics of contrast adaptation with age.

Vision Res 2021 Jul 9;187:129-136. Epub 2021 Jul 9.

University of Nevada, Reno, United States.

Normal aging results in pronounced optical and neural changes in the visual system. Processes of adaptation are thought to help compensate for many of these changes in order to maintain perceptual constancy, but it is uncertain how stable adaptation itself remains with aging. We compared the dynamics of adaptation in young (aged 19-24 years) and older (aged 66-74) adults. Contrast thresholds for Gabor patterns were tracked during and after 300 s adaptation to vertical and horizontal Gabor patches. The time course of contrast adaptation and asymptotic adaptation magnitude were similar between older and young adults when normalized for their respective baseline thresholds. Older adults showed stronger transfer of adaptation to the orthogonal orientation and there was an asymmetry between the transfer of adaptation between the horizontal and vertical orientations for both groups. These results suggest age-related changes in orientation tuning while the processes of cortical contrast adaptation remain largely intact with aging.
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http://dx.doi.org/10.1016/j.visres.2021.03.015DOI Listing
July 2021

Duration Comparisons for Vision and Touch Are Dependent on Presentation Order and Temporal Context.

Front Integr Neurosci 2021 23;15:664264. Epub 2021 Jun 23.

Integrative Neuroscience Program, University of Nevada, Reno, Reno, NV, United States.

Integrating visual and tactile information in the temporal domain is critical for active perception. To accomplish this, coordinated timing is required. Here, we study perceived duration within and across these two modalities. Specifically, we examined how duration comparisons within and across vision and touch were influenced by temporal context and presentation order using a two-interval forced choice task. We asked participants to compare the duration of two temporal intervals defined by tactile or visual events. Two constant standard durations (700 ms and 1,000 ms in 'shorter' sessions; 1,000 ms and 1,500 ms in 'longer' sessions) were compared to variable comparison durations in different sessions. In crossmodal trials, standard and comparison durations were presented in different modalities, whereas in the intramodal trials, the two durations were presented in the same modality. The standard duration was either presented first () or followed the comparison duration (). In both crossmodal and intramodal conditions, we found that the longer standard duration was overestimated in trials and underestimated in trials whereas the estimation of shorter standard duration was unbiased. Importantly, the estimation of 1,000ms was biased when it was the longer standard duration within the shorter sessions but not when it was the shorter standard duration within the longer sessions, indicating an effect of temporal context. The effects of presentation order can be explained by a central tendency effect applied in different ways to different presentation orders. Both crossmodal and intramodal conditions showed better discrimination performance for trials than trials, supporting the Type B effect for both crossmodal and intramodal duration comparison. Moreover, these results were not dependent on whether the standard duration was defined using tactile or visual stimuli. Overall, our results indicate that duration comparison between vision and touch is dependent on presentation order and temporal context, but not modality.
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http://dx.doi.org/10.3389/fnint.2021.664264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261066PMC
June 2021

[Stable isotope ratio characteristics and origin tracing of ].

Ying Yong Sheng Tai Xue Bao 2021 Jun;32(6):2021-2027

Shandong Marine Resource and Environment Research Institute, Yantai 264006, Shandong, China.

A method for geographical discrimination of was explored to provide technical support for the protection of geographical indication products and for tracing the origin of seafood. were collected from three major production areas, including the Yellow Sea, the Bohai Sea, and the East China Sea. The variations of carbon and nitrogen stable isotope values of origins and the correlation of stable isotope ratios in different tissues were analyzed. The results showed that there were significant differences in carbon and nitrogen stable isotope ratio among different origins. Significant isotope fractionation effects were observed among different tissues. The discriminant model was developed and the origin discriminant analysis was performed by the stable isotope ratios of different tissues in The correct rate of origin diffe-rentiationf using carbon and nitrogen stable isotopes in muscle and gills (>95%) was significantly higher than that of hepatopancreas and gonad, indicating that stable isotope ratios of muscle and gills could effectively differentiate in different sea areas. This study filled the gap of stable isotope tracing technology for .
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http://dx.doi.org/10.13287/j.1001-9332.202106.025DOI Listing
June 2021

Course of illness and outcomes in older COVID-19 patients treated with HFNC: a retrospective analysis.

Aging (Albany NY) 2021 06 28;13(12):15801-15814. Epub 2021 Jun 28.

Department of Anesthesiology, The University of Hong Kong, Hong Kong, China.

Coronavirus disease-2019 (COVID-19) has rapidly spread worldwide and causes high mortality of elderly patients. High-flow nasal cannula therapy (HFNC) is an oxygen delivery method for severely ill patients. We retrospectively analyzed the course of illness and outcomes in 110 elderly COVID-19 patients (≥65 years) treated with HFNC from 6 hospitals. 38 patients received HFNC (200 mmHg < PaO/FiO ≤ 300 mmHg, early HFNC group), and 72 patients received HFNC (100 mmHg < PaO/FiO ≤ 200 mmHg, late HFNC group). There were no significant differences of sequential organ failure assessment (SOFA) scores and APECH II scores between early and late HFNC group on admission. Compared with the late HFNC group, patients in the early HFNC group had a lower likelihood of developing severe acute respiratory distress syndrome (ARDS), longer time from illness onset to severe ARDS and shorter duration of viral shedding after illness onset, as well as shorter lengths of ICU and hospital stay. 24 patients died during hospitalization, of whom 22 deaths (30.6%) were in the late HFNC group and 2 (5.3%) in the early HFNC group. The present study suggested that the outcomes were better in severely ill elderly patients with COVID-19 receiving early compared to late HFNC.
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http://dx.doi.org/10.18632/aging.203224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266360PMC
June 2021

InO/oxygen doped g-CN towards photocatalytic BPA degradation: Balance of oxygen between metal oxides and doped g-CN.

J Colloid Interface Sci 2021 Jun 4;602:261-273. Epub 2021 Jun 4.

Key Laboratory of Jiangsu Province for Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address:

Hybrid semi-conductor heterojunction appears to be a promising technology for pollutant removal and wastewater treatment. However, the interface modification of the heterojunction and the working mechanisms remain elusive, thus impeding the development of highly efficient photocatalysis. In this work, we highlighted the key role played by the 3D/2D InO/oxygen doped graphitic carbon nitrides (g-CN) heterojunction, named InO/OGCN, on the photocatalytic performance. The characteristic results showed a balance of oxygen between InO and OGCN, which enabled a stable interaction in the heterojunction to specifically tune the oxidation power, and this strategy can be applied to rationally control the photocatalytic activity of organic pollutants. The optimized InO/OGCN heterojunction demonstrated a notable photocatalytic degradation capability for bisphenol A (BPA), which was better than that of pristine InO and OGCN, respectively. This photocatalyst had a great physical stability and can be recycled for further use. Meanwhile, the exceptional photodegradation capacity was attributed to spatially separated charge carriers, fast-charge transportation characteristics, and the special band gap structure of InO/OGCN heterojunction. In addition, the covalent bond between In-O significantly improved oxygen stability in the lattice, thereby increasing the reliability of the material. This research presents a new opportunity to fabricate metal oxides/OGCN heterojunction photocatalysts which have potential application in wastewater treatment by adjusting the oxygen between the two compounds in heterojunction.
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http://dx.doi.org/10.1016/j.jcis.2021.06.003DOI Listing
June 2021

Task-dependent audiovisual temporal sensitivity is not affected by stimulus intensity levels.

Vision Res 2021 Sep 28;186:71-79. Epub 2021 May 28.

Department of Psychology, University of Nevada, 1664 N. Virginia St., Reno, NV 89557, USA.

Flexibility and robustness of multisensory temporal recalibration is paramount for maintaining perceptual constancy of the surrounding natural world. Different environments impart various impediments, distances and routes that alter the propagation times of sight and sound cues comprising a multimodal event. One's ability to rapidly calibrate and account for these external variations allows for maintained perception of synchrony which is crucial for coherent and consistent perception. The two common paradigms used to compare precision of temporal processing between experimental and control groups, the simultaneity judgment (SJ) and temporal order judgment (TOJ) tasks, often use supra-threshold stimuli. However, few studies have specifically examined the effects of normalizing stimulus intensities to participant's unisensory detection thresholds. The current project presented multiple combinations of auditory and visual stimulus intensity levels, based on individual detection thresholds, during a TOJ and a SJ task. While no effect of stimulus intensity was found on temporal sensitivity or perceived temporal synchrony, there was a significant difference in point of subjective simultaneity (PSS) measures between tasks. In addition, PSS estimates were audio-leading, rather than visual-leading as previously reported, suggesting that exposure to the particular combinations of stimulus intensity levels used influenced temporal synchrony perception. Overall, these results support the use of supra-threshold stimuli in TOJ and SJ tasks as a way of minimizing the confound from differences in unisensory processing.
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http://dx.doi.org/10.1016/j.visres.2021.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273142PMC
September 2021

CoO @Co-NC Catalyst with Dual Active Centers for Enhanced Oxygen Evolution: Breaking Trade-Off of Particle Size and Metal Loading.

Chemistry 2021 Jul 27;27(41):10657-10665. Epub 2021 May 27.

Key Laboratory of Jiangsu Province for Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.

Increasing the metal loading and downsizing the metal particle size are two effective ways to boost the electrochemical performance of catalysts. However, it is difficult to simultaneously increase the metal loading and reduce the particle size since isolated individual atoms are easy to aggregate into nanoparticles when increasing the metal loading. To tackle this contradiction, we report a bottom-up ligand-mediated strategy to facilely prepare ultrafine CoO nanoclusters anchored on a Co-N-containing carbon matrix (CoO @Co-NC). The co-exist of N and O atoms prevent Co atoms agglomerating into large particles and allowing the formation of ultrafine dispersed Co species with large Co loading (up to 20 wt.%). Since the relationship between ultrasmall size and large metal loading is well balanced, the CoO nanoclusters have no inhibitory effect, but facilitate the catalytic performance of Co-N sites during OER process. Consequently, due to the synergistic effect of ultrafine CoO nanoclusters and Co-N macrocycles, the as-synthesized CoO @Co-NC exhibit promising OER activity (η =370 mV, Tafel plot=40 mV/dec), bettering than that of benchmark RuO (η =411 mV, Tafel plot=72 mV/dec). This ligand-mediated strategy to synthesize carbonaceous materials containing dual active centers with large metal loading is promising for developing active and stable catalysts for electrocatalytic applications.
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http://dx.doi.org/10.1002/chem.202100642DOI Listing
July 2021

Electrocatalytic performance of Sb-modified BiFeO for nitrogen fixation.

J Colloid Interface Sci 2021 Jul 9;593:335-344. Epub 2021 Mar 9.

Key Laboratory of Jiangsu Province for Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, PR China.

The Haber-Bosch N fixation method suffers from the power-consuming and harsh conditions. In contrast, the electrochemical conversion of N (NRR) at room temperature and atmospheric pressure is considered a promising alternative route. In this study, we synthesized Sb-modified with BiFeO (BFSO/BFO) by using one-step hydrothermal treatment. The BFSO/BFO catalyst has higher selectivity to NRR than BiFeO (BFO) under the same applied voltage. Such large interfacial interaction area plays a critical role in transfer electron and enhances the density of current. The resulting BFSO/BFO heterojunction showed significant electrocatalytic activity under controllable voltage, which exhibited favorable average ammonia (NH) yield as high as 2.62 μg·h·cm at -0.2 V versus RHE. Moreover, the stability of the BFSO/BFO composite was evaluated for six cycles and the results were desirable. This study provides a new insight into the design of composite catalysts using BFO, which has high activity and selectivity toward NRR.
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http://dx.doi.org/10.1016/j.jcis.2021.02.106DOI Listing
July 2021

Safety and efficacy of remote ischemic conditioning for the treatment of intracerebral hemorrhage: A proof-of-concept randomized controlled trial.

Int J Stroke 2021 Apr 7:17474930211006580. Epub 2021 Apr 7.

Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.

Background: Remote ischemic conditioning can promote hematoma resolution, attenuate brain edema, and improve neurological recovery in animal models of intracerebral hemorrhage.

Aims: This study aimed to evaluate the safety and preliminary efficacy of remote ischemic conditioning in patients with intracerebral hemorrhage.

Methods: In this multicenter, randomized, controlled trial, 40 subjects with supratentorial intracerebral hemorrhage presenting within 24-48 h of onset were randomly assigned to receive medical therapy plus remote ischemic conditioning for consecutive seven days or medical therapy alone. The primary safety outcome was neurological deterioration within seven days of enrollment, and the primary efficacy outcome was the changes of hematoma volume on CT images. Other outcomes included hematoma resolution rate at 7 days ([hematoma volume at 7 days - hematoma volume at baseline]/hematoma volume at baseline), perihematomal edema (PHE), and functional outcome at 90 days.

Results: The mean age was 59.3 ± 11.7 years and hematoma volume was 13.9 ± 4.5 mL. No subjects experienced neurological deterioration within seven days of enrollment, and no subject died or experienced remote ischemic conditioning-associated adverse events during the study period. At baseline, the hematoma volumes were 14.19 ± 5.07 mL in the control group and 13.55 ± 3.99 mL in the remote ischemic conditioning group, and they were 8.54 ± 3.99 mL and 6.95 ± 2.71 mL at seven days after enrollment, respectively, which is not a significant difference ( > 0.05 each). The hematoma resolution rate in the remote ischemic conditioning group (49.25 ± 9.17%) was significantly higher than in the control group (41.92 ± 9.14%; MD, 7.3%; 95% CI, 1.51-13.16%;  = 0.015). The absolute PHE volume was 17.27 ± 8.34 mL in the control group and 12.92 ± 7.30 mL in the remote ischemic conditioning group at seven days after enrollment, which is not a significant between-group difference ( = 0.087), but the relative PHE in the remote ischemic conditioning group (1.77 ± 0.39) was significantly lower than in the control group (2.02 ± 0.27; MD, 0.25; 95% CI, 0.39-0.47;  = 0.023). At 90-day follow-up, 13 subjects (65%) in the remote ischemic conditioning group and 12 subjects (60%) in the control group achieved favorable functional outcomes (modified Rankin Scale score ≤ 3), which is not a significant between-group difference ( = 0.744).

Conclusions: Repeated daily remote ischemic conditioning for consecutive seven days was safe and well tolerated in patients with intracerebral hemorrhage, and it may be able to improve hematoma resolution rate and reduce relative PHE. However, the effects of remote ischemic conditioning on the absolute hematoma and PHE volume and functional outcomes in this patient population need further investigations. http://www.clinicaltrials.gov. Unique identifier: NCT03930940.
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http://dx.doi.org/10.1177/17474930211006580DOI Listing
April 2021

Review of the risk factors for SARS-CoV-2 transmission.

World J Clin Cases 2021 Mar;9(7):1499-1512

Department of Anaesthesiology, Institute of Anaesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which has lasted for nearly a year, has made people deeply aware of the strong transmissibility and pathogenicity of SARS-CoV-2 since its outbreak in December 2019. By December 2020, SARS-CoV-2 had infected over 65 million people globally, resulting in more than 1 million deaths. At present, the exact animal origin of SARS-CoV-2 remains unclear and antiviral vaccines are now undergoing clinical trials. Although the social order of human life is gradually returning to normal, new confirmed cases continue to appear worldwide, and the majority of cases are sporadic due to environmental factors and lax self-protective consciousness. This article provides the latest understanding of the epidemiology and risk factors of nosocomial and community transmission of SARS-CoV-2, as well as strategies to diminish the risk of transmission. We believe that our review will help the public correctly understand and cope with SARS-CoV-2.
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http://dx.doi.org/10.12998/wjcc.v9.i7.1499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942044PMC
March 2021

RNF216 regulates meiosis and PKA stability in the testes.

FASEB J 2021 04;35(4):e21460

Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.

Spermatogenesis is a highly sophisticated process that comprises of mitosis, meiosis, and spermiogenesis. RNF216 (ring finger protein 216), an E3 ubiquitin ligase, has been reported to be essential for spermatogenesis and male fertility in mice. However, the stages affected by Rnf216 deficiency and its underlying molecular pathological mechanisms are still unknown. In this study, we generated Rnf216-deficient mice (Rnf216 ) using CRISPR-Cas9 technology. Knockout of Rnf216 led to infertility in male but not female mice. Rnf216 knockout affected the prophase of meiosis I, as no genotypic difference was observed until 12 dpp (days postpartum). Rnf216 spermatocytes were incompletely arrested at the zygotene stage and underwent apoptosis at approximately the pachytene stage. The proportion of zygotene spermatocytes was significantly increased, whereas the proportion of pachytene spermatocytes was significantly decreased in Rnf216 testes. Nevertheless, there was no significantly genotypic difference in the number of diplotene spermatocytes. We further revealed that the PKA catalytic subunit β (PRKACB) was significantly increased, which subsequently resulted in elevated PKA activity in testes from adult as well as 9 dpp Rnf216 mice. RNF216 interacts with PRKACB and promotes its degradation through the ubiquitin-lysosome pathway. Collectively, our results revealed an important role for RNF216 in regulation of meiosis and PKA stability in the testes.
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http://dx.doi.org/10.1096/fj.202002294RRDOI Listing
April 2021

Cross-modal motion aftereffects transfer between vision and touch in early deaf adults.

Sci Rep 2021 Feb 23;11(1):4395. Epub 2021 Feb 23.

Department of Psychology, University of Nevada, Reno, NV, 89557-0296, USA.

Previous research on early deafness has primarily focused on the behavioral and neural changes in the intact visual and tactile modalities. However, how early deafness changes the interplay of these two modalities is not well understood. In the current study, we investigated the effect of auditory deprivation on visuo-tactile interaction by measuring the cross-modal motion aftereffect. Consistent with previous findings, motion aftereffect transferred between vision and touch in a bidirectional manner in hearing participants. However, for deaf participants, the cross-modal transfer occurred only in the tactile-to-visual direction but not in the visual-to-tactile direction. This unidirectional cross-modal motion aftereffect found in the deaf participants could not be explained by unisensory motion aftereffect or discrimination threshold. The results suggest a reduced visual influence on tactile motion perception in early deaf individuals.
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http://dx.doi.org/10.1038/s41598-021-83960-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902672PMC
February 2021

Obstetric outcomes for twins from different conception methods - A multicenter cross-sectional study from China.

Acta Obstet Gynecol Scand 2021 06 11;100(6):1061-1067. Epub 2021 Mar 11.

Department of Obstetrics and Gynecology, Harbin Nangang District Maternity Hospital, Nangang, Harbin Province, China.

Introduction: The effects of assisted reproductive technology on the outcomes of twin pregnancies are controversial. Therefore, the purpose of this study was to compare the maternal and perinatal outcomes of twin pregnancies conceived spontaneously and those conceived by assisted reproductive technology.

Material And Methods: This was a cross-sectional study performed at Peking Union Medical College Hospital (PUMCH). Data on twin pregnancies (conceived spontaneously and by in vitro fertilization [IVF]/intracytoplasmic sperm injection [ICSI]) were obtained from the National Birth Registry of China for the period between 1 October 2016, and 30 September 2017. The primary obstetric outcomes were compared between twin pregnancies conceived by different methods. Logistic regression analysis with 95% confidence intervals (95% CI) was used for the multivariate analysis.

Results: A total of 3270 twin pregnancies (2003 and 1209 conceived spontaneously and by IVF/ICSI, respectively) were identified. The proportion of twin pregnancies among all pregnancies was 3.4% (3332/97 278). Multiple regression analysis indicated that the incidences of gestational diabetes mellitus (adjusted odds ratio [AOR] = 1.42, 95% CI 1.10-1.83, p = 0.007), preterm premature rupture of membranes (AOR = 1.65, 95% CI 1.21-2.25, p = 0.002), placenta accreta spectrum (AOR = 2.12, 95% CI 1.42-3.17, p < 0.001) and postpartum hemorrhage (AOR = 1.38, 95% CI 1.02-1.86, p = 0.037) were significantly higher in the IVF/ICSI group than in the natural pregnancy group. Multivariate analysis also revealed that conception mode was not an independent risk factor for neonate outcomes.

Conclusions: In twin pregnancies, IVF/ICSI is independently associated with multiple maternal complications, including gestational diabetes mellitus, preterm premature rupture of membranes and placenta accreta spectrum compared with spontaneous conception, although potential residual confounders due to indications for assisted reproductive technology exist.
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http://dx.doi.org/10.1111/aogs.14116DOI Listing
June 2021

Wall Density-Controlled Thermal Conductive and Mechanical Properties of Three-Dimensional Vertically Aligned Boron Nitride Network-Based Polymeric Composites.

ACS Appl Mater Interfaces 2021 Feb 2;13(6):7556-7566. Epub 2021 Feb 2.

School of Materials Science and Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, PR China.

Polymeric composites with good thermal conductive and improved mechanical properties are in high demand in the thermal management materials. Construction of a three-dimensional (3D) structure has been proved to be an effective method to obtain polymeric composites with improved through-plane thermal conductivity (TC) for efficient thermal management of electronics. However, the TC enhancement of the obtained polymeric composites is limited, mainly due to poor control of the 3D thermal conductive network. Additionally, achieving high thermal conductive properties and enhanced mechanical properties simultaneously is of great challenge for polymeric composites. In this work, a 3D boron nitride framework (BNF) with a well-defined vertically aligned open structure and designed wall density fabricated by a unidirectional freezing technique was applied. The as-prepared BNF/polyethylene glycol (PBNF) composites exhibit enhanced through-plane TC, excellent thermal transfer capability (Δ = 34 °C), and improved mechanical properties (Young's modulus enhancement up to 356%) simultaneously, making it attractive to thermal management applications. Strong correlation between the TC and mechanical properties of the PBNF composites and the wall density of the BNF scaffolds was found, providing opportunities to tune the TC and mechanical properties through the controlling of wall density. Furthermore, the models between TC and Young's modulus of PBNF composites were established by using the data-driven method "sure independence screening and sparsifying operator", which enables us to predict TC and Young's modulus of the polymeric composites for designing promising composite materials. The design principles and fabrication strategies proposed in this work could be important for developing advanced composite materials.
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http://dx.doi.org/10.1021/acsami.0c22702DOI Listing
February 2021

[A modified gentamicin protection assay for detecting invasive phenotype of Salmonella enterica serovar Enteritidis].

Sheng Wu Gong Cheng Xue Bao 2020 Nov;36(11):2459-2466

School of Life Sciences, Ludong University, Yantai 264025, Shandong, China.

Salmonella enterica serovar Enteritidis (SE) is one of the most important zoonotic pathogens that cause enteritis and systemic infection in animals and human. Understanding invasive capacities of SE isolates is of vital importance to elucidate pathogenesis of Salmonella infection. To improve the throughput capacity and repeatability of classical gentamicin protection assay (GPA), a modified PGA was developed by taking high-throughput advantage of 96-well cell plates and multichannel pipettes. In addition, drop plate technique rather than spread plate method was applied in the modified GPA protocol for bacterial enumeration. The modified GPA protocol was evaluated by phenotyping intracellular replication of a high virulent and a low virulent SE isolates, JL228 and LN248, in a phagocytic cell line RAW264.7. The protocol was then applied in invasive phenotype determination of 16 SE strains to non-phagocytes (HT-29) and the intracellular replication of 43 SE strains to phagocytes (RAW264.7). Significant lower intra-group and inter-group coefficient of variations of the modified GPA was observed, implying good repeatability and reproducibility over traditional protocol. Further, replication phenotypes were also correlated with those from direct observation by confocal microscopy. Collectively, the improved GPA protocol had advantages of high throughput capacity, good repeatability and reliability, it was also noticed that the protocol also represented a fast and labor-saving alternative scheme for the invasive phenotype determination of Salmonella Enteritidis, and providing reliable phenotype profiles for Salmonella-host interplay interpretation.
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http://dx.doi.org/10.13345/j.cjb.200171DOI Listing
November 2020

Clinical features of a Chinese female nongestational choriocarcinoma cohort: a retrospective study of 37 patients.

Orphanet J Rare Dis 2020 11 18;15(1):325. Epub 2020 Nov 18.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Beijing, 100730, China.

Background: Choriocarcinoma is a rare malignant neoplasm, which is classified as either gestational choriocarcinoma or nongestational choriocarcinoma. The purpose of this study was to examine the clinical characteristics of Chinese female nongestational choriocarcinoma patients and discuss our experience in treating this rare disease.

Results: We conducted a single-center retrospective study on a sample of 37 nongestational choriocarcinoma patients who were diagnosed and treated at Peking Union Medical College Hospital from March 1982 to March 2020. Their demographic, clinical, laboratory, and therapeutic data were collected. Detailed information was available for all 37 individuals in our sample. The primary lesions included 34 in the ovaries, 2 in the pituitary and 1 in the stomach. The median age of onset was 22 years, and the median follow-up period spanned 41 months. The lungs (40.5%) were the most commonly observed metastatic site. All subjects were treated with surgery and multidrug chemotherapies, and a median of 4.0 courses was required to achieve complete remission. The overall complete response rate, relapse rate, and 3-year and 5-year survival rates were 81.1%, 16.7%, 80.0%, and 75.5%, respectively.

Conclusions: Nongestational choriocarcinoma can be managed well using surgery and multidrug chemotherapies, but the overall outcome of nongestational choriocarcinoma is still worse than that of gestational choriocarcinoma. Mixed nongestational choriocarcinoma seems to have similar therapeutic outcomes as pure tumors.
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http://dx.doi.org/10.1186/s13023-020-01610-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672987PMC
November 2020

Electrophysiological Dynamics of Visual-Tactile Temporal Order Perception in Early Deaf Adults.

Front Neurosci 2020 23;14:544472. Epub 2020 Sep 23.

Department of Psychology, University of Nevada, Reno, Reno, NV, United States.

Studies of compensatory plasticity in early deaf (ED) individuals have mainly focused on unisensory processing, and on spatial rather than temporal coding. However, precise discrimination of the temporal relationship between stimuli is imperative for successful perception of and interaction with the complex, multimodal environment. Although the properties of cross-modal temporal processing have been extensively studied in neurotypical populations, remarkably little is known about how the loss of one sense impacts the integrity of temporal interactions among the remaining senses. To understand how auditory deprivation affects multisensory temporal interactions, ED and age-matched normal hearing (NH) controls performed a visual-tactile temporal order judgment task in which visual and tactile stimuli were separated by varying stimulus onset asynchronies (SOAs) and subjects had to discern the leading stimulus. Participants performed the task while EEG data were recorded. Group averaged event-related potential waveforms were compared between groups in occipital and fronto-central electrodes. Despite similar temporal order sensitivities and performance accuracy, ED had larger visual P100 amplitudes for all SOA levels and larger tactile N140 amplitudes for the shortest asynchronous (± 30 ms) and synchronous SOA levels. The enhanced signal strength reflected in these components from ED adults are discussed in terms of compensatory recruitment of cortical areas for visual-tactile processing. In addition, ED adults had similar tactile P200 amplitudes as NH but longer P200 latencies suggesting reduced efficiency in later processing of tactile information. Overall, these results suggest that greater responses by ED for early processing of visual and tactile signals are likely critical for maintained performance in visual-tactile temporal order discrimination.
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http://dx.doi.org/10.3389/fnins.2020.544472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539666PMC
September 2020

Upregulation of Prickle2 Ameliorates Alzheimer's Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer's Disease.

Front Cell Dev Biol 2020 8;8:565020. Epub 2020 Sep 8.

Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that has no effective therapies. Prickle planar cell polarity protein 2 (Prickle2), is an important cytoplasmic regulator of Wnt/PCP signaling. It has been reported that Prickle2 deficiency reduced neurite outgrowth levels in mouse N2a cells and led to autism-like behaviors and hippocampal synaptic dysfunction in mice. However, much less is known about the relationship of Prickle2 to AD pathogenesis. RT-qPCR, Western blot and IHC results showed that the mRNA and protein levels of Prickle2 were reduced in APP/PS1/Tau transgenic (3xTg) mice. Intravenous injection of Prickle2-overexpressing AAV-PHP.eB vectors improved the cognitive deficits in 3xTg mice. We also demonstrated that Prickle2 could repress oxidative stress and neuroinflammation, ameliorate the amyloid β (Aβ) plaque pathology and reduce Tau hyperphosphorylation in APP/PS1 mice. Further investigation of the mechanism of Prickle2 in AD revealed that Prickle2 inhibited Wnt/PCP/JNK pathway in vivo and in vitro. Our results suggest that Prickle2 might be a potential candidate for the diagnosis and treatment of AD.
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http://dx.doi.org/10.3389/fcell.2020.565020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509431PMC
September 2020

Increased Right Posterior STS Recruitment Without Enhanced Directional-Tuning During Tactile Motion Processing in Early Deaf Individuals.

Front Neurosci 2020 25;14:864. Epub 2020 Aug 25.

Department of Psychology, University of Nevada, Reno, Reno, NV, United States.

Upon early sensory deprivation, the remaining modalities often exhibit cross-modal reorganization, such as primary auditory cortex (PAC) recruitment for visual motion processing in early deafness (ED). Previous studies of compensatory plasticity in ED individuals have given less attention to tactile motion processing. In the current study, we aimed to examine the effects of early auditory deprivation on tactile motion processing. We simulated four directions of tactile motion on each participant's right index finger and characterized their tactile motion responses and directional-tuning profiles using population receptive field analysis. Similar tactile motion responses were found within primary (SI) and secondary (SII) somatosensory cortices between ED and hearing control groups, whereas ED individuals showed a reduced proportion of voxels with directionally tuned responses in SI contralateral to stimulation. There were also significant but minimal responses to tactile motion within PAC for both groups. While early deaf individuals show significantly larger recruitment of right posterior superior temporal sulcus (pSTS) region upon tactile motion stimulation, there was no evidence of enhanced directional tuning. Greater recruitment of right pSTS region is consistent with prior studies reporting reorganization of multimodal areas due to sensory deprivation. The absence of increased directional tuning within the right pSTS region may suggest a more distributed population of neurons dedicated to processing tactile spatial information as a consequence of early auditory deprivation.
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http://dx.doi.org/10.3389/fnins.2020.00864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477335PMC
August 2020

Reproductive outcomes after floxuridine-based regimens for gestational trophoblastic neoplasia: A retrospective cohort study in a national referral center in China.

Gynecol Oncol 2020 11 8;159(2):464-469. Epub 2020 Sep 8.

Department of Obstetrics & Gynaecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China.

Objective: To analyze the reproductive outcomes of gestational trophoblastic neoplasia (GTN) patients who were cured only by floxuridine-based regimens.

Methods: This was a retrospective analysis of 464 patients who were treated with only floxuridine-based regimens at Peking Union Medical College Hospital between January 2002 and December 2013 and retained their reproductive ability. Their reproductive outcomes were analyzed. The factors affecting pregnancy intention were identified by logistic regression.

Results: Of the 464 patients (average age, 28.0 ± 5.7 years; median follow-up = 85 months), the livebirth rate was 72.2%, while the rates of spontaneous abortion, induced abortion and ectopic pregnancy were 9.2% (n = 41), 8.7% (n = 39) and 1.8% (n = 8), respectively. The GTN recurrence rate was 2.1%. The time from chemotherapy completion to first conception in the induced abortion group was significantly shorter than those in spontaneous abortion, full-term/premature, and ectopic pregnancy groups (P ≤ 0.001, <0.001, =0.015, respectively). The logistic analysis showed that the age at onset of GTN (OR = 0.899, 95% CI 0.851-0.951, P < 0.001), parity at onset of GTN (parity = 1, OR = 0.123, 95% CI 0.068-0.225, P < 0.001; parity = 2-3, OR = 0.058, 95% CI 0.014-0.232, P < 0.001) and interval from the index pregnancy to chemotherapy were independent factors affecting pregnancy intention. Among the 36 pregnancies occurring within 12 months postchemotherapy, only one choriocarcinoma occurred, and 20 culminated in induced abortions (55.6%).

Conclusions: After floxuridine-based chemotherapy, the pregnancy rate of GTN patients after fertility-preserving treatment is comparable to that of the normal population. Pregnancy losses within one year after chemotherapy completion are mainly caused by induced abortion.
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http://dx.doi.org/10.1016/j.ygyno.2020.08.018DOI Listing
November 2020

Prediction Equations of the Multifrequency Standing and Supine Bioimpedance for Appendicular Skeletal Muscle Mass in Korean Older People.

Int J Environ Res Public Health 2020 08 12;17(16). Epub 2020 Aug 12.

Department of Sports Medicine, Soonchunhyang University, Asan 31438, Korea.

Bioimpedance analysis (BIA) has been demanded for the assessment of appendicular skeletal muscle mass (ASM) in clinical and epidemiological settings. This study aimed to validate BIA equations for predicting ASM in the standing and supine positions; externally to cross-validate the new and published and built-in BIA equations for group and individual predictive accuracy; and to assess the overall agreement between the measured and predicted ASM index as sarcopenia diagnosis. In total, 199 healthy older adults completed the measurements of multifrequency BIA (InBody770 and InBodyS10) and dual-energy X-ray absorptiometry (DXA). Multiple regression analysis was used to validate the new multifrequency bioelectrical impedance analysis (MF-BIA) prediction equations. Each MF-BIA equation in the standing and supine position developed in the entire group included height/resistance, sex, and reactance as predictors ( = 92.7% and 92.8%, SEE = 1.02 kg and 1.01 kg ASM for the standing and supine MF-BIA). The new MF-BIA equations had a specificity positive predictive value and negative predictive value of 85% or more except for a sensitivity of about 60.0%. The new standing and supine MF-BIA prediction equation are useful for epidemiological and field settings as well as a clinical diagnosis of sarcopenia. Future research is needed to improve the sensitivity of diagnosis of sarcopenia using MF-BIA.
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http://dx.doi.org/10.3390/ijerph17165847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459522PMC
August 2020

Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China.

Aging (Albany NY) 2020 07 11;12(13):12504-12516. Epub 2020 Jul 11.

Department of Anesthesiology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei, China.

The mortality rate of elderly patients with Coronavirus Disease 2019 (COVID-19) was significantly higher than the overall mortality rate. However, besides age, leading death risk factors for the high mortality in elderly patients remain unidentified. This retrospective study included 210 elderly COVID-19 patients (aged ≥ 65 years), of whom 175 patients were discharged and 35 died. All deceased patients had at least one comorbidity. A significantly higher proportion of patients in the deceased group had cardiovascular diseases (49% vs. 20%), respiratory diseases (51% vs. 11%), chronic kidney disease (29% vs. 5%) and cerebrovascular disease (20% vs. 3%) than that in the discharged group. The median levels of C-reactive protein (125.8mg/L vs. 9.3mg/L) and blood urea nitrogen (7.2mmol/L vs. 4.4mmol/L) were significantly higher and median lymphocyte counts (0.7×10/L vs. 1.1×10/L) significantly lower in the deceased group than those in the discharged group. The survival curve analysis showed that higher C-reactive protein (≥5mg/L) plus any other abnormalities of lymphocyte, blood urea nitrogen or lactate dehydrogenase significantly predicted poor prognosis of COVID-19 infected elderly patients. This study revealed that the risk factors for the death in these elderly patients included comorbidities, increased levels of C-reactive protein and blood urea nitrogen, and lymphopenia during hospitalization.
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http://dx.doi.org/10.18632/aging.103631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377843PMC
July 2020

A first-in-human, phase 1, dose-escalation study of ABBV-176, an antibody-drug conjugate targeting the prolactin receptor, in patients with advanced solid tumors.

Invest New Drugs 2020 12 10;38(6):1815-1825. Epub 2020 Jun 10.

HonorHealth Research Institute, Scottsdale, AZ, 85258, USA.

ABBV-176 is an antibody-drug conjugate composed of the humanized antibody h16f (PR-1594804) conjugated to a highly potent, cytotoxic cross-linking pyrrolobenzodiazepine dimer (PBD; SGD-1882) targeting the prolactin receptor (PRLR), which is overexpressed in several solid tumor types. This phase 1, dose-escalation study (NCT03145909) evaluated the safety, pharmacokinetics, and preliminary activity of ABBV-176 in patients with advanced solid tumors likely to exhibit elevated levels of PRLR. Patients received ABBV-176 once every 3 weeks. Dose escalation was by an exposure-adjusted, continual reassessment method. Dose-limiting toxicities (DLTs) were assessed from the first day of dosing until the next dose of ABBV-176 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D). Nineteen patients received ABBV-176 at doses from 2.7-109.35 μg/kg. Patients enrolled had colorectal cancer (n = 11), breast cancer (n = 6), or adrenocortical carcinoma (n = 2). DLTs occurred in 4 patients and included thrombocytopenia (n = 2; both at 99.9-μg/kg dose level), neutropenia (n = 2; 78.3-μg/kg and 99.9-μg/kg dose levels), and pancytopenia (n = 1; 109.35-μg/kg dose level). The most common treatment-emergent adverse events related to ABBV-176 were thrombocytopenia, neutropenia, increased aspartate aminotransferase, nausea, fatigue, and pleural effusions. Effusions and edema were common, and timing of onset suggested possible cumulative ABBV-176 toxicity. Tumor expression of PRLR varied among patients enrolled and analyzed. No patient had an objective response. MTD was not formally determined, as identification of a tolerable dose was confounded by late-onset toxicities. ABBV-176 was associated with significant toxicity in this phase 1, dose-escalation study. Although cytopenias were often dose limiting, effusions and edema were also common and had late onset that suggested cumulative toxicity. No responses were observed, although data were available from a small number of patients with variable tumor PRLR expression. This study was terminated after the dosing of 19 patients.
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http://dx.doi.org/10.1007/s10637-020-00960-zDOI Listing
December 2020

Genotypic and phenotypic spectrum of CCDC141 variants in a Chinese cohort with congenital hypogonadotropic hypogonadism.

Eur J Endocrinol 2020 Sep;183(3):245-254

School of Life Sciences, Central South University, Changsha, Hunan, China.

Objective: To identify CCDC141 variants in a large Chinese cohort with congenital hypogonadotropic hypogonadism (CHH) and to assess the contribution of CCDC141 to CHH.

Design: Detailed phenotyping was conducted in CHH patients with CCDC141 variants and co-segregation analysis was performed, when possible.

Methods: Whole-exome sequencing was performed in 177 CHH patients and 450 unrelated, ethnically matched controls from China.

Results: Seven novel CCDC141 rare sequencing variants (RSVs) were identified in 12 CHH pedigrees. Four of the variants were private mutations; however, p.Q409X, p.Q871X and p.G1488S were identified in more than one patient. Up to 75% (9/12) of patients had mutations in other CHH-associated genes, which is significantly higher than CHH patients without CCDC141 RSVs. The co-segregation analysis for eight CHH families showed that 75% (6/8) CCDC141 RSVs were inherited from their fertile parents. Over half (58.3%, 8/18) of the patients exhibited other clinical deformities in addition to hypogonadism. One patient harbouring a CCDC141 RSV showed a reversal of CHH after sex-steroid replacement.

Conclusions: Our results broaden the genotypic spectrum of CCDC141 in CHH, as CCDC141 RSVs alone do not appear sufficient to cause CHH. The phenotypic spectrum in patients with CCDC141 RSVs is much wider than originally believed.
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http://dx.doi.org/10.1530/EJE-19-1018DOI Listing
September 2020

Visual discomfort from flicker: Effects of mean light level and contrast.

Vision Res 2020 08 28;173:50-60. Epub 2020 May 28.

Department of Psychology, University of Nevada, Reno, 1664 N. Virginia Street, Reno, Nevada 89557, USA.

Uncomfortable images generally have a particular spatial structure, which deviates from a reciprocal relationship between amplitude and spatial frequency (f) in the Fourier domain (1/f). Although flickering patterns with similar temporal structure also appear uncomfortable, the discomfort is affected by not only the amplitude spectrum but also the phase spectrum. Here we examined how discomfort from flicker with differing temporal profiles also varies as a function of the mean light level and luminance contrast of the stimulus. Participants were asked to rate discomfort for a 17° flickering uniform field at different light levels from scotopic to photopic. The flicker waveform was varied with a square wave or random phase spectrum and filtered by modulating the slope of the amplitude spectrum relative to 1/f. At photopic levels, the 1/f square wave flicker appeared most comfortable, whereas the discomfort from the random flicker increased monotonically as the slope of the amplitude spectrum decreased. This special status for the 1/f square wave condition was limited to photopic light levels. At the lower mesopic or scotopic levels, the effect of phase spectrum on the discomfort was diminished, with both phase spectra showing a monotonic change with the slope of the amplitude spectrum. We show that these changes cannot be accounted for by changes in the effective luminance contrast of the stimuli or by the responses from a linear model based on the temporal impulse responses under different light levels. However, discomfort from flicker is robustly correlated with judgments of the perceived naturalness of flicker across different contrasts and mean luminance levels.
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http://dx.doi.org/10.1016/j.visres.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311306PMC
August 2020

Remote Ischemic Conditioning for Intracerebral Hemorrhage (RICH-1): Rationale and Study Protocol for a Pilot Open-Label Randomized Controlled Trial.

Front Neurol 2020 28;11:313. Epub 2020 Apr 28.

Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Although many therapies have been investigated for intracerebral hemorrhage (ICH), none have succeeded in improving the functional outcomes. Remote ischemic conditioning (RIC) has been proven to promote hematoma resolution and improve neurological outcomes in an ICH model; whether it is safe and feasible in patients with ICH remains unknown. This trial aims to assess the safety, feasibility, and preliminary efficacy of RIC in patients with ICH and to plan for a phase-2 study. A proof-of-concept, assessor-blinded, pilot open-label randomized controlled trial will be carried out with patients with ICH within 24-48 h of ictus. All participants will be randomly allocated to the intervention group and the control group with a 1:1 ratio ( = 20) and will be treated with standard managements according to the guidelines. Participants allocated to the intervention group will receive RIC once daily for 7 consecutive days. Cranial computed tomography examinations will be performed at baseline, and on days 3, 7, and 14. Neurological outcomes will be assessed at baseline, and on days 1 to 14, 30, and 90. The primary outcome to be tested is safety. Secondary tested outcomes include changes of hematoma and perihematomal edema volume, incidence of hematoma expansion, functional outcomes, and frequency of adverse events. This study will be the first proof-of-concept randomized controlled trial to ascertain the safety, feasibility, and preliminary efficacy of RIC in patients with ICH, results of which will provide parameters for future studies and provide insights into the treatment of ICH. Clinicaltrials.gov, identifier: NCT03930940.
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http://dx.doi.org/10.3389/fneur.2020.00313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198786PMC
April 2020

Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study.

Diabetes Care 2020 07 14;43(7):1382-1391. Epub 2020 May 14.

Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China

Objective: Diabetes is common in COVID-19 patients and associated with unfavorable outcomes. We aimed to describe the characteristics and outcomes and to analyze the risk factors for in-hospital mortality of COVID-19 patients with diabetes.

Research Design And Methods: This two-center retrospective study was performed at two tertiary hospitals in Wuhan, China. Confirmed COVID-19 patients with diabetes ( = 153) who were discharged or died from 1 January 2020 to 8 March 2020 were identified. One sex- and age-matched COVID-19 patient without diabetes was randomly selected for each patient with diabetes. Demographic, clinical, and laboratory data were abstracted. Cox proportional hazards regression analyses were performed to identify the risk factors associated with the mortality in these patients.

Results: Of 1,561 COVID-19 patients, 153 (9.8%) had diabetes, with a median age of 64.0 (interquartile range 56.0-72.0) years. A higher proportion of intensive care unit admission (17.6% vs. 7.8%, = 0.01) and more fatal cases (20.3% vs. 10.5%, = 0.017) were identified in COVID-19 patients with diabetes than in the matched patients. Multivariable Cox regression analyses of these 306 patients showed that hypertension (hazard ratio [HR] 2.50, 95% CI 1.30-4.78), cardiovascular disease (HR 2.24, 95% CI 1.19-4.23), and chronic pulmonary disease (HR 2.51, 95% CI 1.07-5.90) were independently associated with in-hospital death. Diabetes (HR 1.58, 95% CI 0.84-2.99) was not statistically significantly associated with in-hospital death after adjustment. Among patients with diabetes, nonsurvivors were older (76.0 vs. 63.0 years), most were male (71.0% vs. 29.0%), and they were more likely to have underlying hypertension (83.9% vs. 50.0%) and cardiovascular disease (45.2% vs. 14.8%) (all values <0.05). Age ≥70 years (HR 2.39, 95% CI 1.03-5.56) and hypertension (HR 3.10, 95% CI 1.14-8.44) were independent risk factors for in-hospital death of patients with diabetes.

Conclusions: COVID-19 patients with diabetes had worse outcomes compared with the sex- and age-matched patients without diabetes. Older age and comorbid hypertension independently contributed to in-hospital death of patients with diabetes.
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http://dx.doi.org/10.2337/dc20-0598DOI Listing
July 2020

Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism.

J Med Genet 2021 01 10;58(1):66-72. Epub 2020 May 10.

Central South University School of Life Sciences, Changsha, Hunan, China

Background: FGF8-FGFR1 signalling is involved in multiple biological processes, while impairment of this signalling is one of the main reasons for isolated hypogonadotropic hypogonadism (IHH). Recently, several negative modulators of FGF8-FGFR1 signalling were also found to be involved in IHH, including , , and . The aim of this study was to investigate the genotypic and phenotypic spectra of these genes in a large cohort of Chinese patients with IHH.

Methods: A total of 196 patients with IHH were enrolled in this study. Whole-exome sequencing was performed to identify variants, which was verified by PCR and Sanger sequencing.

Results: Four heterozygous variants (p.S157I, p.R83Q, p.P188L and p.N355I) were found in six patients. Cryptorchidism, dental agenesis, syndactyly and blue colour blindness were commonly observed in patients with mutations. Six heterozygous variants (p.P191L, p.G35V, p.S671L, p.A221T, p.I329M and p.I329V) were found in seven patients. Segregation analysis indicated that 100% (5/5) of probands inherited the variants from their unaffected parents, and oligogenicity was found in 4/7 patients. One rare variant (p.T68S) was found in a female patient with Kallmann syndrome who also carried a mutation.

Conclusion: Our study greatly enriched the genotypic and phenotypic spectra of , and in IHH. Mutations in alone seem sufficient to cause IHH in an autosomal dominant manner, whereas or mutations may cause IHH phenotypes in synergy with variants in other IHH-associated genes.
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http://dx.doi.org/10.1136/jmedgenet-2019-106786DOI Listing
January 2021

A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host-guest crosslinker.

Biomater Sci 2020 Jun 6;8(12):3359-3369. Epub 2020 May 6.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Meilong Road No. 130, Shanghai 200237, People's Republic of China.

Supramolecular hydrogels based on host-guest interactions have drawn considerable attention due to their unique properties and promising applications. However, it is still a great challenge to construct supramolecular hydrogels that simultaneously achieve mechanical strength, processability, and biocompatibility. Herein, we present a rational design of a "supramolecular crosslinker" approach to fabricate a new host-guest hydrogel with super-stretchability, self-healing, and injectable properties and excellent biocompatibility. The star-shaped supramolecular crosslinker is formed by the host-guest interactions between octa-cyclodextrin polyhedral oligomeric silsesquioxane (OCDPOSS) and acrylamide-modified adamantane (Ad-AAm). Supramolecular hydrogels can be briefly prepared by UV-initiated copolymerization of acrylamide and supramolecular crosslinkers. Supramolecular hydrogels present impressive mechanical properties due to rigid POSS as the core of the supramolecular crosslinker. Moreover, multivalent host-guest interactions improve the ductility, rapid self-healing and injectable ability of these hydrogels. Simultaneously, these supramolecular hydrogels possess good biocompatibility and can be utilized as carriers for the sustained release of hydrophobic drugs. Thus, such supramolecular hydrogels will have potential applications for tissue engineering and drug delivery systems.
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http://dx.doi.org/10.1039/d0bm00290aDOI Listing
June 2020
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